JP2002505843A5 - - Google Patents
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- Publication number
- JP2002505843A5 JP2002505843A5 JP2000510863A JP2000510863A JP2002505843A5 JP 2002505843 A5 JP2002505843 A5 JP 2002505843A5 JP 2000510863 A JP2000510863 A JP 2000510863A JP 2000510863 A JP2000510863 A JP 2000510863A JP 2002505843 A5 JP2002505843 A5 JP 2002505843A5
- Authority
- JP
- Japan
- Prior art keywords
- dna sequence
- polypeptide
- train receptor
- seq
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 description 34
- 108090000765 processed proteins & peptides Proteins 0.000 description 25
- 229920001184 polypeptide Polymers 0.000 description 24
- 102000004196 processed proteins & peptides Human genes 0.000 description 24
- 102000005962 receptors Human genes 0.000 description 11
- 108020003175 receptors Proteins 0.000 description 11
- 238000000034 method Methods 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 102000053602 DNA Human genes 0.000 description 3
- 108020004511 Recombinant DNA Proteins 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 208000026278 immune system disease Diseases 0.000 description 3
- 239000003087 receptor blocking agent Substances 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002981 blocking agent Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5863197P | 1997-09-12 | 1997-09-12 | |
| US60/058,631 | 1997-09-12 | ||
| US8442298P | 1998-05-06 | 1998-05-06 | |
| US60/084,422 | 1998-05-06 | ||
| PCT/US1998/019030 WO1999013078A1 (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors-train |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002505843A JP2002505843A (ja) | 2002-02-26 |
| JP2002505843A5 true JP2002505843A5 (enExample) | 2006-01-05 |
| JP4357738B2 JP4357738B2 (ja) | 2009-11-04 |
Family
ID=26737837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000510863A Expired - Fee Related JP4357738B2 (ja) | 1997-09-12 | 1998-09-11 | システインリッチなレセプターであるｔｒａｉｎ |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7223852B2 (enExample) |
| EP (2) | EP1012179A2 (enExample) |
| JP (1) | JP4357738B2 (enExample) |
| AT (1) | ATE360032T1 (enExample) |
| AU (2) | AU9386398A (enExample) |
| CA (1) | CA2301173C (enExample) |
| DE (1) | DE69837606T2 (enExample) |
| ES (1) | ES2286856T3 (enExample) |
| WO (2) | WO1999013078A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US7528239B1 (en) | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| DE69839582D1 (de) * | 1997-02-27 | 2008-07-17 | Ono Pharmaceutical Co | Neues polypeptid, dafür kodierende dna und deren verwendungen |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| JP4357738B2 (ja) | 1997-09-12 | 2009-11-04 | アポテック エール エ デ− エス．アー． | システインリッチなレセプターであるｔｒａｉｎ |
| AU748167B2 (en) * | 1997-12-29 | 2002-05-30 | Regeneron Pharmaceuticals, Inc. | Novel nucleic acid and polypeptide |
| WO1999037818A1 (en) * | 1998-01-27 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Novel molecules of the tnf receptor superfamily and uses therefor |
| WO2000039284A1 (en) * | 1998-12-30 | 2000-07-06 | Millennium Pharmaceuticals, Inc. | Secreted proteins and nucleic acids encoding them |
| AU2574200A (en) * | 1999-02-19 | 2000-09-04 | Toshio Kitamura | Novel tnf receptor-like proteins |
| EP1210425B2 (en) | 1999-08-17 | 2015-06-17 | Biogen MA Inc. | Baff receptor (bcma), an immunoregulatory agent |
| EP1212413A1 (en) * | 1999-08-25 | 2002-06-12 | Genome Therapeutics Corporation | A transmembrane trap for isolating membrane bound proteins |
| WO2001030850A1 (en) * | 1999-10-22 | 2001-05-03 | Zymogenetics, Inc. | Umlr polypeptides |
| GB9927681D0 (en) * | 1999-11-23 | 2000-01-19 | Glaxo Group Ltd | Protein |
| ATE383374T1 (de) * | 2000-02-11 | 2008-01-15 | Genetics Inst Llc | Verwendung der extrazellulären domäne von trade molekülen in medikamenten zur behandlung von neoplasie |
| US6900185B1 (en) | 2000-04-12 | 2005-05-31 | University Of Iowa Research Foundation | Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer |
| US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| CA2426710A1 (en) * | 2000-11-08 | 2002-10-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| DK1572874T3 (da) | 2001-05-25 | 2013-12-16 | Human Genome Sciences Inc | Antistoffer, der immunospecifikt binder til TRAIL receptorer |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| EP1756162A1 (en) | 2004-03-23 | 2007-02-28 | Biogen Idec MA Inc. | Receptor coupling agents and therapeutic uses thereof |
| WO2006017673A2 (en) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Taj in neuronal function |
| EP1846034A4 (en) | 2005-02-02 | 2010-11-10 | Uab Research Foundation | AGENTS AND METHODS OF REDUCING THE RESISTANCE TO APOPTOSIS INDUCING DEATH RECEPTOR AGONISTS |
| JP4898126B2 (ja) * | 2005-02-28 | 2012-03-14 | 中外製薬株式会社 | Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物 |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| EP2010917B1 (en) * | 2006-04-10 | 2012-06-27 | Trustees of Boston University | Melanoma biomarker and methods of uses |
| KR20120101050A (ko) | 2009-11-05 | 2012-09-12 | 더 유에이비 리서치 파운데이션 | 기저형 유전자형 암의 치료 방법 |
| US8703712B2 (en) | 2010-03-18 | 2014-04-22 | The Uab Research Foundation | Targeting cancer stem cells with DR5 agonists |
| CN103282495B (zh) | 2010-10-29 | 2017-06-09 | 第一三共株式会社 | 新的抗dr5抗体 |
| ES2847578T3 (es) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Calibración avanzada de sensor de analito y detección de errores |
| US9700253B2 (en) | 2012-03-16 | 2017-07-11 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| CA3077720A1 (en) | 2017-10-24 | 2019-05-02 | Dexcom, Inc. | Pre-connected analyte sensors |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5965388A (en) | 1996-07-09 | 1999-10-12 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| WO2002000690A2 (en) | 2000-06-23 | 2002-01-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| WO2002008284A2 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| ATE321855T1 (de) * | 1997-01-14 | 2006-04-15 | Human Genome Sciences Inc | Tumor-nekrose-faktor rezeptor 5 |
| US6072047A (en) * | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| DE69839582D1 (de) * | 1997-02-27 | 2008-07-17 | Ono Pharmaceutical Co | Neues polypeptid, dafür kodierende dna und deren verwendungen |
| NZ337795A (en) * | 1997-03-17 | 2001-06-29 | Human Genome Sciences Inc | Death domain containing receptor 5 and it's use in the treatment of DR5 related disease |
| AU9376498A (en) | 1997-09-05 | 1999-03-22 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| JP4357738B2 (ja) * | 1997-09-12 | 2009-11-04 | アポテック エール エ デ− エス．アー． | システインリッチなレセプターであるｔｒａｉｎ |
| US20030027272A1 (en) * | 1997-09-18 | 2003-02-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU1101199A (en) | 1997-10-18 | 1999-05-10 | Genetics Institute Inc. | Secreted proteins and polynucleotides encoding them |
| AU748167B2 (en) | 1997-12-29 | 2002-05-30 | Regeneron Pharmaceuticals, Inc. | Novel nucleic acid and polypeptide |
| AU2093499A (en) | 1997-12-30 | 1999-07-19 | Chiron Corporation | Members of tnf and tnfr families |
| WO1999037818A1 (en) | 1998-01-27 | 1999-07-29 | Millennium Pharmaceuticals, Inc. | Novel molecules of the tnf receptor superfamily and uses therefor |
| EP1093516A2 (en) | 1998-07-06 | 2001-04-25 | Schering Corporation | Mammalian genes; dendritic cell prostaglandin-like transporter (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods |
| JP2000098232A (ja) * | 1998-09-25 | 2000-04-07 | Canon Inc | 光学素子及びそれを用いた光学系 |
| AU2574200A (en) | 1999-02-19 | 2000-09-04 | Toshio Kitamura | Novel tnf receptor-like proteins |
| KR20010103046A (ko) | 1999-03-08 | 2001-11-17 | 제넨테크, 인크. | 면역 관련 질환 치료용 조성물 및 치료 방법 |
| GB9927681D0 (en) | 1999-11-23 | 2000-01-19 | Glaxo Group Ltd | Protein |
| ATE383374T1 (de) | 2000-02-11 | 2008-01-15 | Genetics Inst Llc | Verwendung der extrazellulären domäne von trade molekülen in medikamenten zur behandlung von neoplasie |
| AU6802801A (en) | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2416456A1 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2003013578A1 (en) | 2001-08-07 | 2003-02-20 | Genset S.A. | Omoxin agonists and antagonists for use in the treatment of metabolic disorders |
| US8067664B2 (en) | 2003-12-16 | 2011-11-29 | Genentech, Inc. | PRO224 gene disruptions, and methods related thereto |
| WO2006017673A2 (en) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Taj in neuronal function |
| US20070186296A1 (en) * | 2006-02-02 | 2007-08-09 | Wyeth | Cloning, characterization, and application of tnfrsf19 in neurological disorders |
-
1998
- 1998-09-11 JP JP2000510863A patent/JP4357738B2/ja not_active Expired - Fee Related
- 1998-09-11 WO PCT/US1998/019030 patent/WO1999013078A1/en not_active Ceased
- 1998-09-11 AU AU93863/98A patent/AU9386398A/en not_active Abandoned
- 1998-09-11 WO PCT/US1998/019029 patent/WO1999012963A2/en not_active Ceased
- 1998-09-11 CA CA2301173A patent/CA2301173C/en not_active Expired - Lifetime
- 1998-09-11 EP EP98946966A patent/EP1012179A2/en not_active Withdrawn
- 1998-09-11 EP EP98944859A patent/EP1012282B1/en not_active Expired - Lifetime
- 1998-09-11 AU AU92303/98A patent/AU738688B2/en not_active Ceased
- 1998-09-11 DE DE69837606T patent/DE69837606T2/de not_active Expired - Lifetime
- 1998-09-11 ES ES98944859T patent/ES2286856T3/es not_active Expired - Lifetime
- 1998-09-11 AT AT98944859T patent/ATE360032T1/de active
-
2002
- 2002-11-22 US US10/303,502 patent/US7223852B2/en not_active Expired - Fee Related
-
2006
- 2006-04-04 US US11/396,907 patent/US7402658B2/en not_active Expired - Fee Related
-
2008
- 2008-05-30 US US12/130,740 patent/US7838639B2/en not_active Expired - Fee Related
-
2010
- 2010-11-22 US US12/951,761 patent/US20110158993A1/en not_active Abandoned