JP2002508970A5 - - Google Patents
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- Publication number
- JP2002508970A5 JP2002508970A5 JP2000540252A JP2000540252A JP2002508970A5 JP 2002508970 A5 JP2002508970 A5 JP 2002508970A5 JP 2000540252 A JP2000540252 A JP 2000540252A JP 2000540252 A JP2000540252 A JP 2000540252A JP 2002508970 A5 JP2002508970 A5 JP 2002508970A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polynucleotide
- purified
- sequence
- hupm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000040430 polynucleotide Human genes 0.000 description 17
- 108091033319 polynucleotide Proteins 0.000 description 17
- 239000002157 polynucleotide Substances 0.000 description 17
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000009396 hybridization Methods 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/008,271 US6203979B1 (en) | 1998-01-16 | 1998-01-16 | Human protease molecules |
| US09/008,271 | 1998-01-16 | ||
| PCT/US1999/000655 WO1999036550A2 (en) | 1998-01-16 | 1999-01-12 | Human protease molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002508970A JP2002508970A (ja) | 2002-03-26 |
| JP2002508970A5 true JP2002508970A5 (enExample) | 2006-02-16 |
Family
ID=21730708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000540252A Pending JP2002508970A (ja) | 1998-01-16 | 1999-01-12 | ヒトプロテアーゼ分子 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6203979B1 (enExample) |
| EP (1) | EP1045913A2 (enExample) |
| JP (1) | JP2002508970A (enExample) |
| AU (1) | AU2113599A (enExample) |
| CA (1) | CA2317094A1 (enExample) |
| WO (1) | WO1999036550A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6060587A (en) * | 1996-01-29 | 2000-05-09 | The Trustees Of The University Of Pennsylvania | Cellular receptor for HIV-1 VPR essential for G2/M phase transition of the cell cycle |
| EP0897986A3 (en) * | 1997-08-21 | 2000-07-05 | Smithkline Beecham Corporation | Aspartic proteinase 5 (ASP5) |
| US7157084B2 (en) * | 1997-08-21 | 2007-01-02 | The Board Of Trustees Of The University Of Arkansas System | Extracellular serine protease |
| US6642013B1 (en) * | 1997-08-21 | 2003-11-04 | The University Of Arkansas For Medical Sciences | Extracellular serine protease |
| US7732163B2 (en) * | 1997-08-21 | 2010-06-08 | Board Of Trustees Of The University Of Arkansas | Extracellular serine protease |
| US20030060612A1 (en) * | 1997-10-28 | 2003-03-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US7045333B1 (en) * | 1998-01-16 | 2006-05-16 | Incyte Corporation | Human protease molecules |
| US6140056A (en) * | 1999-01-27 | 2000-10-31 | Millennium Pharmaceuticals, Inc. | MSP-18 protein and nucleic acid molecules and uses therefor |
| US20020072089A1 (en) * | 1999-11-23 | 2002-06-13 | Holtzman Douglas A. | Novel ITALY, Lor-2, STRIFE, TRASH, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor |
| WO1999040183A1 (en) | 1998-02-06 | 1999-08-12 | Human Genome Sciences, Inc. | Human serine protease and serpin polypeptides |
| JPH11225765A (ja) * | 1998-02-13 | 1999-08-24 | Suntory Ltd | 新規セリンプロテアーゼ |
| US6861215B1 (en) * | 1998-05-21 | 2005-03-01 | Diadexus, Inc. | Method of diagnosing, monitoring, and staging prostate cancer |
| CA2328138A1 (en) * | 1998-05-21 | 1999-11-25 | Diadexus Llc | A novel method of diagnosing, monitoring, and staging lung cancer |
| US7160679B1 (en) * | 1998-05-21 | 2007-01-09 | Diadexus, Inc. | Method of diagnosing, monitoring, and staging lung cancer |
| US6902721B1 (en) * | 1998-07-10 | 2005-06-07 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| ATE413466T1 (de) | 1998-09-02 | 2008-11-15 | Diadexus Inc | Verfahren zur diagnose, bewertung sowie bilddarstellung verschiedener krebserkrankungen |
| US6902892B1 (en) * | 1998-10-19 | 2005-06-07 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating prostate cancer |
| US20030009013A1 (en) * | 1998-12-30 | 2003-01-09 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| JP2003506017A (ja) * | 1999-07-12 | 2003-02-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | セリパンクリン |
| US20020151047A1 (en) * | 2001-01-08 | 2002-10-17 | Yi Hu | Novel human protease and polynucleotides encoding the same |
| JP2003512036A (ja) * | 1999-10-20 | 2003-04-02 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー | Ｔａｄｇ−１５：癌において過剰発現されている細胞外セリンプロテアーゼ |
| US6677442B1 (en) * | 1999-10-29 | 2004-01-13 | University Of Kentucky Research Foundation | Nucleic acid encoding human REV1 protein |
| AU784746B2 (en) | 1999-11-18 | 2006-06-08 | Dendreon Corporation | Nucleic acids encoding endotheliases, endotheliases and uses thereof |
| JP2004502402A (ja) * | 2000-01-06 | 2004-01-29 | レキシコン・ジェネティクス・インコーポレーテッド | 新規ヒトプロテアーゼおよびそれをコードするポリヌクレオチド |
| US6455668B1 (en) * | 2000-01-28 | 2002-09-24 | Eos Biotechnology, Inc. | Methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators |
| AU2001233262A1 (en) * | 2000-02-03 | 2001-08-14 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
| US6750034B1 (en) | 2000-06-30 | 2004-06-15 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human serine protease D-G |
| US7125703B2 (en) | 2001-03-13 | 2006-10-24 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
| US6294368B1 (en) * | 2001-03-22 | 2001-09-25 | Applera Corporation | Isolated human metalloprotease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof |
| US7172892B2 (en) | 2001-03-22 | 2007-02-06 | Dendreon Corporation | Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon |
| JP2005506047A (ja) | 2001-03-27 | 2005-03-03 | デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー | 膜貫通型セリンプロテアーゼ９をコード化する核酸分子、コード化されたポリペプチドおよびそれらに基づく方法 |
| US20040236091A1 (en) * | 2001-03-28 | 2004-11-25 | Chicz Roman M. | Translational profiling |
| US7112430B2 (en) | 2001-05-14 | 2006-09-26 | Dendreon Corporation | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon |
| US7196163B2 (en) * | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
| US7132401B2 (en) * | 2001-05-22 | 2006-11-07 | Merck & Co., Inc. | Beta-secretase substrates and uses thereof |
| JP2005511513A (ja) * | 2001-09-17 | 2005-04-28 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 新規ヒトアミノプロテアーゼファミリーメンバー２２４１７を使用する方法 |
| WO2003027145A1 (fr) * | 2001-09-26 | 2003-04-03 | Riken | Inducteur de mort cellulaire, cellules et animaux exprimant cet inducteur, et procede de criblage de medicament anti-mort cellulaire |
| EP1542699A4 (en) * | 2002-07-15 | 2009-03-25 | Myriad Genetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF |
| CN1833020A (zh) * | 2003-06-27 | 2006-09-13 | 迪亚德克瑟斯公司 | Pro104抗体组合物及其使用方法 |
| EP1687630A2 (en) * | 2003-10-17 | 2006-08-09 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with aminopeptidase-like 1 (npepl1) |
| DE102004004924B4 (de) * | 2004-01-27 | 2007-04-26 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | A141S-und G399S-Mutation im Omi/HtrA2-Protein bei Morbus Parkinson |
| WO2006013016A2 (en) * | 2004-08-04 | 2006-02-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with eosinophil serine protease 1 (prss21) |
| WO2006013012A2 (en) * | 2004-08-04 | 2006-02-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with napsin 1 (nap1) |
| AU2005316169B2 (en) | 2004-12-13 | 2011-11-17 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0828003A3 (en) * | 1996-09-06 | 2003-01-15 | SmithKline Beecham plc | Human serine protease |
| US20030092175A1 (en) | 1996-11-13 | 2003-05-15 | Seishi Kato | Human proteins having transmembrane domains and dnas encoding these proteins |
| DE69738653T2 (de) | 1996-11-20 | 2009-06-04 | Oklahoma Medical Research Foundation, Oklahoma | Klonierung und charakterisierung von napsin, einer aspartat-protease |
| WO1998056804A1 (en) | 1997-06-13 | 1998-12-17 | Human Genome Sciences, Inc. | 86 human secreted proteins |
| JP3809709B2 (ja) | 1997-07-16 | 2006-08-16 | 小野薬品工業株式会社 | 新規な好酸球セリンプロテアーゼ |
| US7014993B1 (en) | 1997-08-21 | 2006-03-21 | The Board Of Trustees Of The University Of Arkansas | Extracellular serine protease |
| NZ503343A (en) | 1997-09-17 | 2002-09-27 | Genentech Inc | Secreted and transmembrane polypeptides and use to induce apoptosis of tumour cells |
| ES2312205T3 (es) | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
| NZ510464A (en) | 1998-09-01 | 2004-05-28 | Genentech Inc | Further pro polypeptides and sequences thereof |
-
1998
- 1998-01-16 US US09/008,271 patent/US6203979B1/en not_active Expired - Lifetime
-
1999
- 1999-01-12 JP JP2000540252A patent/JP2002508970A/ja active Pending
- 1999-01-12 EP EP99901444A patent/EP1045913A2/en not_active Withdrawn
- 1999-01-12 CA CA002317094A patent/CA2317094A1/en not_active Abandoned
- 1999-01-12 AU AU21135/99A patent/AU2113599A/en not_active Abandoned
- 1999-01-12 WO PCT/US1999/000655 patent/WO1999036550A2/en not_active Ceased
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