JP2002538775A5 - - Google Patents
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- Publication number
- JP2002538775A5 JP2002538775A5 JP2000593635A JP2000593635A JP2002538775A5 JP 2002538775 A5 JP2002538775 A5 JP 2002538775A5 JP 2000593635 A JP2000593635 A JP 2000593635A JP 2000593635 A JP2000593635 A JP 2000593635A JP 2002538775 A5 JP2002538775 A5 JP 2002538775A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- amino acid
- amino acids
- dna fragment
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 description 27
- 102000004196 processed proteins & peptides Human genes 0.000 description 27
- 108090000765 processed proteins & peptides Proteins 0.000 description 27
- 125000003275 alpha amino acid group Chemical group 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 8
- 239000012634 fragment Substances 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 6
- 230000008468 bone growth Effects 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
- 208000029725 Metabolic bone disease Diseases 0.000 description 1
- 206010049088 Osteopenia Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/229,304 | 1999-01-13 | ||
| US09/229,304 US6693081B2 (en) | 1995-09-26 | 1999-01-13 | Bone stimulating factor |
| PCT/CA2000/000031 WO2000042069A1 (en) | 1999-01-13 | 2000-01-13 | Bone stimulating factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002538775A JP2002538775A (ja) | 2002-11-19 |
| JP2002538775A5 true JP2002538775A5 (enExample) | 2007-03-01 |
Family
ID=22860649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593635A Pending JP2002538775A (ja) | 1999-01-13 | 2000-01-13 | 骨刺激因子 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6693081B2 (enExample) |
| EP (1) | EP1161450A1 (enExample) |
| JP (1) | JP2002538775A (enExample) |
| KR (1) | KR20010101425A (enExample) |
| CN (1) | CN1341120A (enExample) |
| AU (1) | AU779261B2 (enExample) |
| BG (1) | BG105682A (enExample) |
| BR (1) | BR0007816A (enExample) |
| CA (1) | CA2358908A1 (enExample) |
| CZ (1) | CZ20012456A3 (enExample) |
| HU (1) | HUP0105004A2 (enExample) |
| IL (1) | IL143990A0 (enExample) |
| IS (1) | IS5999A (enExample) |
| MA (1) | MA25594A1 (enExample) |
| MX (1) | MXPA01007043A (enExample) |
| NO (1) | NO20013257L (enExample) |
| NZ (1) | NZ512637A (enExample) |
| PL (1) | PL349786A1 (enExample) |
| WO (1) | WO2000042069A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693081B2 (en) * | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| AU5379200A (en) * | 1999-06-02 | 2000-12-28 | Osteopharm Inc. | Bone stimulating factor |
| EP1520155A1 (en) * | 2002-07-05 | 2005-04-06 | Gaspardo Seminatrici S.P.A. | Volumetric metering device for the metered delivery of granular and powdery materials |
| US7399826B1 (en) | 2003-10-02 | 2008-07-15 | Ali Sadat M | Peptide for promoting healing of fractures |
| JP2014517002A (ja) * | 2011-06-10 | 2014-07-17 | ユニベルシテ リブル ドゥ ブリュッセル | 損なわれた骨折治癒の処置のための標的及び薬剤 |
| CN103159762B (zh) * | 2013-03-25 | 2015-04-15 | 华东理工大学 | 表吲哚二酮衍生物及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4320118A (en) | 1980-12-22 | 1982-03-16 | Syntex (U.S.A.) Inc. | Deca-, undeca-, dodeca- and tridecapeptides with thymic activity |
| US4897348A (en) | 1983-08-25 | 1990-01-30 | Sri International | Recombinant materials and methods for producing human connective tissue-activating peptide-III and analogs thereof |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
| US5024841A (en) | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US4950483A (en) | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5264214A (en) | 1988-11-21 | 1993-11-23 | Collagen Corporation | Composition for bone repair |
| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| JP3051160B2 (ja) | 1988-12-08 | 2000-06-12 | ノバルティス・アクチエンゲゼルシャフト | 好中球活性化ペプチド‐２ |
| US5461034A (en) | 1989-02-23 | 1995-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Osteogenic growth polypeptides identified from regenerating bone marrow |
| JP3159216B2 (ja) | 1990-02-01 | 2001-04-23 | ユニバーシティ オブ サウス フロリダ | 白血球由来の成長因子 |
| CA2040264A1 (en) | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| JP3523252B2 (ja) | 1990-11-21 | 2004-04-26 | ホウテン ファーマシューティカルズ インコーポレイテッド | 等モル多種オリゴマー混合物、特にオリゴペプチド混合物の合成 |
| US5776892A (en) * | 1990-12-21 | 1998-07-07 | Curative Health Services, Inc. | Anti-inflammatory peptides |
| ES2117045T3 (es) * | 1990-12-21 | 1998-08-01 | Curative Tech Inc | Peptidos angiogenicos. |
| US5208219A (en) | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
| ATE139700T1 (de) | 1991-02-15 | 1996-07-15 | Takeda Chemical Industries Ltd | Mit einem zellwachstumsfaktor bewirkte anregung von wachstum im knocheninneren |
| EP0504938A3 (en) | 1991-03-22 | 1993-04-14 | Suntory Limited | Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient |
| US5643549A (en) * | 1992-02-20 | 1997-07-01 | Rhomed Incorporated | Leukostimulatory agent for in vivo leukocyte tagging |
| US5792664A (en) | 1992-05-29 | 1998-08-11 | The Rockefeller University | Methods for producing and analyzing biopolymer ladders |
| NZ255041A (en) * | 1992-07-13 | 1996-11-26 | Bionebraska Inc | Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups |
| US5304542A (en) | 1992-08-28 | 1994-04-19 | University Of Louisville Research Foundation, Inc. | Use of platelet factor 4 to inhibit osteoblast proliferation |
| US5786327A (en) | 1993-03-12 | 1998-07-28 | Gensci Regeneration Sciences Inc. | Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same |
| IL108947A0 (en) | 1993-03-12 | 1994-06-24 | Osteopharm Ltd | Bone stimulating factor |
| US5578569A (en) | 1993-03-12 | 1996-11-26 | Tam; Cherk S. | Method of increasing bone growth |
| US5661127A (en) | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
| US6117839A (en) | 1995-06-07 | 2000-09-12 | Gensci Regeneration Sciences, Inc. | Bone stimulating factor |
| US6352973B1 (en) | 1995-06-07 | 2002-03-05 | Osteopharm Inc. | Bone stimulating factor |
| US5880094A (en) | 1995-06-07 | 1999-03-09 | Osteopharm Limited | Polypeptides that stimulate bone growth |
| US6693081B2 (en) * | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| ZA968062B (en) | 1995-09-26 | 1997-06-18 | Osteopharm Ltd | Bone stimulating factor |
-
1999
- 1999-01-13 US US09/229,304 patent/US6693081B2/en not_active Expired - Fee Related
-
2000
- 2000-01-13 MX MXPA01007043A patent/MXPA01007043A/es not_active Application Discontinuation
- 2000-01-13 CN CN00802780A patent/CN1341120A/zh active Pending
- 2000-01-13 CA CA002358908A patent/CA2358908A1/en not_active Abandoned
- 2000-01-13 PL PL00349786A patent/PL349786A1/xx not_active Application Discontinuation
- 2000-01-13 BR BR0007816-6A patent/BR0007816A/pt not_active Application Discontinuation
- 2000-01-13 JP JP2000593635A patent/JP2002538775A/ja active Pending
- 2000-01-13 CZ CZ20012456A patent/CZ20012456A3/cs unknown
- 2000-01-13 HU HU0105004A patent/HUP0105004A2/hu unknown
- 2000-01-13 WO PCT/CA2000/000031 patent/WO2000042069A1/en not_active Ceased
- 2000-01-13 AU AU30282/00A patent/AU779261B2/en not_active Ceased
- 2000-01-13 IL IL143990A patent/IL143990A0/xx unknown
- 2000-01-13 KR KR1020017008634A patent/KR20010101425A/ko not_active Withdrawn
- 2000-01-13 NZ NZ512637A patent/NZ512637A/en unknown
- 2000-01-13 EP EP00900467A patent/EP1161450A1/en not_active Withdrawn
-
2001
- 2001-06-29 NO NO20013257A patent/NO20013257L/no not_active Application Discontinuation
- 2001-07-09 BG BG105682A patent/BG105682A/xx unknown
- 2001-07-09 MA MA26261A patent/MA25594A1/fr unknown
- 2001-07-11 IS IS5999A patent/IS5999A/is unknown
-
2003
- 2003-11-24 US US10/718,526 patent/US20040147450A1/en not_active Abandoned
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