JP2004511208A5 - - Google Patents

Info

Publication number

JP2004511208A5

JP2004511208A5 JP2001580948A JP2001580948A JP2004511208A5 JP 2004511208 A5 JP2004511208 A5 JP 2004511208A5 JP 2001580948 A JP2001580948 A JP 2001580948A JP 2001580948 A JP2001580948 A JP 2001580948A JP 2004511208 A5 JP2004511208 A5 JP 2004511208A5

Authority

JP

Japan

Prior art keywords

polynucleotide

seq

polypeptide

amino acid

acid sequence

Prior art date

2001-04-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 102000040430 polynucleotide Human genes 0.000 claims 139
• 108091033319 polynucleotide Proteins 0.000 claims 139
• 239000002157 polynucleotide Substances 0.000 claims 139
• 229920001184 polypeptide Polymers 0.000 claims 93
• 102000004196 processed proteins & peptides Human genes 0.000 claims 93
• 108090000765 processed proteins & peptides Proteins 0.000 claims 93
• 125000003275 alpha amino acid group Chemical group 0.000 claims 60
• 238000000034 method Methods 0.000 claims 26
• 150000001875 compounds Chemical class 0.000 claims 25
• 239000000523 sample Substances 0.000 claims 21
• 230000014509 gene expression Effects 0.000 claims 12
• 230000000694 effects Effects 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 9
• 238000012216 screening Methods 0.000 claims 9
• 239000012472 biological sample Substances 0.000 claims 8
• 238000009396 hybridization Methods 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 230000027455 binding Effects 0.000 claims 5
• 238000004519 manufacturing process Methods 0.000 claims 5
• 210000004027 cell Anatomy 0.000 claims 4
• 239000002773 nucleotide Substances 0.000 claims 4
• 125000003729 nucleotide group Chemical group 0.000 claims 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims 4
• 230000009870 specific binding Effects 0.000 claims 4
• 239000000556 agonist Substances 0.000 claims 3
• 239000005557 antagonist Substances 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 3
• 230000002163 immunogen Effects 0.000 claims 3
• 230000001988 toxicity Effects 0.000 claims 3
• 231100000419 toxicity Toxicity 0.000 claims 3
• 230000005875 antibody response Effects 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 238000002405 diagnostic procedure Methods 0.000 claims 2
• 210000004408 hybridoma Anatomy 0.000 claims 2
• 230000003053 immunization Effects 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 238000012408 PCR amplification Methods 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 210000000628 antibody-producing cell Anatomy 0.000 claims 1
• 230000002596 correlated effect Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 235000003869 genetically modified organism Nutrition 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 230000002018 overexpression Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1