JP2007523644A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007523644A5 JP2007523644A5 JP2006552204A JP2006552204A JP2007523644A5 JP 2007523644 A5 JP2007523644 A5 JP 2007523644A5 JP 2006552204 A JP2006552204 A JP 2006552204A JP 2006552204 A JP2006552204 A JP 2006552204A JP 2007523644 A5 JP2007523644 A5 JP 2007523644A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pla2
- sample
- enzymatically active
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000016752 1-Alkyl-2-acetylglycerophosphocholine Esterase Human genes 0.000 claims 30
- 108010024976 Asparaginase Proteins 0.000 claims 30
- 238000000034 method Methods 0.000 claims 27
- 239000000758 substrate Substances 0.000 claims 9
- 150000003573 thiols Chemical class 0.000 claims 8
- 239000011230 binding agent Substances 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 208000019553 vascular disease Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 230000002452 interceptive effect Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 102100026918 Phospholipase A2 Human genes 0.000 claims 1
- 101710096328 Phospholipase A2 Proteins 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000002823 phage display Methods 0.000 claims 1
- 0 C[N+](C)(C)CCOP([O-])(OC[C@@](CO*)*C(*Ic(cc1)ccc1[N+]([O-])=O)=O)=O Chemical compound C[N+](C)(C)CCOP([O-])(OC[C@@](CO*)*C(*Ic(cc1)ccc1[N+]([O-])=O)=O)=O 0.000 description 2
- YPPZOKNKENLFTE-AREMUKBSSA-N CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)SC(C)=O Chemical compound CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(OCC[N+](C)(C)C)=O)SC(C)=O YPPZOKNKENLFTE-AREMUKBSSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54158304P | 2004-02-03 | 2004-02-03 | |
| US60/541,583 | 2004-02-03 | ||
| PCT/US2005/003211 WO2005074604A2 (en) | 2004-02-03 | 2005-02-03 | METHODS OF DETECTING Lp-PLA2 ACTIVITY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011083991A Division JP2011177182A (ja) | 2004-02-03 | 2011-04-05 | Ｌｐ−ＰＬＡ２活性を検出する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007523644A JP2007523644A (ja) | 2007-08-23 |
| JP2007523644A5 true JP2007523644A5 (enExample) | 2008-03-21 |
| JP5155564B2 JP5155564B2 (ja) | 2013-03-06 |
Family
ID=34837507
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006552204A Expired - Fee Related JP5155564B2 (ja) | 2004-02-03 | 2005-02-03 | Ｌｐ−ＰＬＡ２活性を検出する方法 |
| JP2011083991A Ceased JP2011177182A (ja) | 2004-02-03 | 2011-04-05 | Ｌｐ−ＰＬＡ２活性を検出する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011083991A Ceased JP2011177182A (ja) | 2004-02-03 | 2011-04-05 | Ｌｐ−ＰＬＡ２活性を検出する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070281323A1 (enExample) |
| EP (2) | EP2280282A1 (enExample) |
| JP (2) | JP5155564B2 (enExample) |
| DK (1) | DK1718967T3 (enExample) |
| ES (1) | ES2416344T3 (enExample) |
| WO (1) | WO2005074604A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004026439D1 (de) | 2003-05-28 | 2010-05-20 | Glaxo Group Ltd | Lp-pla2-aktivitätstest mit hohem durchsatz |
| US20070166777A1 (en) * | 2004-04-16 | 2007-07-19 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
| US20150017671A1 (en) | 2004-04-16 | 2015-01-15 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
| EP2313778B1 (en) * | 2008-07-18 | 2015-01-28 | Boston Medical Center Corporation | Diagnostics for membranous nephropathy |
| EP2246440A1 (en) * | 2009-04-29 | 2010-11-03 | Aterovax | Enzymatic assay for the quantitative determination of phospholipase a1 or a2 activity in a sample |
| WO2012003475A1 (en) * | 2010-07-02 | 2012-01-05 | Bg Medicine, Inc. | Statin therapy monitored by galectin- 3 measurement |
| CN102692507B (zh) * | 2011-07-29 | 2015-09-16 | 南京诺尔曼生物技术有限公司 | 脂蛋白相关磷脂酶a2(lppla2)测定试剂盒(胶乳增强免疫比浊法) |
| CN103048457B (zh) * | 2012-11-27 | 2014-12-17 | 同昕生物技术（北京）有限公司 | 心肌梗死预警胶体金试剂盒及其制备方法 |
| US20140283157A1 (en) * | 2013-03-15 | 2014-09-18 | Diadexus, Inc. | Lipoprotein-associated phospholipase a2 antibody compositions and methods of use |
| CN104237517B (zh) * | 2013-06-18 | 2016-05-18 | 深圳市安群生物工程有限公司 | 检测人Lp-PLA2蛋白的荧光免疫层析试纸及其制备方法 |
| US20150086998A1 (en) * | 2013-09-24 | 2015-03-26 | Thomas D. Schaal | Value-assigned solutions of lipoprotein-associated phospholipase a2 having a long shelf-life |
| CN103792353B (zh) * | 2013-10-17 | 2015-07-15 | 武汉生之源生物科技有限公司 | 一种脂蛋白相关磷脂酶a2含量检测试剂盒及其制备方法 |
| WO2015058158A1 (en) * | 2013-10-18 | 2015-04-23 | Diadexus, Inc. | METHOD FOR DETECTION OF LIPOPROTEIN-SPECIFIC Lp-PLA2 ASSOCIATION |
| CN104634970B (zh) * | 2015-02-10 | 2017-04-05 | 深圳市新产业生物医学工程股份有限公司 | 用于检测脂蛋白相关磷脂酶a2的试剂盒及其制备和应用 |
| WO2016127319A1 (zh) | 2015-02-10 | 2016-08-18 | 深圳市新产业生物医学工程股份有限公司 | 用于检测脂蛋白相关磷脂酶a2的试剂盒及其制备和应用 |
| CN104820097A (zh) * | 2015-05-22 | 2015-08-05 | 北京协和洛克生物技术有限责任公司 | 一种定量检测样本中脂蛋白磷脂酶a2浓度的液态芯片试剂盒及其制备方法 |
| US11237167B2 (en) * | 2017-01-24 | 2022-02-01 | Cleveland Heartlab, Inc. | Lp-PLA2 assays and composition with detergent |
| CN109917131B (zh) * | 2019-03-26 | 2021-12-17 | 苏州博源医疗科技有限公司 | 一种脂蛋白磷脂酶a2检测试剂及其制备和使用方法 |
| CN111175242A (zh) * | 2020-03-17 | 2020-05-19 | 湖南新大陆生物技术有限公司 | 一种脂蛋白磷脂酶a2检测试剂盒及其应用 |
| CN111662387A (zh) * | 2020-07-14 | 2020-09-15 | 重庆中元汇吉生物技术有限公司 | 抗人脂蛋白相关磷脂酶a2单克隆抗体及其应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4925788A (en) | 1986-10-24 | 1990-05-15 | Immunicon Corporation | Immunoassay system and procedure based on precipitin-like interaction between immune complex and Clq or other non-immunospecific factor |
| US5108933A (en) | 1988-09-16 | 1992-04-28 | Immunicon Corporation | Manipulation of colloids for facilitating magnetic separations |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| US5186827A (en) | 1991-03-25 | 1993-02-16 | Immunicon Corporation | Apparatus for magnetic separation featuring external magnetic means |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| DE69233204T2 (de) | 1991-12-13 | 2004-07-15 | Xoma Corp., Berkeley | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
| EP0590327B1 (en) | 1992-09-11 | 2003-04-09 | F. Hoffmann-La Roche Ag | Detection of nucleic acids in blood |
| AU670108B2 (en) * | 1992-09-11 | 1996-07-04 | Becton Dickinson & Company | Improved antibodies to plasmodium falciparum |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| US5981252A (en) | 1993-06-25 | 1999-11-09 | Smithkline Beecham | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy |
| US5977308A (en) | 1993-10-06 | 1999-11-02 | Icos Corporation | Platelet-activating factor acetylhydrolase |
| DE69434609T2 (de) | 1993-10-06 | 2006-09-21 | Icos Corp., Bothell | Acethylhydrolase des Plättchen aktivierenden Faktors |
| US5847088A (en) | 1993-10-06 | 1998-12-08 | Icos Corporation | Antibodies specific for platelet-activating factor acetylhydrolase |
| US5656431A (en) | 1993-10-06 | 1997-08-12 | Icos Corporation | Platelet-activating factor acetylhydrolase |
| US6156504A (en) | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
| US6630301B1 (en) | 1997-03-14 | 2003-10-07 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum |
| US6013256A (en) | 1996-09-24 | 2000-01-11 | Protein Design Labs, Inc. | Method of preventing acute rejection following solid organ transplantation |
| EP1057024A4 (en) * | 1998-02-23 | 2002-10-30 | Diadexus Inc | METHOD FOR USING PLA 2? AS A METASTASE MARKER AND ASU-SELECTED CARCINOMAS FOR DIAGNOSIS |
| WO2000024910A1 (en) | 1998-10-28 | 2000-05-04 | Smithkline Beecham Plc | Process of purification of low density lipoprotein associated phospholipase a2 using immobilized metal affinity chromatography |
| EP1133523A1 (en) | 1998-11-16 | 2001-09-19 | Genway Biotech, Inc. | Generation of antibodies using polynucleotide vaccination in avian species |
| JP4220603B2 (ja) | 1998-12-02 | 2009-02-04 | アルフレッサファーマ株式会社 | 血小板活性化因子アセチルヒドロラーゼ活性の測定方法 |
| WO2000047998A1 (en) | 1999-02-10 | 2000-08-17 | Cell Works Inc. | Class characterization of circulating cancer cells isolated from body fluids and methods of use |
| JP2002051164A (ja) * | 2000-05-24 | 2002-02-15 | Victor Co Of Japan Ltd | 音声コンテンツ試聴システム及びシステムサーバ並びに携帯電話機 |
| DE50102625D1 (de) | 2001-12-07 | 2004-07-22 | Sirs Lab Gmbh | Verbindungen zur Bestimmung der Aktivität von Phospholipase A2 |
| DE602004026439D1 (de) | 2003-05-28 | 2010-05-20 | Glaxo Group Ltd | Lp-pla2-aktivitätstest mit hohem durchsatz |
-
2005
- 2005-02-03 DK DK05712595.7T patent/DK1718967T3/da active
- 2005-02-03 JP JP2006552204A patent/JP5155564B2/ja not_active Expired - Fee Related
- 2005-02-03 EP EP10185947A patent/EP2280282A1/en not_active Withdrawn
- 2005-02-03 ES ES05712595T patent/ES2416344T3/es not_active Expired - Lifetime
- 2005-02-03 US US10/588,339 patent/US20070281323A1/en not_active Abandoned
- 2005-02-03 EP EP05712595.7A patent/EP1718967B1/en not_active Expired - Lifetime
- 2005-02-03 WO PCT/US2005/003211 patent/WO2005074604A2/en not_active Ceased
-
2011
- 2011-04-05 JP JP2011083991A patent/JP2011177182A/ja not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007523644A5 (enExample) | ||
| US11927596B2 (en) | Assays for detecting the presence or amount of an anti-drug antibody | |
| Wang et al. | Competitive immunoassays for the detection of small molecules using single molecule arrays | |
| Kuznetsov et al. | On applicability of laccase as label in the mediated and mediatorless electroimmunoassay: effect of distance on the direct electron transfer between laccase and electrode | |
| Ferreira et al. | Disposable immunosensor using a simple method for oriented antibody immobilization for label-free real-time detection of an oxidative stress biomarker implicated in cancer diseases | |
| CN109661578A (zh) | 用于区分细菌和病毒感染的蛋白质特征 | |
| Spengler et al. | Highly sensitive ligand-binding assays in pre-clinical and clinical applications: immuno-PCR and other emerging techniques | |
| JP2024502865A (ja) | 標的被検体を検出するための方法、アッセイ及びシステム | |
| Kim et al. | Development of 6E3 antibody-mediated SERS immunoassay for drug-resistant influenza virus | |
| Ahmad et al. | An affordable label-free ultrasensitive immunosensor based on gold nanoparticles deposited on glassy carbon electrode for the transferrin receptor detection | |
| Mashazi et al. | Electrochemical impedimetric immunosensor for the detection of measles-specific IgG antibodies after measles infections | |
| Makower et al. | New principle of direct real-time monitoring of the interaction of cholinesterase and its inhibitors by piezolectric biosensor | |
| Kanungo et al. | Miniaturised hybrid immunoassay for high sensitivity analysis of aflatoxin M1 in milk | |
| Jarczewska et al. | Studies on the Affinity‐based Biosensors for Electrochemical Detection of HER2 Cancer Biomarker | |
| Watanabe et al. | The immune complex transfer enzyme immunoassay: Mechanism of improved sensitivity compared with conventional sandwich enzyme immunoassay | |
| JP2009109426A (ja) | 検体前処理液、ウイルス測定用キット及びウイルス検出方法 | |
| Zapatero-Rodríguez et al. | Detection of free prostate-specific antigen using a novel single-chain antibody (scAb)-based magneto-immunosensor | |
| Rafat et al. | Enhanced Enzymatically Amplified Metallization on Nanostructured Surfaces for Multiplexed Point‐of‐Care Electrical Detection of COVID‐19 Biomarkers | |
| JP2015505371A5 (enExample) | ||
| JP2022058435A (ja) | ウイルス抗原の血清学的検出方法 | |
| Gholami et al. | A paper-based optical sensor for the screening of viruses through the cysteine residues of their surface proteins: A proof of concept on the detection of coronavirus infection | |
| JP7216949B1 (ja) | 等電点９．５以上のタンパク質の免疫測定方法及びそれに用いる検体希釈液、並びにイムノクロマトグラフィーキット | |
| JP6366047B2 (ja) | 抗体抗原反応評価方法 | |
| Agafonova et al. | Quartz crystal microbalance for the cardiac markers/antibodies binding kinetic measurements in the plasma samples | |
| CN114624195A (zh) | 一种结合抗体的生物传感检测方法及检测系统 |