CA2301173C - Cysteine rich receptors-train - Google Patents
Cysteine rich receptors-train Download PDFInfo
- Publication number
- CA2301173C CA2301173C CA2301173A CA2301173A CA2301173C CA 2301173 C CA2301173 C CA 2301173C CA 2301173 A CA2301173 A CA 2301173A CA 2301173 A CA2301173 A CA 2301173A CA 2301173 C CA2301173 C CA 2301173C
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- Prior art keywords
- polypeptide
- train
- receptor
- seq
- dna molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5863197P | 1997-09-12 | 1997-09-12 | |
| US60/058,631 | 1997-09-12 | ||
| US8442298P | 1998-05-06 | 1998-05-06 | |
| US60/084,422 | 1998-05-06 | ||
| PCT/US1998/019030 WO1999013078A1 (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors-train |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2301173A1 CA2301173A1 (en) | 1999-03-18 |
| CA2301173C true CA2301173C (en) | 2015-04-14 |
Family
ID=26737837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2301173A Expired - Lifetime CA2301173C (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors-train |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7223852B2 (enExample) |
| EP (2) | EP1012179A2 (enExample) |
| JP (1) | JP4357738B2 (enExample) |
| AT (1) | ATE360032T1 (enExample) |
| AU (2) | AU738688B2 (enExample) |
| CA (1) | CA2301173C (enExample) |
| DE (1) | DE69837606T2 (enExample) |
| ES (1) | ES2286856T3 (enExample) |
| WO (2) | WO1999012963A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US7528239B1 (en) | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| KR20000075749A (ko) * | 1997-02-27 | 2000-12-26 | 오노 야꾸힝 고교 가부시키가이샤 | 신규의 폴리펩티드, 그 폴리펩티드를 암호하는 ｄｎａ 및 그용도 |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| ES2286856T3 (es) | 1997-09-12 | 2007-12-01 | Biogen Idec Ma Inc. | Receptores train ricos en cisteina. |
| IL136988A0 (en) * | 1997-12-29 | 2001-06-14 | Regeneron Pharma | Novel nucleic acid and polypeptide |
| EP1053351A4 (en) * | 1998-01-27 | 2002-09-25 | Millennium Pharm Inc | NOVEL TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMIL MOLECULES AND USES THEREOF |
| AU2486300A (en) * | 1998-12-30 | 2000-07-31 | Millennium Pharmaceuticals, Inc. | Secreted proteins and nucleic acids encoding them |
| WO2000049149A1 (fr) * | 1999-02-19 | 2000-08-24 | Toshio Kitamura | Nouvelles proteines du type recepteurs des tnf |
| JP4787439B2 (ja) | 1999-08-17 | 2011-10-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 免疫調節因子であるｂａｆｆレセプター（ｂｃｍａ） |
| AU6928200A (en) * | 1999-08-25 | 2001-03-19 | Genome Therapeutics Corporation | A transmembrane trap for isolating membrane bound proteins |
| CA2391820A1 (en) * | 1999-10-22 | 2001-05-03 | Zymogenetics, Inc. | Umlr polypeptides |
| GB9927681D0 (en) * | 1999-11-23 | 2000-01-19 | Glaxo Group Ltd | Protein |
| WO2001058954A2 (en) * | 2000-02-11 | 2001-08-16 | Genetics Institute, Llc. | Trade molecules and uses related thereto |
| US6900185B1 (en) | 2000-04-12 | 2005-05-31 | University Of Iowa Research Foundation | Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer |
| US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| CA2426710A1 (en) * | 2000-11-08 | 2002-10-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| ES2437992T3 (es) | 2001-05-25 | 2014-01-15 | Human Genome Sciences, Inc. | Anticuerpos que se unen inmunoespecíficamente a los receptores de TRAIL |
| US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| WO2005092927A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| CA2576193A1 (en) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Taj in neuronal function |
| BRPI0606791A2 (pt) | 2005-02-02 | 2010-02-09 | Uab Research Foundation | métodos de reverter ou prevenir a resistência de uma célula a um agonista do receptor da morte, de triar uma célula quanto a um biomarcador da resistência a um agonista do receptor da morte, de monitorar a resistência a um agonista do receptor da morte em um indivìduo, de induzir seletivamente a apoptose em uma célula alvo expressando um receptor da morte, de tratar de um indivìduo com cáncer, de tratar de um indivìduo com uma doença inflamatória ou autoimune, de bloquear a ligação da proteìna contendo card a um receptor da morte em uma célula, de bloquear a associação de um iap com o receptor da morte e de triar um modulador de uma proteìna contendo card, composição, ácido nucleico isolado, vetor, célula, e, polipeptìdeo isolado |
| JP4898126B2 (ja) * | 2005-02-28 | 2012-03-14 | 中外製薬株式会社 | Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物 |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| US7888044B2 (en) | 2006-04-10 | 2011-02-15 | Trustees Of Boston University | Melanoma biomarker and methods of uses |
| US9149220B2 (en) | 2011-04-15 | 2015-10-06 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
| KR20120101050A (ko) | 2009-11-05 | 2012-09-12 | 더 유에이비 리서치 파운데이션 | 기저형 유전자형 암의 치료 방법 |
| US8703712B2 (en) | 2010-03-18 | 2014-04-22 | The Uab Research Foundation | Targeting cancer stem cells with DR5 agonists |
| RU2644678C1 (ru) | 2010-10-29 | 2018-02-13 | Дайити Санкио Компани, Лимитед | Новое антитело против dr5 |
| EP4218571B1 (en) | 2012-03-16 | 2025-07-30 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| JP2021500162A (ja) | 2017-10-24 | 2021-01-07 | デックスコム・インコーポレーテッド | 事前接続された分析物センサ |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5965388A (en) | 1996-07-09 | 1999-10-12 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6261801B1 (en) * | 1997-01-14 | 2001-07-17 | Human Genome Sceineces, Inc. | Nucleic acids encoding tumor necrosis factor receptor 5 |
| US6072047A (en) * | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| KR20000075749A (ko) * | 1997-02-27 | 2000-12-26 | 오노 야꾸힝 고교 가부시키가이샤 | 신규의 폴리펩티드, 그 폴리펩티드를 암호하는 ｄｎａ 및 그용도 |
| ES2281126T3 (es) * | 1997-03-17 | 2007-09-16 | Human Genome Sciences, Inc. | Receptor 5 que contiene un dominio de muerte. |
| AU9376498A (en) | 1997-09-05 | 1999-03-22 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| ES2286856T3 (es) * | 1997-09-12 | 2007-12-01 | Biogen Idec Ma Inc. | Receptores train ricos en cisteina. |
| US20030027272A1 (en) * | 1997-09-18 | 2003-02-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1037899A1 (en) | 1997-10-18 | 2000-09-27 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| IL136988A0 (en) | 1997-12-29 | 2001-06-14 | Regeneron Pharma | Novel nucleic acid and polypeptide |
| WO1999033980A2 (en) | 1997-12-30 | 1999-07-08 | Chiron Corporation | Members of tnf and tnfr families |
| EP1053351A4 (en) | 1998-01-27 | 2002-09-25 | Millennium Pharm Inc | NOVEL TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMIL MOLECULES AND USES THEREOF |
| JP2002519062A (ja) | 1998-07-06 | 2002-07-02 | シェーリング コーポレイション | 哺乳動物遺伝子；樹状細胞プロスタグランジン様トランスポーター（ｄｃ−ｐｇｔ）、ｈｄｔｅａ，ｈｓｌｊｄ３７ｒおよびｒａｎｋｌ、ｈｃｃ５ケモカイン、脱ユビキチン化１１および１２（ｄｕｂ１１、ｄｕｂ１２）、ｍｄ−１、ｍｄ−２およびサイクリンｅ２、関連試薬および方法 |
| JP2000098232A (ja) * | 1998-09-25 | 2000-04-07 | Canon Inc | 光学素子及びそれを用いた光学系 |
| WO2000049149A1 (fr) | 1999-02-19 | 2000-08-24 | Toshio Kitamura | Nouvelles proteines du type recepteurs des tnf |
| CA2362427A1 (en) | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| GB9927681D0 (en) | 1999-11-23 | 2000-01-19 | Glaxo Group Ltd | Protein |
| WO2001058954A2 (en) | 2000-02-11 | 2001-08-16 | Genetics Institute, Llc. | Trade molecules and uses related thereto |
| AU6802801A (en) | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| JP2004506413A (ja) | 2000-06-23 | 2004-03-04 | ジェネンテック・インコーポレーテッド | 血管形成に関与する疾患の診断と治療のための組成物と方法 |
| EP1354040A2 (en) | 2000-07-20 | 2003-10-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU2001271973A1 (en) | 2000-07-20 | 2002-02-05 | Kevin P. Baker | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| WO2003013578A1 (en) | 2001-08-07 | 2003-02-20 | Genset S.A. | Omoxin agonists and antagonists for use in the treatment of metabolic disorders |
| AU2004299044B2 (en) | 2003-12-16 | 2008-10-30 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| CA2576193A1 (en) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Taj in neuronal function |
| US20070186296A1 (en) * | 2006-02-02 | 2007-08-09 | Wyeth | Cloning, characterization, and application of tnfrsf19 in neurological disorders |
-
1998
- 1998-09-11 ES ES98944859T patent/ES2286856T3/es not_active Expired - Lifetime
- 1998-09-11 EP EP98946966A patent/EP1012179A2/en not_active Withdrawn
- 1998-09-11 AU AU92303/98A patent/AU738688B2/en not_active Ceased
- 1998-09-11 AU AU93863/98A patent/AU9386398A/en not_active Abandoned
- 1998-09-11 AT AT98944859T patent/ATE360032T1/de active
- 1998-09-11 EP EP98944859A patent/EP1012282B1/en not_active Expired - Lifetime
- 1998-09-11 WO PCT/US1998/019029 patent/WO1999012963A2/en not_active Ceased
- 1998-09-11 JP JP2000510863A patent/JP4357738B2/ja not_active Expired - Fee Related
- 1998-09-11 WO PCT/US1998/019030 patent/WO1999013078A1/en not_active Ceased
- 1998-09-11 DE DE69837606T patent/DE69837606T2/de not_active Expired - Lifetime
- 1998-09-11 CA CA2301173A patent/CA2301173C/en not_active Expired - Lifetime
-
2002
- 2002-11-22 US US10/303,502 patent/US7223852B2/en not_active Expired - Fee Related
-
2006
- 2006-04-04 US US11/396,907 patent/US7402658B2/en not_active Expired - Fee Related
-
2008
- 2008-05-30 US US12/130,740 patent/US7838639B2/en not_active Expired - Fee Related
-
2010
- 2010-11-22 US US12/951,761 patent/US20110158993A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE360032T1 (de) | 2007-05-15 |
| US7223852B2 (en) | 2007-05-29 |
| US20090004188A1 (en) | 2009-01-01 |
| JP4357738B2 (ja) | 2009-11-04 |
| DE69837606T2 (de) | 2008-02-14 |
| DE69837606D1 (de) | 2007-05-31 |
| EP1012282B1 (en) | 2007-04-18 |
| US7402658B2 (en) | 2008-07-22 |
| US7838639B2 (en) | 2010-11-23 |
| US20030219860A1 (en) | 2003-11-27 |
| EP1012282A1 (en) | 2000-06-28 |
| AU9230398A (en) | 1999-03-29 |
| WO1999013078A1 (en) | 1999-03-18 |
| WO1999012963A3 (en) | 1999-05-06 |
| ES2286856T3 (es) | 2007-12-01 |
| JP2002505843A (ja) | 2002-02-26 |
| AU9386398A (en) | 1999-03-29 |
| EP1012179A2 (en) | 2000-06-28 |
| US20110158993A1 (en) | 2011-06-30 |
| US20060233792A1 (en) | 2006-10-19 |
| WO1999012963A2 (en) | 1999-03-18 |
| AU738688B2 (en) | 2001-09-27 |
| HK1028417A1 (en) | 2001-02-16 |
| CA2301173A1 (en) | 1999-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |