JP2005522228A5 - - Google Patents

Info

Publication number

JP2005522228A5

JP2005522228A5 JP2003584732A JP2003584732A JP2005522228A5 JP 2005522228 A5 JP2005522228 A5 JP 2005522228A5 JP 2003584732 A JP2003584732 A JP 2003584732A JP 2003584732 A JP2003584732 A JP 2003584732A JP 2005522228 A5 JP2005522228 A5 JP 2005522228A5

Authority

JP

Japan

Prior art keywords

polypeptide

expression

nkcc1

nucleic acid

antibody

Prior art date

2003-04-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 229920001184 polypeptide Polymers 0.000 claims 20
• 102000004196 processed proteins & peptides Human genes 0.000 claims 20
• 108090000765 processed proteins & peptides Proteins 0.000 claims 20
• 239000000126 substance Substances 0.000 claims 16
• 102000047724 Member 2 Solute Carrier Family 12 Human genes 0.000 claims 14
• 108091006620 SLC12A2 Proteins 0.000 claims 14
• 108020004707 nucleic acids Proteins 0.000 claims 12
• 102000039446 nucleic acids Human genes 0.000 claims 12
• 150000007523 nucleic acids Chemical class 0.000 claims 12
• 206010006187 Breast cancer Diseases 0.000 claims 8
• 208000026310 Breast neoplasm Diseases 0.000 claims 8
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 8
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 8
• 201000005202 lung cancer Diseases 0.000 claims 8
• 208000020816 lung neoplasm Diseases 0.000 claims 8
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 8
• 238000000034 method Methods 0.000 claims 8
• 201000002528 pancreatic cancer Diseases 0.000 claims 8
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 8
• 230000000694 effects Effects 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 7
• 239000003153 chemical reaction reagent Substances 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 238000012216 screening Methods 0.000 claims 4
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 238000009007 Diagnostic Kit Methods 0.000 claims 2
• 108020004711 Nucleic Acid Probes Proteins 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 2
• 230000002946 anti-pancreatic effect Effects 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 231100000433 cytotoxic Toxicity 0.000 claims 2
• 230000001472 cytotoxic effect Effects 0.000 claims 2
• 238000001514 detection method Methods 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000012544 monitoring process Methods 0.000 claims 2
• 239000002853 nucleic acid probe Substances 0.000 claims 2
• 239000007790 solid phase Substances 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 238000012217 deletion Methods 0.000 claims 1
• 230000037430 deletion Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 230000001900 immune effect Effects 0.000 claims 1
• 238000003780 insertion Methods 0.000 claims 1
• 230000037431 insertion Effects 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 238000012986 modification Methods 0.000 claims 1
• 230000004048 modification Effects 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 238000012360 testing method Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1