JP2008504266A - 異脂肪血症を治療するための化合物及び方法 - Google Patents

異脂肪血症を治療するための化合物及び方法 Download PDF

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Publication number
JP2008504266A
JP2008504266A JP2007518182A JP2007518182A JP2008504266A JP 2008504266 A JP2008504266 A JP 2008504266A JP 2007518182 A JP2007518182 A JP 2007518182A JP 2007518182 A JP2007518182 A JP 2007518182A JP 2008504266 A JP2008504266 A JP 2008504266A
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Prior art keywords
alkyl
trifluoromethyl
amino
dihydro
quinoline
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Japanese (ja)
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JP2008504266A5 (OSRAM
Inventor
アナ・マリア・エスクリバノ
マリア・カルメン・フェルナンデス
ネイサン・ブライアン・マントロ
アナ・イサベル・マテオ−エランス
エバ・マリア・マルティン・デ・ラ・ナバ
シャオドン・ワン
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イーライ リリー アンド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007518182A 2004-06-24 2005-06-22 異脂肪血症を治療するための化合物及び方法 Pending JP2008504266A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58270804P 2004-06-24 2004-06-24
US62724104P 2004-11-12 2004-11-12
US66486205P 2005-03-24 2005-03-24
PCT/US2005/021789 WO2006012093A1 (en) 2004-06-24 2005-06-22 Compounds and methods for treating dyslipidemia

Publications (2)

Publication Number Publication Date
JP2008504266A true JP2008504266A (ja) 2008-02-14
JP2008504266A5 JP2008504266A5 (OSRAM) 2008-08-07

Family

ID=35056992

Family Applications (2)

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JP2007518182A Pending JP2008504266A (ja) 2004-06-24 2005-06-22 異脂肪血症を治療するための化合物及び方法
JP2007518296A Expired - Fee Related JP4836945B2 (ja) 2004-06-24 2005-06-23 異常脂質血症を治療するための化合物および方法

Family Applications After (1)

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JP2007518296A Expired - Fee Related JP4836945B2 (ja) 2004-06-24 2005-06-23 異常脂質血症を治療するための化合物および方法

Country Status (26)

Country Link
US (3) US20080269284A1 (OSRAM)
EP (3) EP1761521A1 (OSRAM)
JP (2) JP2008504266A (OSRAM)
KR (1) KR20070041452A (OSRAM)
CN (1) CN1972932B (OSRAM)
AT (1) ATE528304T1 (OSRAM)
AU (2) AU2005267436A1 (OSRAM)
BR (2) BRPI0512523A (OSRAM)
CA (2) CA2570688A1 (OSRAM)
CR (1) CR8831A (OSRAM)
CY (1) CY1112124T1 (OSRAM)
DK (1) DK1761522T3 (OSRAM)
EA (2) EA200700119A1 (OSRAM)
EC (2) ECSP067095A (OSRAM)
ES (1) ES2372291T3 (OSRAM)
HR (1) HRP20110761T1 (OSRAM)
IL (2) IL180276A0 (OSRAM)
MA (2) MA28730B1 (OSRAM)
MX (2) MXPA06014716A (OSRAM)
NO (2) NO20070470L (OSRAM)
NZ (1) NZ550978A (OSRAM)
PL (1) PL1761522T3 (OSRAM)
PT (1) PT1761522E (OSRAM)
RS (1) RS52064B (OSRAM)
SI (1) SI1761522T1 (OSRAM)
WO (2) WO2006012093A1 (OSRAM)

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UA90269C2 (ru) 2004-04-02 2010-04-26 Мицубиси Танабе Фарма Корпорейшн Тетрагидрохинолиновые производные и способ их получения
BRPI0512523A (pt) 2004-06-24 2008-03-11 Lilly Co Eli composto ou um sal, enanciÈmero, racemato, diastereÈmero ou mistura de diastereÈmeros farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um composto
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WO2012120050A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
EP2683701B1 (de) 2011-03-08 2014-12-24 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
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EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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CN106232121A (zh) * 2014-02-05 2016-12-14 田边三菱制药株式会社 用于治疗或预防心血管疾病的胆固醇酯转移蛋白(cetp)抑制剂和含所述抑制剂的药物组合物
CN103833637B (zh) * 2014-03-31 2016-01-06 武汉武药制药有限公司 一种制备依塞曲匹（Evacetrapib）中间体的方法
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WO2005095409A2 (en) * 2004-04-02 2005-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroquinoline derivatives and a process for preparing the same

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AU2005258241A1 (en) 2006-01-05
ECSP067098A (es) 2007-01-26
NZ550978A (en) 2010-08-27
RS52064B (sr) 2012-06-30
DK1761522T3 (da) 2012-01-02
US20070244095A1 (en) 2007-10-18
HK1104528A1 (en) 2008-01-18
CA2570673C (en) 2013-01-29
ES2372291T3 (es) 2012-01-18
US20100204207A1 (en) 2010-08-12
CA2570673A1 (en) 2006-01-05
IL180277A (en) 2011-08-31
EP1761522B1 (en) 2011-10-12
CN1972932B (zh) 2011-06-29
MA28729B1 (fr) 2007-07-02
CN1972932A (zh) 2007-05-30
WO2006012093A1 (en) 2006-02-02
EA012585B1 (ru) 2009-10-30
EP1761522A1 (en) 2007-03-14
BRPI0512516A (pt) 2008-03-11
US20080269284A1 (en) 2008-10-30
AU2005267436A1 (en) 2006-02-02
ATE528304T1 (de) 2011-10-15
SI1761522T1 (sl) 2012-02-29
WO2006002342A1 (en) 2006-01-05
EA200700119A1 (ru) 2007-10-26
US7786108B2 (en) 2010-08-31
IL180276A0 (en) 2007-07-04
MXPA06014706A (es) 2007-03-12
EP1761521A1 (en) 2007-03-14
IL180277A0 (en) 2007-07-04
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PL1761522T3 (pl) 2012-03-30
HRP20110761T1 (hr) 2011-11-30
NO20070468L (no) 2007-03-12
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PT1761522E (pt) 2011-12-21
CY1112124T1 (el) 2015-11-04
EA200700120A1 (ru) 2007-06-29
JP2008504277A (ja) 2008-02-14
NO20070470L (no) 2007-03-26
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CR8831A (es) 2008-11-13
KR20070041452A (ko) 2007-04-18
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MA28730B1 (fr) 2007-07-02

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