JP2008504274A - アミド化合物およびその医薬としての使用 - Google Patents
アミド化合物およびその医薬としての使用 Download PDFInfo
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- JP2008504274A JP2008504274A JP2007518256A JP2007518256A JP2008504274A JP 2008504274 A JP2008504274 A JP 2008504274A JP 2007518256 A JP2007518256 A JP 2007518256A JP 2007518256 A JP2007518256 A JP 2007518256A JP 2008504274 A JP2008504274 A JP 2008504274A
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- Prior art keywords
- aryl
- alkyl
- cycloalkyl
- heteroaryl
- haloalkyl
- Prior art date
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- 125000000217 alkyl group Chemical group 0.000 claims description 183
- 125000001072 heteroaryl group Chemical group 0.000 claims description 179
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 128
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- 125000005843 halogen group Chemical group 0.000 claims description 83
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 77
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 77
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 77
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims description 76
- 238000000034 method Methods 0.000 claims description 68
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 53
- 229910052799 carbon Inorganic materials 0.000 claims description 48
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
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- 125000003545 alkoxy group Chemical group 0.000 claims description 36
- 125000004429 atom Chemical group 0.000 claims description 35
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- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 24
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- YVYUWSZAJHKIGM-UHFFFAOYSA-N 1,3,3a,4,5,9b-hexahydrobenzo[e]isoindol-2-yl-[1-(benzenesulfonyl)piperidin-3-yl]methanone Chemical compound C1C2CCC3=CC=CC=C3C2CN1C(=O)C(C1)CCCN1S(=O)(=O)C1=CC=CC=C1 YVYUWSZAJHKIGM-UHFFFAOYSA-N 0.000 claims description 2
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- JUPAKBAVGWUQPS-GNZRSQJKSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl-[(3s)-1-(3-bromophenyl)sulfonylpiperidin-3-yl]methanone Chemical compound BrC1=CC=CC(S(=O)(=O)N2C[C@H](CCC2)C(=O)N2C3CCCCC3CCC2)=C1 JUPAKBAVGWUQPS-GNZRSQJKSA-N 0.000 claims description 2
- AHXMVKYKVRBJSO-FDYSRKEFSA-N 3,4,4a,5,6,7,8,8a-octahydro-2h-quinolin-1-yl-[(3s)-1-(3-chloro-2-methylphenyl)sulfonylpiperidin-3-yl]methanone Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)N2C3CCCCC3CCC2)CCC1 AHXMVKYKVRBJSO-FDYSRKEFSA-N 0.000 claims description 2
- PXUURYWUNSXDKI-QGZVFWFLSA-N 3,4-dihydro-2h-quinolin-1-yl-[(3r)-1-(2-nitrophenyl)sulfonylpiperidin-3-yl]methanone Chemical compound [O-][N+](=O)C1=CC=CC=C1S(=O)(=O)N1C[C@H](C(=O)N2C3=CC=CC=C3CCC2)CCC1 PXUURYWUNSXDKI-QGZVFWFLSA-N 0.000 claims description 2
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- DQICGTZZGCTBOK-KSZLIROESA-N [(3ar,7as)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-[(3s)-1-(3-chloro-2-methylphenyl)sulfonylpiperidin-3-yl]methanone Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)N2C[C@@H]3CCCC[C@@H]3C2)CCC1 DQICGTZZGCTBOK-KSZLIROESA-N 0.000 claims description 2
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- ZKOOSEKUIZQMKP-GOSISDBHSA-N [(3r)-1-(benzenesulfonyl)piperidin-3-yl]-(3,4-dihydro-2h-quinolin-1-yl)methanone Chemical compound C([C@H](C1)C(=O)N2C3=CC=CC=C3CCC2)CCN1S(=O)(=O)C1=CC=CC=C1 ZKOOSEKUIZQMKP-GOSISDBHSA-N 0.000 claims description 2
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- XOZBTMPFBWBSMA-MOPGFXCFSA-N [(3s)-1-(3-chloro-2-methylphenyl)sulfonylpiperidin-3-yl]-[(3s)-3-pyridin-3-ylpyrrolidin-1-yl]methanone Chemical compound CC1=C(Cl)C=CC=C1S(=O)(=O)N1C[C@@H](C(=O)N2C[C@@H](CC2)C=2C=NC=CC=2)CCC1 XOZBTMPFBWBSMA-MOPGFXCFSA-N 0.000 claims description 2
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
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- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58247804P | 2004-06-24 | 2004-06-24 | |
| PCT/US2005/022170 WO2006012173A1 (en) | 2004-06-24 | 2005-06-23 | Amido compounds and their use as pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
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| JP2008504274A true JP2008504274A (ja) | 2008-02-14 |
| JP2008504274A5 JP2008504274A5 (cg-RX-API-DMAC7.html) | 2008-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518256A Withdrawn JP2008504274A (ja) | 2004-06-24 | 2005-06-23 | アミド化合物およびその医薬としての使用 |
Country Status (9)
| Country | Link |
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| US (1) | US20050288317A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1758882A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008504274A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101001850A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005267331A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0512630A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2569507A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA06014573A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006012173A1 (cg-RX-API-DMAC7.html) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008531616A (ja) * | 2005-03-03 | 2008-08-14 | エフ．ホフマン−ラ ロシュ アーゲー | ＩＩ型糖尿病の処置用の１１−β−ヒドロキシステロイド・デヒドロゲナーゼのインヒビターとしての１−スルホニル−ピペリジン−３−カルボン酸アミド誘導体 |
| JP2010535834A (ja) * | 2007-08-13 | 2010-11-25 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ピペラジンアミド誘導体 |
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| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| CA2589565A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| EP1768954A4 (en) * | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
| MXPA06014572A (es) * | 2004-06-24 | 2007-03-12 | Incyte Corp | Compuestos amido y su uso como farmaceuticos. |
| JP2008504276A (ja) * | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| EA200700117A1 (ru) | 2004-06-24 | 2007-06-29 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| EP1778229A4 (en) * | 2004-08-10 | 2009-06-17 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
| ES2547724T3 (es) * | 2004-11-10 | 2015-10-08 | Incyte Corporation | Compuestos de lactama y su uso como productos farmacéuticos |
| US8110581B2 (en) | 2004-11-10 | 2012-02-07 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
| BRPI0518281A2 (pt) * | 2004-11-18 | 2008-11-18 | Incyte Corp | inibidores de 11-beta hidroxilesteràide desidrogenase do tipo i e mÉtodos uso dos mesmos |
| NZ555971A (en) | 2005-01-05 | 2011-01-28 | Abbott Lab | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| ATE555081T1 (de) | 2005-01-05 | 2012-05-15 | Abbott Lab | Adamantyl-derivate als inhibitoren des 11-beta- hydroxysteroid-dehydrogenase-1-enzyms |
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| JP5140577B2 (ja) * | 2005-03-31 | 2013-02-06 | タケダ カリフォルニア インコーポレイテッド | ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
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-
2005
- 2005-06-23 EP EP05762850A patent/EP1758882A4/en not_active Withdrawn
- 2005-06-23 WO PCT/US2005/022170 patent/WO2006012173A1/en not_active Ceased
- 2005-06-23 BR BRPI0512630-4A patent/BRPI0512630A/pt not_active IP Right Cessation
- 2005-06-23 CA CA002569507A patent/CA2569507A1/en not_active Abandoned
- 2005-06-23 AU AU2005267331A patent/AU2005267331A1/en not_active Abandoned
- 2005-06-23 CN CNA2005800205246A patent/CN101001850A/zh active Pending
- 2005-06-23 US US11/159,863 patent/US20050288317A1/en not_active Abandoned
- 2005-06-23 MX MXPA06014573A patent/MXPA06014573A/es not_active Application Discontinuation
- 2005-06-23 JP JP2007518256A patent/JP2008504274A/ja not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008531616A (ja) * | 2005-03-03 | 2008-08-14 | エフ．ホフマン−ラ ロシュ アーゲー | ＩＩ型糖尿病の処置用の１１−β−ヒドロキシステロイド・デヒドロゲナーゼのインヒビターとしての１−スルホニル−ピペリジン−３−カルボン酸アミド誘導体 |
| JP2010535834A (ja) * | 2007-08-13 | 2010-11-25 | エフ．ホフマン−ラ ロシュ アーゲー | 新規ピペラジンアミド誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06014573A (es) | 2007-03-12 |
| EP1758882A1 (en) | 2007-03-07 |
| CA2569507A1 (en) | 2006-02-02 |
| AU2005267331A1 (en) | 2006-02-02 |
| CN101001850A (zh) | 2007-07-18 |
| WO2006012173A1 (en) | 2006-02-02 |
| BRPI0512630A (pt) | 2008-03-25 |
| EP1758882A4 (en) | 2008-01-23 |
| US20050288317A1 (en) | 2005-12-29 |
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