JP2005511023A5 - - Google Patents

Info

Publication number

JP2005511023A5

JP2005511023A5 JP2003530730A JP2003530730A JP2005511023A5 JP 2005511023 A5 JP2005511023 A5 JP 2005511023A5 JP 2003530730 A JP2003530730 A JP 2003530730A JP 2003530730 A JP2003530730 A JP 2003530730A JP 2005511023 A5 JP2005511023 A5 JP 2005511023A5

Authority

JP

Japan

Prior art keywords

protein

dna

compound

seq

test compound

Prior art date

2002-09-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000623 proteins and genes Proteins 0.000 claims 25
• 102000004169 proteins and genes Human genes 0.000 claims 24
• 108020004414 DNA Proteins 0.000 claims 16
• 150000001875 compounds Chemical class 0.000 claims 16
• 238000000034 method Methods 0.000 claims 10
• 239000000523 sample Substances 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 230000001093 anti-cancer Effects 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 239000002773 nucleotide Substances 0.000 claims 4
• 125000003729 nucleotide group Chemical group 0.000 claims 4
• 238000012216 screening Methods 0.000 claims 4
• 101000708574 Homo sapiens Histone-lysine N-methyltransferase SMYD3 Proteins 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 108700008625 Reporter Genes Proteins 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 230000004663 cell proliferation Effects 0.000 claims 2
• 230000003081 coactivator Effects 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims 2
• 230000035755 proliferation Effects 0.000 claims 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
• 102000053642 Catalytic RNA Human genes 0.000 claims 1
• 108090000994 Catalytic RNA Proteins 0.000 claims 1
• 108091026890 Coding region Proteins 0.000 claims 1
• 108091034117 Oligonucleotide Proteins 0.000 claims 1
• 108090000944 RNA Helicases Proteins 0.000 claims 1
• 102000004409 RNA Helicases Human genes 0.000 claims 1
• 102000009572 RNA Polymerase II Human genes 0.000 claims 1
• 108010009460 RNA Polymerase II Proteins 0.000 claims 1
• 230000004913 activation Effects 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000000074 antisense oligonucleotide Substances 0.000 claims 1
• 238000012230 antisense oligonucleotides Methods 0.000 claims 1
• 230000027455 binding Effects 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 230000009918 complex formation Effects 0.000 claims 1
• 239000012228 culture supernatant Substances 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
• 230000002452 interceptive effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 108091092562 ribozyme Proteins 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 230000002103 transcriptional effect Effects 0.000 claims 1