AU738688B2 - Cysteine rich receptors-train - Google Patents
Cysteine rich receptors-train Download PDFInfo
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- AU738688B2 AU738688B2 AU92303/98A AU9230398A AU738688B2 AU 738688 B2 AU738688 B2 AU 738688B2 AU 92303/98 A AU92303/98 A AU 92303/98A AU 9230398 A AU9230398 A AU 9230398A AU 738688 B2 AU738688 B2 AU 738688B2
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- Prior art keywords
- train
- receptor
- receptors
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153 or CD154
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5863197P | 1997-09-12 | 1997-09-12 | |
| US60/058631 | 1997-09-12 | ||
| US8442298P | 1998-05-06 | 1998-05-06 | |
| US60/084422 | 1998-05-06 | ||
| PCT/US1998/019030 WO1999013078A1 (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors-train |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU9230398A AU9230398A (en) | 1999-03-29 |
| AU738688B2 true AU738688B2 (en) | 2001-09-27 |
Family
ID=26737837
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU92303/98A Ceased AU738688B2 (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors-train |
| AU93863/98A Abandoned AU9386398A (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors: trail |
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| AU93863/98A Abandoned AU9386398A (en) | 1997-09-12 | 1998-09-11 | Cysteine rich receptors: trail |
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| AT (1) | ATE360032T1 (enExample) |
| AU (2) | AU738688B2 (enExample) |
| CA (1) | CA2301173C (enExample) |
| DE (1) | DE69837606T2 (enExample) |
| ES (1) | ES2286856T3 (enExample) |
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Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7528239B1 (en) | 1997-02-13 | 2009-05-05 | Immunex Corporation | Receptor that binds trail |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| DK0990703T3 (da) * | 1997-02-27 | 2008-09-29 | Ono Pharmaceutical Co | Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| DE69837606T2 (de) | 1997-09-12 | 2008-02-14 | Biogen Idec Ma Inc., Cambridge | Cystein-reiche rezeptoren-train |
| WO1999033967A2 (en) * | 1997-12-29 | 1999-07-08 | Regeneron Pharmaceuticals, Inc. | Novel nucleic acid and polypeptide with homology to the tnf-receptors |
| EP1053351A4 (en) * | 1998-01-27 | 2002-09-25 | Millennium Pharm Inc | NOVEL TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMIL MOLECULES AND USES THEREOF |
| EP1155117A4 (en) * | 1998-12-30 | 2003-05-14 | Millennium Pharm Inc | SECRETED PROTEINS AND NUCLEIC ACIDS ENCODING THESE PROTEINS |
| AU2574200A (en) * | 1999-02-19 | 2000-09-04 | Toshio Kitamura | Novel tnf receptor-like proteins |
| PL207501B1 (pl) | 1999-08-17 | 2010-12-31 | Apotech R & D Sa | Zastosowanie polipeptydu BCMA oraz przeciwciała skierowanego przeciwko BCMA |
| AU6928200A (en) * | 1999-08-25 | 2001-03-19 | Genome Therapeutics Corporation | A transmembrane trap for isolating membrane bound proteins |
| WO2001030850A1 (en) * | 1999-10-22 | 2001-05-03 | Zymogenetics, Inc. | Umlr polypeptides |
| GB9927681D0 (en) * | 1999-11-23 | 2000-01-19 | Glaxo Group Ltd | Protein |
| JP2004501604A (ja) * | 2000-02-11 | 2004-01-22 | ジェネティクス インスティテュート，エルエルシー | Ｔｒａｄｅ分子およびそれに関連する使用 |
| US6900185B1 (en) | 2000-04-12 | 2005-05-31 | University Of Iowa Research Foundation | Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer |
| US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
| US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
| TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
| AU2001297702A1 (en) * | 2000-11-08 | 2002-10-15 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| KR100942393B1 (ko) | 2001-05-25 | 2010-02-17 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Ｔｒａｉｌ 수용체에 면역특이적으로 결합하는 항체 |
| US7361341B2 (en) | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| JP2007530588A (ja) | 2004-03-23 | 2007-11-01 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | レセプターカップリング剤およびその治療用途 |
| EP2329714A1 (en) | 2004-08-03 | 2011-06-08 | Biogen Idec MA Inc. | Influence of TAJ in the neuronal functions |
| CN101495646A (zh) | 2005-02-02 | 2009-07-29 | Uab研究基金会 | 与降低对细胞凋亡诱导性死亡受体激动剂的抗性有关的试剂和方法 |
| JP4898126B2 (ja) * | 2005-02-28 | 2012-03-14 | 中外製薬株式会社 | Ｔｒｏｙシグナルが阻害されたトランスジェニック非ヒト動物 |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| WO2007120658A1 (en) * | 2006-04-10 | 2007-10-25 | Trustees Of Boston University | Melanoma biomarker and methods of uses |
| US9149220B2 (en) | 2011-04-15 | 2015-10-06 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
| JP6292748B2 (ja) | 2009-11-05 | 2018-03-14 | ザ ユーエービー リサーチ ファンデーション | 基底細胞様遺伝子型癌の処置 |
| WO2011116344A2 (en) | 2010-03-18 | 2011-09-22 | The Uab Research Foundation | Targeting cancer stem cells |
| RS54846B1 (sr) | 2010-10-29 | 2016-10-31 | Daiichi Sankyo Co Ltd | Novo anti-dr5 antitelo |
| US9433376B2 (en) | 2012-03-16 | 2016-09-06 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| EP3700416B1 (en) | 2017-10-24 | 2024-06-26 | Dexcom, Inc. | Pre-connected analyte sensors |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US5965388A (en) | 1996-07-09 | 1999-10-12 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| WO2002008284A2 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| US6261801B1 (en) * | 1997-01-14 | 2001-07-17 | Human Genome Sceineces, Inc. | Nucleic acids encoding tumor necrosis factor receptor 5 |
| US6072047A (en) * | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| DK0990703T3 (da) * | 1997-02-27 | 2008-09-29 | Ono Pharmaceutical Co | Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf |
| JP4330180B2 (ja) * | 1997-03-17 | 2009-09-16 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 死ドメイン含有レセプター５ |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| DE69837606T2 (de) | 1997-09-12 | 2008-02-14 | Biogen Idec Ma Inc., Cambridge | Cystein-reiche rezeptoren-train |
| US20030027272A1 (en) * | 1997-09-18 | 2003-02-06 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2306457A1 (en) | 1997-10-18 | 1999-04-29 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| WO1999033967A2 (en) | 1997-12-29 | 1999-07-08 | Regeneron Pharmaceuticals, Inc. | Novel nucleic acid and polypeptide with homology to the tnf-receptors |
| WO1999033980A2 (en) | 1997-12-30 | 1999-07-08 | Chiron Corporation | Members of tnf and tnfr families |
| EP1053351A4 (en) | 1998-01-27 | 2002-09-25 | Millennium Pharm Inc | NOVEL TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMIL MOLECULES AND USES THEREOF |
| AU4818599A (en) | 1998-07-06 | 2000-01-24 | Schering Corporation | Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12),md-1, md2 and cyclin e2, related reagents and methods |
| JP2000098232A (ja) * | 1998-09-25 | 2000-04-07 | Canon Inc | 光学素子及びそれを用いた光学系 |
| AU2574200A (en) | 1999-02-19 | 2000-09-04 | Toshio Kitamura | Novel tnf receptor-like proteins |
| EP1220905A2 (en) | 1999-03-08 | 2002-07-10 | Genentech Inc. | Composition and methods for the treatment of immune related diseases |
| GB9927681D0 (en) | 1999-11-23 | 2000-01-19 | Glaxo Group Ltd | Protein |
| JP2004501604A (ja) | 2000-02-11 | 2004-01-22 | ジェネティクス インスティテュート，エルエルシー | Ｔｒａｄｅ分子およびそれに関連する使用 |
| AU6802801A (en) | 2000-03-01 | 2001-09-24 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2412211A1 (en) | 2000-06-23 | 2002-01-03 | Genetech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| EP1354040A2 (en) | 2000-07-20 | 2003-10-22 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| WO2003013578A1 (en) | 2001-08-07 | 2003-02-20 | Genset S.A. | Omoxin agonists and antagonists for use in the treatment of metabolic disorders |
| AU2004299044B2 (en) | 2003-12-16 | 2008-10-30 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| EP2329714A1 (en) | 2004-08-03 | 2011-06-08 | Biogen Idec MA Inc. | Influence of TAJ in the neuronal functions |
| US20070186296A1 (en) | 2006-02-02 | 2007-08-09 | Wyeth | Cloning, characterization, and application of tnfrsf19 in neurological disorders |
-
1998
- 1998-09-11 DE DE69837606T patent/DE69837606T2/de not_active Expired - Lifetime
- 1998-09-11 AU AU92303/98A patent/AU738688B2/en not_active Ceased
- 1998-09-11 CA CA2301173A patent/CA2301173C/en not_active Expired - Lifetime
- 1998-09-11 AU AU93863/98A patent/AU9386398A/en not_active Abandoned
- 1998-09-11 WO PCT/US1998/019029 patent/WO1999012963A2/en not_active Ceased
- 1998-09-11 ES ES98944859T patent/ES2286856T3/es not_active Expired - Lifetime
- 1998-09-11 EP EP98944859A patent/EP1012282B1/en not_active Expired - Lifetime
- 1998-09-11 AT AT98944859T patent/ATE360032T1/de active
- 1998-09-11 JP JP2000510863A patent/JP4357738B2/ja not_active Expired - Fee Related
- 1998-09-11 WO PCT/US1998/019030 patent/WO1999013078A1/en not_active Ceased
- 1998-09-11 EP EP98946966A patent/EP1012179A2/en not_active Withdrawn
-
2002
- 2002-11-22 US US10/303,502 patent/US7223852B2/en not_active Expired - Fee Related
-
2006
- 2006-04-04 US US11/396,907 patent/US7402658B2/en not_active Expired - Fee Related
-
2008
- 2008-05-30 US US12/130,740 patent/US7838639B2/en not_active Expired - Fee Related
-
2010
- 2010-11-22 US US12/951,761 patent/US20110158993A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69837606D1 (de) | 2007-05-31 |
| EP1012282B1 (en) | 2007-04-18 |
| CA2301173A1 (en) | 1999-03-18 |
| US20030219860A1 (en) | 2003-11-27 |
| AU9230398A (en) | 1999-03-29 |
| WO1999012963A3 (en) | 1999-05-06 |
| AU9386398A (en) | 1999-03-29 |
| EP1012282A1 (en) | 2000-06-28 |
| ATE360032T1 (de) | 2007-05-15 |
| EP1012179A2 (en) | 2000-06-28 |
| ES2286856T3 (es) | 2007-12-01 |
| US7402658B2 (en) | 2008-07-22 |
| US20060233792A1 (en) | 2006-10-19 |
| US7223852B2 (en) | 2007-05-29 |
| HK1028417A1 (en) | 2001-02-16 |
| CA2301173C (en) | 2015-04-14 |
| US20090004188A1 (en) | 2009-01-01 |
| WO1999012963A2 (en) | 1999-03-18 |
| US7838639B2 (en) | 2010-11-23 |
| WO1999013078A1 (en) | 1999-03-18 |
| US20110158993A1 (en) | 2011-06-30 |
| DE69837606T2 (de) | 2008-02-14 |
| JP2002505843A (ja) | 2002-02-26 |
| JP4357738B2 (ja) | 2009-11-04 |
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Opponent name: GENENTECH INC. |
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| FGA | Letters patent sealed or granted (standard patent) | ||
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Owner name: BIOGEN, INC., APOXIS SA Free format text: FORMER NAME WAS: BIOGEN, INC., APOTECH S.A. |