JP2004533848A5 - - Google Patents

Info

Publication number

JP2004533848A5

JP2004533848A5 JP2003512404A JP2003512404A JP2004533848A5 JP 2004533848 A5 JP2004533848 A5 JP 2004533848A5 JP 2003512404 A JP2003512404 A JP 2003512404A JP 2003512404 A JP2003512404 A JP 2003512404A JP 2004533848 A5 JP2004533848 A5 JP 2004533848A5

Authority

JP

Japan

Prior art keywords

polypeptide

polynucleotide

human aminopeptidase

activity

aminopeptidase

Prior art date

2002-06-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 28
• 229920001184 polypeptide Polymers 0.000 claims 27
• 102000004196 processed proteins & peptides Human genes 0.000 claims 27
• 108090000765 processed proteins & peptides Proteins 0.000 claims 27
• 102000040430 polynucleotide Human genes 0.000 claims 21
• 108091033319 polynucleotide Proteins 0.000 claims 21
• 239000002157 polynucleotide Substances 0.000 claims 21
• 230000000694 effects Effects 0.000 claims 14
• 238000000034 method Methods 0.000 claims 11
• 150000001875 compounds Chemical class 0.000 claims 8
• 239000003153 chemical reaction reagent Substances 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 239000012472 biological sample Substances 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 239000013604 expression vector Substances 0.000 claims 4
• 239000000126 substance Substances 0.000 claims 4
• 230000007423 decrease Effects 0.000 claims 3
• 238000009396 hybridization Methods 0.000 claims 3
• 238000012216 screening Methods 0.000 claims 3
• 229940124597 therapeutic agent Drugs 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 108090000915 Aminopeptidases Proteins 0.000 claims 1
• 102000004400 Aminopeptidases Human genes 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 238000009007 Diagnostic Kit Methods 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 208000015114 central nervous system disease Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000002068 genetic effect Effects 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1