JP2004500117A5 - - Google Patents
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- Publication number
- JP2004500117A5 JP2004500117A5 JP2001572526A JP2001572526A JP2004500117A5 JP 2004500117 A5 JP2004500117 A5 JP 2004500117A5 JP 2001572526 A JP2001572526 A JP 2001572526A JP 2001572526 A JP2001572526 A JP 2001572526A JP 2004500117 A5 JP2004500117 A5 JP 2004500117A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- nucleic acid
- acid molecule
- seq
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 description 18
- 125000003729 nucleotide group Chemical group 0.000 description 18
- 239000003814 drug Substances 0.000 description 15
- 108020004707 nucleic acids Proteins 0.000 description 12
- 102000039446 nucleic acids Human genes 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- 229920001184 polypeptide Polymers 0.000 description 9
- 102000004196 processed proteins & peptides Human genes 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 108010035597 sphingosine kinase Proteins 0.000 description 8
- 239000000523 sample Substances 0.000 description 6
- 108020004511 Recombinant DNA Proteins 0.000 description 5
- 239000013598 vector Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- ZDRVLAOYDGQLFI-UHFFFAOYSA-N 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol;hydrochloride Chemical compound Cl.C1=CC(O)=CC=C1NC1=NC(C=2C=CC(Cl)=CC=2)=CS1 ZDRVLAOYDGQLFI-UHFFFAOYSA-N 0.000 description 3
- 102000001708 Protein Isoforms Human genes 0.000 description 3
- 108010029485 Protein Isoforms Proteins 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 230000031018 biological processes and functions Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 230000026731 phosphorylation Effects 0.000 description 3
- 238000006366 phosphorylation reaction Methods 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 102100027662 Sphingosine kinase 2 Human genes 0.000 description 2
- 101710156532 Sphingosine kinase 2 Proteins 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002269 analeptic agent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19431800P | 2000-04-03 | 2000-04-03 | |
| US09/817,676 US6800470B2 (en) | 2000-04-03 | 2001-03-26 | Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof |
| PCT/US2001/009664 WO2001074837A1 (en) | 2000-04-03 | 2001-03-26 | Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004500117A JP2004500117A (ja) | 2004-01-08 |
| JP2004500117A5 true JP2004500117A5 (enExample) | 2007-12-13 |
| JP4584525B2 JP4584525B2 (ja) | 2010-11-24 |
Family
ID=26889896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001572526A Expired - Fee Related JP4584525B2 (ja) | 2000-04-03 | 2001-03-26 | 哺乳類スフィンゴシンキナーゼタイプ２アイソフォーム、そのクローニング、発現及び使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6800470B2 (enExample) |
| JP (1) | JP4584525B2 (enExample) |
| KR (1) | KR20020093017A (enExample) |
| AU (1) | AU5100201A (enExample) |
| CA (1) | CA2404965A1 (enExample) |
| DK (1) | DK1268509T3 (enExample) |
| HU (1) | HUP0301691A3 (enExample) |
| MX (1) | MXPA02009781A (enExample) |
| WO (1) | WO2001074837A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1268509T3 (da) * | 2000-04-03 | 2010-03-08 | Daiichi Sankyo Co Ltd | Type 2 isoformer af sphingosin-kinase fra pattedyr, kloning, ekspression og fremgangsmåder til anvendelse deraf |
| AUPQ744700A0 (en) * | 2000-05-11 | 2000-06-01 | Medvet Science Pty. Ltd. | A method of treatment and agents useful for same |
| JP2005522999A (ja) * | 2002-01-31 | 2005-08-04 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 癌を処置するための方法および組成物 |
| WO2004035786A1 (en) * | 2002-10-14 | 2004-04-29 | Medvet Science Pty. Ltd. | A method of modulating epithelial cell activity by modulating the functional levels of sphingosine kinase |
| AU2003292636A1 (en) * | 2002-12-27 | 2004-07-29 | The New Industry Research Organization | Cell growth inhibitor using sphingosine kinase 2, method of constructing fused protein having its nuclear localization signal, method of screening drug candidate, and screening kit |
| US8372888B2 (en) * | 2008-04-29 | 2013-02-12 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, compositions and processes for using same |
| US8314151B2 (en) | 2008-04-29 | 2012-11-20 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, and processes for using same |
| US10660879B2 (en) | 2017-06-23 | 2020-05-26 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| US10675255B2 (en) | 2017-06-23 | 2020-06-09 | Enzo Bochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374616A (en) * | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
| AU4097999A (en) * | 1998-05-26 | 1999-12-13 | Sarah Spiegel | Sphingosine kinase, cloning, expression and methods of use |
| AU3828301A (en) * | 2000-02-14 | 2001-08-27 | Curagen Corp | Novel sphingosine kinases |
| DK1268509T3 (da) * | 2000-04-03 | 2010-03-08 | Daiichi Sankyo Co Ltd | Type 2 isoformer af sphingosin-kinase fra pattedyr, kloning, ekspression og fremgangsmåder til anvendelse deraf |
-
2001
- 2001-03-26 DK DK01924340.1T patent/DK1268509T3/da active
- 2001-03-26 KR KR1020027013149A patent/KR20020093017A/ko not_active Withdrawn
- 2001-03-26 AU AU5100201A patent/AU5100201A/xx active Pending
- 2001-03-26 HU HU0301691A patent/HUP0301691A3/hu unknown
- 2001-03-26 US US09/817,676 patent/US6800470B2/en not_active Expired - Fee Related
- 2001-03-26 JP JP2001572526A patent/JP4584525B2/ja not_active Expired - Fee Related
- 2001-03-26 MX MXPA02009781A patent/MXPA02009781A/es unknown
- 2001-03-26 WO PCT/US2001/009664 patent/WO2001074837A1/en not_active Ceased
- 2001-03-26 CA CA002404965A patent/CA2404965A1/en not_active Abandoned
-
2004
- 2004-04-22 US US10/830,677 patent/US7419814B2/en not_active Expired - Fee Related
-
2007
- 2007-08-14 US US11/891,964 patent/US7803595B2/en not_active Expired - Fee Related
-
2010
- 2010-07-27 US US12/804,664 patent/US8263349B2/en not_active Expired - Fee Related
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