JP4281947B2 - ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 - Google Patents

ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 Download PDF

Info

Publication number
JP4281947B2
JP4281947B2 JP2002576908A JP2002576908A JP4281947B2 JP 4281947 B2 JP4281947 B2 JP 4281947B2 JP 2002576908 A JP2002576908 A JP 2002576908A JP 2002576908 A JP2002576908 A JP 2002576908A JP 4281947 B2 JP4281947 B2 JP 4281947B2
Authority
JP
Japan
Prior art keywords
protein
peptide
cells
seq
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002576908A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004537284A5 (enExample
JP2004537284A (ja
Inventor
ゲーリー エフ． トバック，
テレンス イー． マーティン，
マーガレット ウォルシュ−レイツ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25234151&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4281947(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Chicago filed Critical University of Chicago
Publication of JP2004537284A publication Critical patent/JP2004537284A/ja
Publication of JP2004537284A5 publication Critical patent/JP2004537284A5/ja
Application granted granted Critical
Publication of JP4281947B2 publication Critical patent/JP4281947B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002576908A 2001-03-29 2002-03-29 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 Expired - Fee Related JP4281947B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/821,726 US6734289B2 (en) 2001-03-29 2001-03-29 Gastrokines and derived peptides including inhibitors
PCT/US2002/009885 WO2002078640A2 (en) 2001-03-29 2002-03-29 Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007121196A Division JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Publications (3)

Publication Number Publication Date
JP2004537284A JP2004537284A (ja) 2004-12-16
JP2004537284A5 JP2004537284A5 (enExample) 2005-08-18
JP4281947B2 true JP4281947B2 (ja) 2009-06-17

Family

ID=25234151

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002576908A Expired - Fee Related JP4281947B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節
JP2002589626A Expired - Fee Related JP4295516B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターを含むその誘導ペプチド
JP2007121196A Pending JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002589626A Expired - Fee Related JP4295516B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターを含むその誘導ペプチド
JP2007121196A Pending JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Country Status (10)

Country Link
US (4) US6734289B2 (enExample)
EP (2) EP1423409A4 (enExample)
JP (3) JP4281947B2 (enExample)
AT (1) ATE446510T1 (enExample)
AU (2) AU2002303199B2 (enExample)
CA (2) CA2442684C (enExample)
DE (1) DE60234103D1 (enExample)
ES (1) ES2332882T3 (enExample)
MX (2) MXPA03008861A (enExample)
WO (2) WO2002078640A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734289B2 (en) 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US7629317B2 (en) 2001-03-29 2009-12-08 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
DE102004047968A1 (de) * 2004-10-01 2006-04-06 B.R.A.H.M.S Ag Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen
ATE526983T1 (de) * 2005-05-10 2011-10-15 Univ Chicago Verwendung von peptiden aus dem wachstumsfaktors amp-18 zur behandlung von stomatitis
US8017576B2 (en) * 2005-05-10 2011-09-13 The University Of Chicago Methods and compositions to treat mucositis
AU2006244080C1 (en) * 2005-05-10 2012-02-02 The University Of Chicago Use of peptides derived from the growth factor AMP-18 for the treatment of mucositis
ES2474573T3 (es) 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
EP2082674A1 (en) 2008-01-22 2009-07-29 Trelleborg Building Systems AB Waterproof sealing profile
US20100331827A1 (en) * 2008-02-18 2010-12-30 Koninklijke Philips Electronics N.V. Administration of drugs to a patient
US9957316B2 (en) 2012-12-19 2018-05-01 Lumen Bio Llc Weight loss by inhibition of gastrokine
ES2927977T3 (es) * 2017-02-06 2022-11-14 Biotempt Bv Moduladores peptídicos de la interacción entre el péptido C humano y el receptor de elastina humana para uso terapéutico
US11207376B2 (en) 2017-04-07 2021-12-28 Second Genome, Inc. Proteins for the treatment of epithelial barrier function disorders
KR102590757B1 (ko) * 2020-12-11 2023-10-17 가톨릭대학교 산학협력단 GKN1(Gastrokine 1) 특이적 항체 및 이의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476922A (en) 1987-06-24 1995-12-19 Arch Development Corporation Methods and compositions for the preparation and use of autocrine growth factors
US5135856A (en) 1987-06-24 1992-08-04 Arch Development Corp. Production of autocrine growth factors
US5102870A (en) 1989-04-14 1992-04-07 Schering Ag Treatment and prevention of oral mucositis with growth factors
JP2938129B2 (ja) 1989-05-02 1999-08-23 武田薬品工業株式会社 虚血性腎疾患の予防・治療剤
US5644026A (en) * 1994-05-03 1997-07-01 La Jolla Cancer Research Foundation Epitaxin, a cell motility factor
JPH08231413A (ja) 1994-12-29 1996-09-10 Mochida Pharmaceut Co Ltd 臓器障害に基づく疾患の予防・治療剤
WO1996032960A1 (fr) 1995-04-21 1996-10-24 Mitsubishi Chemical Corporation Medicament preventif ou therapeutique, ou les deux, pour les affections ischemiques
AU6229098A (en) 1997-02-21 1998-09-09 Takara Shuzo Co., Ltd. Cancer-associated genes
US20020132252A1 (en) * 1997-06-16 2002-09-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2003516709A (ja) * 1997-08-06 2003-05-20 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 分泌蛋白およびそれらをコードするポリヌクレオチド
CA2331386A1 (en) 1998-06-26 2000-01-06 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
JP2003517580A (ja) 1999-01-21 2003-05-27 メタモーフイクス・インコーポレーテツド 増殖分化因子インヒビター及びそれらの用途
DK1185648T3 (da) 1999-06-02 2007-07-30 Genentech Inc Fremgangsmåder og sammensætninger til inhibition af neoplastisk cellevækst
JP2004522402A (ja) * 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸
US6734289B2 (en) * 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US7629317B2 (en) 2001-03-29 2009-12-08 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
US8017576B2 (en) 2005-05-10 2011-09-13 The University Of Chicago Methods and compositions to treat mucositis

Also Published As

Publication number Publication date
JP4295516B2 (ja) 2009-07-15
US20130086701A1 (en) 2013-04-04
WO2002078640A3 (en) 2004-03-04
AU2002258663B2 (en) 2008-02-21
JP2004532037A (ja) 2004-10-21
US8791068B2 (en) 2014-07-29
EP1415154A2 (en) 2004-05-06
EP1415154B1 (en) 2009-10-21
CA2442684C (en) 2013-11-19
JP2007217422A (ja) 2007-08-30
WO2002092758A3 (en) 2004-04-01
US20050065328A1 (en) 2005-03-24
DE60234103D1 (de) 2009-12-03
US20030017548A1 (en) 2003-01-23
AU2002303199B2 (en) 2008-03-13
WO2002092758A2 (en) 2002-11-21
WO2002092758A9 (en) 2004-06-24
ES2332882T3 (es) 2010-02-15
CA2442684A1 (en) 2002-10-10
US20050054564A1 (en) 2005-03-10
MXPA03008861A (es) 2004-10-15
ATE446510T1 (de) 2009-11-15
US6734289B2 (en) 2004-05-11
WO2002078640A2 (en) 2002-10-10
MXPA03008855A (es) 2004-12-06
WO2002092758A8 (en) 2003-02-20
JP2004537284A (ja) 2004-12-16
US8278269B2 (en) 2012-10-02
US7557083B2 (en) 2009-07-07
CA2442635A1 (en) 2002-11-21
EP1423409A2 (en) 2004-06-02
EP1423409A4 (en) 2005-12-07
EP1415154A4 (en) 2004-12-22

Similar Documents

Publication Publication Date Title
US8791068B2 (en) Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
US8741838B2 (en) Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
US6221840B1 (en) Intestinal trefoil proteins
CA2848368C (en) Compositions and methods for brown fat induction and activity using fndc5
US20090227513A1 (en) Treating eye disorders using intestinal trefoil proteins
AU2002258663A1 (en) Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
WO1997032020A2 (en) Shc proteins
AU2002303199A1 (en) Gastrokines and derived peptides including inhibitors
JP2002530064A (ja) Ｅｇｆ様核酸およびポリペプチド、ならびにその使用
KR20020013477A (ko) 염색체 17ｐ 연관된 전립선암 감수성 유전자
JPWO2001002564A1 (ja) 新規ポリペプチドおよびそのｄｎａ
WO2004080485A1 (ja) 上部消化管疾患の予防・治療剤
MXPA98008434A (en) Proteins trifolias intestine

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050328

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070129

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070501

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080603

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080828

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090127

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090216

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090312

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120327

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120327

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120327

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120327

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120327

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130327

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees