JP2008505927A - ポリマー部分を含む多価ｖｌａ−４拮抗薬 - Google Patents

ポリマー部分を含む多価ｖｌａ−４拮抗薬 Download PDF

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JP2008505927A
JP2008505927A JP2007520561A JP2007520561A JP2008505927A JP 2008505927 A JP2008505927 A JP 2008505927A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2008505927 A JP2008505927 A JP 2008505927A
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alkyl
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formula
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コンラディ、アンドレイ、ダブリュー．
プレイス、マイケル、エー．
セムコ、クリストファー、エム．
イェドノック、テオドール
スミス、ジェニファー、エル．
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イーラン ファーマスーティカルズ、インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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JP2007520561A 2004-07-08 2005-07-08 ポリマー部分を含む多価ｖｌａ−４拮抗薬 Pending JP2008505927A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58697504P 2004-07-08 2004-07-08
PCT/US2005/024369 WO2006010054A2 (en) 2004-07-08 2005-07-08 Multivalent vla-4 antagonists comprising polyethylene glycol moieties

Publications (1)

Publication Number Publication Date
JP2008505927A true JP2008505927A (ja) 2008-02-28

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JP2007520561A Pending JP2008505927A (ja) 2004-07-08 2005-07-08 ポリマー部分を含む多価ｖｌａ−４拮抗薬

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US (4) US7794700B2 (US07794700-20100914-C00065.png)
EP (4) EP2298356A3 (US07794700-20100914-C00065.png)
JP (1) JP2008505927A (US07794700-20100914-C00065.png)
KR (1) KR101273614B1 (US07794700-20100914-C00065.png)
CN (1) CN101035563B (US07794700-20100914-C00065.png)
AR (1) AR050425A1 (US07794700-20100914-C00065.png)
AU (1) AU2005265316B2 (US07794700-20100914-C00065.png)
BR (1) BRPI0513143A (US07794700-20100914-C00065.png)
CA (1) CA2573245C (US07794700-20100914-C00065.png)
EA (1) EA012433B1 (US07794700-20100914-C00065.png)
EC (1) ECSP077231A (US07794700-20100914-C00065.png)
HK (1) HK1111674A1 (US07794700-20100914-C00065.png)
IL (1) IL180558A0 (US07794700-20100914-C00065.png)
MA (1) MA28786B1 (US07794700-20100914-C00065.png)
MX (1) MX2007000228A (US07794700-20100914-C00065.png)
NO (1) NO20070216L (US07794700-20100914-C00065.png)
NZ (1) NZ588839A (US07794700-20100914-C00065.png)
TW (1) TWI418346B (US07794700-20100914-C00065.png)
WO (1) WO2006010054A2 (US07794700-20100914-C00065.png)
ZA (1) ZA200700238B (US07794700-20100914-C00065.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008540686A (ja) * 2005-05-20 2008-11-20 イーラン ファーマスーティカルズ、インコーポレイテッド Ｖｌａ−４アンタゴニストとしてのイミダゾロンフェニルアラニン誘導体
JP2009501246A (ja) * 2005-07-08 2009-01-15 イーラン ファーマスーティカルズ、インコーポレイテッド 治療用、農業用、及び食品用添加剤化合物のポリマー複合体の調製
JP2009510097A (ja) * 2005-09-29 2009-03-12 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４によって媒介される白血球接着を阻害するピリミジニルアミド化合物
JP2012197319A (ja) * 2005-09-29 2012-10-18 Elan Pharmaceuticals Inc Ｖｌａ−４によって媒介される白血球粘着を阻害するカルバメート化合物

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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IL143929A0 (en) * 1999-01-22 2002-04-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
US7595318B2 (en) * 2004-01-23 2009-09-29 Elan Pharmaceuticals, Inc. Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
CN101035563B (zh) * 2004-07-08 2012-03-28 艾伦药物公司 包括聚合物部分的多价vla-4拮抗剂
WO2007060409A1 (en) * 2005-11-23 2007-05-31 Astrazeneca Ab L-alanine derivatives
CA2643838A1 (en) * 2006-02-27 2007-09-07 Elan Pharmaceuticals, Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
WO2007100763A2 (en) 2006-02-28 2007-09-07 Elan Pharmaceuticals, Inc. Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
JP2009528359A (ja) * 2006-02-28 2009-08-06 エラン ファーマシューティカルズ，インコーポレイテッド ナタリズマブを用いて炎症性疾患および自己免疫性疾患を治療する方法
KR20080104343A (ko) * 2006-03-03 2008-12-02 엘란 파마슈티칼스, 인크. 나탈리주마브로 염증 및 자가면역 질환을 치료하는 방법
JP2009538338A (ja) * 2006-05-22 2009-11-05 イーラン ファーマスーティカルズ、インコーポレイテッド 治療用、農業用及び食品添加用化合物のポリマー複合体の調製
JP2009539815A (ja) * 2006-06-09 2009-11-19 アストラゼネカ アクチボラグ 固形腫瘍の治療用のａ５ｂ１アンタゴニストとしてのＮ−（ベンゾイル）−Ｏ−［２−（ピリジン−２−イルアミノ）エチル］−Ｌ−チロシン誘導体と関連化合物
WO2008093065A1 (en) * 2007-01-29 2008-08-07 Astrazeneca Ab L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
US20100150915A1 (en) 2007-02-20 2010-06-17 Stewart Edward J Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
WO2008153967A1 (en) * 2007-06-08 2008-12-18 Contec Therapeutics, Inc. Bk1 antagonist conjugates
JP2011506322A (ja) * 2007-12-07 2011-03-03 エラン ファーマシューティカルズ，インコーポレイテッド 液性腫瘍を治療するための方法および組成物
EP2085407A1 (en) 2008-02-04 2009-08-05 Sahltech I Göteborg AB Treatment of idiopathic thrombocytopenic purpura
CN102459179A (zh) * 2009-04-27 2012-05-16 艾伦药物公司 α-4整联蛋白的吡啶酮拮抗剂
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