CN101142232B - Kunitz型重组抑制剂 - Google Patents

Kunitz型重组抑制剂 Download PDF

Info

Publication number
CN101142232B
CN101142232B CN2005800389926A CN200580038992A CN101142232B CN 101142232 B CN101142232 B CN 101142232B CN 2005800389926 A CN2005800389926 A CN 2005800389926A CN 200580038992 A CN200580038992 A CN 200580038992A CN 101142232 B CN101142232 B CN 101142232B
Authority
CN
China
Prior art keywords
polypeptide
medicine
purposes
preparation
experimenter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800389926A
Other languages
English (en)
Chinese (zh)
Other versions
CN101142232A (zh
Inventor
安娜·玛丽莎·朱德津斯基-塔瓦西
D·A·玛丽亚
I·d·F·C·巴蒂斯塔
P·L·何
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sao Paulo State Support Research Foundation
UNIAO QUIMICA FARMACEUTICA NAC
Original Assignee
Sao Paulo State Support Research Foundation
UNIAO QUIMICA FARMACEUTICA NAC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sao Paulo State Support Research Foundation, UNIAO QUIMICA FARMACEUTICA NAC filed Critical Sao Paulo State Support Research Foundation
Publication of CN101142232A publication Critical patent/CN101142232A/zh
Application granted granted Critical
Publication of CN101142232B publication Critical patent/CN101142232B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43527—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from ticks

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN2005800389926A 2004-09-15 2005-09-15 Kunitz型重组抑制剂 Expired - Fee Related CN101142232B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
BRPI04060571 2004-09-15
BRPI0406057-1A BRPI0406057B1 (pt) 2004-09-15 2004-09-15 Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante
BRPI0406057-1 2004-09-15
PCT/BR2005/000185 WO2006029492A1 (en) 2004-09-15 2005-09-15 Kunitz-type recombinant inhibitor.

Publications (2)

Publication Number Publication Date
CN101142232A CN101142232A (zh) 2008-03-12
CN101142232B true CN101142232B (zh) 2013-03-13

Family

ID=36273230

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800389926A Expired - Fee Related CN101142232B (zh) 2004-09-15 2005-09-15 Kunitz型重组抑制剂

Country Status (10)

Country Link
US (1) US8440795B2 (enExample)
EP (1) EP1799707B1 (enExample)
JP (1) JP4980220B2 (enExample)
CN (1) CN101142232B (enExample)
AU (1) AU2005284615B2 (enExample)
BR (1) BRPI0406057B1 (enExample)
CA (2) CA2581001C (enExample)
DK (1) DK1799707T3 (enExample)
ES (1) ES2410160T3 (enExample)
WO (1) WO2006029492A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109976A1 (en) * 2007-03-14 2008-09-18 União Química Farmacêutica Nacional S/A Kunitz-type recombinant inhibitor
BRPI0406057B1 (pt) 2004-09-15 2021-10-26 União Química Farmacêutica Nacional S/A Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante
NZ593815A (en) 2008-12-19 2013-05-31 Tissue factor pathway inhibitor (tfpi) inhibitors and methods of use
US8772238B2 (en) 2009-03-18 2014-07-08 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer
BR102018074043A2 (pt) * 2018-11-22 2020-06-02 Inst Butantan composto para a modulação de vias de rlr, tlr, oas e/ou oncostatina m, uso do mesmo para a preparação de um medicamento, composição e método para modulação das ditas vias
BR102018074037A2 (pt) * 2018-11-22 2021-05-11 Inst Butantan composto para direcionar entidades moleculares para o domínio intracelular de células neoplásicas, ingrediente farmacêutico ativo compreendendo o referido composto, composição farmacêutica, método para o diagnóstico, prognóstico e/ou tratamento de câncer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672252A (en) * 1980-02-15 1987-06-09 Siemens Aktiengesellschaft Electrical machine with a stator lamination of grain-oriented sheets

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819078A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie
BRPI0406057B1 (pt) 2004-09-15 2021-10-26 União Química Farmacêutica Nacional S/A Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4672252A (en) * 1980-02-15 1987-06-09 Siemens Aktiengesellschaft Electrical machine with a stator lamination of grain-oriented sheets

Also Published As

Publication number Publication date
BRPI0406057B1 (pt) 2021-10-26
CA2581001C (en) 2011-05-03
US20090042786A1 (en) 2009-02-12
ES2410160T3 (es) 2013-07-01
WO2006029492A1 (en) 2006-03-23
DK1799707T3 (da) 2013-05-21
CN101142232A (zh) 2008-03-12
BRPI0406057A (pt) 2006-05-02
JP2008512992A (ja) 2008-05-01
AU2005284615A1 (en) 2006-03-23
JP4980220B2 (ja) 2012-07-18
US8440795B2 (en) 2013-05-14
CA2680759A1 (en) 2008-09-18
AU2005284615B2 (en) 2011-03-31
EP1799707A1 (en) 2007-06-27
CA2581001A1 (en) 2006-03-23
EP1799707B1 (en) 2013-03-27

Similar Documents

Publication Publication Date Title
Silverman et al. Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis
Jia et al. Function of disintegrin-like/cysteine-rich domains of atrolysin A: inhibition of platelet aggregation by recombinant protein and peptide antagonists
Beauchamp et al. Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation
Roberts et al. Molecular biology and biochemistry of the coagulation factors and pathways of hemostasis
Björk et al. Antithrombin: A bloody important serpin
US6689582B1 (en) Polynucleotide molecules encoding proteins having proteinase inhibitor activity
ES2537328T3 (es) Polipéptidos de factor VII modificados y usos de los mismos
Jiang et al. Three pairs of protease-serpin complexes cooperatively regulate the insect innate immune responses
Bovenschen et al. Orphan granzymes find a home
Mende et al. Dipetalogastin, a potent thrombin inhibitor from the blood‐sucking insectDipetalogaster maximus: cDNA cloning, expression and characterization
Hou et al. MMP-12 activates protease-activated receptor-1, upregulates placenta growth factor, and leads to pulmonary emphysema
Batista et al. A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition
US8440795B2 (en) Kunitz-type recombinant inhibitor
Sajevic et al. VaH3, one of the principal hemorrhagins in Vipera ammodytes ammodytes venom, is a homodimeric P-IIIc metalloproteinase
Dekhil et al. Molecular cloning and expression of a functional snake venom serine proteinase, with platelet aggregating activity, from the Cerastes cerastes viper
Le et al. Gene duplication of coagulation factor V and origin of venom prothrombin activator in Pseudonaja textilis snake
Li et al. LCTX-F2, a novel potentiator of coagulation factors from the spider venom of Lycosa singoriensis
JP2002524076A (ja) ＫｕｎｉｔｚドメインポリペプチドＺＫＵＮ６
Hakim et al. Discoveries of serine protease inhibitors from scorpions
EP2134843A1 (en) Kunitz-type recombinant inhibitor
CN100494366C (zh) 血凝酶
WO2001064888A2 (en) Kunitz domain polypeptide zkun8
Zagariya et al. Characterization of serine/cysteine protease inhibitor α1‐antitripsin from meconium‐instilled rabbit lungs
CN106928334A (zh) 约安巨马陆抗血栓肽Joannsin及其应用
US20040229312A1 (en) Engineered human kunitz-type protease inhibitor

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130313

CF01 Termination of patent right due to non-payment of annual fee