JP2007297407A5 - - Google Patents

Info

Publication number

JP2007297407A5

JP2007297407A5 JP2007196770A JP2007196770A JP2007297407A5 JP 2007297407 A5 JP2007297407 A5 JP 2007297407A5 JP 2007196770 A JP2007196770 A JP 2007196770A JP 2007196770 A JP2007196770 A JP 2007196770A JP 2007297407 A5 JP2007297407 A5 JP 2007297407A5

Authority

JP

Japan

Prior art keywords

presenilin

protein

sequence

amino acid

nucleic acid

Prior art date

2007-07-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010036908 Presenilin-2 Proteins 0.000 claims 28
• 102100022036 Presenilin-2 Human genes 0.000 claims 23
• 102000039446 nucleic acids Human genes 0.000 claims 20
• 108020004707 nucleic acids Proteins 0.000 claims 20
• 150000007523 nucleic acids Chemical class 0.000 claims 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims 19
• 239000013604 expression vector Substances 0.000 claims 16
• 108010050254 Presenilins Proteins 0.000 claims 12
• 102000015499 Presenilins Human genes 0.000 claims 10
• 230000035772 mutation Effects 0.000 claims 10
• 238000000034 method Methods 0.000 claims 9
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 150000001875 compounds Chemical class 0.000 claims 7
• 230000000692 anti-sense effect Effects 0.000 claims 6
• 235000018102 proteins Nutrition 0.000 claims 6
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 102100022033 Presenilin-1 Human genes 0.000 claims 4
• 108010036933 Presenilin-1 Proteins 0.000 claims 4
• 235000004279 alanine Nutrition 0.000 claims 4
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
• 241001465754 Metazoa Species 0.000 claims 3
• 235000001014 amino acid Nutrition 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 101000617546 Homo sapiens Presenilin-2 Proteins 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 102000055037 human PSEN2 Human genes 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 230000001105 regulatory effect Effects 0.000 claims 2
• 230000009261 transgenic effect Effects 0.000 claims 2
• 239000013598 vector Substances 0.000 claims 2
• 101100433464 African swine fever virus (strain Badajoz 1971 Vero-adapted) BA71V-013 gene Proteins 0.000 claims 1
• 108091026890 Coding region Proteins 0.000 claims 1
• 238000009007 Diagnostic Kit Methods 0.000 claims 1
• 108700026244 Open Reading Frames Proteins 0.000 claims 1
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000009396 hybridization Methods 0.000 claims 1
• 230000002779 inactivation Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102200001906 rs104894322 Human genes 0.000 claims 1
• 102200081526 rs121913583 Human genes 0.000 claims 1
• 102220324100 rs1555229716 Human genes 0.000 claims 1
• 102200136864 rs397516183 Human genes 0.000 claims 1
• 102200061617 rs63749836 Human genes 0.000 claims 1
• 102200061590 rs63749885 Human genes 0.000 claims 1
• 102200058106 rs63749967 Human genes 0.000 claims 1
• 102200058176 rs63750004 Human genes 0.000 claims 1
• 102200061599 rs63750053 Human genes 0.000 claims 1
• 102200061553 rs63750231 Human genes 0.000 claims 1
• 102200061555 rs63750231 Human genes 0.000 claims 1
• 102200061540 rs63750301 Human genes 0.000 claims 1
• 102200058165 rs63750306 Human genes 0.000 claims 1
• 102200058168 rs63750306 Human genes 0.000 claims 1
• 102200061534 rs63750526 Human genes 0.000 claims 1
• 102200061543 rs63750543 Human genes 0.000 claims 1
• 102200058171 rs63750590 Human genes 0.000 claims 1
• 102200058131 rs63750601 Human genes 0.000 claims 1
• 102200061473 rs63750646 Human genes 0.000 claims 1
• 102200061593 rs63750963 Human genes 0.000 claims 1
• 102200058150 rs63751106 Human genes 0.000 claims 1
• 102200061544 rs63751229 Human genes 0.000 claims 1
• 102200061551 rs63751235 Human genes 0.000 claims 1
• 102200061470 rs63751416 Human genes 0.000 claims 1
• 102200061526 rs63751420 Human genes 0.000 claims 1
• 102200061469 rs661 Human genes 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1