JP2007502101A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007502101A5 JP2007502101A5 JP2006521226A JP2006521226A JP2007502101A5 JP 2007502101 A5 JP2007502101 A5 JP 2007502101A5 JP 2006521226 A JP2006521226 A JP 2006521226A JP 2006521226 A JP2006521226 A JP 2006521226A JP 2007502101 A5 JP2007502101 A5 JP 2007502101A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- acid sequence
- amino acid
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims 30
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 230000001681 protective effect Effects 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 7
- 230000036039 immunity Effects 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 4
- 210000002421 cell wall Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 230000004807 localization Effects 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108020004705 Codon Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48984003P | 2003-07-24 | 2003-07-24 | |
| US52011503P | 2003-11-14 | 2003-11-14 | |
| PCT/US2004/023523 WO2005009379A2 (en) | 2003-07-24 | 2004-07-22 | Polypeptides for inducing a protective immune response against staphylococcus aureus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007502101A JP2007502101A (ja) | 2007-02-08 |
| JP2007502101A5 true JP2007502101A5 (enExample) | 2007-05-24 |
Family
ID=34107815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006521226A Pending JP2007502101A (ja) | 2003-07-24 | 2004-07-22 | スタフィロコッカス・アウレウスに対して防御免疫応答を誘導するポリペプチド |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20060177462A1 (enExample) |
| EP (1) | EP1651166B8 (enExample) |
| JP (1) | JP2007502101A (enExample) |
| KR (1) | KR20060065643A (enExample) |
| AT (1) | ATE457737T1 (enExample) |
| AU (1) | AU2004258979B2 (enExample) |
| BR (1) | BRPI0412799A (enExample) |
| CA (1) | CA2532370A1 (enExample) |
| CY (1) | CY1110028T1 (enExample) |
| DE (1) | DE602004025579D1 (enExample) |
| DK (1) | DK1651166T3 (enExample) |
| ES (1) | ES2342778T3 (enExample) |
| HR (1) | HRP20100240T1 (enExample) |
| IL (1) | IL173253A0 (enExample) |
| IS (1) | IS8213A (enExample) |
| MX (1) | MXPA06000854A (enExample) |
| NO (1) | NO20060898L (enExample) |
| NZ (2) | NZ544542A (enExample) |
| PL (1) | PL1651166T3 (enExample) |
| PT (1) | PT1651166E (enExample) |
| RU (1) | RU2337108C2 (enExample) |
| SI (1) | SI1651166T1 (enExample) |
| WO (1) | WO2005009379A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| JP2007528217A (ja) * | 2004-02-18 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | スタヒロコッカス・アウレウスに対する防御免疫応答を誘導するためのポリペプチド |
| AU2005310981A1 (en) * | 2004-10-25 | 2006-06-08 | The University Of Western Ontario | Vaccines, compositions and methods based on Staphylococcus aureus iron-regulated surface determinants IsdA, IsdB, and IsdC |
| GB0526038D0 (en) * | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| WO2007089470A2 (en) * | 2006-01-27 | 2007-08-09 | Merck & Co., Inc. | Antigen-binding proteins targeting s. aureus orf0657n |
| US8124108B2 (en) | 2007-01-24 | 2012-02-28 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against Staphylococcus epidermidis |
| EP2374466B1 (en) * | 2007-05-04 | 2013-08-28 | Krönke, Martin | Protective staphylococcus aureus vaccine based on cell wall-associated proteins |
| BRPI0811193A2 (pt) * | 2007-05-31 | 2014-11-11 | Merck & Co Inc | Proteína de ligação a antígeno isolada, ácido nucleico, célula recombinante, métodos para produzir uma proteína e para proteger ou tratar contra uma infecção por s. aureus em paciente, composição farmacêutica, uso da proteína de ligação a antígeno, e, polipeptídeo. |
| US8071561B2 (en) | 2007-08-16 | 2011-12-06 | Chrontech Pharma Ab | Immunogen platform |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| KR101661946B1 (ko) | 2007-08-31 | 2016-10-05 | 유니버시티 오브 시카고 | 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물 |
| US8758765B2 (en) | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| JP2012509665A (ja) | 2008-11-26 | 2012-04-26 | メルク・シャープ・エンド・ドーム・コーポレイション | スタフィロコッカス・アウレウス(staphylococcusaureus)に対する防御免疫応答を誘導するポリペプチド |
| SMT202000246T1 (it) | 2009-04-03 | 2020-07-08 | Univ Chicago | Composizioni e metodi relativi a varianti della proteina a (spa) |
| AU2010238255B2 (en) | 2009-04-14 | 2014-10-16 | Novartis Ag | Compositions for immunising against Staphylococcus aureus |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| MX338753B (es) | 2009-09-30 | 2016-04-29 | Novartis Ag | Conjugacion de polisacaridos capsulares de tipo 5 y de tipo 8 de staphylococcus aureus. |
| CN109134677A (zh) | 2009-10-30 | 2019-01-04 | 诺华股份有限公司 | 金黄色葡萄球菌5型和8型荚膜多糖的纯化 |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| WO2011113056A1 (en) * | 2010-03-12 | 2011-09-15 | The Trustees Of The University Of Pennsylvania | Methods for preventing and treating staphylococcus aureus colonization, infection, and disease |
| US8821894B2 (en) | 2010-07-02 | 2014-09-02 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
| EP2593133A4 (en) | 2010-07-13 | 2014-11-26 | Merck Sharp & Dohme | STAPHYLOCOCCUS AUREUS SURFACE PROTEIN SA1789 AND PROTECTIVE VACCINE BASED ON IT |
| EP2638058B1 (en) | 2010-11-12 | 2017-01-11 | Merck Sharp & Dohme Corp. | Enolase peptide conjugate vaccines against staphylococcus aureus |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| MX2014002363A (es) | 2011-09-01 | 2014-04-14 | Novartis Ag | Formulaciones de antigenos de staphylococcus aureus con adyuvante. |
| US9527892B2 (en) | 2011-10-31 | 2016-12-27 | Merck Sharp & Dohme Corp. | Protective vaccine based on Staphylococcus aureus SA2451 protein |
| EP2867254B1 (en) | 2012-06-27 | 2017-10-25 | F. Hoffmann-La Roche AG | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
| MX354862B (es) | 2012-06-27 | 2018-03-23 | Hoffmann La Roche | Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes. |
| WO2014011645A1 (en) | 2012-07-10 | 2014-01-16 | Merck Sharp & Dohme Corp. | Protective vaccine based on staphylococcus aureus sa2493 protein |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| BR112021022902A2 (pt) | 2019-05-14 | 2022-01-25 | Univ Chicago | Métodos e composições que compreendem variantes de proteína a staphylococcus (spa) |
| US12528882B2 (en) | 2019-09-13 | 2026-01-20 | The University Of Chicago | Methods and compositions for treating staphylococcal infections |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| AU5867100A (en) * | 1999-05-03 | 2000-12-12 | Medarex, Inc. | Human antibodies to staphylococcus aureus |
| GB0014907D0 (en) * | 2000-06-20 | 2000-08-09 | Univ Sheffield | Antigenic polypeptides |
| AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
| WO2002102829A2 (en) * | 2001-06-15 | 2002-12-27 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
| WO2003042249A2 (en) * | 2001-11-12 | 2003-05-22 | Novo Nordisk A/S | Peptide purification by means of metal ion affinity chromatography |
| CA2469132A1 (en) * | 2001-12-11 | 2003-07-03 | Merck & Co., Inc. | Staphylococcus aureus exopolysaccharide and process |
| US20080050361A1 (en) * | 2004-10-25 | 2008-02-28 | Heinrichs David E | Staphylococcus aureas specific anti-infectives |
| CA2637598A1 (en) * | 2006-01-18 | 2007-02-14 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
-
2004
- 2004-07-22 US US10/564,458 patent/US20060177462A1/en not_active Abandoned
- 2004-07-22 AU AU2004258979A patent/AU2004258979B2/en not_active Ceased
- 2004-07-22 KR KR1020067001610A patent/KR20060065643A/ko not_active Ceased
- 2004-07-22 CA CA002532370A patent/CA2532370A1/en not_active Abandoned
- 2004-07-22 EP EP04778847A patent/EP1651166B8/en not_active Expired - Lifetime
- 2004-07-22 ES ES04778847T patent/ES2342778T3/es not_active Expired - Lifetime
- 2004-07-22 PT PT04778847T patent/PT1651166E/pt unknown
- 2004-07-22 BR BRPI0412799-4A patent/BRPI0412799A/pt not_active Application Discontinuation
- 2004-07-22 NZ NZ544542A patent/NZ544542A/en not_active IP Right Cessation
- 2004-07-22 HR HR20100240T patent/HRP20100240T1/hr unknown
- 2004-07-22 JP JP2006521226A patent/JP2007502101A/ja active Pending
- 2004-07-22 DK DK04778847.6T patent/DK1651166T3/da active
- 2004-07-22 SI SI200431389T patent/SI1651166T1/sl unknown
- 2004-07-22 AT AT04778847T patent/ATE457737T1/de active
- 2004-07-22 DE DE602004025579T patent/DE602004025579D1/de not_active Expired - Lifetime
- 2004-07-22 NZ NZ570750A patent/NZ570750A/en not_active IP Right Cessation
- 2004-07-22 PL PL04778847T patent/PL1651166T3/pl unknown
- 2004-07-22 WO PCT/US2004/023523 patent/WO2005009379A2/en not_active Ceased
- 2004-07-22 MX MXPA06000854A patent/MXPA06000854A/es active IP Right Grant
- 2004-07-22 RU RU2006105498/13A patent/RU2337108C2/ru not_active IP Right Cessation
-
2005
- 2005-12-30 IS IS8213A patent/IS8213A/is unknown
-
2006
- 2006-01-19 IL IL173253A patent/IL173253A0/en unknown
- 2006-02-23 NO NO20060898A patent/NO20060898L/no not_active Application Discontinuation
-
2010
- 2010-04-30 US US12/771,345 patent/US20100247561A1/en not_active Abandoned
- 2010-05-14 CY CY20101100419T patent/CY1110028T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007502101A5 (enExample) | ||
| RU2006105498A (ru) | Полипептиды для индукции защитного иммунного ответа против staphylococcus aureus | |
| CN114634556B (zh) | 一种新冠病毒Delta和Omicron变异株嵌合抗原、其制备方法和应用 | |
| Lecordier et al. | Characterization of a dense granule antigen of Toxoplasma gondii (GRA6) associated to the network of the parasitophorous vacuole | |
| JP2008529558A5 (enExample) | ||
| JP2002537791A5 (enExample) | ||
| JP2002510494A5 (enExample) | ||
| JP2006516189A5 (enExample) | ||
| ES2612741T3 (es) | Proteínas de fusión proteína n de un virus de la familia paramyxoviridae-proteína de interés | |
| JPH09322781A5 (enExample) | ||
| JP2002542827A5 (enExample) | ||
| JP2002531129A5 (enExample) | ||
| JP2008538183A5 (enExample) | ||
| WO1993020844A1 (en) | Papillomavirus e7 protein | |
| CN116041448B (zh) | 新型冠状病毒免疫原性物质、其制备方法和应用 | |
| JP2004502446A5 (enExample) | ||
| JP2002517193A5 (enExample) | ||
| CN117050193B (zh) | 一种β冠状病毒重组嵌合抗原、其制备方法及应用 | |
| WO2024067725A1 (zh) | 一种融合前构象的呼吸道合胞病毒重组融合蛋白、其制备方法及用途 | |
| Deleersnijder et al. | Molecular cloning and sequence analysis of the gene encoding the major merozoite surface antigen of Plasmodium chabaudi chabaudi IP-PC1 | |
| JP2005512518A5 (enExample) | ||
| JP2004532037A5 (enExample) | ||
| TW200716166A (en) | Lawsonia intracellularis immunological proteins | |
| US20230220012A1 (en) | High-potency sars coronavirus 2 antigen and vaccine composition comprising same | |
| Kitada et al. | Multi-gene family of major surface glycoproteins of Pneumocystis carinii: full-size cDNA cloning and expression |