JP2008501780A5 - - Google Patents
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- JP2008501780A5 JP2008501780A5 JP2007526692A JP2007526692A JP2008501780A5 JP 2008501780 A5 JP2008501780 A5 JP 2008501780A5 JP 2007526692 A JP2007526692 A JP 2007526692A JP 2007526692 A JP2007526692 A JP 2007526692A JP 2008501780 A5 JP2008501780 A5 JP 2008501780A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amide
- group
- compound
- methoxycarbonylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 132
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 claims 80
- 229910052763 palladium Inorganic materials 0.000 claims 67
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 52
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 35
- -1 thiazolium Chemical compound 0.000 claims 33
- 150000001408 amides Chemical class 0.000 claims 31
- 125000000623 heterocyclic group Chemical group 0.000 claims 28
- 229910052760 oxygen Inorganic materials 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001768 cations Chemical class 0.000 claims 16
- 125000005842 heteroatom Chemical group 0.000 claims 16
- 229920006395 saturated elastomer Polymers 0.000 claims 16
- 230000004962 physiological condition Effects 0.000 claims 13
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 11
- 229910052751 metal Inorganic materials 0.000 claims 11
- 239000002184 metal Substances 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 11
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 10
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 10
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 10
- 125000002837 carbocyclic group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 150000001450 anions Chemical class 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 8
- 125000000524 functional group Chemical group 0.000 claims 8
- 229910052748 manganese Inorganic materials 0.000 claims 8
- 150000002772 monosaccharides Chemical class 0.000 claims 8
- 229920001542 oligosaccharide Polymers 0.000 claims 8
- 150000002482 oligosaccharides Chemical class 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 7
- 150000004676 glycans Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000004430 oxygen atom Chemical group O* 0.000 claims 7
- 125000004434 sulfur atom Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 5
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims 5
- 125000004069 aziridinyl group Chemical group 0.000 claims 5
- 150000004036 bacteriochlorins Chemical class 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 229910052698 phosphorus Inorganic materials 0.000 claims 5
- 239000011574 phosphorus Substances 0.000 claims 5
- 238000002428 photodynamic therapy Methods 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- SBMSLRMNBSMKQC-UHFFFAOYSA-N pyrrolidin-1-amine Chemical group NN1CCCC1 SBMSLRMNBSMKQC-UHFFFAOYSA-N 0.000 claims 5
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 5
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 4
- 239000004593 Epoxy Substances 0.000 claims 4
- 229910052691 Erbium Inorganic materials 0.000 claims 4
- 229910052688 Gadolinium Inorganic materials 0.000 claims 4
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 claims 4
- WTKZEGDFNFYCGP-UHFFFAOYSA-O Pyrazolium Chemical compound C1=CN[NH+]=C1 WTKZEGDFNFYCGP-UHFFFAOYSA-O 0.000 claims 4
- 229910052769 Ytterbium Inorganic materials 0.000 claims 4
- 229910052782 aluminium Inorganic materials 0.000 claims 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 4
- 229910052804 chromium Inorganic materials 0.000 claims 4
- 229910052802 copper Inorganic materials 0.000 claims 4
- 229910052737 gold Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- ZCQWOFVYLHDMMC-UHFFFAOYSA-O hydron;1,3-oxazole Chemical compound C1=COC=[NH+]1 ZCQWOFVYLHDMMC-UHFFFAOYSA-O 0.000 claims 4
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-O isoquinolin-2-ium Chemical compound C1=[NH+]C=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-O 0.000 claims 4
- 229910052759 nickel Inorganic materials 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 229910052697 platinum Inorganic materials 0.000 claims 4
- 150000004804 polysaccharides Polymers 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052718 tin Inorganic materials 0.000 claims 4
- 229910052725 zinc Inorganic materials 0.000 claims 4
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical compound C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 claims 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-O hydron;pyrimidine Chemical compound C1=CN=C[NH+]=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-O 0.000 claims 3
- 150000002892 organic cations Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 claims 3
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 2
- IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 claims 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 2
- 125000004530 1,2,4-triazinyl group Chemical group N1=NC(=NC=C1)* 0.000 claims 2
- 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 2
- 108010003118 Bacteriochlorophylls Proteins 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- BHPNXACHQYJJJS-UHFFFAOYSA-N bacteriochlorin Chemical compound N1C(C=C2N=C(C=C3NC(=C4)C=C3)CC2)=CC=C1C=C1CCC4=N1 BHPNXACHQYJJJS-UHFFFAOYSA-N 0.000 claims 2
- 229940125758 compound 15 Drugs 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 150000002390 heteroarenes Chemical class 0.000 claims 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 239000012678 infectious agent Substances 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 claims 1
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 claims 1
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 claims 1
- ABJSOROVZZKJGI-OCYUSGCXSA-N (1r,2r,4r)-2-(4-bromophenyl)-n-[(4-chlorophenyl)-(2-fluoropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide Chemical compound C1=NC(F)=CC(C(NC(=O)[C@H]2[C@@H](C[C@@H](CC2)N2CCOCC2)C=2C=CC(Br)=CC=2)C=2C=CC(Cl)=CC=2)=C1 ABJSOROVZZKJGI-OCYUSGCXSA-N 0.000 claims 1
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 1
- GCTFTMWXZFLTRR-GFCCVEGCSA-N (2r)-2-amino-n-[3-(difluoromethoxy)-4-(1,3-oxazol-5-yl)phenyl]-4-methylpentanamide Chemical compound FC(F)OC1=CC(NC(=O)[C@H](N)CC(C)C)=CC=C1C1=CN=CO1 GCTFTMWXZFLTRR-GFCCVEGCSA-N 0.000 claims 1
- IUSARDYWEPUTPN-OZBXUNDUSA-N (2r)-n-[(2s,3r)-4-[[(4s)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide Chemical compound C([C@H](NC(=O)[C@@H](C)OC)[C@H](O)CN[C@@H]1C2=CC(CC(C)(C)C)=CN=C2OC2(CCC2)C1)C(C=1)=CC=CC=1C1=NC=CS1 IUSARDYWEPUTPN-OZBXUNDUSA-N 0.000 claims 1
- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 claims 1
- VIJSPAIQWVPKQZ-BLECARSGSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-4,4-dimethylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O VIJSPAIQWVPKQZ-BLECARSGSA-N 0.000 claims 1
- WWTBZEKOSBFBEM-SPWPXUSOSA-N (2s)-2-[[2-benzyl-3-[hydroxy-[(1r)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphoryl]propanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)O)C(=O)C(CP(O)(=O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1 WWTBZEKOSBFBEM-SPWPXUSOSA-N 0.000 claims 1
- STBLNCCBQMHSRC-BATDWUPUSA-N (2s)-n-[(3s,4s)-5-acetyl-7-cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)[C@H](C)N(C(C)=O)C2=CC(C#N)=CC=C2N1CC1=C(C)C=CC2=CC=CC=C12 STBLNCCBQMHSRC-BATDWUPUSA-N 0.000 claims 1
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims 1
- FNHHVPPSBFQMEL-KQHDFZBMSA-N (3S)-5-N-[(1S,5R)-3-hydroxy-6-bicyclo[3.1.0]hexanyl]-7-N,3-dimethyl-3-phenyl-2H-1-benzofuran-5,7-dicarboxamide Chemical compound CNC(=O)c1cc(cc2c1OC[C@@]2(C)c1ccccc1)C(=O)NC1[C@H]2CC(O)C[C@@H]12 FNHHVPPSBFQMEL-KQHDFZBMSA-N 0.000 claims 1
- UDQTXCHQKHIQMH-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O UDQTXCHQKHIQMH-KYGLGHNPSA-N 0.000 claims 1
- OOKAZRDERJMRCJ-KOUAFAAESA-N (3r)-7-[(1s,2s,4ar,6s,8s)-2,6-dimethyl-8-[(2s)-2-methylbutanoyl]oxy-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-3-hydroxy-5-oxoheptanoic acid Chemical compound C1=C[C@H](C)[C@H](CCC(=O)C[C@@H](O)CC(O)=O)C2[C@@H](OC(=O)[C@@H](C)CC)C[C@@H](C)C[C@@H]21 OOKAZRDERJMRCJ-KOUAFAAESA-N 0.000 claims 1
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 claims 1
- MPDDTAJMJCESGV-CTUHWIOQSA-M (3r,5r)-7-[2-(4-fluorophenyl)-5-[methyl-[(1r)-1-phenylethyl]carbamoyl]-4-propan-2-ylpyrazol-3-yl]-3,5-dihydroxyheptanoate Chemical compound C1([C@@H](C)N(C)C(=O)C2=NN(C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C2C(C)C)C=2C=CC(F)=CC=2)=CC=CC=C1 MPDDTAJMJCESGV-CTUHWIOQSA-M 0.000 claims 1
- OMBVEVHRIQULKW-DNQXCXABSA-M (3r,5r)-7-[3-(4-fluorophenyl)-8-oxo-7-phenyl-1-propan-2-yl-5,6-dihydro-4h-pyrrolo[2,3-c]azepin-2-yl]-3,5-dihydroxyheptanoate Chemical compound O=C1C=2N(C(C)C)C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C=3C=CC(F)=CC=3)C=2CCCN1C1=CC=CC=C1 OMBVEVHRIQULKW-DNQXCXABSA-M 0.000 claims 1
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| JP (1) | JP5372371B2 (https=) |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2008665A1 (fr) * | 2007-06-25 | 2008-12-31 | Steba Biotech N.V. | Formulation injectable pour thérapie photodynamique |
| AU2009219682B2 (en) | 2008-02-27 | 2015-06-18 | Yeda Research & Development Co. Ltd | RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors |
| RU2632439C2 (ru) * | 2011-08-23 | 2017-10-04 | Йеда Рисерч Энд Дивелопмент Ко., Лтд. | Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств |
| ES2849427T3 (es) | 2013-03-11 | 2021-08-18 | Tookad Ip Sarl | Método de producción de bacterioclorofila A |
| RU2548675C9 (ru) * | 2013-05-29 | 2015-11-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) | Аминоамиды в ряду бактериохлорофилла a, обладающие фотодинамической активностью, и способ их получения |
| JP6218073B2 (ja) * | 2013-11-26 | 2017-10-25 | 国立大学法人群馬大学 | 細胞・組織内酸素濃度測定のための高感度近赤外りん光イリジウム錯体 |
| RU2549953C2 (ru) * | 2013-12-25 | 2015-05-10 | Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Фотосенсибилизатор для фотодинамической терапии |
| RU2610566C1 (ru) * | 2015-09-17 | 2017-02-13 | Сергей Сергеевич Брусов | Способ фотодинамической терапии локальных очагов инфекции |
| CN105424857A (zh) * | 2015-12-01 | 2016-03-23 | 浙江汇能生物股份有限公司 | 一种二甲基半胱胺盐酸盐的高效液相色谱分析方法 |
| WO2018102252A1 (en) * | 2016-11-30 | 2018-06-07 | North Carolina State University | Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds |
| BR112021014592A2 (pt) * | 2019-01-25 | 2021-10-05 | Suncor Energy Inc. | Compostos fotosensibilizadores, métodos de fabricação e aplicação em plantas |
| US20250269031A1 (en) * | 2020-11-24 | 2025-08-28 | The Regents Of The University Of California | Mitochondria targeting quinolinium-drug conjugates and their self-assembling nanoformulations for cancer therapy |
| CN115093422B (zh) * | 2022-06-15 | 2023-06-20 | 西北工业大学 | 一种基于代谢标记策略的新型光敏剂及其制备方法和应用 |
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| US3050296A (en) * | 1960-12-19 | 1962-08-21 | Trimborn Hans | Transport roller for industrial furnaces |
| US3203888A (en) * | 1961-04-24 | 1965-08-31 | Exxon Research Engineering Co | Treating athabaska sands utilizing a flotation gas |
| DE2018970A1 (de) | 1970-04-21 | 1971-11-11 | Badische Anilin- & Soda Fabrik AG, 6700 Ludwigshafen | Verfahren zur Herstellung von beta-Aminoäthylsulfoniumverbindungen |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| US5744598A (en) | 1992-06-19 | 1998-04-28 | University Of Toledo | Imines of porphyrins, of porphyrin derivatives, and of related compounds, and pharmaceutical compositions containing such imines |
| IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| US6147195A (en) | 1993-07-26 | 2000-11-14 | Yeda Research And Development Co., Ltd. | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| IL116126A0 (en) | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
| US5770730A (en) * | 1996-03-08 | 1998-06-23 | Health Research, Inc. | Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer |
| ATE347554T1 (de) * | 1998-12-09 | 2006-12-15 | Yeda Res & Dev | Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung |
| IL133253A0 (en) * | 1999-12-01 | 2001-04-30 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them |
| US6573258B2 (en) * | 2000-09-27 | 2003-06-03 | Frontier Scientific, Inc. | Photodynamic porphyrin antimicrobial agents |
| WO2002098882A1 (en) * | 2001-06-01 | 2002-12-12 | Ceramoptec Industries, Inc. | Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture |
| US20030203888A1 (en) * | 2001-06-06 | 2003-10-30 | Boyle Ross William | Chromophores |
| EP1450790A4 (en) | 2001-10-03 | 2005-10-26 | Miravant Pharm Inc | PHOTOSENSIBILIZING CARBAMATE DERIVATIVES |
| EP1450774A4 (en) | 2001-10-03 | 2005-10-26 | Miravant Pharm Inc | CHLORINE PHOTOSENSIBILIZERS FOR USE IN PHOTODYNAMIC THERAPY |
| DE10154436A1 (de) | 2001-11-07 | 2003-05-15 | Rodotech Gmbh | pyro-Bakteriopheophorbidderivate |
| GB0130778D0 (en) * | 2001-12-21 | 2002-02-06 | Catalyst Biomedica Ltd | Novel compounds |
| RU2343829C2 (ru) | 2002-05-08 | 2009-01-20 | Йеда Рисерч Энд Дивелопмент Ко. Лтд | Сенсибилизированный оперативный bold-mri способ получения изображения |
| EP1517684B1 (en) * | 2002-06-27 | 2009-07-22 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| RU2223274C1 (ru) * | 2002-09-04 | 2004-02-10 | ООО "Фотогем" | ГИДРАЗИДЫ В РЯДУ БАКТЕРИОХЛОРОФИЛЛА a, ОБЛАДАЮЩИЕ ФОТОДИНАМИЧЕСКОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| IL152900A0 (en) | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
-
2005
- 2005-06-07 ZA ZA200700169A patent/ZA200700169B/en unknown
- 2005-06-07 ES ES10012927.9T patent/ES2602460T3/es not_active Expired - Lifetime
- 2005-06-07 US US11/628,719 patent/US8207154B2/en not_active Expired - Fee Related
- 2005-06-07 HU HUE10012927A patent/HUE031075T2/en unknown
- 2005-06-07 CN CN2005800185365A patent/CN1980661B/zh not_active Expired - Fee Related
- 2005-06-07 PT PT100129279T patent/PT2322173T/pt unknown
- 2005-06-07 DK DK05749886.7T patent/DK1753457T3/en active
- 2005-06-07 ES ES05749886.7T patent/ES2602204T3/es not_active Expired - Lifetime
- 2005-06-07 MX MXPA06014326A patent/MXPA06014326A/es active IP Right Grant
- 2005-06-07 WO PCT/IL2005/000602 patent/WO2005120573A2/en not_active Ceased
- 2005-06-07 EP EP05749886.7A patent/EP1753457B8/en not_active Expired - Lifetime
- 2005-06-07 EP EP10012927.9A patent/EP2322173B1/en not_active Expired - Lifetime
- 2005-06-07 HU HUE05749886A patent/HUE030586T2/en unknown
- 2005-06-07 NZ NZ551845A patent/NZ551845A/en not_active IP Right Cessation
- 2005-06-07 RU RU2006146677/04A patent/RU2397172C2/ru not_active IP Right Cessation
- 2005-06-07 CA CA2569675A patent/CA2569675C/en not_active Expired - Fee Related
- 2005-06-07 DK DK10012927.9T patent/DK2322173T3/en active
- 2005-06-07 AU AU2005251556A patent/AU2005251556B2/en not_active Ceased
- 2005-06-07 JP JP2007526692A patent/JP5372371B2/ja not_active Expired - Fee Related
- 2005-06-07 BR BRPI0511909-0A patent/BRPI0511909A/pt not_active IP Right Cessation
- 2005-06-07 KR KR1020067025726A patent/KR101191700B1/ko not_active Expired - Fee Related
- 2005-06-07 PT PT57498867T patent/PT1753457T/pt unknown
-
2007
- 2007-01-05 NO NO20070083A patent/NO339304B1/no not_active IP Right Cessation
-
2016
- 2016-09-19 NO NO20161485A patent/NO20161485A1/no not_active Application Discontinuation
- 2016-10-27 CY CY20161101097T patent/CY1118203T1/el unknown
- 2016-10-27 CY CY20161101099T patent/CY1118194T1/el unknown
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