JP2007502101A5 - - Google Patents
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- Publication number
- JP2007502101A5 JP2007502101A5 JP2006521226A JP2006521226A JP2007502101A5 JP 2007502101 A5 JP2007502101 A5 JP 2007502101A5 JP 2006521226 A JP2006521226 A JP 2006521226A JP 2006521226 A JP2006521226 A JP 2006521226A JP 2007502101 A5 JP2007502101 A5 JP 2007502101A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- acid sequence
- amino acid
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 230000001681 protective effect Effects 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 7
- 230000036039 immunity Effects 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 210000002421 cell wall Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 230000004807 localization Effects 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48984003P | 2003-07-24 | 2003-07-24 | |
| US52011503P | 2003-11-14 | 2003-11-14 | |
| PCT/US2004/023523 WO2005009379A2 (en) | 2003-07-24 | 2004-07-22 | Polypeptides for inducing a protective immune response against staphylococcus aureus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007502101A JP2007502101A (ja) | 2007-02-08 |
| JP2007502101A5 true JP2007502101A5 (enExample) | 2007-05-24 |
Family
ID=34107815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521226A Pending JP2007502101A (ja) | 2003-07-24 | 2004-07-22 | スタフィロコッカス・アウレウスに対して防御免疫応答を誘導するポリペプチド |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20060177462A1 (enExample) |
| EP (1) | EP1651166B8 (enExample) |
| JP (1) | JP2007502101A (enExample) |
| KR (1) | KR20060065643A (enExample) |
| AT (1) | ATE457737T1 (enExample) |
| AU (1) | AU2004258979B2 (enExample) |
| BR (1) | BRPI0412799A (enExample) |
| CA (1) | CA2532370A1 (enExample) |
| CY (1) | CY1110028T1 (enExample) |
| DE (1) | DE602004025579D1 (enExample) |
| DK (1) | DK1651166T3 (enExample) |
| ES (1) | ES2342778T3 (enExample) |
| HR (1) | HRP20100240T1 (enExample) |
| IL (1) | IL173253A0 (enExample) |
| IS (1) | IS8213A (enExample) |
| MX (1) | MXPA06000854A (enExample) |
| NO (1) | NO20060898L (enExample) |
| NZ (2) | NZ544542A (enExample) |
| PL (1) | PL1651166T3 (enExample) |
| PT (1) | PT1651166E (enExample) |
| RU (1) | RU2337108C2 (enExample) |
| SI (1) | SI1651166T1 (enExample) |
| WO (1) | WO2005009379A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| US20070134263A1 (en) * | 2004-02-18 | 2007-06-14 | Anderson Annaliesa S | Polypeptides for inducing a protective immune response against staphyloococcus aureus |
| EP1812066A4 (en) * | 2004-10-25 | 2010-06-30 | Univ Western Ontario | STAINLOCOCCUS AUREUS-BASED ANTI-INFECTION AGENTS ON ISD PROTEIN |
| GB0526038D0 (en) * | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| AU2007210170A1 (en) * | 2006-01-27 | 2007-08-09 | Merck Sharp & Dohme Corp. | Antigen-binding proteins targeting S. aureus ORF0657n |
| EP2117574A4 (en) | 2007-01-24 | 2010-06-16 | Merck Sharp & Dohme | POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS EPIDERMIDIS |
| EP1987836B1 (en) * | 2007-05-04 | 2011-12-21 | Martin Krönke | Protective staphylococcus aureus vaccine based on cell wall-associated proteins |
| AU2008294038A1 (en) * | 2007-05-31 | 2009-03-05 | Merck Sharp & Dohme Corp. | Antigen-binding proteins targeting S. aureus ORF0657n |
| EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| US8840906B2 (en) | 2007-08-31 | 2014-09-23 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung disease and conditions |
| WO2010014304A1 (en) | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
| WO2010062815A1 (en) | 2008-11-26 | 2010-06-03 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| WO2011005341A2 (en) | 2009-04-03 | 2011-01-13 | University Of Chicago | Compositions and methods related to protein a (spa) variants |
| EP2419129A2 (en) | 2009-04-14 | 2012-02-22 | Novartis AG | Compositions for immunising against staphylococcus aerus |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| JP2013506651A (ja) | 2009-09-30 | 2013-02-28 | ノバルティス アーゲー | Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ．ａｕｒｅｕｓ５型および８型莢膜多糖の結合体 |
| CN102971009A (zh) | 2009-10-30 | 2013-03-13 | 诺华有限公司 | 金黄色葡萄球菌5型和8型荚膜多糖的纯化 |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| WO2011113056A1 (en) * | 2010-03-12 | 2011-09-15 | The Trustees Of The University Of Pennsylvania | Methods for preventing and treating staphylococcus aureus colonization, infection, and disease |
| US8821894B2 (en) | 2010-07-02 | 2014-09-02 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
| WO2012021229A1 (en) | 2010-07-13 | 2012-02-16 | Merck Sharp & Dohme Corp. | Staphylococcus aureus surface protein sa1789 and protective vaccine based thereon |
| WO2012065034A1 (en) | 2010-11-12 | 2012-05-18 | Merck Sharp & Dohme Corp. | Enolase peptide conjugate vaccines against staphylococcus aureus |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| CN104093418A (zh) | 2011-09-01 | 2014-10-08 | 诺华股份有限公司 | 金黄色葡萄球菌抗原的含佐剂制剂 |
| EP2773370A4 (en) | 2011-10-31 | 2016-09-28 | Merck Sharp & Dohme | PROTECTIVE VACCINE BASED ON THE STAPHYLOCOCCUS AUREUS PROTEIN SA2451 |
| JP6309002B2 (ja) | 2012-06-27 | 2018-04-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的に特異的に結合する少なくとも１つの結合実体を含む抗体Ｆｃ領域結合体を作製するための方法およびその使用 |
| CN110256567B (zh) | 2012-06-27 | 2023-04-25 | 弗·哈夫曼-拉罗切有限公司 | 用于选择并产生含有至少两种不同结合实体的定制靶向实体的方法及其用途 |
| WO2014011645A1 (en) | 2012-07-10 | 2014-01-16 | Merck Sharp & Dohme Corp. | Protective vaccine based on staphylococcus aureus sa2493 protein |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| JP2003503015A (ja) * | 1999-05-03 | 2003-01-28 | メダレツクス・インコーポレーテツド | スタフィロコッカス・アウレウスに対するヒト抗体 |
| GB0014907D0 (en) * | 2000-06-20 | 2000-08-09 | Univ Sheffield | Antigenic polypeptides |
| AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| AU2002322127B2 (en) * | 2001-06-15 | 2008-08-21 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
| ATE509943T1 (de) * | 2001-11-12 | 2011-06-15 | Novo Nordisk As | Peptidreinigung mittels metallionenaffinitätschromatographie |
| CA2469132A1 (en) * | 2001-12-11 | 2003-07-03 | Merck & Co., Inc. | Staphylococcus aureus exopolysaccharide and process |
| US20080050361A1 (en) * | 2004-10-25 | 2008-02-28 | Heinrichs David E | Staphylococcus aureas specific anti-infectives |
| US20090317421A1 (en) * | 2006-01-18 | 2009-12-24 | Dominique Missiakas | Compositions and methods related to staphylococcal bacterium proteins |
-
2004
- 2004-07-22 HR HR20100240T patent/HRP20100240T1/hr unknown
- 2004-07-22 NZ NZ544542A patent/NZ544542A/en not_active IP Right Cessation
- 2004-07-22 EP EP04778847A patent/EP1651166B8/en not_active Expired - Lifetime
- 2004-07-22 DK DK04778847.6T patent/DK1651166T3/da active
- 2004-07-22 RU RU2006105498/13A patent/RU2337108C2/ru not_active IP Right Cessation
- 2004-07-22 PL PL04778847T patent/PL1651166T3/pl unknown
- 2004-07-22 US US10/564,458 patent/US20060177462A1/en not_active Abandoned
- 2004-07-22 SI SI200431389T patent/SI1651166T1/sl unknown
- 2004-07-22 AT AT04778847T patent/ATE457737T1/de active
- 2004-07-22 AU AU2004258979A patent/AU2004258979B2/en not_active Ceased
- 2004-07-22 DE DE602004025579T patent/DE602004025579D1/de not_active Expired - Lifetime
- 2004-07-22 PT PT04778847T patent/PT1651166E/pt unknown
- 2004-07-22 BR BRPI0412799-4A patent/BRPI0412799A/pt not_active Application Discontinuation
- 2004-07-22 MX MXPA06000854A patent/MXPA06000854A/es active IP Right Grant
- 2004-07-22 NZ NZ570750A patent/NZ570750A/en not_active IP Right Cessation
- 2004-07-22 JP JP2006521226A patent/JP2007502101A/ja active Pending
- 2004-07-22 ES ES04778847T patent/ES2342778T3/es not_active Expired - Lifetime
- 2004-07-22 WO PCT/US2004/023523 patent/WO2005009379A2/en not_active Ceased
- 2004-07-22 KR KR1020067001610A patent/KR20060065643A/ko not_active Ceased
- 2004-07-22 CA CA002532370A patent/CA2532370A1/en not_active Abandoned
-
2005
- 2005-12-30 IS IS8213A patent/IS8213A/is unknown
-
2006
- 2006-01-19 IL IL173253A patent/IL173253A0/en unknown
- 2006-02-23 NO NO20060898A patent/NO20060898L/no not_active Application Discontinuation
-
2010
- 2010-04-30 US US12/771,345 patent/US20100247561A1/en not_active Abandoned
- 2010-05-14 CY CY20101100419T patent/CY1110028T1/el unknown
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