JP2003527844A5 - - Google Patents
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- Publication number
- JP2003527844A5 JP2003527844A5 JP2001558238A JP2001558238A JP2003527844A5 JP 2003527844 A5 JP2003527844 A5 JP 2003527844A5 JP 2001558238 A JP2001558238 A JP 2001558238A JP 2001558238 A JP2001558238 A JP 2001558238A JP 2003527844 A5 JP2003527844 A5 JP 2003527844A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- pro256
- test compound
- antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 46
- 229920001184 polypeptide Polymers 0.000 description 45
- 102000004196 processed proteins & peptides Human genes 0.000 description 45
- 150000001875 compounds Chemical class 0.000 description 26
- 238000000034 method Methods 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 13
- 239000000556 agonist Substances 0.000 description 12
- 125000003275 alpha amino acid group Chemical group 0.000 description 12
- 230000036755 cellular response Effects 0.000 description 10
- 239000005557 antagonist Substances 0.000 description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 7
- 230000006698 induction Effects 0.000 description 7
- 230000001177 retroviral effect Effects 0.000 description 7
- 230000027455 binding Effects 0.000 description 5
- 108010076504 Protein Sorting Signals Proteins 0.000 description 4
- 239000000074 antisense oligonucleotide Substances 0.000 description 4
- 238000012230 antisense oligonucleotides Methods 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 101710172711 Structural protein Proteins 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 230000035409 positive regulation of cell proliferation Effects 0.000 description 1
- 230000036332 sexual response Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00/03565 | 2000-02-11 | ||
| PCT/US2000/003565 WO2001053486A1 (en) | 1999-03-08 | 2000-02-11 | Compositions and methods for the treatment of tumor |
| PCT/US2000/006884 WO2001005972A1 (en) | 1999-07-20 | 2000-03-15 | Compositions and methods for the treatment of immune related diseases |
| US00/06884 | 2000-03-15 | ||
| US25366500P | 2000-11-28 | 2000-11-28 | |
| US60/253,665 | 2000-11-28 | ||
| PCT/US2000/034756 WO2001059100A2 (en) | 2000-02-11 | 2000-12-19 | Inhibitor of hepatocyte growth factor activator for use in modulation of angiogenesis and cardiovascularization |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012160868A Division JP2012246296A (ja) | 2000-02-11 | 2012-07-19 | 血管形成及び心血管疾患の調節に使用する肝細胞成長因子の新規インヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003527844A JP2003527844A (ja) | 2003-09-24 |
| JP2003527844A5 true JP2003527844A5 (enExample) | 2011-03-31 |
Family
ID=39048807
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001558238A Pending JP2003527844A (ja) | 2000-02-11 | 2000-12-19 | 血管形成及び心血管疾患の調節に使用する肝細胞成長因子の新規インヒビター |
| JP2012160868A Pending JP2012246296A (ja) | 2000-02-11 | 2012-07-19 | 血管形成及び心血管疾患の調節に使用する肝細胞成長因子の新規インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012160868A Pending JP2012246296A (ja) | 2000-02-11 | 2012-07-19 | 血管形成及び心血管疾患の調節に使用する肝細胞成長因子の新規インヒビター |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6800604B2 (enExample) |
| EP (1) | EP1255829B1 (enExample) |
| JP (2) | JP2003527844A (enExample) |
| AT (1) | ATE440139T1 (enExample) |
| AU (1) | AU3075701A (enExample) |
| CA (1) | CA2398775A1 (enExample) |
| CY (1) | CY1109518T1 (enExample) |
| DE (1) | DE60042793D1 (enExample) |
| DK (1) | DK1255829T3 (enExample) |
| ES (1) | ES2330918T3 (enExample) |
| IL (2) | IL150987A0 (enExample) |
| PT (1) | PT1255829E (enExample) |
| WO (1) | WO2001059100A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030119113A1 (en) * | 1999-07-20 | 2003-06-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU2003277283A1 (en) * | 2002-10-07 | 2004-05-04 | Genentech, Inc. | Hepatocyte growth factor variants |
| EP1631679A2 (en) * | 2003-05-21 | 2006-03-08 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with dipeptidylpeptidase 7 (dpp7) |
| RS53476B (sr) * | 2003-07-18 | 2014-12-31 | Amgen Fremont Inc. | Sredstva za specifično vezivanje faktora rasta hepatocita |
| WO2005112619A2 (en) * | 2004-05-12 | 2005-12-01 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| EP2402323A3 (en) | 2004-10-13 | 2012-05-30 | PTC Therapeutics, Inc. | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases |
| WO2009045370A2 (en) | 2007-09-28 | 2009-04-09 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| US20110206704A1 (en) * | 2009-10-19 | 2011-08-25 | Genentech, Inc. | Methods and compositions for modulating hepatocyte growth factor activator |
| JP5889794B2 (ja) * | 2009-10-19 | 2016-03-22 | ジェネンテック， インコーポレイテッド | 肝細胞増殖因子アクチベーターの調節 |
| US20130149788A1 (en) * | 2011-12-09 | 2013-06-13 | Cornell University | Assay for quantifying elemental sulfur levels in a sample |
| US10743996B2 (en) * | 2017-03-24 | 2020-08-18 | Robert L. Bundy | Amnion putty for cartilage repair |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US5382569A (en) | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
| EP0694080B1 (en) | 1993-04-05 | 2005-12-07 | University of Utah Research Foundation | Diagnosis and treatment of supravalvular aortic stenosis |
| US5773223A (en) | 1993-09-02 | 1998-06-30 | Chiron Corporation | Endothelin B1, (ETB1) receptor polypeptide and its encoding nucleic acid methods, and uses thereof |
| US5610134A (en) | 1994-04-15 | 1997-03-11 | Genentech, Inc. | Treatment of congestive heart failure |
| US5661122A (en) | 1994-04-15 | 1997-08-26 | Genentech, Inc. | Treatment of congestive heart failure |
| US5935924A (en) | 1994-04-15 | 1999-08-10 | Genentech, Inc. | Treatment of congestive heart failure |
| CA2188017C (en) | 1994-04-25 | 2010-09-28 | Joffre Baker | Cardiotrophin and uses therefor |
| US5573762A (en) | 1995-04-24 | 1996-11-12 | Genentech, Inc. | Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy |
| DE69631500T2 (de) * | 1995-07-24 | 2004-12-02 | Mitsubishi Chemical Corp. | Inhibitor des Hepatozytwachstumsfaktoraktivators |
| AU7254896A (en) | 1995-10-05 | 1997-04-28 | Genentech Inc. | Improved angiogenesis using hepatocyte growth factor |
| JPH1135480A (ja) * | 1997-07-15 | 1999-02-09 | Mitsubishi Chem Corp | プロテアーゼの活性亢進に起因する疾患の予防及び／または治療剤 |
| AU4011300A (en) | 1999-07-20 | 2001-02-05 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
-
2000
- 2000-12-19 WO PCT/US2000/034756 patent/WO2001059100A2/en not_active Ceased
- 2000-12-19 JP JP2001558238A patent/JP2003527844A/ja active Pending
- 2000-12-19 EP EP00990950A patent/EP1255829B1/en not_active Expired - Lifetime
- 2000-12-19 AU AU30757/01A patent/AU3075701A/en not_active Abandoned
- 2000-12-19 DK DK00990950T patent/DK1255829T3/da active
- 2000-12-19 IL IL15098700A patent/IL150987A0/xx unknown
- 2000-12-19 AT AT00990950T patent/ATE440139T1/de active
- 2000-12-19 US US09/742,201 patent/US6800604B2/en not_active Expired - Lifetime
- 2000-12-19 CA CA002398775A patent/CA2398775A1/en not_active Abandoned
- 2000-12-19 DE DE60042793T patent/DE60042793D1/de not_active Expired - Lifetime
- 2000-12-19 PT PT00990950T patent/PT1255829E/pt unknown
- 2000-12-19 ES ES00990950T patent/ES2330918T3/es not_active Expired - Lifetime
-
2002
- 2002-07-30 IL IL150987A patent/IL150987A/en not_active IP Right Cessation
-
2003
- 2003-12-11 US US10/733,890 patent/US20040132660A1/en not_active Abandoned
-
2009
- 2009-10-26 CY CY20091101110T patent/CY1109518T1/el unknown
-
2012
- 2012-07-19 JP JP2012160868A patent/JP2012246296A/ja active Pending
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