JP2001520037A5 - - Google Patents
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- Publication number
- JP2001520037A5 JP2001520037A5 JP2000517068A JP2000517068A JP2001520037A5 JP 2001520037 A5 JP2001520037 A5 JP 2001520037A5 JP 2000517068 A JP2000517068 A JP 2000517068A JP 2000517068 A JP2000517068 A JP 2000517068A JP 2001520037 A5 JP2001520037 A5 JP 2001520037A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid according
- modification
- isolated
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 description 24
- 102000039446 nucleic acids Human genes 0.000 description 21
- 108020004707 nucleic acids Proteins 0.000 description 20
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9722320.0 | 1997-10-22 | ||
| GBGB9722320.0A GB9722320D0 (en) | 1997-10-22 | 1997-10-22 | Human cell cycle checkpoint proteins |
| PCT/EP1998/006982 WO1999020747A2 (en) | 1997-10-22 | 1998-10-21 | HUMAN CHECKPOINT KINASE, hCDS1, COMPOSITIONS AND METHODS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001520037A JP2001520037A (ja) | 2001-10-30 |
| JP2001520037A5 true JP2001520037A5 (enExample) | 2006-01-05 |
| JP4418103B2 JP4418103B2 (ja) | 2010-02-17 |
Family
ID=10820925
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000517068A Expired - Lifetime JP4418103B2 (ja) | 1997-10-22 | 1998-10-21 | 新規なヒトチェックポイントキナーゼ、ｈＣＤＳ１、組成物および方法 |
| JP2000521208A Expired - Fee Related JP4261050B2 (ja) | 1997-10-22 | 1998-10-21 | ヒト・チェックポイントキナーゼｈｃｄｓ１の組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521208A Expired - Fee Related JP4261050B2 (ja) | 1997-10-22 | 1998-10-21 | ヒト・チェックポイントキナーゼｈｃｄｓ１の組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6531312B1 (enExample) |
| EP (2) | EP1025237B1 (enExample) |
| JP (2) | JP4418103B2 (enExample) |
| AT (2) | ATE304052T1 (enExample) |
| AU (2) | AU760544B2 (enExample) |
| CA (2) | CA2306492C (enExample) |
| DE (2) | DE69831500T2 (enExample) |
| DK (2) | DK1025237T3 (enExample) |
| ES (2) | ES2245050T3 (enExample) |
| GB (1) | GB9722320D0 (enExample) |
| IL (2) | IL135687A (enExample) |
| NZ (2) | NZ503965A (enExample) |
| WO (2) | WO1999025843A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9722320D0 (en) * | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
| CA2331152A1 (en) * | 1998-06-23 | 1999-12-29 | Chugai Seiyaku Kabushiki Kaisha | Cell cycle regulating factor |
| GB9827430D0 (en) * | 1998-12-11 | 1999-02-03 | Ludwig Inst Cancer Res | Differential expression in primary breast cancer |
| EP1257652A2 (en) * | 2000-02-18 | 2002-11-20 | Lexicon Genetics Incorporated | Human kinases and polynucleotides encoding the same |
| EP1265992A2 (en) * | 2000-03-08 | 2002-12-18 | Zealand Pharma A/S | Materials and methods relating to the degradation of cdc25a in response to dna damage |
| WO2001081555A2 (en) * | 2000-04-20 | 2001-11-01 | Incyte Genomics, Inc. | Human kinases |
| US6323016B1 (en) | 2000-06-09 | 2001-11-27 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| FR2812945B1 (fr) * | 2000-08-10 | 2002-10-04 | Aventis Pharma Sa | Utilisation de la proteine grf1 et cellules exprimant la proteine grf1 pour le criblage de molecules |
| US6372468B1 (en) * | 2000-09-14 | 2002-04-16 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| WO2002048328A2 (en) * | 2000-12-14 | 2002-06-20 | Pe Corporation (Ny) | Isolated human kinase proteins, their encoding nucleic acid molecules, and uses thereof |
| WO2002051858A2 (en) * | 2000-12-22 | 2002-07-04 | Isis Pharmaceuticals, Inc. | Antisense modulation of chk2 expression |
| US6451538B1 (en) | 2000-12-22 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of CHK2 expression |
| WO2002059325A2 (en) * | 2000-12-27 | 2002-08-01 | Lexicon Genetics Incorporated | Human kinases and polynucleotides encoding the same |
| EP1224942A1 (en) * | 2001-01-23 | 2002-07-24 | Bernhard Dr. Nieswandt | Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases |
| SI1585749T1 (sl) * | 2003-01-09 | 2008-10-31 | Pfizer | Derivati diazepinoindola kot inhibitorji kinaze |
| BRPI0414011A (pt) * | 2003-08-29 | 2006-10-24 | Pfizer | naftalencarboxamidas e seus derivados úteis como novos agentes antiangiogênicos |
| JP2007504122A (ja) * | 2003-08-29 | 2007-03-01 | ファイザー・インク | 新規抗血管形成剤として有用なチエノピリジン−フェニルアセトアミドおよびその誘導体 |
| US8572169B2 (en) * | 2006-08-28 | 2013-10-29 | Myspace, Llc | System, apparatus and method for discovery of music within a social network |
| TW200845962A (en) | 2007-05-08 | 2008-12-01 | Schering Corp | Methods of treatment using intravenous formulations comprising temozolomide |
| CA2731368C (en) * | 2008-08-06 | 2013-05-14 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5443962A (en) * | 1993-06-04 | 1995-08-22 | Mitotix, Inc. | Methods of identifying inhibitors of cdc25 phosphatase |
| US5674748A (en) * | 1995-03-14 | 1997-10-07 | Thomas Jefferson University | Human cyclin-dependent kinase-like proteins and methods of using the same |
| CN1199420A (zh) * | 1995-11-16 | 1998-11-18 | 艾科斯有限公司 | 细胞周期关卡与pik相关的激酶材料和方法 |
| US5744349A (en) * | 1996-03-05 | 1998-04-28 | Washington University | DNA sequences encoding human Myt1 kinase |
| US6218109B1 (en) * | 1997-09-05 | 2001-04-17 | Baylor College Of Medicine | Mammalian checkpoint genes and proteins |
| GB9722320D0 (en) * | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
-
1997
- 1997-10-22 GB GBGB9722320.0A patent/GB9722320D0/en not_active Ceased
-
1998
- 1998-10-21 EP EP98966890A patent/EP1025237B1/en not_active Expired - Lifetime
- 1998-10-21 AU AU26126/99A patent/AU760544B2/en not_active Ceased
- 1998-10-21 NZ NZ503965A patent/NZ503965A/en not_active IP Right Cessation
- 1998-10-21 EP EP98955533A patent/EP1025236B1/en not_active Expired - Lifetime
- 1998-10-21 AT AT98966890T patent/ATE304052T1/de not_active IP Right Cessation
- 1998-10-21 WO PCT/EP1998/006981 patent/WO1999025843A2/en not_active Ceased
- 1998-10-21 DE DE69831500T patent/DE69831500T2/de not_active Expired - Lifetime
- 1998-10-21 AU AU12322/99A patent/AU752617B2/en not_active Expired
- 1998-10-21 IL IL135687A patent/IL135687A/en not_active IP Right Cessation
- 1998-10-21 JP JP2000517068A patent/JP4418103B2/ja not_active Expired - Lifetime
- 1998-10-21 DK DK98966890T patent/DK1025237T3/da active
- 1998-10-21 CA CA2306492A patent/CA2306492C/en not_active Expired - Fee Related
- 1998-10-21 US US09/529,154 patent/US6531312B1/en not_active Expired - Lifetime
- 1998-10-21 NZ NZ503983A patent/NZ503983A/en not_active IP Right Cessation
- 1998-10-21 WO PCT/EP1998/006982 patent/WO1999020747A2/en not_active Ceased
- 1998-10-21 US US09/529,093 patent/US6413755B1/en not_active Expired - Lifetime
- 1998-10-21 DE DE69831007T patent/DE69831007T2/de not_active Expired - Lifetime
- 1998-10-21 IL IL135688A patent/IL135688A/en not_active IP Right Cessation
- 1998-10-21 AT AT98955533T patent/ATE300619T1/de not_active IP Right Cessation
- 1998-10-21 JP JP2000521208A patent/JP4261050B2/ja not_active Expired - Fee Related
- 1998-10-21 ES ES98955533T patent/ES2245050T3/es not_active Expired - Lifetime
- 1998-10-21 DK DK98955533T patent/DK1025236T3/da active
- 1998-10-21 ES ES98966890T patent/ES2245807T3/es not_active Expired - Lifetime
- 1998-10-21 CA CA002308013A patent/CA2308013A1/en not_active Abandoned
-
2002
- 2002-06-27 US US10/185,182 patent/US6943013B2/en not_active Expired - Lifetime
-
2005
- 2005-04-12 US US11/103,704 patent/US7414020B2/en not_active Expired - Fee Related
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