JP2003507029A5 - - Google Patents

Info

Publication number

JP2003507029A5

JP2003507029A5 JP2001517562A JP2001517562A JP2003507029A5 JP 2003507029 A5 JP2003507029 A5 JP 2003507029A5 JP 2001517562 A JP2001517562 A JP 2001517562A JP 2001517562 A JP2001517562 A JP 2001517562A JP 2003507029 A5 JP2003507029 A5 JP 2003507029A5

Authority

JP

Japan

Prior art keywords

seq

amino acids

polypeptide

polynucleotide

amino acid

Prior art date

2000-08-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001413 amino acids Chemical class 0.000 description 25
• 229920001184 polypeptide Polymers 0.000 description 17
• 102000004196 processed proteins & peptides Human genes 0.000 description 17
• 108090000765 processed proteins & peptides Proteins 0.000 description 17
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 14
• 108091033319 polynucleotide Proteins 0.000 description 14
• 102000040430 polynucleotide Human genes 0.000 description 14
• 239000002157 polynucleotide Substances 0.000 description 14
• 238000000034 method Methods 0.000 description 11
• 102000039446 nucleic acids Human genes 0.000 description 10
• 108020004707 nucleic acids Proteins 0.000 description 10
• 150000007523 nucleic acids Chemical class 0.000 description 10
• 125000003275 alpha amino acid group Chemical group 0.000 description 6
• 239000003446 ligand Substances 0.000 description 6
• 239000000203 mixture Substances 0.000 description 5
• 108090000623 proteins and genes Proteins 0.000 description 5
• 108020004999 messenger RNA Proteins 0.000 description 4
• 230000000295 complement effect Effects 0.000 description 3
• 239000002773 nucleotide Substances 0.000 description 3
• 125000003729 nucleotide group Chemical group 0.000 description 3
• 102000004169 proteins and genes Human genes 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 2
• 239000012634 fragment Substances 0.000 description 2
• 238000009396 hybridization Methods 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 108091026890 Coding region Proteins 0.000 description 1
• 108020004414 DNA Proteins 0.000 description 1
• 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
• 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
• 206010028980 Neoplasm Diseases 0.000 description 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
• 230000033115 angiogenesis Effects 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 208000028867 ischemia Diseases 0.000 description 1
• 201000001441 melanoma Diseases 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1