JP2004513614A5 - - Google Patents
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- Publication number
- JP2004513614A5 JP2004513614A5 JP2002504278A JP2002504278A JP2004513614A5 JP 2004513614 A5 JP2004513614 A5 JP 2004513614A5 JP 2002504278 A JP2002504278 A JP 2002504278A JP 2002504278 A JP2002504278 A JP 2002504278A JP 2004513614 A5 JP2004513614 A5 JP 2004513614A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- polynucleotide
- seq
- antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000040430 polynucleotide Human genes 0.000 description 61
- 108091033319 polynucleotide Proteins 0.000 description 61
- 239000002157 polynucleotide Substances 0.000 description 61
- 229920001184 polypeptide Polymers 0.000 description 55
- 102000004196 processed proteins & peptides Human genes 0.000 description 55
- 108090000765 processed proteins & peptides Proteins 0.000 description 55
- 238000000034 method Methods 0.000 description 26
- 125000003275 alpha amino acid group Chemical group 0.000 description 24
- 150000001875 compounds Chemical class 0.000 description 23
- 239000000523 sample Substances 0.000 description 19
- 239000012634 fragment Substances 0.000 description 11
- 230000014509 gene expression Effects 0.000 description 11
- 239000012472 biological sample Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000009396 hybridization Methods 0.000 description 9
- 238000012216 screening Methods 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000027455 binding Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- 239000000556 agonist Substances 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000005875 antibody response Effects 0.000 description 2
- 210000000628 antibody-producing cell Anatomy 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21248300P | 2000-06-16 | 2000-06-16 | |
| US21395000P | 2000-06-23 | 2000-06-23 | |
| US21406200P | 2000-06-26 | 2000-06-26 | |
| US21659500P | 2000-07-07 | 2000-07-07 | |
| US21893600P | 2000-07-14 | 2000-07-14 | |
| US21915400P | 2000-07-19 | 2000-07-19 | |
| PCT/US2001/019354 WO2001098323A2 (en) | 2000-06-16 | 2001-06-15 | G-protein coupled receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004513614A JP2004513614A (ja) | 2004-05-13 |
| JP2004513614A5 true JP2004513614A5 (enExample) | 2008-04-17 |
Family
ID=27559053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002504278A Pending JP2004513614A (ja) | 2000-06-16 | 2001-06-15 | Ｇタンパク質結合受容体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040086877A1 (enExample) |
| EP (2) | EP1292678B8 (enExample) |
| JP (1) | JP2004513614A (enExample) |
| AT (1) | ATE432350T1 (enExample) |
| AU (1) | AU2001266975A1 (enExample) |
| CA (1) | CA2412484A1 (enExample) |
| DE (1) | DE60138808D1 (enExample) |
| WO (1) | WO2001098323A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201006846A (en) | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| JP2004515215A (ja) * | 2000-05-22 | 2004-05-27 | インサイト・ゲノミックス・インコーポレイテッド | Ｇタンパク質結合受容体 |
| US20030166845A1 (en) * | 2000-07-17 | 2003-09-04 | Muralidhara Padigaru | Novel proteins and nucleic acids encoding same |
| US20020160449A1 (en) * | 2000-07-27 | 2002-10-31 | Holloway James L. | Human vomeronasal receptor |
| TW201022287A (en) | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US7368285B2 (en) * | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| US7763431B1 (en) | 2001-03-07 | 2010-07-27 | Senomyx, Inc. | Binding assays that use the T1R2/T1R3 (sweet) taste receptor to identify compounds that elicit or modulate sweet taste |
| US20080244761A1 (en) | 2001-03-07 | 2008-10-02 | Senomyx, Inc. | T1r hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds |
| US7309577B2 (en) * | 2001-03-07 | 2007-12-18 | Senomyx, Inc. | Binding assays that use the T1R1/T1R3 (umami) taste receptor to identify compounds that elicit or modulate umami taste |
| US7301009B2 (en) | 2001-06-26 | 2007-11-27 | Senomyx, Inc. | Isolated (T1R1/T1R3) umami taste receptors that respond to umami taste stimuli |
| US7803982B2 (en) | 2001-04-20 | 2010-09-28 | The Mount Sinai School Of Medicine Of New York University | T1R3 transgenic animals, cells and related methods |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| US20040029789A1 (en) * | 2001-07-05 | 2004-02-12 | Anderson David W. | Novel proteins and nucleic acids encoding same |
| US20030143541A1 (en) * | 2001-12-27 | 2003-07-31 | Lakshmi Sangameswaran | Human pheromone receptors |
| EP1576141A4 (en) * | 2002-05-14 | 2006-03-22 | Bristol Myers Squibb Co | NEW HUMAN G-PROTEIN-COUPLED RECEPTORS CODING POLYNUCLEOTIDE AND SPLEISS VARIANTS THEREOF |
| US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| AU2580892A (en) | 1991-09-05 | 1993-04-05 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
| US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US5427942A (en) * | 1991-11-13 | 1995-06-27 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Human D5 dopamine recepltor gene and uses |
| US5840484A (en) | 1992-07-17 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| EP0748213B1 (en) | 1994-03-07 | 2004-04-14 | Nektar Therapeutics | Methods and compositions for pulmonary delivery of insulin |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| AUPM516994A0 (en) | 1994-04-20 | 1994-05-12 | Gene Shears Pty. Limited | An in vivo gene expression system |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5707618A (en) | 1995-03-24 | 1998-01-13 | Genzyme Corporation | Adenovirus vectors for gene therapy |
| US5767337A (en) | 1995-07-31 | 1998-06-16 | Duke University | Creation of human apolipoprotein E isoform specific transgenic mice in apolipoprotein deficient "knockout" mice |
| AU7450096A (en) * | 1995-10-19 | 1997-05-07 | Trustees Of Columbia University In The City Of New York, The | Cloning of vertebrate pheromone receptors and uses thereof |
| US5910434A (en) | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
| US6083693A (en) | 1996-06-14 | 2000-07-04 | Curagen Corporation | Identification and comparison of protein-protein interactions that occur in populations |
| US5891720A (en) * | 1997-04-17 | 1999-04-06 | Millennium Pharmaceuticals, Inc. | Isolated DNA encoding a novel human G-protein coupled receptor |
| EP0996635A4 (en) * | 1997-06-30 | 2003-08-27 | Harvard College | NEW FAMILY OF PHEROMONE RECEPTORS |
| US6093545A (en) * | 1997-12-04 | 2000-07-25 | Millennium Pharmaceuticals, Inc. | Methods for detecting nucleic acid molecules encoding a member of the muscarinic family of receptors |
| WO1999033978A1 (fr) * | 1997-12-26 | 1999-07-08 | Banyu Pharmaceutical Co., Ltd. | Nouvelles proteines receptrices du type conjugue guanosine triphosphate (gtp)-proteine de liaison |
| EP1690939B8 (en) * | 1998-03-12 | 2010-10-13 | Astellas Pharma Inc. | Novel G protein-coupled receptor proteins |
| US20020061522A1 (en) * | 2000-02-29 | 2002-05-23 | Glucksmann Maria Alexandra | 1983, 52881, 2398, 45449, 50289, and 52872 novel G protein-coupled receptors and uses therefor |
| AU4544999A (en) * | 1998-06-02 | 1999-12-20 | Millennium Pharmaceuticals, Inc. | G-protein coupled receptor, named 2871 receptor |
| CN1198836C (zh) * | 1998-07-28 | 2005-04-27 | 加利福尼亚大学董事会 | 编码与感觉转导有关的g－蛋白偶联受体的核酸 |
| WO2000055375A1 (en) * | 1999-03-17 | 2000-09-21 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
| WO2001025431A1 (en) * | 1999-10-01 | 2001-04-12 | The Rockefeller University | Primate, particularly human, vomeronasal-like receptor |
| US20030036089A1 (en) * | 1999-12-20 | 2003-02-20 | Applera Corporation | Isolated human G-protein coupled receptors, nucleic acid molecules encoding human GPCR proteins, and uses thereof |
| WO2001048189A1 (fr) * | 1999-12-28 | 2001-07-05 | Helix Research Institute | Nouveaux recepteurs couples a une proteine de liaison au guanosine triphosphate, genes de ces derniers, et production et utilisation de ces derniers |
| AU2001238347A1 (en) * | 2000-02-28 | 2001-09-12 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| TW201006846A (en) * | 2000-03-07 | 2010-02-16 | Senomyx Inc | T1R taste receptor and genes encidung same |
| AU2001249961A1 (en) * | 2000-04-11 | 2001-10-23 | Telecommunication Systems, Inc. | Individualized network information server |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
-
2001
- 2001-06-15 EP EP01944579A patent/EP1292678B8/en not_active Expired - Lifetime
- 2001-06-15 WO PCT/US2001/019354 patent/WO2001098323A2/en not_active Ceased
- 2001-06-15 CA CA002412484A patent/CA2412484A1/en not_active Abandoned
- 2001-06-15 EP EP09004715A patent/EP2093293A3/en not_active Withdrawn
- 2001-06-15 AT AT01944579T patent/ATE432350T1/de not_active IP Right Cessation
- 2001-06-15 AU AU2001266975A patent/AU2001266975A1/en not_active Abandoned
- 2001-06-15 US US10/311,196 patent/US20040086877A1/en not_active Abandoned
- 2001-06-15 DE DE60138808T patent/DE60138808D1/de not_active Expired - Lifetime
- 2001-06-15 JP JP2002504278A patent/JP2004513614A/ja active Pending
-
2007
- 2007-08-29 US US11/896,125 patent/US20080241158A1/en not_active Abandoned
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