JP2004531226A5 - - Google Patents

Info

Publication number

JP2004531226A5

JP2004531226A5 JP2002559589A JP2002559589A JP2004531226A5 JP 2004531226 A5 JP2004531226 A5 JP 2004531226A5 JP 2002559589 A JP2002559589 A JP 2002559589A JP 2002559589 A JP2002559589 A JP 2002559589A JP 2004531226 A5 JP2004531226 A5 JP 2004531226A5

Authority

JP

Japan

Prior art keywords

serotonin

protein

coupled receptor

polynucleotide

activity

Prior art date

2002-01-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 28
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 28
• 102000040430 polynucleotide Human genes 0.000 claims 22
• 108091033319 polynucleotide Proteins 0.000 claims 22
• 239000002157 polynucleotide Substances 0.000 claims 22
• 229920001184 polypeptide Polymers 0.000 claims 21
• 102000004196 processed proteins & peptides Human genes 0.000 claims 21
• 108090000765 processed proteins & peptides Proteins 0.000 claims 21
• 230000000694 effects Effects 0.000 claims 14
• 238000000034 method Methods 0.000 claims 10
• 150000001875 compounds Chemical class 0.000 claims 9
• 239000000126 substance Substances 0.000 claims 7
• 239000003153 chemical reaction reagent Substances 0.000 claims 5
• 239000012472 biological sample Substances 0.000 claims 4
• 230000007423 decrease Effects 0.000 claims 4
• 239000013604 expression vector Substances 0.000 claims 4
• 230000001225 therapeutic effect Effects 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 238000009396 hybridization Methods 0.000 claims 3
• 238000012216 screening Methods 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 208000019838 Blood disease Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 238000009007 Diagnostic Kit Methods 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 208000012931 Urologic disease Diseases 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 238000004113 cell culture Methods 0.000 claims 1
• 208000015114 central nervous system disease Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000002068 genetic effect Effects 0.000 claims 1
• 208000019622 heart disease Diseases 0.000 claims 1
• 208000014951 hematologic disease Diseases 0.000 claims 1
• 208000018706 hematopoietic system disease Diseases 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 208000014001 urinary system disease Diseases 0.000 claims 1