JP2005046146A5 - - Google Patents
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- Publication number
- JP2005046146A5 JP2005046146A5 JP2004212340A JP2004212340A JP2005046146A5 JP 2005046146 A5 JP2005046146 A5 JP 2005046146A5 JP 2004212340 A JP2004212340 A JP 2004212340A JP 2004212340 A JP2004212340 A JP 2004212340A JP 2005046146 A5 JP2005046146 A5 JP 2005046146A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- cell
- antibody
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 41
- 229920001184 polypeptide Polymers 0.000 claims 40
- 102000004196 processed proteins & peptides Human genes 0.000 claims 40
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 29
- 102000039446 nucleic acids Human genes 0.000 claims 29
- 210000004027 cell Anatomy 0.000 claims 23
- 239000013598 vector Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 210000001043 capillary endothelial cell Anatomy 0.000 claims 8
- 230000035755 proliferation Effects 0.000 claims 8
- 230000001177 retroviral effect Effects 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 230000001780 adrenocortical effect Effects 0.000 claims 5
- 230000000295 complement effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 3
- 101710172711 Structural protein Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 230000001919 adrenal effect Effects 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000001054 cortical effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000018448 secretion by cell Effects 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 210000004404 adrenal cortex Anatomy 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/025108 WO1999028462A2 (en) | 1997-12-03 | 1998-12-01 | Polypeptides and nucleic acids encoding the same |
| US11285098P | 1998-12-16 | 1998-12-16 | |
| US11555499P | 1999-01-12 | 1999-01-12 | |
| PCT/US1999/005028 WO1999046281A2 (en) | 1998-03-10 | 1999-03-08 | Novel polypeptides and nucleic acids encoding the same |
| US12395799P | 1999-03-12 | 1999-03-12 | |
| US13144599P | 1999-04-28 | 1999-04-28 | |
| US13428799P | 1999-05-14 | 1999-05-14 | |
| PCT/US1999/012252 WO1999063088A2 (en) | 1998-06-02 | 1999-06-02 | Membrane-bound proteins and nucleic acids encoding the same |
| US14103799P | 1999-06-23 | 1999-06-23 | |
| US14475899P | 1999-07-20 | 1999-07-20 | |
| US14569899P | 1999-07-26 | 1999-07-26 | |
| PCT/US1999/020111 WO2000012708A2 (en) | 1998-09-01 | 1999-09-01 | Further pro polypeptides and sequences thereof |
| PCT/US1999/020594 WO2000015666A2 (en) | 1998-09-10 | 1999-09-08 | Compositions and methods for the treatment of tumors |
| PCT/US1999/020944 WO2000015792A2 (en) | 1998-09-14 | 1999-09-13 | Promotion or inhibition of angiogenesis and cardiovascularization |
| PCT/US1999/021547 WO2000015797A2 (en) | 1998-09-17 | 1999-09-15 | Compositions and methods for the treatment of immune related diseases |
| PCT/US1999/021090 WO2000015796A2 (en) | 1998-09-16 | 1999-09-15 | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| PCT/US1999/023089 WO2000021996A2 (en) | 1998-10-13 | 1999-10-05 | Methods and compositions for inhibiting neoplastic cell growth |
| US16250699P | 1999-10-29 | 1999-10-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584912A Division JP3695642B2 (ja) | 1998-12-01 | 1999-11-30 | 血管形成及び心臓血管新生の促進又は阻害 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005180188A Division JP4358159B2 (ja) | 1998-12-01 | 2005-06-21 | 血管形成及び心臓血管新生の促進又は阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005046146A JP2005046146A (ja) | 2005-02-24 |
| JP2005046146A5 true JP2005046146A5 (enExample) | 2005-09-22 |
| JP3803681B2 JP3803681B2 (ja) | 2006-08-02 |
Family
ID=37398593
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584912A Expired - Fee Related JP3695642B2 (ja) | 1998-12-01 | 1999-11-30 | 血管形成及び心臓血管新生の促進又は阻害 |
| JP2004212340A Expired - Lifetime JP3803681B2 (ja) | 1998-12-01 | 2004-07-20 | 血管形成及び心臓血管新生の促進又は阻害 |
| JP2005180188A Expired - Lifetime JP4358159B2 (ja) | 1998-12-01 | 2005-06-21 | 血管形成及び心臓血管新生の促進又は阻害 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000584912A Expired - Fee Related JP3695642B2 (ja) | 1998-12-01 | 1999-11-30 | 血管形成及び心臓血管新生の促進又は阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005180188A Expired - Lifetime JP4358159B2 (ja) | 1998-12-01 | 2005-06-21 | 血管形成及び心臓血管新生の促進又は阻害 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1135485B1 (enExample) |
| JP (3) | JP3695642B2 (enExample) |
| KR (1) | KR100529270B1 (enExample) |
| AT (1) | ATE458050T1 (enExample) |
| AU (1) | AU771751C (enExample) |
| CA (1) | CA2347835A1 (enExample) |
| IL (1) | IL202176A0 (enExample) |
| MX (1) | MXPA01005169A (enExample) |
| WO (1) | WO2000032221A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001019991A1 (en) * | 1999-09-15 | 2001-03-22 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2000053760A2 (en) * | 1999-03-12 | 2000-09-14 | Genentech, Inc. | Method of preventing the death of retinal neurons and treating ocular diseases |
| WO2002008284A2 (en) * | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| CA2277925A1 (en) | 1997-01-14 | 1998-07-16 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6.alpha. and 6.beta. |
| US7285267B2 (en) | 1997-01-14 | 2007-10-23 | Human Genome Sciences, Inc. | Tumor necrosis factor receptors 6α & 6β |
| WO1999066041A1 (en) | 1998-06-16 | 1999-12-23 | Human Genome Sciences, Inc. | 94 human secreted proteins |
| WO1999047677A2 (en) | 1998-03-17 | 1999-09-23 | Genentech, Inc. | Polypeptides homologous to vegf and bmp1 |
| US20030083461A1 (en) * | 1997-06-16 | 2003-05-01 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| ATE393222T1 (de) | 1997-09-18 | 2008-05-15 | Genentech Inc | Dcr3 polypeptid, ein tnfr homolog |
| US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6689607B2 (en) | 1997-10-21 | 2004-02-10 | Human Genome Sciences, Inc. | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
| US6949339B1 (en) | 1998-05-21 | 2005-09-27 | Diadexus, Inc. | Method of diagnosing, monitoring, and staging colon cancer |
| US7014996B1 (en) | 1998-10-02 | 2006-03-21 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers |
| ES2279647T3 (es) | 1998-11-10 | 2007-08-16 | Emory University | Reguladores mitogenicos. |
| US6432673B1 (en) | 1998-12-07 | 2002-08-13 | Zymogenetics, Inc. | Growth factor homolog ZVEGF3 |
| EP1143005A4 (en) * | 1998-12-09 | 2002-11-06 | Shionogi & Co | PHOSPHOLIPASE A 2? HUMAN SECRETORY |
| WO2000039284A1 (en) * | 1998-12-30 | 2000-07-06 | Millennium Pharmaceuticals, Inc. | Secreted proteins and nucleic acids encoding them |
| AU768694B2 (en) * | 1999-03-08 | 2004-01-08 | Genentech Inc. | Promotion or inhibition of angiogenesis and cardiovascularization |
| CA2362885A1 (en) * | 1999-03-11 | 2000-09-14 | Mount Sinai Hospital | Human kallikrein-like genes |
| AU6085700A (en) * | 1999-07-12 | 2001-01-30 | Genentech Inc. | Promotion or inhibition of angiogenesis and cardiovascularization by tumor necrosis factor ligand/receptor homologs |
| AU4011300A (en) * | 1999-07-20 | 2001-02-05 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
| MXPA02005758A (es) * | 1999-12-09 | 2002-09-18 | Sankyo Co | Metodo para evaluar un remedio o agente preventivo para hiperlipidemia. |
| PL356887A1 (en) * | 2000-01-12 | 2004-07-12 | Yale University | Nogo receptor-mediated blockade of axonal growth |
| US7119165B2 (en) | 2000-01-12 | 2006-10-10 | Yale University | Nogo receptor-mediated blockade of axonal growth |
| US7135303B2 (en) | 2000-02-28 | 2006-11-14 | The United States Of America As Represented By The Department Of Health And Human Services | Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding |
| US7049403B2 (en) | 2000-04-21 | 2006-05-23 | Takeda Pharmaceutical Company Limited | Insulin/IGF/relaxin family polypeptides and DNAS thereof |
| DE60141409D1 (de) | 2000-10-06 | 2010-04-08 | Biogen Idec Inc | Homologe des nogo rezeptors |
| US20020111302A1 (en) * | 2000-11-30 | 2002-08-15 | Y. Tom Tang | Novel nucleic acids and polypeptides |
| WO2002057448A1 (en) * | 2000-12-27 | 2002-07-25 | Daiichi Fine Chemical Co., Ltd. | Novel peptides and activities thereof |
| US7736654B2 (en) | 2001-04-10 | 2010-06-15 | Agensys, Inc. | Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers |
| WO2003006687A2 (en) * | 2001-07-10 | 2003-01-23 | Medigene Ag | Novel target genes for diseases of the heart |
| WO2003053334A2 (en) * | 2001-12-19 | 2003-07-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP1487268A4 (en) * | 2002-03-01 | 2005-08-24 | Blood Ct Res Foundation | BAX REDUCER PEPTIDES DERIVED FROM KU-70 AND THEIR USE IN THE PROTECTION OF DAMAGED CELLS |
| AU2003220805A1 (en) * | 2002-03-28 | 2003-10-13 | Yamanouchi Pharmaceutical Co., Ltd. | Antiopoietin-related growth factor |
| AU2003246085A1 (en) * | 2002-06-28 | 2004-01-19 | Takeda Chemical Industries, Ltd. | Diagnostics/preventives/remedies for respiratory diseases |
| MXPA05001615A (es) | 2002-08-10 | 2005-08-19 | Biogen Idec Inc | Antagonistas del nogo receptor. |
| WO2005068497A1 (en) * | 2004-01-06 | 2005-07-28 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Iis: a novel ifn-gamma-inducible protein, member of the secretoglobin family, that modulates cellular invasion and migration |
| EP1904091A4 (en) | 2005-07-07 | 2009-12-23 | Univ Yale | COMPOSITIONS AND METHODS FOR SUPPRESSING THE INHIBITION OF AXON GROWTH |
| DK3151921T3 (da) | 2014-06-06 | 2019-12-02 | Bristol Myers Squibb Co | Antistoffer mod glucocorticoid-induceret tumornekrosefaktor- receptorer (gitr) og anvendelser deraf |
| CN107743586B (zh) | 2015-06-03 | 2021-07-02 | 百时美施贵宝公司 | 用于癌症诊断的抗gitr抗体 |
| BR112018010172A2 (pt) | 2015-11-19 | 2018-11-21 | Bristol Myers Squibb Co | anticorpos contra receptor de fator de necrose de tumor induzido por glicocorticoide (gitr) e usos dos mesmos |
| JP7274426B2 (ja) | 2017-05-16 | 2023-05-16 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｇｉｔｒアゴニスト抗体での癌の処置 |
| CN109136275B (zh) * | 2017-06-19 | 2021-03-16 | 百奥赛图(北京)医药科技股份有限公司 | 人源化gitr基因改造动物模型的制备方法及应用 |
| CN114507677B (zh) * | 2022-02-16 | 2023-09-05 | 中国人民解放军空军军医大学 | Ndufs1基因在治疗心梗后心衰中的应用和相关产品 |
| EP4484444A1 (en) * | 2023-06-28 | 2025-01-01 | Centre National de la Recherche Scientifique | Protein and fragments thereof, and their use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900673A (en) * | 1988-03-28 | 1990-02-13 | President And Fellows Of Harvard College | Mutant human angiogenin (angiogenesis factor with superior angiogenin activity) genes therefor and methods of expression |
| AU4528493A (en) | 1992-06-04 | 1994-01-04 | Regents Of The University Of California, The | In vivo gene therapy with intron-free sequence of interest |
| CZ312296A3 (en) * | 1994-04-26 | 1997-05-14 | Childrens Medical Center | Angiostatin and its application for angiogenesis inhibition |
| US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| DE69635899T2 (de) * | 1995-11-17 | 2006-11-23 | Asahi Kasei Kabushiki Kaisha | Polypeptid, das die differenzierung unterdrueckt |
-
1999
- 1999-11-30 AT AT99960624T patent/ATE458050T1/de not_active IP Right Cessation
- 1999-11-30 AU AU17482/00A patent/AU771751C/en not_active Expired
- 1999-11-30 EP EP99960624A patent/EP1135485B1/en not_active Expired - Lifetime
- 1999-11-30 KR KR10-2001-7006818A patent/KR100529270B1/ko not_active Expired - Lifetime
- 1999-11-30 CA CA002347835A patent/CA2347835A1/en not_active Abandoned
- 1999-11-30 WO PCT/US1999/028313 patent/WO2000032221A2/en not_active Ceased
- 1999-11-30 JP JP2000584912A patent/JP3695642B2/ja not_active Expired - Fee Related
- 1999-11-30 MX MXPA01005169A patent/MXPA01005169A/es not_active Application Discontinuation
-
2004
- 2004-07-20 JP JP2004212340A patent/JP3803681B2/ja not_active Expired - Lifetime
-
2005
- 2005-06-21 JP JP2005180188A patent/JP4358159B2/ja not_active Expired - Lifetime
-
2009
- 2009-11-17 IL IL202176A patent/IL202176A0/en unknown