JP2005027667A5 - - Google Patents

Info

Publication number

JP2005027667A5

JP2005027667A5 JP2004186386A JP2004186386A JP2005027667A5 JP 2005027667 A5 JP2005027667 A5 JP 2005027667A5 JP 2004186386 A JP2004186386 A JP 2004186386A JP 2004186386 A JP2004186386 A JP 2004186386A JP 2005027667 A5 JP2005027667 A5 JP 2005027667A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

amino acid

antibody

acid sequence

Prior art date

2004-06-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920001184 polypeptide Polymers 0.000 claims 43
• 108090000765 processed proteins & peptides Proteins 0.000 claims 43
• 102000004196 processed proteins & peptides Human genes 0.000 claims 43
• 210000004027 cell Anatomy 0.000 claims 26
• 125000003275 alpha amino acid group Chemical group 0.000 claims 25
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 22
• 239000002773 nucleotide Substances 0.000 claims 21
• 125000003729 nucleotide group Chemical group 0.000 claims 21
• 208000037841 lung tumor Diseases 0.000 claims 12
• 210000004881 tumor cell Anatomy 0.000 claims 12
• 238000000034 method Methods 0.000 claims 11
• 150000007523 nucleic acids Chemical class 0.000 claims 11
• 210000004072 lung Anatomy 0.000 claims 10
• 108020004707 nucleic acids Proteins 0.000 claims 10
• 102000039446 nucleic acids Human genes 0.000 claims 10
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 9
• 208000015634 Rectal Neoplasms Diseases 0.000 claims 8
• 230000014509 gene expression Effects 0.000 claims 7
• 208000020816 lung neoplasm Diseases 0.000 claims 7
• 125000000539 amino acid group Chemical group 0.000 claims 6
• 208000013718 rectal benign neoplasm Diseases 0.000 claims 6
• 239000000523 sample Substances 0.000 claims 6
• 239000013598 vector Substances 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 241000124008 Mammalia Species 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 150000001875 compounds Chemical class 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 108091026890 Coding region Proteins 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000000074 antisense oligonucleotide Substances 0.000 claims 2
• 238000012230 antisense oligonucleotides Methods 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 238000004113 cell culture Methods 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 239000013068 control sample Substances 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 239000002254 cytotoxic agent Substances 0.000 claims 2
• 230000012010 growth Effects 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 230000004565 tumor cell growth Effects 0.000 claims 2
• 241000588724 Escherichia coli Species 0.000 claims 1
• 241000238631 Hexapoda Species 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
• 239000013599 cloning vector Substances 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 208000029742 colonic neoplasm Diseases 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 230000002018 overexpression Effects 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 241000701447 unidentified baculovirus Species 0.000 claims 1
• 210000005253 yeast cell Anatomy 0.000 claims 1