JP2004537284A5 - - Google Patents
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- Publication number
- JP2004537284A5 JP2004537284A5 JP2002576908A JP2002576908A JP2004537284A5 JP 2004537284 A5 JP2004537284 A5 JP 2004537284A5 JP 2002576908 A JP2002576908 A JP 2002576908A JP 2002576908 A JP2002576908 A JP 2002576908A JP 2004537284 A5 JP2004537284 A5 JP 2004537284A5
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- JP
- Japan
- Prior art keywords
- protein
- seq
- vke
- ppk
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000004169 proteins and genes Human genes 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 238000000034 method Methods 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 239000003112 inhibitor Substances 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 210000002919 epithelial cell Anatomy 0.000 claims 6
- 230000004936 stimulating effect Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000007613 environmental effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000002299 complementary DNA Substances 0.000 claims 3
- 210000000981 epithelium Anatomy 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 108020004511 Recombinant DNA Proteins 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 102000003839 Human Proteins Human genes 0.000 claims 1
- 108090000144 Human Proteins Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000010393 epithelial cell migration Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/821,726 US6734289B2 (en) | 2001-03-29 | 2001-03-29 | Gastrokines and derived peptides including inhibitors |
| PCT/US2002/009885 WO2002078640A2 (en) | 2001-03-29 | 2002-03-29 | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007121196A Division JP2007217422A (ja) | 2001-03-29 | 2007-05-01 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004537284A JP2004537284A (ja) | 2004-12-16 |
| JP2004537284A5 true JP2004537284A5 (enExample) | 2005-08-18 |
| JP4281947B2 JP4281947B2 (ja) | 2009-06-17 |
Family
ID=25234151
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576908A Expired - Fee Related JP4281947B2 (ja) | 2001-03-29 | 2002-03-29 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
| JP2002589626A Expired - Fee Related JP4295516B2 (ja) | 2001-03-29 | 2002-03-29 | ガストロカインおよびインヒビターを含むその誘導ペプチド |
| JP2007121196A Pending JP2007217422A (ja) | 2001-03-29 | 2007-05-01 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002589626A Expired - Fee Related JP4295516B2 (ja) | 2001-03-29 | 2002-03-29 | ガストロカインおよびインヒビターを含むその誘導ペプチド |
| JP2007121196A Pending JP2007217422A (ja) | 2001-03-29 | 2007-05-01 | ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6734289B2 (enExample) |
| EP (2) | EP1423409A4 (enExample) |
| JP (3) | JP4281947B2 (enExample) |
| AT (1) | ATE446510T1 (enExample) |
| AU (2) | AU2002303199B2 (enExample) |
| CA (2) | CA2442684C (enExample) |
| DE (1) | DE60234103D1 (enExample) |
| ES (1) | ES2332882T3 (enExample) |
| MX (2) | MXPA03008861A (enExample) |
| WO (2) | WO2002078640A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6734289B2 (en) | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| US7629317B2 (en) | 2001-03-29 | 2009-12-08 | The University Of Chicago | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors |
| DE102004047968A1 (de) * | 2004-10-01 | 2006-04-06 | B.R.A.H.M.S Ag | Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen |
| ATE526983T1 (de) * | 2005-05-10 | 2011-10-15 | Univ Chicago | Verwendung von peptiden aus dem wachstumsfaktors amp-18 zur behandlung von stomatitis |
| US8017576B2 (en) * | 2005-05-10 | 2011-09-13 | The University Of Chicago | Methods and compositions to treat mucositis |
| AU2006244080C1 (en) * | 2005-05-10 | 2012-02-02 | The University Of Chicago | Use of peptides derived from the growth factor AMP-18 for the treatment of mucositis |
| ES2474573T3 (es) | 2006-01-04 | 2014-07-09 | Baxter International Inc | Medio de cultivo celular sin oligop�ptidos |
| EP2082674A1 (en) | 2008-01-22 | 2009-07-29 | Trelleborg Building Systems AB | Waterproof sealing profile |
| US20100331827A1 (en) * | 2008-02-18 | 2010-12-30 | Koninklijke Philips Electronics N.V. | Administration of drugs to a patient |
| US9957316B2 (en) | 2012-12-19 | 2018-05-01 | Lumen Bio Llc | Weight loss by inhibition of gastrokine |
| ES2927977T3 (es) * | 2017-02-06 | 2022-11-14 | Biotempt Bv | Moduladores peptídicos de la interacción entre el péptido C humano y el receptor de elastina humana para uso terapéutico |
| US11207376B2 (en) | 2017-04-07 | 2021-12-28 | Second Genome, Inc. | Proteins for the treatment of epithelial barrier function disorders |
| KR102590757B1 (ko) * | 2020-12-11 | 2023-10-17 | 가톨릭대학교 산학협력단 | GKN1(Gastrokine 1) 특이적 항체 및 이의 용도 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5476922A (en) | 1987-06-24 | 1995-12-19 | Arch Development Corporation | Methods and compositions for the preparation and use of autocrine growth factors |
| US5135856A (en) | 1987-06-24 | 1992-08-04 | Arch Development Corp. | Production of autocrine growth factors |
| US5102870A (en) | 1989-04-14 | 1992-04-07 | Schering Ag | Treatment and prevention of oral mucositis with growth factors |
| JP2938129B2 (ja) | 1989-05-02 | 1999-08-23 | 武田薬品工業株式会社 | 虚血性腎疾患の予防・治療剤 |
| US5644026A (en) * | 1994-05-03 | 1997-07-01 | La Jolla Cancer Research Foundation | Epitaxin, a cell motility factor |
| JPH08231413A (ja) | 1994-12-29 | 1996-09-10 | Mochida Pharmaceut Co Ltd | 臓器障害に基づく疾患の予防・治療剤 |
| WO1996032960A1 (fr) | 1995-04-21 | 1996-10-24 | Mitsubishi Chemical Corporation | Medicament preventif ou therapeutique, ou les deux, pour les affections ischemiques |
| AU6229098A (en) | 1997-02-21 | 1998-09-09 | Takara Shuzo Co., Ltd. | Cancer-associated genes |
| US20020132252A1 (en) * | 1997-06-16 | 2002-09-19 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| JP2003516709A (ja) * | 1997-08-06 | 2003-05-20 | ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー | 分泌蛋白およびそれらをコードするポリヌクレオチド |
| CA2331386A1 (en) | 1998-06-26 | 2000-01-06 | Incyte Pharmaceuticals, Inc. | Human signal peptide-containing proteins |
| JP2003517580A (ja) | 1999-01-21 | 2003-05-27 | メタモーフイクス・インコーポレーテツド | 増殖分化因子インヒビター及びそれらの用途 |
| DK1185648T3 (da) | 1999-06-02 | 2007-07-30 | Genentech Inc | Fremgangsmåder og sammensætninger til inhibition af neoplastisk cellevækst |
| JP2004522402A (ja) * | 1999-06-02 | 2004-07-29 | ジェネンテック・インコーポレーテッド | 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸 |
| US6734289B2 (en) * | 2001-03-29 | 2004-05-11 | The University Of Chicago | Gastrokines and derived peptides including inhibitors |
| US7629317B2 (en) | 2001-03-29 | 2009-12-08 | The University Of Chicago | Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors |
| US8017576B2 (en) | 2005-05-10 | 2011-09-13 | The University Of Chicago | Methods and compositions to treat mucositis |
-
2001
- 2001-03-29 US US09/821,726 patent/US6734289B2/en not_active Expired - Lifetime
-
2002
- 2002-03-29 EP EP02731209A patent/EP1423409A4/en not_active Withdrawn
- 2002-03-29 US US10/473,571 patent/US8278269B2/en not_active Expired - Fee Related
- 2002-03-29 AU AU2002303199A patent/AU2002303199B2/en not_active Ceased
- 2002-03-29 CA CA2442684A patent/CA2442684C/en not_active Expired - Fee Related
- 2002-03-29 WO PCT/US2002/009885 patent/WO2002078640A2/en not_active Ceased
- 2002-03-29 CA CA002442635A patent/CA2442635A1/en not_active Abandoned
- 2002-03-29 MX MXPA03008861A patent/MXPA03008861A/es active IP Right Grant
- 2002-03-29 ES ES02728619T patent/ES2332882T3/es not_active Expired - Lifetime
- 2002-03-29 MX MXPA03008855A patent/MXPA03008855A/es active IP Right Grant
- 2002-03-29 AT AT02728619T patent/ATE446510T1/de not_active IP Right Cessation
- 2002-03-29 JP JP2002576908A patent/JP4281947B2/ja not_active Expired - Fee Related
- 2002-03-29 EP EP02728619A patent/EP1415154B1/en not_active Expired - Lifetime
- 2002-03-29 DE DE60234103T patent/DE60234103D1/de not_active Expired - Lifetime
- 2002-03-29 AU AU2002258663A patent/AU2002258663B2/en not_active Ceased
- 2002-03-29 JP JP2002589626A patent/JP4295516B2/ja not_active Expired - Fee Related
- 2002-03-29 US US10/473,524 patent/US7557083B2/en not_active Expired - Fee Related
- 2002-03-29 WO PCT/US2002/010148 patent/WO2002092758A2/en not_active Ceased
-
2007
- 2007-05-01 JP JP2007121196A patent/JP2007217422A/ja active Pending
-
2012
- 2012-08-30 US US13/599,417 patent/US8791068B2/en not_active Expired - Fee Related