BRPI0511909A - derivado catiÈnico de bacterioclorofilas e respectiva composição farmacêutica - Google Patents

derivado catiÈnico de bacterioclorofilas e respectiva composição farmacêutica

Info

Publication number
BRPI0511909A
BRPI0511909A BRPI0511909-0A BRPI0511909A BRPI0511909A BR PI0511909 A BRPI0511909 A BR PI0511909A BR PI0511909 A BRPI0511909 A BR PI0511909A BR PI0511909 A BRPI0511909 A BR PI0511909A
Authority
BR
Brazil
Prior art keywords
group
bchls
bacteriochlorophylls
pharmaceutical composition
converted
Prior art date
Application number
BRPI0511909-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Avigdor Scherz
Alexander Brandis
Yoram Salomon
Doron Eren
Avraham Cohen
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of BRPI0511909A publication Critical patent/BRPI0511909A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D229/00—Heterocyclic compounds containing rings of less than five members having two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0511909-0A 2004-06-07 2005-06-07 derivado catiÈnico de bacterioclorofilas e respectiva composição farmacêutica BRPI0511909A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57719604P 2004-06-07 2004-06-07
PCT/IL2005/000602 WO2005120573A2 (en) 2004-06-07 2005-06-07 Cationic bacteriochlorophyll derivatives and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0511909A true BRPI0511909A (pt) 2008-01-15

Family

ID=35044538

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511909-0A BRPI0511909A (pt) 2004-06-07 2005-06-07 derivado catiÈnico de bacterioclorofilas e respectiva composição farmacêutica

Country Status (19)

Country Link
US (1) US8207154B2 (https=)
EP (2) EP1753457B8 (https=)
JP (1) JP5372371B2 (https=)
KR (1) KR101191700B1 (https=)
CN (1) CN1980661B (https=)
AU (1) AU2005251556B2 (https=)
BR (1) BRPI0511909A (https=)
CA (1) CA2569675C (https=)
CY (2) CY1118203T1 (https=)
DK (2) DK1753457T3 (https=)
ES (2) ES2602460T3 (https=)
HU (2) HUE031075T2 (https=)
MX (1) MXPA06014326A (https=)
NO (2) NO339304B1 (https=)
NZ (1) NZ551845A (https=)
PT (2) PT2322173T (https=)
RU (1) RU2397172C2 (https=)
WO (1) WO2005120573A2 (https=)
ZA (1) ZA200700169B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2008665A1 (fr) * 2007-06-25 2008-12-31 Steba Biotech N.V. Formulation injectable pour thérapie photodynamique
AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
RU2632439C2 (ru) * 2011-08-23 2017-10-04 Йеда Рисерч Энд Дивелопмент Ко., Лтд. Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств
ES2849427T3 (es) 2013-03-11 2021-08-18 Tookad Ip Sarl Método de producción de bacterioclorofila A
RU2548675C9 (ru) * 2013-05-29 2015-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) Аминоамиды в ряду бактериохлорофилла a, обладающие фотодинамической активностью, и способ их получения
JP6218073B2 (ja) * 2013-11-26 2017-10-25 国立大学法人群馬大学 細胞・組織内酸素濃度測定のための高感度近赤外りん光イリジウム錯体
RU2549953C2 (ru) * 2013-12-25 2015-05-10 Федеральное государственное унитарное предприятие Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизатор для фотодинамической терапии
RU2610566C1 (ru) * 2015-09-17 2017-02-13 Сергей Сергеевич Брусов Способ фотодинамической терапии локальных очагов инфекции
CN105424857A (zh) * 2015-12-01 2016-03-23 浙江汇能生物股份有限公司 一种二甲基半胱胺盐酸盐的高效液相色谱分析方法
WO2018102252A1 (en) * 2016-11-30 2018-06-07 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
BR112021014592A2 (pt) * 2019-01-25 2021-10-05 Suncor Energy Inc. Compostos fotosensibilizadores, métodos de fabricação e aplicação em plantas
US20250269031A1 (en) * 2020-11-24 2025-08-28 The Regents Of The University Of California Mitochondria targeting quinolinium-drug conjugates and their self-assembling nanoformulations for cancer therapy
CN115093422B (zh) * 2022-06-15 2023-06-20 西北工业大学 一种基于代谢标记策略的新型光敏剂及其制备方法和应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050296A (en) * 1960-12-19 1962-08-21 Trimborn Hans Transport roller for industrial furnaces
US3203888A (en) * 1961-04-24 1965-08-31 Exxon Research Engineering Co Treating athabaska sands utilizing a flotation gas
DE2018970A1 (de) 1970-04-21 1971-11-11 Badische Anilin- & Soda Fabrik AG, 6700 Ludwigshafen Verfahren zur Herstellung von beta-Aminoäthylsulfoniumverbindungen
US5330741A (en) * 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors
US5744598A (en) 1992-06-19 1998-04-28 University Of Toledo Imines of porphyrins, of porphyrin derivatives, and of related compounds, and pharmaceutical compositions containing such imines
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US6147195A (en) 1993-07-26 2000-11-14 Yeda Research And Development Co., Ltd. Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
IL116126A0 (en) 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
US5770730A (en) * 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
ATE347554T1 (de) * 1998-12-09 2006-12-15 Yeda Res & Dev Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung
IL133253A0 (en) * 1999-12-01 2001-04-30 Yeda Res & Dev Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
US6573258B2 (en) * 2000-09-27 2003-06-03 Frontier Scientific, Inc. Photodynamic porphyrin antimicrobial agents
WO2002098882A1 (en) * 2001-06-01 2002-12-12 Ceramoptec Industries, Inc. Water-soluble porphyrin derivatives for photodynamic therapy, their use and manufacture
US20030203888A1 (en) * 2001-06-06 2003-10-30 Boyle Ross William Chromophores
EP1450790A4 (en) 2001-10-03 2005-10-26 Miravant Pharm Inc PHOTOSENSIBILIZING CARBAMATE DERIVATIVES
EP1450774A4 (en) 2001-10-03 2005-10-26 Miravant Pharm Inc CHLORINE PHOTOSENSIBILIZERS FOR USE IN PHOTODYNAMIC THERAPY
DE10154436A1 (de) 2001-11-07 2003-05-15 Rodotech Gmbh pyro-Bakteriopheophorbidderivate
GB0130778D0 (en) * 2001-12-21 2002-02-06 Catalyst Biomedica Ltd Novel compounds
RU2343829C2 (ru) 2002-05-08 2009-01-20 Йеда Рисерч Энд Дивелопмент Ко. Лтд Сенсибилизированный оперативный bold-mri способ получения изображения
EP1517684B1 (en) * 2002-06-27 2009-07-22 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
RU2223274C1 (ru) * 2002-09-04 2004-02-10 ООО "Фотогем" ГИДРАЗИДЫ В РЯДУ БАКТЕРИОХЛОРОФИЛЛА a, ОБЛАДАЮЩИЕ ФОТОДИНАМИЧЕСКОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ
IL152900A0 (en) 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses

Also Published As

Publication number Publication date
RU2397172C2 (ru) 2010-08-20
AU2005251556A1 (en) 2005-12-22
CA2569675A1 (en) 2005-12-22
NO20161485A1 (no) 2007-03-06
CN1980661A (zh) 2007-06-13
NO339304B1 (no) 2016-11-21
WO2005120573A3 (en) 2006-01-26
DK1753457T3 (en) 2016-12-05
CN1980661B (zh) 2011-09-28
JP2008501780A (ja) 2008-01-24
ES2602204T3 (es) 2017-02-20
CA2569675C (en) 2015-03-17
ZA200700169B (en) 2008-05-28
EP1753457B1 (en) 2016-08-10
DK2322173T3 (en) 2016-12-05
NO20070083L (no) 2007-03-06
CY1118203T1 (el) 2017-06-28
EP2322173A1 (en) 2011-05-18
CY1118194T1 (el) 2017-06-28
EP1753457B8 (en) 2016-09-21
US8207154B2 (en) 2012-06-26
RU2006146677A (ru) 2008-07-20
ES2602460T3 (es) 2017-02-21
PT1753457T (pt) 2016-11-10
HUE031075T2 (en) 2017-06-28
NZ551845A (en) 2010-08-27
EP2322173B1 (en) 2016-08-10
HUE030586T2 (en) 2017-06-28
PT2322173T (pt) 2016-11-14
AU2005251556B2 (en) 2011-04-14
KR20070026563A (ko) 2007-03-08
WO2005120573A2 (en) 2005-12-22
JP5372371B2 (ja) 2013-12-18
US20080076748A1 (en) 2008-03-27
KR101191700B1 (ko) 2012-10-16
EP1753457A2 (en) 2007-02-21
MXPA06014326A (es) 2007-02-19

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 16A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2623 DE 13/04/2021.