JP2011101650A5 - - Google Patents
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- Publication number
- JP2011101650A5 JP2011101650A5 JP2010282454A JP2010282454A JP2011101650A5 JP 2011101650 A5 JP2011101650 A5 JP 2011101650A5 JP 2010282454 A JP2010282454 A JP 2010282454A JP 2010282454 A JP2010282454 A JP 2010282454A JP 2011101650 A5 JP2011101650 A5 JP 2011101650A5
- Authority
- JP
- Japan
- Prior art keywords
- presenilin
- protein
- pharmaceutical preparation
- preparation
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010036908 Presenilin-2 Proteins 0.000 claims 43
- 102000012419 Presenilin-2 Human genes 0.000 claims 38
- 102100022033 Presenilin-1 Human genes 0.000 claims 37
- 108010036933 Presenilin-1 Proteins 0.000 claims 37
- 239000000825 pharmaceutical preparation Substances 0.000 claims 37
- 238000000034 method Methods 0.000 claims 18
- 238000002360 preparation method Methods 0.000 claims 17
- 239000003937 drug carrier Substances 0.000 claims 16
- 239000013604 expression vector Substances 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 102000015499 Presenilins Human genes 0.000 claims 10
- 108010050254 Presenilins Proteins 0.000 claims 10
- 235000018102 proteins Nutrition 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 230000000890 antigenic effect Effects 0.000 claims 9
- 230000000692 anti-sense effect Effects 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 101000617536 Homo sapiens Presenilin-1 Proteins 0.000 claims 4
- 101000617546 Homo sapiens Presenilin-2 Proteins 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 102000055060 human PSEN1 Human genes 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- 239000002299 complementary DNA Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002797 proteolythic effect Effects 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000002216 heart Anatomy 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- 210000002027 skeletal muscle Anatomy 0.000 claims 2
- 101100433464 African swine fever virus (strain Badajoz 1971 Vero-adapted) BA71V-013 gene Proteins 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 238000012408 PCR amplification Methods 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 102000055037 human PSEN2 Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102200001906 rs104894322 Human genes 0.000 claims 1
- 102220324100 rs1555229716 Human genes 0.000 claims 1
- 102200136864 rs397516183 Human genes 0.000 claims 1
- 102200061617 rs63749836 Human genes 0.000 claims 1
- 102200061590 rs63749885 Human genes 0.000 claims 1
- 102200058106 rs63749967 Human genes 0.000 claims 1
- 102200058176 rs63750004 Human genes 0.000 claims 1
- 102200061599 rs63750053 Human genes 0.000 claims 1
- 102200061553 rs63750231 Human genes 0.000 claims 1
- 102200061555 rs63750231 Human genes 0.000 claims 1
- 102200061540 rs63750301 Human genes 0.000 claims 1
- 102200058165 rs63750306 Human genes 0.000 claims 1
- 102200058168 rs63750306 Human genes 0.000 claims 1
- 102200061534 rs63750526 Human genes 0.000 claims 1
- 102200061543 rs63750543 Human genes 0.000 claims 1
- 102200058171 rs63750590 Human genes 0.000 claims 1
- 102200058131 rs63750601 Human genes 0.000 claims 1
- 102200061473 rs63750646 Human genes 0.000 claims 1
- 102200061593 rs63750963 Human genes 0.000 claims 1
- 102200058150 rs63751106 Human genes 0.000 claims 1
- 102200061547 rs63751139 Human genes 0.000 claims 1
- 102200061544 rs63751229 Human genes 0.000 claims 1
- 102200061551 rs63751235 Human genes 0.000 claims 1
- 102200061470 rs63751416 Human genes 0.000 claims 1
- 102200061526 rs63751420 Human genes 0.000 claims 1
- 102200061469 rs661 Human genes 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/431,048 | 1995-04-28 | ||
| US08/431,048 US6531586B1 (en) | 1995-04-28 | 1995-04-28 | Genetic sequences related to Alzheimer's Disease |
| US08/496,841 US6210919B1 (en) | 1995-04-28 | 1995-06-28 | Genetic sequences and proteins related to alzheimer's disease |
| US08/496,841 | 1995-06-28 | ||
| US50935995A | 1995-07-31 | 1995-07-31 | |
| US08/509,359 | 1995-07-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007196770A Division JP5053746B2 (ja) | 1995-04-28 | 2007-07-27 | アルツハイマー病に関連する遺伝子配列およびタンパク質、ならびにその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012282617A Division JP2013107890A (ja) | 1995-04-28 | 2012-12-26 | アルツハイマー病に関連する遺伝子配列およびタンパク質、ならびにその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011101650A JP2011101650A (ja) | 2011-05-26 |
| JP2011101650A5 true JP2011101650A5 (enExample) | 2011-11-10 |
| JP5379119B2 JP5379119B2 (ja) | 2013-12-25 |
Family
ID=44192304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010282454A Expired - Lifetime JP5379119B2 (ja) | 1995-04-28 | 2010-12-17 | アルツハイマー病に関連する遺伝子配列およびタンパク質、ならびにその使用 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5379119B2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4562145A1 (en) * | 2022-07-25 | 2025-06-04 | Vico Therapeutics B.V. | Antisense oligonucleotides for treating a disease or condition associated with an abnormal processing of app |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69635207T2 (de) * | 1995-07-07 | 2006-06-22 | Darwin Molecular Corp. | Auf Chromosom 1 lokalisiertes Gen dessen Genprodukt mit der Alzheimerschen Krankheit assoziiert ist. |
-
2010
- 2010-12-17 JP JP2010282454A patent/JP5379119B2/ja not_active Expired - Lifetime
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