JP2008529536A5 - - Google Patents

Info

Publication number

JP2008529536A5

JP2008529536A5 JP2007555366A JP2007555366A JP2008529536A5 JP 2008529536 A5 JP2008529536 A5 JP 2008529536A5 JP 2007555366 A JP2007555366 A JP 2007555366A JP 2007555366 A JP2007555366 A JP 2007555366A JP 2008529536 A5 JP2008529536 A5 JP 2008529536A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

complement factor

cfh

composition

Prior art date

2006-02-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 108010053085 Complement Factor H Proteins 0.000 claims 54
• 102100035432 Complement factor H Human genes 0.000 claims 49
• 229920001184 polypeptide Polymers 0.000 claims 35
• 102000004196 processed proteins & peptides Human genes 0.000 claims 35
• 108090000765 processed proteins & peptides Proteins 0.000 claims 35
• 206010064930 age-related macular degeneration Diseases 0.000 claims 26
• 208000002780 macular degeneration Diseases 0.000 claims 26
• 239000000203 mixture Substances 0.000 claims 20
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 18
• 238000000034 method Methods 0.000 claims 10
• 229960000310 isoleucine Drugs 0.000 claims 9
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 9
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 8
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 7
• 150000001413 amino acids Chemical group 0.000 claims 7
• 239000003814 drug Substances 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 5
• 108010078015 Complement C3b Proteins 0.000 claims 4
• 108020004459 Small interfering RNA Proteins 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 102000054766 genetic haplotypes Human genes 0.000 claims 4
• 108091033319 polynucleotide Proteins 0.000 claims 4
• 102000040430 polynucleotide Human genes 0.000 claims 4
• 239000002157 polynucleotide Substances 0.000 claims 4
• 210000003583 retinal pigment epithelium Anatomy 0.000 claims 4
• 239000000523 sample Substances 0.000 claims 4
• 239000004055 small Interfering RNA Substances 0.000 claims 4
• 238000002360 preparation method Methods 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
• 108020005544 Antisense RNA Proteins 0.000 claims 2
• 102000016550 Complement Factor H Human genes 0.000 claims 2
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 239000003184 complementary RNA Substances 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 244000052769 pathogen Species 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 238000012216 screening Methods 0.000 claims 2
• 108700028369 Alleles Proteins 0.000 claims 1
• 101150030967 CFH gene Proteins 0.000 claims 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
• 230000003321 amplification Effects 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000003199 nucleic acid amplification method Methods 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 230000037452 priming Effects 0.000 claims 1
• 102220005747 rs1061170 Human genes 0.000 claims 1
• 102200031812 rs1065489 Human genes 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• 239000004474 valine Substances 0.000 claims 1