HUP0105004A2 - Csontstimuláló faktor - Google Patents
Csontstimuláló faktor Download PDFInfo
- Publication number
- HUP0105004A2 HUP0105004A2 HU0105004A HUP0105004A HUP0105004A2 HU P0105004 A2 HUP0105004 A2 HU P0105004A2 HU 0105004 A HU0105004 A HU 0105004A HU P0105004 A HUP0105004 A HU P0105004A HU P0105004 A2 HUP0105004 A2 HU P0105004A2
- Authority
- HU
- Hungary
- Prior art keywords
- polypeptide
- fragment
- amino acid
- amino acids
- acid sequence
- Prior art date
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- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
- 229940096397 interleukin-8 Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 235000014413 iron hydroxide Nutrition 0.000 description 1
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical class [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 108010064235 lysylglycine Proteins 0.000 description 1
- 108010038320 lysylphenylalanine Proteins 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- NKAAEMMYHLFEFN-UHFFFAOYSA-M monosodium tartrate Chemical compound [Na+].OC(=O)C(O)C(O)C([O-])=O NKAAEMMYHLFEFN-UHFFFAOYSA-M 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000035407 negative regulation of cell proliferation Effects 0.000 description 1
- 238000006384 oligomerization reaction Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 210000000963 osteoblast Anatomy 0.000 description 1
- 208000028776 osteoblastic osteosarcoma Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- GJSGGHOYGKMUPT-UHFFFAOYSA-N phenoxathiine Chemical group C1=CC=C2OC3=CC=CC=C3SC2=C1 GJSGGHOYGKMUPT-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 210000004896 polypeptide structure Anatomy 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 108010051110 tyrosyl-lysine Proteins 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/229,304 US6693081B2 (en) | 1995-09-26 | 1999-01-13 | Bone stimulating factor |
| PCT/CA2000/000031 WO2000042069A1 (en) | 1999-01-13 | 2000-01-13 | Bone stimulating factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0105004A2 true HUP0105004A2 (hu) | 2002-04-29 |
Family
ID=22860649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105004A HUP0105004A2 (hu) | 1999-01-13 | 2000-01-13 | Csontstimuláló faktor |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6693081B2 (enExample) |
| EP (1) | EP1161450A1 (enExample) |
| JP (1) | JP2002538775A (enExample) |
| KR (1) | KR20010101425A (enExample) |
| CN (1) | CN1341120A (enExample) |
| AU (1) | AU779261B2 (enExample) |
| BG (1) | BG105682A (enExample) |
| BR (1) | BR0007816A (enExample) |
| CA (1) | CA2358908A1 (enExample) |
| CZ (1) | CZ20012456A3 (enExample) |
| HU (1) | HUP0105004A2 (enExample) |
| IL (1) | IL143990A0 (enExample) |
| IS (1) | IS5999A (enExample) |
| MA (1) | MA25594A1 (enExample) |
| MX (1) | MXPA01007043A (enExample) |
| NO (1) | NO20013257L (enExample) |
| NZ (1) | NZ512637A (enExample) |
| PL (1) | PL349786A1 (enExample) |
| WO (1) | WO2000042069A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693081B2 (en) * | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| AU5379200A (en) * | 1999-06-02 | 2000-12-28 | Osteopharm Inc. | Bone stimulating factor |
| CA2490876A1 (en) * | 2002-07-05 | 2004-02-19 | Gaspardo Seminatrici S.P.A. | A volumetric metering device for the metered delivery of granular and powdery materials, particularly for machines for distributing the said materials |
| AU2003272814A1 (en) | 2003-10-02 | 2005-05-19 | Ibrahim Al-Habdan | Peptide for promoting healing of fractures |
| CA2838490A1 (en) * | 2011-06-10 | 2012-12-13 | Universite Libre De Bruxelles | Targets and agents for the treatment of impaired bone fracture healing |
| CN103159762B (zh) * | 2013-03-25 | 2015-04-15 | 华东理工大学 | 表吲哚二酮衍生物及其用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4320118A (en) | 1980-12-22 | 1982-03-16 | Syntex (U.S.A.) Inc. | Deca-, undeca-, dodeca- and tridecapeptides with thymic activity |
| US4897348A (en) | 1983-08-25 | 1990-01-30 | Sri International | Recombinant materials and methods for producing human connective tissue-activating peptide-III and analogs thereof |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| US5354557A (en) | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US4950483A (en) | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5024841A (en) | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5264214A (en) | 1988-11-21 | 1993-11-23 | Collagen Corporation | Composition for bone repair |
| FI903931A7 (fi) | 1988-12-08 | 1990-08-08 | Sandoz Ag | Neutrofiiliaktivoiva peptidi-2 |
| US5461034A (en) | 1989-02-23 | 1995-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Osteogenic growth polypeptides identified from regenerating bone marrow |
| EP0513201A1 (en) | 1990-02-01 | 1992-11-19 | University Of South Florida | Leukocyte-derived growth factor |
| CA2040264A1 (en) | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
| ATE176239T1 (de) | 1990-11-21 | 1999-02-15 | Iterex Pharma Lp | Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen |
| US5776892A (en) * | 1990-12-21 | 1998-07-07 | Curative Health Services, Inc. | Anti-inflammatory peptides |
| ATE164167T1 (de) * | 1990-12-21 | 1998-04-15 | Curative Tech Inc | Angiogene peptide |
| US5208219A (en) | 1991-02-14 | 1993-05-04 | Celtrix Pharmaceuticals Inc. | Method for inducing bone growth |
| ATE139700T1 (de) | 1991-02-15 | 1996-07-15 | Takeda Chemical Industries Ltd | Mit einem zellwachstumsfaktor bewirkte anregung von wachstum im knocheninneren |
| EP0504938A3 (en) | 1991-03-22 | 1993-04-14 | Suntory Limited | Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient |
| US5643549A (en) * | 1992-02-20 | 1997-07-01 | Rhomed Incorporated | Leukostimulatory agent for in vivo leukocyte tagging |
| US5792664A (en) | 1992-05-29 | 1998-08-11 | The Rockefeller University | Methods for producing and analyzing biopolymer ladders |
| NZ255041A (en) * | 1992-07-13 | 1996-11-26 | Bionebraska Inc | Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups |
| US5304542A (en) | 1992-08-28 | 1994-04-19 | University Of Louisville Research Foundation, Inc. | Use of platelet factor 4 to inhibit osteoblast proliferation |
| US5578569A (en) | 1993-03-12 | 1996-11-26 | Tam; Cherk S. | Method of increasing bone growth |
| IL108947A0 (en) | 1993-03-12 | 1994-06-24 | Osteopharm Ltd | Bone stimulating factor |
| US5786327A (en) | 1993-03-12 | 1998-07-28 | Gensci Regeneration Sciences Inc. | Bone stimulating factor, methods of isolating same, and methods of increasing bone growth comprising administering same |
| US5661127A (en) | 1995-05-01 | 1997-08-26 | The Regents Of The University Of California | Peptide compositions with growth factor-like activity |
| US6352973B1 (en) | 1995-06-07 | 2002-03-05 | Osteopharm Inc. | Bone stimulating factor |
| US6117839A (en) | 1995-06-07 | 2000-09-12 | Gensci Regeneration Sciences, Inc. | Bone stimulating factor |
| US5880094A (en) | 1995-06-07 | 1999-03-09 | Osteopharm Limited | Polypeptides that stimulate bone growth |
| US6693081B2 (en) * | 1995-09-26 | 2004-02-17 | Osteopharm Inc. | Bone stimulating factor |
| ZA968062B (en) | 1995-09-26 | 1997-06-18 | Osteopharm Ltd | Bone stimulating factor |
-
1999
- 1999-01-13 US US09/229,304 patent/US6693081B2/en not_active Expired - Fee Related
-
2000
- 2000-01-13 JP JP2000593635A patent/JP2002538775A/ja active Pending
- 2000-01-13 EP EP00900467A patent/EP1161450A1/en not_active Withdrawn
- 2000-01-13 NZ NZ512637A patent/NZ512637A/en unknown
- 2000-01-13 KR KR1020017008634A patent/KR20010101425A/ko not_active Withdrawn
- 2000-01-13 HU HU0105004A patent/HUP0105004A2/hu unknown
- 2000-01-13 WO PCT/CA2000/000031 patent/WO2000042069A1/en not_active Ceased
- 2000-01-13 MX MXPA01007043A patent/MXPA01007043A/es not_active Application Discontinuation
- 2000-01-13 CN CN00802780A patent/CN1341120A/zh active Pending
- 2000-01-13 CA CA002358908A patent/CA2358908A1/en not_active Abandoned
- 2000-01-13 BR BR0007816-6A patent/BR0007816A/pt not_active Application Discontinuation
- 2000-01-13 IL IL143990A patent/IL143990A0/xx unknown
- 2000-01-13 PL PL00349786A patent/PL349786A1/xx not_active Application Discontinuation
- 2000-01-13 AU AU30282/00A patent/AU779261B2/en not_active Ceased
- 2000-01-13 CZ CZ20012456A patent/CZ20012456A3/cs unknown
-
2001
- 2001-06-29 NO NO20013257A patent/NO20013257L/no not_active Application Discontinuation
- 2001-07-09 MA MA26261A patent/MA25594A1/fr unknown
- 2001-07-09 BG BG105682A patent/BG105682A/xx unknown
- 2001-07-11 IS IS5999A patent/IS5999A/is unknown
-
2003
- 2003-11-24 US US10/718,526 patent/US20040147450A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01007043A (es) | 2002-03-27 |
| CA2358908A1 (en) | 2000-07-20 |
| EP1161450A1 (en) | 2001-12-12 |
| PL349786A1 (en) | 2002-09-09 |
| NO20013257D0 (no) | 2001-06-29 |
| IL143990A0 (en) | 2002-04-21 |
| KR20010101425A (ko) | 2001-11-14 |
| WO2000042069A1 (en) | 2000-07-20 |
| IS5999A (is) | 2001-07-11 |
| NZ512637A (en) | 2003-08-29 |
| JP2002538775A (ja) | 2002-11-19 |
| AU779261B2 (en) | 2005-01-13 |
| CN1341120A (zh) | 2002-03-20 |
| CZ20012456A3 (cs) | 2002-02-13 |
| US6693081B2 (en) | 2004-02-17 |
| BR0007816A (pt) | 2002-12-31 |
| US20020090671A1 (en) | 2002-07-11 |
| AU3028200A (en) | 2000-08-01 |
| US20040147450A1 (en) | 2004-07-29 |
| NO20013257L (no) | 2001-08-17 |
| MA25594A1 (fr) | 2002-12-31 |
| BG105682A (en) | 2003-04-30 |
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