JP2008503712A5 - - Google Patents

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Publication number
JP2008503712A5
JP2008503712A5 JP2007515968A JP2007515968A JP2008503712A5 JP 2008503712 A5 JP2008503712 A5 JP 2008503712A5 JP 2007515968 A JP2007515968 A JP 2007515968A JP 2007515968 A JP2007515968 A JP 2007515968A JP 2008503712 A5 JP2008503712 A5 JP 2008503712A5
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JP
Japan
Prior art keywords
acid sequence
group
seq
polypeptide
nos
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2007515968A
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English (en)
Japanese (ja)
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JP2008503712A (ja
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Priority claimed from PCT/EP2005/052875 external-priority patent/WO2005124342A2/en
Publication of JP2008503712A publication Critical patent/JP2008503712A/ja
Publication of JP2008503712A5 publication Critical patent/JP2008503712A5/ja
Pending legal-status Critical Current

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JP2007515968A 2004-06-21 2005-06-21 骨関節炎治療の方法及び手段 Pending JP2008503712A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58156804P 2004-06-21 2004-06-21
PCT/EP2005/052875 WO2005124342A2 (en) 2004-06-21 2005-06-21 Methods and means for treatment of osteoarthritis

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011171363A Division JP5595989B2 (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段
JP2011171061A Division JP2012021995A (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段

Publications (2)

Publication Number Publication Date
JP2008503712A JP2008503712A (ja) 2008-02-07
JP2008503712A5 true JP2008503712A5 (https=) 2008-07-31

Family

ID=35510369

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007515968A Pending JP2008503712A (ja) 2004-06-21 2005-06-21 骨関節炎治療の方法及び手段
JP2011171363A Expired - Fee Related JP5595989B2 (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段
JP2011171061A Pending JP2012021995A (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2011171363A Expired - Fee Related JP5595989B2 (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段
JP2011171061A Pending JP2012021995A (ja) 2004-06-21 2011-08-04 骨関節炎治療の方法及び手段

Country Status (5)

Country Link
US (4) US20070004658A1 (https=)
EP (3) EP1759203A2 (https=)
JP (3) JP2008503712A (https=)
ES (2) ES2427136T3 (https=)
WO (1) WO2005124342A2 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008503712A (ja) 2004-06-21 2008-02-07 ガラパゴス・ナムローゼ・フェンノートシャップ 骨関節炎治療の方法及び手段
US8673268B2 (en) 2004-10-15 2014-03-18 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
US7485468B2 (en) * 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
ES2310469B1 (es) * 2007-03-08 2009-11-16 Consejo Superior Investig. Cientificas Uso compuestos inhibidores actividad snail1 en elaboracion composiciones farmaceuticas utiles para tratamiento de condrodisplasias, procedimiento identificacion compuestos inhibidores, dichas composiciones farmaceuticas, procedimiento diagnostico condrodisplasias y aplicaciones.
US20100034898A1 (en) * 2007-03-12 2010-02-11 Thomas Joseph Lally Cartilage simulating bio-material composition and method
WO2008155397A2 (en) 2007-06-20 2008-12-24 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases
US8501449B2 (en) 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JO3030B1 (ar) 2009-06-26 2016-09-05 Galapagos Nv مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات
RU2405490C1 (ru) * 2009-06-29 2010-12-10 Анатолий Дмитриевич Олейник Способ превентивного лечения рецидива болевого синдрома при хирургических вмешательствах на поясничных межпозвонковых дисках
CN103547580B (zh) 2011-03-22 2016-12-07 阿迪维纳斯疗法有限公司 取代的稠合三环化合物、其组合物及医药用途
AR086042A1 (es) 2011-04-28 2013-11-13 Galapagos Nv Compuesto util para el tratamiento de enfermedades degenerativas e inflamatorias y composicion farmaceutica
US9593115B2 (en) 2012-09-21 2017-03-14 Advinus Therapeutics Ltd. Substituted fused tricyclic compounds, compositions, and medicinal applications thereof
WO2015019365A1 (en) 2013-08-07 2015-02-12 Cadila Healthcare Limited N-cyanomethylamides as inhibitors of janus kinase
GB201401086D0 (en) 2014-01-23 2014-03-12 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
GB201402070D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Pharmaceutical compositions for the treatment of inflammatory disorders
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
KR101710127B1 (ko) 2014-08-29 2017-02-27 한화제약주식회사 야누스인산화효소 억제제로서의 치환된 N-(피롤리딘-3-일)-7H-피롤로[2,3-d]피리미딘-4-아민
GB201512733D0 (en) * 2015-07-20 2015-08-26 Genagon Therapeutics Ab Therapeutic agents for treating conditions associated with elevated GDF15
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
WO2019192978A1 (en) * 2018-04-03 2019-10-10 Sanofi Lateral flow immunoassay strip device
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
EP0786522A2 (en) 1992-07-17 1997-07-30 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecules for treatment of stenotic conditions
FR2714830B1 (fr) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2715847B1 (fr) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
FR2727679B1 (fr) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
US20050043234A1 (en) * 1996-10-16 2005-02-24 Deisher Theresa A. Novel FGF homologs
US6413776B1 (en) 1998-06-12 2002-07-02 Galapagos Geonomics N.V. High throughput screening of gene function using adenoviral libraries for functional genomics applications
EP1156037B1 (en) 1999-01-29 2004-12-01 Chugai Seiyaku Kabushiki Kaisha Chondrongenesis promotors and indolin-2-one derivatives
US6706267B1 (en) * 1999-09-14 2004-03-16 Arkion Life Sciences Llc Glucosamine and egg for reducing inflammation
US7332337B2 (en) 2000-05-16 2008-02-19 Galapagos Nv Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
EP1287021A2 (en) * 2000-05-18 2003-03-05 Bayer Aktiengesellschaft Human galanin receptor-like g protein coupled receptor
DE60138403D1 (de) 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
WO2002070744A2 (en) 2001-03-07 2002-09-12 Galapagos Genomics B.V. Adenoviral library assay for e2f regulatory genes and methods and compositions for screening compounds
JPWO2002087620A1 (ja) 2001-04-27 2004-08-12 中外製薬株式会社 軟骨形成促進剤
US20030068783A1 (en) * 2001-05-09 2003-04-10 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
DK1385882T3 (da) * 2001-05-11 2008-02-11 Amgen Inc Peptider og relaterede molekyler, der binder til TALL-1
KR20020096368A (ko) * 2001-06-19 2002-12-31 주식회사 티지 바이오텍 연골세포의 분화촉진, 연골세포의 탈분화 억제 또는탈분화된 연골세포의 재분화 촉진제, 그것의 스크리닝방법 및 그것을 이용한 연골세포의 제조방법
CA2457879A1 (en) 2001-08-22 2003-03-06 Galapagos Genomics N.V. Modulators of bone homeostasis identified in a high-throughput screen
US20030198627A1 (en) 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
WO2003072827A1 (en) * 2001-10-31 2003-09-04 Children's Hospital Medical Center Method for diagnosis and treatment of rheumatoid arthritis
AU2003209340A1 (en) * 2002-01-18 2003-09-02 Bristol-Myers Squibb Company Predictor sets for tyrosine kinase pathways
JP2004000209A (ja) * 2002-04-26 2004-01-08 Sumitomo Pharmaceut Co Ltd 軟骨障害マーカー及びその利用
US20070155662A1 (en) * 2003-03-11 2007-07-05 Stefan Golz Diagnostics and therapeutics for diseases associated with phosphodiesterase 1a (pde1a)
WO2004094636A1 (en) 2003-04-24 2004-11-04 Galapagos Genomics N.V. Effective sirna knock-down constructs
WO2005063983A1 (en) * 2003-12-29 2005-07-14 Galapagos Genomics N.V. Modulators of bone homeostasis identified in a high-throughput screen
JP2008503712A (ja) * 2004-06-21 2008-02-07 ガラパゴス・ナムローゼ・フェンノートシャップ 骨関節炎治療の方法及び手段

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