KR101191700B1 - 양이온성 박테리오클로로필 유도체 및 이의 용도 - Google Patents

양이온성 박테리오클로로필 유도체 및 이의 용도 Download PDF

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KR101191700B1
KR101191700B1 KR1020067025726A KR20067025726A KR101191700B1 KR 101191700 B1 KR101191700 B1 KR 101191700B1 KR 1020067025726 A KR1020067025726 A KR 1020067025726A KR 20067025726 A KR20067025726 A KR 20067025726A KR 101191700 B1 KR101191700 B1 KR 101191700B1
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amide
compound
oxo
palladium
rhodobacteriochlorin
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KR20070026563A (ko
Inventor
아비그도르 스케르츠
알렉산더 브란디스
요람 살로몬
도론 에렌
아브라함 코헨
Original Assignee
예다 리서치 앤드 디벨럽먼트 캄파니 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D229/00—Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020067025726A 2004-06-07 2005-06-07 양이온성 박테리오클로로필 유도체 및 이의 용도 Expired - Fee Related KR101191700B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57719604P 2004-06-07 2004-06-07
US60/577,196 2004-06-07
PCT/IL2005/000602 WO2005120573A2 (en) 2004-06-07 2005-06-07 Cationic bacteriochlorophyll derivatives and uses thereof

Publications (2)

Publication Number Publication Date
KR20070026563A KR20070026563A (ko) 2007-03-08
KR101191700B1 true KR101191700B1 (ko) 2012-10-16

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KR1020067025726A Expired - Fee Related KR101191700B1 (ko) 2004-06-07 2005-06-07 양이온성 박테리오클로로필 유도체 및 이의 용도

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Country Link
US (1) US8207154B2 (https=)
EP (2) EP1753457B8 (https=)
JP (1) JP5372371B2 (https=)
KR (1) KR101191700B1 (https=)
CN (1) CN1980661B (https=)
AU (1) AU2005251556B2 (https=)
BR (1) BRPI0511909A (https=)
CA (1) CA2569675C (https=)
CY (2) CY1118203T1 (https=)
DK (2) DK1753457T3 (https=)
ES (2) ES2602460T3 (https=)
HU (2) HUE031075T2 (https=)
MX (1) MXPA06014326A (https=)
NO (2) NO339304B1 (https=)
NZ (1) NZ551845A (https=)
PT (2) PT2322173T (https=)
RU (1) RU2397172C2 (https=)
WO (1) WO2005120573A2 (https=)
ZA (1) ZA200700169B (https=)

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EP2008665A1 (fr) * 2007-06-25 2008-12-31 Steba Biotech N.V. Formulation injectable pour thérapie photodynamique
AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
RU2632439C2 (ru) * 2011-08-23 2017-10-04 Йеда Рисерч Энд Дивелопмент Ко., Лтд. Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств
ES2849427T3 (es) 2013-03-11 2021-08-18 Tookad Ip Sarl Método de producción de bacterioclorofila A
RU2548675C9 (ru) * 2013-05-29 2015-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) Аминоамиды в ряду бактериохлорофилла a, обладающие фотодинамической активностью, и способ их получения
JP6218073B2 (ja) * 2013-11-26 2017-10-25 国立大学法人群馬大学 細胞・組織内酸素濃度測定のための高感度近赤外りん光イリジウム錯体
RU2549953C2 (ru) * 2013-12-25 2015-05-10 Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизатор для фотодинамической терапии
RU2610566C1 (ru) * 2015-09-17 2017-02-13 Сергей Сергеевич Брусов Способ фотодинамической терапии локальных очагов инфекции
CN105424857A (zh) * 2015-12-01 2016-03-23 浙江汇能生物股份有限公司 一种二甲基半胱胺盐酸盐的高效液相色谱分析方法
WO2018102252A1 (en) * 2016-11-30 2018-06-07 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
BR112021014592A2 (pt) * 2019-01-25 2021-10-05 Suncor Energy Inc. Compostos fotosensibilizadores, métodos de fabricação e aplicação em plantas
US20250269031A1 (en) * 2020-11-24 2025-08-28 The Regents Of The University Of California Mitochondria targeting quinolinium-drug conjugates and their self-assembling nanoformulations for cancer therapy
CN115093422B (zh) * 2022-06-15 2023-06-20 西北工业大学 一种基于代谢标记策略的新型光敏剂及其制备方法和应用

Citations (1)

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US20030148926A1 (en) * 1999-12-01 2003-08-07 Hugo Scheer Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them

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US5330741A (en) * 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors
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Also Published As

Publication number Publication date
RU2397172C2 (ru) 2010-08-20
AU2005251556A1 (en) 2005-12-22
CA2569675A1 (en) 2005-12-22
NO20161485A1 (no) 2007-03-06
CN1980661A (zh) 2007-06-13
NO339304B1 (no) 2016-11-21
WO2005120573A3 (en) 2006-01-26
DK1753457T3 (en) 2016-12-05
CN1980661B (zh) 2011-09-28
JP2008501780A (ja) 2008-01-24
ES2602204T3 (es) 2017-02-20
CA2569675C (en) 2015-03-17
ZA200700169B (en) 2008-05-28
EP1753457B1 (en) 2016-08-10
DK2322173T3 (en) 2016-12-05
NO20070083L (no) 2007-03-06
CY1118203T1 (el) 2017-06-28
BRPI0511909A (pt) 2008-01-15
EP2322173A1 (en) 2011-05-18
CY1118194T1 (el) 2017-06-28
EP1753457B8 (en) 2016-09-21
US8207154B2 (en) 2012-06-26
RU2006146677A (ru) 2008-07-20
ES2602460T3 (es) 2017-02-21
PT1753457T (pt) 2016-11-10
HUE031075T2 (en) 2017-06-28
NZ551845A (en) 2010-08-27
EP2322173B1 (en) 2016-08-10
HUE030586T2 (en) 2017-06-28
PT2322173T (pt) 2016-11-14
AU2005251556B2 (en) 2011-04-14
KR20070026563A (ko) 2007-03-08
WO2005120573A2 (en) 2005-12-22
JP5372371B2 (ja) 2013-12-18
US20080076748A1 (en) 2008-03-27
EP1753457A2 (en) 2007-02-21
MXPA06014326A (es) 2007-02-19

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