JP4281947B2 - ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 - Google Patents

ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 Download PDF

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Publication number
JP4281947B2
JP4281947B2 JP2002576908A JP2002576908A JP4281947B2 JP 4281947 B2 JP4281947 B2 JP 4281947B2 JP 2002576908 A JP2002576908 A JP 2002576908A JP 2002576908 A JP2002576908 A JP 2002576908A JP 4281947 B2 JP4281947 B2 JP 4281947B2
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Japan
Prior art keywords
protein
peptide
cells
seq
cell
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Expired - Fee Related
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JP2002576908A
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English (en)
Japanese (ja)
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JP2004537284A5 (enExample
JP2004537284A (ja
Inventor
ゲーリー エフ． トバック，
テレンス イー． マーティン，
マーガレット ウォルシュ−レイツ，
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University of Chicago
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University of Chicago
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002576908A 2001-03-29 2002-03-29 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節 Expired - Fee Related JP4281947B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/821,726 US6734289B2 (en) 2001-03-29 2001-03-29 Gastrokines and derived peptides including inhibitors
PCT/US2002/009885 WO2002078640A2 (en) 2001-03-29 2002-03-29 Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007121196A Division JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Publications (3)

Publication Number Publication Date
JP2004537284A JP2004537284A (ja) 2004-12-16
JP2004537284A5 JP2004537284A5 (enExample) 2005-08-18
JP4281947B2 true JP4281947B2 (ja) 2009-06-17

Family

ID=25234151

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2002576908A Expired - Fee Related JP4281947B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節
JP2002589626A Expired - Fee Related JP4295516B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターを含むその誘導ペプチド
JP2007121196A Pending JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002589626A Expired - Fee Related JP4295516B2 (ja) 2001-03-29 2002-03-29 ガストロカインおよびインヒビターを含むその誘導ペプチド
JP2007121196A Pending JP2007217422A (ja) 2001-03-29 2007-05-01 ガストロカインおよびインヒビターによる、胃腸組織の増殖および修復の調節

Country Status (10)

Country Link
US (4) US6734289B2 (enExample)
EP (2) EP1415154B1 (enExample)
JP (3) JP4281947B2 (enExample)
AT (1) ATE446510T1 (enExample)
AU (2) AU2002303199B2 (enExample)
CA (2) CA2442635A1 (enExample)
DE (1) DE60234103D1 (enExample)
ES (1) ES2332882T3 (enExample)
MX (2) MXPA03008855A (enExample)
WO (2) WO2002092758A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734289B2 (en) * 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US7629317B2 (en) 2001-03-29 2009-12-08 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
DE102004047968A1 (de) * 2004-10-01 2006-04-06 B.R.A.H.M.S Ag Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen
AU2006244080C1 (en) * 2005-05-10 2012-02-02 The University Of Chicago Use of peptides derived from the growth factor AMP-18 for the treatment of mucositis
MX2007013982A (es) * 2005-05-10 2008-03-13 Univ Chicago Uso de peptidos derivados del factor de crecimiento amp-18 para el tratamiento de la mucositis.
US8017576B2 (en) * 2005-05-10 2011-09-13 The University Of Chicago Methods and compositions to treat mucositis
ES2474573T3 (es) 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
EP2082674A1 (en) 2008-01-22 2009-07-29 Trelleborg Building Systems AB Waterproof sealing profile
EP2254464B1 (en) * 2008-02-18 2017-01-04 Medimetrics Personalized Drug Delivery B.V. Administration of drugs to a patient
US9957316B2 (en) 2012-12-19 2018-05-01 Lumen Bio Llc Weight loss by inhibition of gastrokine
WO2018141969A1 (en) * 2017-02-06 2018-08-09 Biotempt B.V. Peptide modulators of the interaction between human c-peptide and human elastin receptor for therapeutic use
KR102590757B1 (ko) * 2020-12-11 2023-10-17 가톨릭대학교 산학협력단 GKN1(Gastrokine 1) 특이적 항체 및 이의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476922A (en) 1987-06-24 1995-12-19 Arch Development Corporation Methods and compositions for the preparation and use of autocrine growth factors
US5135856A (en) 1987-06-24 1992-08-04 Arch Development Corp. Production of autocrine growth factors
US5102870A (en) 1989-04-14 1992-04-07 Schering Ag Treatment and prevention of oral mucositis with growth factors
JP2938129B2 (ja) 1989-05-02 1999-08-23 武田薬品工業株式会社 虚血性腎疾患の予防・治療剤
US5644026A (en) * 1994-05-03 1997-07-01 La Jolla Cancer Research Foundation Epitaxin, a cell motility factor
JPH08231413A (ja) 1994-12-29 1996-09-10 Mochida Pharmaceut Co Ltd 臓器障害に基づく疾患の予防・治療剤
JP3859710B2 (ja) 1995-04-21 2006-12-20 三菱化学株式会社 虚血性疾患の予防及び／又は治療剤
AU6229098A (en) 1997-02-21 1998-09-09 Takara Shuzo Co., Ltd. Cancer-associated genes
US20030083461A1 (en) * 1997-06-16 2003-05-01 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU8824098A (en) * 1997-08-06 1999-03-01 Genetics Institute Inc. Secreted proteins and polynucleotides encoding them
EP1090118A2 (en) 1998-06-26 2001-04-11 Incyte Pharmaceuticals, Inc. Human signal peptide-containing proteins
BR0008188A (pt) 1999-01-21 2002-02-13 Metamorphix Inc Inibidores de fator de diferenciação de crescimento e usos para os mesmos
CA2373915A1 (en) * 1999-06-02 2000-12-07 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
JP2004522402A (ja) * 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸
US7629317B2 (en) 2001-03-29 2009-12-08 The University Of Chicago Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors
US6734289B2 (en) * 2001-03-29 2004-05-11 The University Of Chicago Gastrokines and derived peptides including inhibitors
US8017576B2 (en) 2005-05-10 2011-09-13 The University Of Chicago Methods and compositions to treat mucositis

Also Published As

Publication number Publication date
CA2442684A1 (en) 2002-10-10
EP1423409A4 (en) 2005-12-07
WO2002092758A8 (en) 2003-02-20
CA2442635A1 (en) 2002-11-21
EP1415154A2 (en) 2004-05-06
AU2002258663B2 (en) 2008-02-21
US6734289B2 (en) 2004-05-11
AU2002303199B2 (en) 2008-03-13
ATE446510T1 (de) 2009-11-15
EP1423409A2 (en) 2004-06-02
EP1415154B1 (en) 2009-10-21
US7557083B2 (en) 2009-07-07
US8791068B2 (en) 2014-07-29
US20050054564A1 (en) 2005-03-10
US20050065328A1 (en) 2005-03-24
EP1415154A4 (en) 2004-12-22
WO2002078640A3 (en) 2004-03-04
ES2332882T3 (es) 2010-02-15
CA2442684C (en) 2013-11-19
JP2004532037A (ja) 2004-10-21
WO2002092758A3 (en) 2004-04-01
MXPA03008855A (es) 2004-12-06
JP4295516B2 (ja) 2009-07-15
US20130086701A1 (en) 2013-04-04
DE60234103D1 (de) 2009-12-03
JP2007217422A (ja) 2007-08-30
WO2002092758A2 (en) 2002-11-21
US8278269B2 (en) 2012-10-02
WO2002092758A9 (en) 2004-06-24
JP2004537284A (ja) 2004-12-16
WO2002078640A2 (en) 2002-10-10
MXPA03008861A (es) 2004-10-15
US20030017548A1 (en) 2003-01-23

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