JP2008512992A5 - - Google Patents
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- Publication number
- JP2008512992A5 JP2008512992A5 JP2007531547A JP2007531547A JP2008512992A5 JP 2008512992 A5 JP2008512992 A5 JP 2008512992A5 JP 2007531547 A JP2007531547 A JP 2007531547A JP 2007531547 A JP2007531547 A JP 2007531547A JP 2008512992 A5 JP2008512992 A5 JP 2008512992A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- subject
- tumor
- c57bl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 210000004881 tumor cell Anatomy 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 108010074860 Factor Xa Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 206010027476 Metastases Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000006907 apoptotic process Effects 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 230000009401 metastasis Effects 0.000 claims 4
- 230000000242 pagocytic effect Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000005189 Embolism Diseases 0.000 claims 2
- 206010061309 Neoplasm progression Diseases 0.000 claims 2
- 208000001435 Thromboembolism Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 230000023555 blood coagulation Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 230000002980 postoperative effect Effects 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 230000005747 tumor angiogenesis Effects 0.000 claims 2
- 230000005751 tumor progression Effects 0.000 claims 2
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000035602 clotting Effects 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0406057-1A BRPI0406057B1 (pt) | 2004-09-15 | 2004-09-15 | Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante |
| BRPI0406057-1 | 2004-09-15 | ||
| PCT/BR2005/000185 WO2006029492A1 (en) | 2004-09-15 | 2005-09-15 | Kunitz-type recombinant inhibitor. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008512992A JP2008512992A (ja) | 2008-05-01 |
| JP2008512992A5 true JP2008512992A5 (enExample) | 2008-10-30 |
| JP4980220B2 JP4980220B2 (ja) | 2012-07-18 |
Family
ID=36273230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531547A Expired - Lifetime JP4980220B2 (ja) | 2004-09-15 | 2005-09-15 | Ｋｕｎｉｔｚ型組換え阻害因子 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8440795B2 (enExample) |
| EP (1) | EP1799707B1 (enExample) |
| JP (1) | JP4980220B2 (enExample) |
| CN (1) | CN101142232B (enExample) |
| AU (1) | AU2005284615B2 (enExample) |
| BR (1) | BRPI0406057B1 (enExample) |
| CA (2) | CA2581001C (enExample) |
| DK (1) | DK1799707T3 (enExample) |
| ES (1) | ES2410160T3 (enExample) |
| WO (1) | WO2006029492A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008109976A1 (en) * | 2007-03-14 | 2008-09-18 | União Química Farmacêutica Nacional S/A | Kunitz-type recombinant inhibitor |
| BRPI0406057B1 (pt) | 2004-09-15 | 2021-10-26 | União Química Farmacêutica Nacional S/A | Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante |
| NZ593815A (en) | 2008-12-19 | 2013-05-31 | Tissue factor pathway inhibitor (tfpi) inhibitors and methods of use | |
| US8772238B2 (en) | 2009-03-18 | 2014-07-08 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer |
| BR102018074043A2 (pt) * | 2018-11-22 | 2020-06-02 | Inst Butantan | composto para a modulação de vias de rlr, tlr, oas e/ou oncostatina m, uso do mesmo para a preparação de um medicamento, composição e método para modulação das ditas vias |
| BR102018074037A2 (pt) * | 2018-11-22 | 2021-05-11 | Inst Butantan | composto para direcionar entidades moleculares para o domínio intracelular de células neoplásicas, ingrediente farmacêutico ativo compreendendo o referido composto, composição farmacêutica, método para o diagnóstico, prognóstico e/ou tratamento de câncer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3006207C2 (de) * | 1980-02-15 | 1982-10-21 | Siemens AG, 1000 Berlin und 8000 München | Elektrische Maschine mit einem Ständerblechpaket aus kornorientierten Blechen |
| DE3819078A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie |
| BRPI0406057B1 (pt) | 2004-09-15 | 2021-10-26 | União Química Farmacêutica Nacional S/A | Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante |
-
2004
- 2004-09-15 BR BRPI0406057-1A patent/BRPI0406057B1/pt not_active IP Right Cessation
-
2005
- 2005-09-15 AU AU2005284615A patent/AU2005284615B2/en not_active Ceased
- 2005-09-15 CN CN2005800389926A patent/CN101142232B/zh not_active Expired - Fee Related
- 2005-09-15 JP JP2007531547A patent/JP4980220B2/ja not_active Expired - Lifetime
- 2005-09-15 ES ES05782904T patent/ES2410160T3/es not_active Expired - Lifetime
- 2005-09-15 DK DK05782904.6T patent/DK1799707T3/da active
- 2005-09-15 WO PCT/BR2005/000185 patent/WO2006029492A1/en not_active Ceased
- 2005-09-15 EP EP05782904A patent/EP1799707B1/en not_active Expired - Lifetime
- 2005-09-15 CA CA2581001A patent/CA2581001C/en not_active Expired - Lifetime
-
2007
- 2007-03-14 US US11/724,557 patent/US8440795B2/en not_active Expired - Fee Related
-
2008
- 2008-03-14 CA CA002680759A patent/CA2680759A1/en not_active Abandoned
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