JP4357738B2 - システインリッチなレセプターであるｔｒａｉｎ - Google Patents

システインリッチなレセプターであるｔｒａｉｎ Download PDF

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Publication number
JP4357738B2
JP4357738B2 JP2000510863A JP2000510863A JP4357738B2 JP 4357738 B2 JP4357738 B2 JP 4357738B2 JP 2000510863 A JP2000510863 A JP 2000510863A JP 2000510863 A JP2000510863 A JP 2000510863A JP 4357738 B2 JP4357738 B2 JP 4357738B2
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JP
Japan
Prior art keywords
receptor
train
dna molecule
sequence
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000510863A
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English (en)
Japanese (ja)
Other versions
JP2002505843A (ja
JP2002505843A5 (enExample
Inventor
ユルク チョップ，
キャサリン ヘッション，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Inc
Biogen Idec Inc
Biogen Idec MA Inc
Biogen MA Inc
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Publication date
Application filed by Biogen Inc, Biogen Idec Inc, Biogen Idec MA Inc, Biogen MA Inc filed Critical Biogen Inc
Publication of JP2002505843A publication Critical patent/JP2002505843A/ja
Publication of JP2002505843A5 publication Critical patent/JP2002505843A5/ja
Application granted granted Critical
Publication of JP4357738B2 publication Critical patent/JP4357738B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2000510863A 1997-09-12 1998-09-11 システインリッチなレセプターであるｔｒａｉｎ Expired - Fee Related JP4357738B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5863197P 1997-09-12 1997-09-12
US60/058,631 1997-09-12
US8442298P 1998-05-06 1998-05-06
US60/084,422 1998-05-06
PCT/US1998/019030 WO1999013078A1 (en) 1997-09-12 1998-09-11 Cysteine rich receptors-train

Publications (3)

Publication Number Publication Date
JP2002505843A JP2002505843A (ja) 2002-02-26
JP2002505843A5 JP2002505843A5 (enExample) 2006-01-05
JP4357738B2 true JP4357738B2 (ja) 2009-11-04

Family

ID=26737837

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000510863A Expired - Fee Related JP4357738B2 (ja) 1997-09-12 1998-09-11 システインリッチなレセプターであるｔｒａｉｎ

Country Status (9)

Country Link
US (4) US7223852B2 (enExample)
EP (2) EP1012282B1 (enExample)
JP (1) JP4357738B2 (enExample)
AT (1) ATE360032T1 (enExample)
AU (2) AU738688B2 (enExample)
CA (1) CA2301173C (enExample)
DE (1) DE69837606T2 (enExample)
ES (1) ES2286856T3 (enExample)
WO (2) WO1999013078A1 (enExample)

Families Citing this family (36)

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US6072047A (en) 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
US7528239B1 (en) 1997-02-13 2009-05-05 Immunex Corporation Receptor that binds trail
ES2307313T3 (es) * 1997-02-27 2008-11-16 Ono Pharmaceutical Co., Ltd. Nuevos polipeptidos, adn que codifican y utilizan estos polpeptidos.
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
DE69837606T2 (de) 1997-09-12 2008-02-14 Biogen Idec Ma Inc., Cambridge Cystein-reiche rezeptoren-train
AU748167B2 (en) * 1997-12-29 2002-05-30 Regeneron Pharmaceuticals, Inc. Novel nucleic acid and polypeptide
AU2472899A (en) * 1998-01-27 1999-08-09 Millennium Pharmaceuticals, Inc. Novel molecules of the tnf receptor superfamily and uses therefor
EP1710299A3 (en) * 1998-12-30 2007-01-10 Millennium Pharmaceuticals, Inc. Secreted proteins and nucleic acids encoding them
AU2574200A (en) * 1999-02-19 2000-09-04 Toshio Kitamura Novel tnf receptor-like proteins
DK1210425T4 (en) 1999-08-17 2015-08-10 Apotech R & D Sa BAFF receptor (BCMA), an immunoregulatory agent
EP1212413A1 (en) * 1999-08-25 2002-06-12 Genome Therapeutics Corporation A transmembrane trap for isolating membrane bound proteins
WO2001030850A1 (en) 1999-10-22 2001-05-03 Zymogenetics, Inc. Umlr polypeptides
GB9927681D0 (en) * 1999-11-23 2000-01-19 Glaxo Group Ltd Protein
JP2004501604A (ja) * 2000-02-11 2004-01-22 ジェネティクス　インスティテュート，エルエルシー Ｔｒａｄｅ分子およびそれに関連する使用
US6900185B1 (en) 2000-04-12 2005-05-31 University Of Iowa Research Foundation Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
EP1339426A4 (en) * 2000-11-08 2004-06-30 Human Genome Sciences Inc ANTIBODIES WITH IMMUNOSPECIFIC BINDING TO TRAIL RECEPTORS
CA2446723C (en) 2001-05-25 2014-01-21 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
KR20060132006A (ko) 2004-03-23 2006-12-20 비오겐 아이덱 엠에이 아이엔씨. 수용체 커플링제 및 이의 치료적 용도
US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides
CN101495646A (zh) 2005-02-02 2009-07-29 Uab研究基金会 与降低对细胞凋亡诱导性死亡受体激动剂的抗性有关的试剂和方法
JP4898126B2 (ja) * 2005-02-28 2012-03-14 中外製薬株式会社 Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
WO2007120658A1 (en) * 2006-04-10 2007-10-25 Trustees Of Boston University Melanoma biomarker and methods of uses
EP2496606A2 (en) 2009-11-05 2012-09-12 The UAB Research Foundation Treating basal-like genotype cancers
WO2011116344A2 (en) 2010-03-18 2011-09-22 The Uab Research Foundation Targeting cancer stem cells
MX344200B (es) 2010-10-29 2016-12-08 Daiichi Sankyo Co Ltd Novedoso anticuerpo anti-dr5.
EP4324399A3 (en) 2011-04-15 2024-05-15 DexCom, Inc. Advanced analyte sensor calibration and error detection
US9700253B2 (en) 2012-03-16 2017-07-11 Dexcom, Inc. Systems and methods for processing analyte sensor data
DK3700416T3 (da) 2017-10-24 2024-09-30 Dexcom Inc På forhånd forbundne analytsensorer
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5965388A (en) 1996-07-09 1999-10-12 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998030693A2 (en) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptor 5
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
ES2307313T3 (es) 1997-02-27 2008-11-16 Ono Pharmaceutical Co., Ltd. Nuevos polipeptidos, adn que codifican y utilizan estos polpeptidos.
ATE352618T1 (de) * 1997-03-17 2007-02-15 Human Genome Sciences Inc Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält
WO1999011791A2 (en) 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
DE69837606T2 (de) * 1997-09-12 2008-02-14 Biogen Idec Ma Inc., Cambridge Cystein-reiche rezeptoren-train
US20030027272A1 (en) * 1997-09-18 2003-02-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2306457A1 (en) 1997-10-18 1999-04-29 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU748167B2 (en) 1997-12-29 2002-05-30 Regeneron Pharmaceuticals, Inc. Novel nucleic acid and polypeptide
WO1999033980A2 (en) 1997-12-30 1999-07-08 Chiron Corporation Members of tnf and tnfr families
AU2472899A (en) 1998-01-27 1999-08-09 Millennium Pharmaceuticals, Inc. Novel molecules of the tnf receptor superfamily and uses therefor
EP1093516A2 (en) 1998-07-06 2001-04-25 Schering Corporation Mammalian genes; dendritic cell prostaglandin-like transporter (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
JP2000098232A (ja) * 1998-09-25 2000-04-07 Canon Inc 光学素子及びそれを用いた光学系
AU2574200A (en) 1999-02-19 2000-09-04 Toshio Kitamura Novel tnf receptor-like proteins
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JP2004501604A (ja) 2000-02-11 2004-01-22 ジェネティクス　インスティテュート，エルエルシー Ｔｒａｄｅ分子およびそれに関連する使用
AU6802801A (en) 2000-03-01 2001-09-24 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
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JP2004516013A (ja) 2000-07-20 2004-06-03 ジェネンテック・インコーポレーテッド 血管形成に関連する障害を診断及び治療するための組成物と方法
EP1354040A2 (en) 2000-07-20 2003-10-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
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US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides
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Also Published As

Publication number Publication date
US7402658B2 (en) 2008-07-22
AU9230398A (en) 1999-03-29
ATE360032T1 (de) 2007-05-15
ES2286856T3 (es) 2007-12-01
US7838639B2 (en) 2010-11-23
US7223852B2 (en) 2007-05-29
EP1012179A2 (en) 2000-06-28
JP2002505843A (ja) 2002-02-26
EP1012282B1 (en) 2007-04-18
WO1999013078A1 (en) 1999-03-18
CA2301173C (en) 2015-04-14
AU738688B2 (en) 2001-09-27
HK1028417A1 (en) 2001-02-16
AU9386398A (en) 1999-03-29
EP1012282A1 (en) 2000-06-28
DE69837606D1 (de) 2007-05-31
US20110158993A1 (en) 2011-06-30
US20090004188A1 (en) 2009-01-01
US20060233792A1 (en) 2006-10-19
DE69837606T2 (de) 2008-02-14
WO1999012963A2 (en) 1999-03-18
WO1999012963A3 (en) 1999-05-06
CA2301173A1 (en) 1999-03-18
US20030219860A1 (en) 2003-11-27

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