JP2008516593A5 - - Google Patents
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- JP2008516593A5 JP2008516593A5 JP2007536196A JP2007536196A JP2008516593A5 JP 2008516593 A5 JP2008516593 A5 JP 2008516593A5 JP 2007536196 A JP2007536196 A JP 2007536196A JP 2007536196 A JP2007536196 A JP 2007536196A JP 2008516593 A5 JP2008516593 A5 JP 2008516593A5
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- 239000003795 chemical substances by application Substances 0.000 claims 16
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 13
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 13
- 210000002744 extracellular matrix Anatomy 0.000 claims 13
- 238000000034 method Methods 0.000 claims 10
- 229920001184 polypeptide Polymers 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 9
- 230000015556 catabolic process Effects 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 238000006731 degradation reaction Methods 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 108020004459 Small interfering RNA Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 108091081021 Sense strand Proteins 0.000 claims 5
- 230000000692 anti-sense effect Effects 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 102000053642 Catalytic RNA Human genes 0.000 claims 2
- 108090000994 Catalytic RNA Proteins 0.000 claims 2
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 108091092562 ribozyme Proteins 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- 241000711408 Murine respirovirus Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000003150 biochemical marker Substances 0.000 claims 1
- 230000008236 biological pathway Effects 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 238000002823 phage display Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61938404P | 2004-10-15 | 2004-10-15 | |
| US60/619,384 | 2004-10-15 | ||
| PCT/EP2005/055315 WO2006040357A2 (en) | 2004-10-15 | 2005-10-17 | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516593A JP2008516593A (ja) | 2008-05-22 |
| JP2008516593A5 true JP2008516593A5 (https=) | 2008-12-04 |
| JP4879906B2 JP4879906B2 (ja) | 2012-02-22 |
Family
ID=35840637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536196A Expired - Fee Related JP4879906B2 (ja) | 2004-10-15 | 2005-10-17 | 関節変性疾患及び炎症性疾患の治療に有用な分子標的及び化合物、並びにそれらの同定方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7485468B2 (https=) |
| EP (2) | EP1817411B1 (https=) |
| JP (1) | JP4879906B2 (https=) |
| AT (1) | ATE534732T1 (https=) |
| WO (1) | WO2006040357A2 (https=) |
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| IL159756A0 (en) | 2001-07-12 | 2004-06-20 | Univ Massachusetts | IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING |
| WO2005121778A2 (en) * | 2004-06-14 | 2005-12-22 | Galapagos N.V. | Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases |
| CN103336129A (zh) | 2005-11-01 | 2013-10-02 | 阿布维生物技术有限公司 | 使用生物标志物诊断强直性脊柱炎的方法和组合物 |
| WO2008058018A2 (en) | 2006-11-02 | 2008-05-15 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| WO2008155397A2 (en) | 2007-06-20 | 2008-12-24 | Galapagos N.V. | Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases |
| WO2009143372A2 (en) * | 2008-05-21 | 2009-11-26 | Intradigm Corporation | Compositions comprising a-raf, b-raf, and c-raf sirna and methods of use thereof |
| AU2009253675A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| WO2010004051A1 (en) * | 2008-07-11 | 2010-01-14 | Medizinische Universität Innsbruck | Antagonists of nr2f6 for augmenting the immune response |
| CN105169389A (zh) | 2008-08-01 | 2015-12-23 | 阿克西斯股份有限公司 | 骨关节炎治疗剂及预防剂 |
| US20150203846A1 (en) * | 2008-11-14 | 2015-07-23 | Christine Victoria Ichim | Treatment of Myelodysplastic Syndrome by Inhibition of NR2F6 |
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| US20150283164A1 (en) * | 2008-11-14 | 2015-10-08 | Christine Victoria Ichim | Treatment of Myelodysplastic Syndrome by Inhibition of NR2F2 |
| GB2512153B (en) * | 2008-11-17 | 2014-11-12 | Veracyte Inc | Methods and compositions of molecular profiling for disease diagnostics |
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| US9074258B2 (en) | 2009-03-04 | 2015-07-07 | Genomedx Biosciences Inc. | Compositions and methods for classifying thyroid nodule disease |
| US8663930B2 (en) | 2009-04-01 | 2014-03-04 | Galapagos Nv | Methods and means for treatment of osteoarthritis |
| EP3360978A3 (en) | 2009-05-07 | 2018-09-26 | Veracyte, Inc. | Methods for diagnosis of thyroid conditions |
| CN102781963B (zh) * | 2009-10-27 | 2018-02-16 | Ucb医药有限公司 | 功能修饰性NAv1.7抗体 |
| US10446272B2 (en) | 2009-12-09 | 2019-10-15 | Veracyte, Inc. | Methods and compositions for classification of samples |
| WO2011084711A2 (en) * | 2009-12-17 | 2011-07-14 | Five Prime Therapeutics, Inc. | Hair growth methods using fgfr3 extracellular domains |
| JP2012246222A (ja) | 2010-01-29 | 2012-12-13 | Axis Inc | 変形性関節症治療剤または予防剤を製造するための使用 |
| KR101684246B1 (ko) | 2010-01-29 | 2016-12-08 | 가부시키가이샤 아크시스 | 변형성 관절증 치료제를 포함하는 주사제 |
| JPWO2011093083A1 (ja) | 2010-01-29 | 2013-05-30 | Ａｘｉｓ株式会社 | 変形性関節症治療又は予防用医薬組成物及びその製造方法 |
| CN109112126B (zh) | 2010-06-23 | 2024-06-14 | 库尔纳公司 | 通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病 |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| US10513737B2 (en) | 2011-12-13 | 2019-12-24 | Decipher Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| WO2013166264A2 (en) * | 2012-05-02 | 2013-11-07 | University Of Georgia Research Foundation, Inc. | Methods for altering virus replication |
| EP2885640B1 (en) | 2012-08-16 | 2018-07-18 | Genomedx Biosciences, Inc. | Prostate cancer prognostics using biomarkers |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| EP3617234A1 (en) | 2013-08-07 | 2020-03-04 | Astute Medical, Inc. | Assays for timp2 having improved performance in biological samples |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US20170335396A1 (en) | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| WO2017019660A1 (en) * | 2015-07-27 | 2017-02-02 | Alnylam Pharmaceuticals, Inc. | Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof |
| WO2017141157A1 (en) * | 2016-02-15 | 2017-08-24 | Istituti Clinici Scientifici Maugeri Spa Sb | Method of allele specific silencing for the treatment of autosomal dominant catecholaminergic polymorphic ventricular tachycardia (cpvt) |
| EP3504348B1 (en) | 2016-08-24 | 2022-12-14 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| WO2018132916A1 (en) | 2017-01-20 | 2018-07-26 | Genomedx Biosciences, Inc. | Molecular subtyping, prognosis, and treatment of bladder cancer |
| CA3055925A1 (en) | 2017-03-09 | 2018-09-13 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| US11718682B2 (en) | 2017-04-05 | 2023-08-08 | Astute Medical, Inc. | Assays for TIMP2 having improved performance in biological samples |
| AU2018266733A1 (en) | 2017-05-12 | 2020-01-16 | Veracyte, Inc. | Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness |
| US11217329B1 (en) | 2017-06-23 | 2022-01-04 | Veracyte, Inc. | Methods and systems for determining biological sample integrity |
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| EP3659609B1 (en) | 2017-07-28 | 2024-05-08 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for fibrosis |
| WO2019028285A2 (en) | 2017-08-04 | 2019-02-07 | Genomedx, Inc. | USE OF SPECIFIC GENE EXPRESSION OF IMMUNE CELLS FOR THE PROGNOSIS OF PROSTATE CANCER AND THE PREDICTION OF SENSITIVITY TO RADIOTHERAPY |
| CN111712252A (zh) | 2017-12-13 | 2020-09-25 | 纽约州立大学研究基金会 | 用于治疗疼痛和提高疼痛敏感性的肽和其它药剂 |
| JP2023521094A (ja) * | 2020-04-07 | 2023-05-23 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | Ｓｃｎ９ａ発現をサイレンシングするための組成物および方法 |
| WO2021257782A1 (en) | 2020-06-18 | 2021-12-23 | Alnylam Pharmaceuticals, Inc. | XANTHINE DEHYDROGENASE (XDH) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2025059345A1 (en) * | 2023-09-14 | 2025-03-20 | Empirico Inc. | Treatment of hgfac related diseases and disorders |
| WO2025264067A1 (ko) * | 2024-06-21 | 2025-12-26 | 기초과학연구원 | Axl의 세포내 도메인 또는 이의 유래 단편 및 이를 이용한 오토파지 조절 용도 |
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-
2005
- 2005-10-14 US US11/251,465 patent/US7485468B2/en not_active Expired - Fee Related
- 2005-10-17 EP EP05803408A patent/EP1817411B1/en not_active Expired - Lifetime
- 2005-10-17 JP JP2007536196A patent/JP4879906B2/ja not_active Expired - Fee Related
- 2005-10-17 EP EP11154125.6A patent/EP2360478B1/en not_active Expired - Lifetime
- 2005-10-17 WO PCT/EP2005/055315 patent/WO2006040357A2/en not_active Ceased
- 2005-10-17 AT AT05803408T patent/ATE534732T1/de active
-
2009
- 2009-01-27 US US12/360,332 patent/US8097408B2/en not_active Expired - Fee Related
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