MXPA06014573A - Compuestos amido y su uso como farmaceuticos. - Google Patents

Info

Publication number

MXPA06014573A

MXPA06014573A MXPA06014573A MXPA06014573A MXPA06014573A MX PA06014573 A MXPA06014573 A MX PA06014573A MX PA06014573 A MXPA06014573 A MX PA06014573A MX PA06014573 A MXPA06014573 A MX PA06014573A MX PA06014573 A MXPA06014573 A MX PA06014573A

Authority

MX

Mexico

Prior art keywords

heterocycloalkyl

cycloalkyl

alkyl

optionally substituted

members

Prior art date

2004-06-24

Links

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• Global Dossier
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• 239000003814 drug Substances 0.000 title description 7
• 125000003368 amide group Chemical group 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 182
• -1 hydroxyl steroid Chemical class 0.000 claims abstract description 141
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 50
• 201000010099 disease Diseases 0.000 claims abstract description 36
• 230000000694 effects Effects 0.000 claims abstract description 36
• PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims abstract description 23
• PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims abstract description 23
• 229960002478 aldosterone Drugs 0.000 claims abstract description 23
• 230000014509 gene expression Effects 0.000 claims abstract description 13
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 233
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 231
• 125000000217 alkyl group Chemical group 0.000 claims description 184
• 125000001072 heteroaryl group Chemical group 0.000 claims description 153
• 125000003118 aryl group Chemical group 0.000 claims description 145
• 125000001188 haloalkyl group Chemical group 0.000 claims description 139
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 85
• 125000005843 halogen group Chemical group 0.000 claims description 85
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 76
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 71
• 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims description 70
• 238000000034 method Methods 0.000 claims description 69
• 125000003342 alkenyl group Chemical group 0.000 claims description 57
• 229910052799 carbon Inorganic materials 0.000 claims description 57
• 239000000203 mixture Substances 0.000 claims description 51
• 125000003545 alkoxy group Chemical group 0.000 claims description 37
• 125000000304 alkynyl group Chemical group 0.000 claims description 37
• 125000004429 atom Chemical group 0.000 claims description 36
• 229910052717 sulfur Inorganic materials 0.000 claims description 36
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 34
• 125000005466 alkylenyl group Chemical group 0.000 claims description 32
• 229910052739 hydrogen Inorganic materials 0.000 claims description 29
• 229910002091 carbon monoxide Inorganic materials 0.000 claims description 26
• 229910052760 oxygen Inorganic materials 0.000 claims description 26
• 150000003839 salts Chemical class 0.000 claims description 26
• 206010020772 Hypertension Diseases 0.000 claims description 24
• 229910052757 nitrogen Inorganic materials 0.000 claims description 24
• 101100073357 Streptomyces halstedii sch2 gene Proteins 0.000 claims description 23
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 23
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 23
• 150000001721 carbon Chemical group 0.000 claims description 22
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• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 21
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• 125000004432 carbon atom Chemical group C* 0.000 claims description 20
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• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 18
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• 125000004404 heteroalkyl group Chemical group 0.000 claims description 18
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 18
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• 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 12
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 11
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 10
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 10
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• 125000003282 alkyl amino group Chemical group 0.000 claims description 9
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 9
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• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 6
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 6
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• 125000005343 heterocyclic alkyl group Chemical group 0.000 claims description 5
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• 230000002526 effect on cardiovascular system Effects 0.000 claims description 4
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 4
• WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims description 3
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• NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical compound C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 claims description 2
• 208000028698 Cognitive impairment Diseases 0.000 claims description 2
• 230000008816 organ damage Effects 0.000 claims description 2
• RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 claims 5
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 3
• 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 2
• KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
• 241000009298 Trigla lyra Species 0.000 claims 2
• 125000002947 alkylene group Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000006526 (C1-C2) alkyl group Chemical group 0.000 claims 1
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
• 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 1
• VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical compound C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 claims 1
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• 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000005266 diarylamine group Chemical group 0.000 claims 1
• LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
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• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
• 230000036651 mood Effects 0.000 claims 1
• IZUPBVBPLAPZRR-UHFFFAOYSA-N pentachlorophenol Chemical compound OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl IZUPBVBPLAPZRR-UHFFFAOYSA-N 0.000 claims 1
• HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
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