JP4980220B2 - Kunitz型組換え阻害因子 - Google Patents
Kunitz型組換え阻害因子 Download PDFInfo
- Publication number
- JP4980220B2 JP4980220B2 JP2007531547A JP2007531547A JP4980220B2 JP 4980220 B2 JP4980220 B2 JP 4980220B2 JP 2007531547 A JP2007531547 A JP 2007531547A JP 2007531547 A JP2007531547 A JP 2007531547A JP 4980220 B2 JP4980220 B2 JP 4980220B2
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- tumor
- composition according
- cells
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43527—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from ticks
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Insects & Arthropods (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0406057-1A BRPI0406057B1 (pt) | 2004-09-15 | 2004-09-15 | Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante |
| BRPI0406057-1 | 2004-09-15 | ||
| PCT/BR2005/000185 WO2006029492A1 (en) | 2004-09-15 | 2005-09-15 | Kunitz-type recombinant inhibitor. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008512992A JP2008512992A (ja) | 2008-05-01 |
| JP2008512992A5 JP2008512992A5 (enExample) | 2008-10-30 |
| JP4980220B2 true JP4980220B2 (ja) | 2012-07-18 |
Family
ID=36273230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531547A Expired - Lifetime JP4980220B2 (ja) | 2004-09-15 | 2005-09-15 | Kunitz型組換え阻害因子 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8440795B2 (enExample) |
| EP (1) | EP1799707B1 (enExample) |
| JP (1) | JP4980220B2 (enExample) |
| CN (1) | CN101142232B (enExample) |
| AU (1) | AU2005284615B2 (enExample) |
| BR (1) | BRPI0406057B1 (enExample) |
| CA (2) | CA2581001C (enExample) |
| DK (1) | DK1799707T3 (enExample) |
| ES (1) | ES2410160T3 (enExample) |
| WO (1) | WO2006029492A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008109976A1 (en) * | 2007-03-14 | 2008-09-18 | União Química Farmacêutica Nacional S/A | Kunitz-type recombinant inhibitor |
| BRPI0406057B1 (pt) | 2004-09-15 | 2021-10-26 | União Química Farmacêutica Nacional S/A | Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante |
| NZ593815A (en) | 2008-12-19 | 2013-05-31 | Tissue factor pathway inhibitor (tfpi) inhibitors and methods of use | |
| US8772238B2 (en) | 2009-03-18 | 2014-07-08 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of ixolaris, a tissue factor inhibitor, for the treatment of cancer |
| BR102018074043A2 (pt) * | 2018-11-22 | 2020-06-02 | Inst Butantan | composto para a modulação de vias de rlr, tlr, oas e/ou oncostatina m, uso do mesmo para a preparação de um medicamento, composição e método para modulação das ditas vias |
| BR102018074037A2 (pt) * | 2018-11-22 | 2021-05-11 | Inst Butantan | composto para direcionar entidades moleculares para o domínio intracelular de células neoplásicas, ingrediente farmacêutico ativo compreendendo o referido composto, composição farmacêutica, método para o diagnóstico, prognóstico e/ou tratamento de câncer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3006207C2 (de) * | 1980-02-15 | 1982-10-21 | Siemens AG, 1000 Berlin und 8000 München | Elektrische Maschine mit einem Ständerblechpaket aus kornorientierten Blechen |
| DE3819078A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Amblyommin, ein neuer wirkstoff fuer die antikoagulationstherapie |
| BRPI0406057B1 (pt) | 2004-09-15 | 2021-10-26 | União Química Farmacêutica Nacional S/A | Sequência nucleotídica de um inibidor de proteases do tipo kunitz obtida a partir de uma biblioteca de cdna de glândulas salivarares de carrapatos amblyomma cajennese uso da proteína recombinante |
-
2004
- 2004-09-15 BR BRPI0406057-1A patent/BRPI0406057B1/pt not_active IP Right Cessation
-
2005
- 2005-09-15 AU AU2005284615A patent/AU2005284615B2/en not_active Ceased
- 2005-09-15 CN CN2005800389926A patent/CN101142232B/zh not_active Expired - Fee Related
- 2005-09-15 JP JP2007531547A patent/JP4980220B2/ja not_active Expired - Lifetime
- 2005-09-15 ES ES05782904T patent/ES2410160T3/es not_active Expired - Lifetime
- 2005-09-15 DK DK05782904.6T patent/DK1799707T3/da active
- 2005-09-15 WO PCT/BR2005/000185 patent/WO2006029492A1/en not_active Ceased
- 2005-09-15 EP EP05782904A patent/EP1799707B1/en not_active Expired - Lifetime
- 2005-09-15 CA CA2581001A patent/CA2581001C/en not_active Expired - Lifetime
-
2007
- 2007-03-14 US US11/724,557 patent/US8440795B2/en not_active Expired - Fee Related
-
2008
- 2008-03-14 CA CA002680759A patent/CA2680759A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0406057B1 (pt) | 2021-10-26 |
| CA2581001C (en) | 2011-05-03 |
| US20090042786A1 (en) | 2009-02-12 |
| ES2410160T3 (es) | 2013-07-01 |
| WO2006029492A1 (en) | 2006-03-23 |
| DK1799707T3 (da) | 2013-05-21 |
| CN101142232A (zh) | 2008-03-12 |
| BRPI0406057A (pt) | 2006-05-02 |
| JP2008512992A (ja) | 2008-05-01 |
| AU2005284615A1 (en) | 2006-03-23 |
| US8440795B2 (en) | 2013-05-14 |
| CA2680759A1 (en) | 2008-09-18 |
| AU2005284615B2 (en) | 2011-03-31 |
| EP1799707A1 (en) | 2007-06-27 |
| CA2581001A1 (en) | 2006-03-23 |
| EP1799707B1 (en) | 2013-03-27 |
| CN101142232B (zh) | 2013-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jiang et al. | Three pairs of protease-serpin complexes cooperatively regulate the insect innate immune responses | |
| JP4163517B2 (ja) | フォンビルブラント因子(vWF)切断酵素 | |
| Moreau et al. | Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family | |
| US6689582B1 (en) | Polynucleotide molecules encoding proteins having proteinase inhibitor activity | |
| JPH0584083A (ja) | 新規ポリペプチド、それをコードする新規dna、新規ポリペプチドの製造方法、新規医薬組成物、および新規酵素阻害方法 | |
| KR20030057545A (ko) | 잠복형 안티트롬빈 iii의 제조방법 | |
| US8440795B2 (en) | Kunitz-type recombinant inhibitor | |
| KR100335536B1 (ko) | 트롬빈억제제 | |
| EP2970434B1 (en) | Dual reactivity potent kunitz inhibitor of fibrinolysis | |
| KR101296367B1 (ko) | 프로테아제 억제 단백질 및 그 이용 | |
| JP2011506489A (ja) | 止血をモジュレートする組成物およびその使用法 | |
| WO2007101602A9 (en) | Chimeric kunitz domains and their use | |
| CN106432483A (zh) | 沼水蛙皮肤丝氨酸蛋白酶抑制肽及其基因和制药应用 | |
| AU2008226358A1 (en) | Kunitz-type recombinant inhibitor | |
| CN100494366C (zh) | 血凝酶 | |
| US8106002B2 (en) | Anti-cancer agent comprising protein C inhibitor | |
| CN106928334A (zh) | 约安巨马陆抗血栓肽Joannsin及其应用 | |
| CN1298743C (zh) | 一种融合蛋白及其编码基因与应用 | |
| CN100480264C (zh) | 一种广谱抑制癌细胞生长的蚯蚓蛋白及其编码序列 | |
| WO2009030093A1 (fr) | Fonctions et utilisations de l'inhibiteur 2 de la protéine phosphatase 1 humaine | |
| TW200846356A (en) | Preparation and use of variants of the kunitz domain 2 of the human placental bikunin gene | |
| CN100389125C (zh) | 无指盘臭蛙丙精肽、基因和变异体 | |
| CN102924606A (zh) | 靶向肿瘤细胞抗肿瘤溶栓双效嵌合蛋白及其制备方法和应用 | |
| WO2009123573A1 (en) | Anticoagulants derived from naja nigricollis snake venom | |
| JPH07242700A (ja) | 新規ポリペプチド |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080910 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080910 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110524 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110818 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110825 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111116 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120403 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120418 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150427 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4980220 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |