JP2002500043A5 - - Google Patents
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- Publication number
- JP2002500043A5 JP2002500043A5 JP2000527646A JP2000527646A JP2002500043A5 JP 2002500043 A5 JP2002500043 A5 JP 2002500043A5 JP 2000527646 A JP2000527646 A JP 2000527646A JP 2000527646 A JP2000527646 A JP 2000527646A JP 2002500043 A5 JP2002500043 A5 JP 2002500043A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- polypeptide
- deletion
- isolated polypeptide
- acid residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229920001184 polypeptide Polymers 0.000 description 105
- 102000004196 processed proteins & peptides Human genes 0.000 description 105
- 108090000765 processed proteins & peptides Proteins 0.000 description 105
- 238000012217 deletion Methods 0.000 description 44
- 230000037430 deletion Effects 0.000 description 44
- 125000003275 alpha amino acid group Chemical group 0.000 description 43
- 125000000539 amino acid group Chemical group 0.000 description 33
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 31
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 21
- 239000002773 nucleotide Substances 0.000 description 16
- 125000003729 nucleotide group Chemical group 0.000 description 16
- 102000039446 nucleic acids Human genes 0.000 description 11
- 108020004707 nucleic acids Proteins 0.000 description 11
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 102000040430 polynucleotide Human genes 0.000 description 6
- 108091033319 polynucleotide Proteins 0.000 description 6
- 239000002157 polynucleotide Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 238000012258 culturing Methods 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 3
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 230000009826 neoplastic cell growth Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000010188 recombinant method Methods 0.000 description 2
- 241000024188 Andala Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US388698A | 1998-01-07 | 1998-01-07 | |
| US09/003,886 | 1998-01-07 | ||
| US09/027,287 | 1998-02-20 | ||
| US09/027,287 US6479254B2 (en) | 1996-03-22 | 1998-02-20 | Apoptosis inducing molecule II |
| PCT/US1999/000242 WO1999035262A2 (en) | 1998-01-07 | 1999-01-07 | Apoptosis inducing molecule ii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002500043A JP2002500043A (ja) | 2002-01-08 |
| JP2002500043A5 true JP2002500043A5 (enExample) | 2006-02-23 |
Family
ID=26672322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000527646A Withdrawn JP2002500043A (ja) | 1998-01-07 | 1999-01-07 | アポトーシス誘導分子ｉｉ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6479254B2 (enExample) |
| EP (1) | EP1044270A2 (enExample) |
| JP (1) | JP2002500043A (enExample) |
| AU (1) | AU2106399A (enExample) |
| CA (1) | CA2317057A1 (enExample) |
| WO (1) | WO1999035262A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7964190B2 (en) | 1996-03-22 | 2011-06-21 | Human Genome Sciences, Inc. | Methods and compositions for decreasing T-cell activity |
| US6635743B1 (en) | 1996-03-22 | 2003-10-21 | Human Genome Sciences, Inc. | Apoptosis inducing molecule II and methods of use |
| US7118742B2 (en) * | 1997-07-07 | 2006-10-10 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| US6140467A (en) * | 1997-07-07 | 2000-10-31 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| US6998108B1 (en) | 1997-07-07 | 2006-02-14 | La Jolla Institute For Allergy And Immunology | Antibodies to p30 polypeptides and methods making and using same |
| EP1016721B1 (en) * | 1997-09-17 | 2010-03-10 | Mochida Pharmaceutical Co., Ltd. | Fas ligand derivative |
| CA2374273A1 (en) * | 1999-05-21 | 2000-11-30 | Takeda Chemical Industries, Ltd. | Liver function controlling agents |
| WO2001079496A2 (en) * | 2000-03-13 | 2001-10-25 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| AU5338701A (en) * | 2000-04-12 | 2001-10-30 | Jolla Inst Allergy Immunolog | Ligand for herpes simplex virus entry mediator and methods of use |
| WO2002066049A1 (fr) * | 2001-02-23 | 2002-08-29 | Takeda Chemical Industries, Ltd. | Agents pour changement plasmique |
| EP1364653A4 (en) * | 2001-02-23 | 2005-01-26 | Takeda Pharmaceutical | CASOASE-3 INHIBITORS |
| EP1376134A1 (en) * | 2002-06-28 | 2004-01-02 | Universitätsklinikum Charité Medizinische Fakultät der Humboldt-Universität zu Berlin | A method of screening for TRAIL-inhibitors |
| AT412145B (de) * | 2002-09-13 | 2004-10-25 | Forsch Krebskranke Kinder | Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen |
| EP2322203A3 (en) * | 2002-10-29 | 2011-07-27 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| EA021255B1 (ru) * | 2006-08-28 | 2015-05-29 | Киова Хакко Кирин Ко., Лимитед | Антагонистические моноклональные антитела человека, специфичные в отношении light человека |
| JP2010508020A (ja) * | 2006-10-25 | 2010-03-18 | ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー | Ｌｉｇｈｔを介する抗細胞増殖性組成物および方法 |
| CA2779436A1 (en) * | 2008-10-31 | 2010-05-06 | Biogen Idec Ma Inc. | Light targeting molecules and uses thereof |
| WO2012048275A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| CN105793411B (zh) | 2013-11-16 | 2018-04-17 | 泰尔茂比司特公司 | 生物反应器中的细胞扩增 |
| JP6783143B2 (ja) | 2014-03-25 | 2020-11-11 | テルモ ビーシーティー、インコーポレーテッド | 培地の受動的補充 |
| US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879111A (en) * | 1986-04-17 | 1989-11-07 | Cetus Corporation | Treatment of infections with lymphokines |
| JPH08211695A (ja) | 1992-12-14 | 1996-08-20 | Canon Inc | 画像形成装置の帯電部材 |
| US5534881A (en) | 1994-08-31 | 1996-07-09 | Hughes Aircraft Company | Microwave filter assembly having a nonsymmetrical waveguide and an antenna |
| JPH11505124A (ja) | 1995-05-16 | 1999-05-18 | ブリストル−マイヤーズ・スクイブ・カンパニー | 組換えヒレグリンおよび受容体活性化後のその生物学的機能 |
| JPH0919330A (ja) | 1995-07-07 | 1997-01-21 | Manhin Denki Seisakusho:Kk | キッチンキャビネットのスイッチ装置 |
| US6509313B1 (en) | 1996-02-28 | 2003-01-21 | Cornell Research Foundation, Inc. | Stimulation of immune response with low doses of cytokines |
| EP0904278A4 (en) | 1996-03-22 | 1999-09-15 | Human Genome Sciences Inc | MOLECULE II INDUCER OF APOPTOSIS |
| US6235878B1 (en) | 1996-07-19 | 2001-05-22 | Takeda Chemical Industries, Ltd. | Fas ligand-like protein, its production and use |
| WO1998025967A1 (en) | 1996-12-12 | 1998-06-18 | Genentech, Inc. | Hvem polypeptides and uses thereof |
| EP2003203A1 (en) | 1996-12-23 | 2008-12-17 | Immunex Corporation | Ligand for receptor activator of nf-kappa b, ligand is member of TNF superfamily |
| US6010853A (en) | 1997-05-29 | 2000-01-04 | Dana-Farber Cancer Institute | Siva genes, novel genes involved in CD27-mediated apoptosis |
| US6140467A (en) | 1997-07-07 | 2000-10-31 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
| US6346388B1 (en) | 1997-08-13 | 2002-02-12 | Smithkline Beecham Corporation | Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2 |
| AU9222698A (en) | 1997-09-05 | 1999-03-22 | Millennium Biotherapeutics, Inc. | Novel molecules of the tnfr-ligand-related protein family and uses thereof |
| JP2002504333A (ja) | 1998-02-20 | 2002-02-12 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | アポトーシス誘導分子ｉｉおよび使用方法 |
-
1998
- 1998-02-20 US US09/027,287 patent/US6479254B2/en not_active Expired - Lifetime
-
1999
- 1999-01-07 JP JP2000527646A patent/JP2002500043A/ja not_active Withdrawn
- 1999-01-07 CA CA002317057A patent/CA2317057A1/en not_active Abandoned
- 1999-01-07 EP EP99901341A patent/EP1044270A2/en not_active Withdrawn
- 1999-01-07 WO PCT/US1999/000242 patent/WO1999035262A2/en not_active Ceased
- 1999-01-07 AU AU21063/99A patent/AU2106399A/en not_active Abandoned
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