JP2008500274A5 - - Google Patents
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- JP2008500274A5 JP2008500274A5 JP2006546489A JP2006546489A JP2008500274A5 JP 2008500274 A5 JP2008500274 A5 JP 2008500274A5 JP 2006546489 A JP2006546489 A JP 2006546489A JP 2006546489 A JP2006546489 A JP 2006546489A JP 2008500274 A5 JP2008500274 A5 JP 2008500274A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- animal
- humanized
- sequence
- animal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 241001465754 Metazoa Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000601A ITRM20030601A1 (it) | 2003-12-24 | 2003-12-24 | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| ITRM2003A000601 | 2003-12-24 | ||
| PCT/IT2004/000722 WO2005061540A2 (en) | 2003-12-24 | 2004-12-23 | Method for the humanization of antibodies and humanized antibodies thereby obtained |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213454A Division JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2008500274A JP2008500274A (ja) | 2008-01-10 |
| JP2008500274A6 JP2008500274A6 (ja) | 2008-05-01 |
| JP2008500274A5 true JP2008500274A5 (OSRAM) | 2009-11-05 |
| JP4652341B2 JP4652341B2 (ja) | 2011-03-16 |
Family
ID=34708536
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546489A Expired - Fee Related JP4652341B2 (ja) | 2003-12-24 | 2004-12-23 | 抗体のヒト化の方法およびそれによって得られるヒト化抗体 |
| JP2009213454A Pending JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
| JP2012015219A Pending JP2012126726A (ja) | 2003-12-24 | 2012-01-27 | ヒト化抗ngf抗体 |
| JP2015001407A Pending JP2015110601A (ja) | 2003-12-24 | 2015-01-07 | ヒト化抗ngf抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009213454A Pending JP2009291211A (ja) | 2003-12-24 | 2009-09-15 | ヒト化抗ngf抗体 |
| JP2012015219A Pending JP2012126726A (ja) | 2003-12-24 | 2012-01-27 | ヒト化抗ngf抗体 |
| JP2015001407A Pending JP2015110601A (ja) | 2003-12-24 | 2015-01-07 | ヒト化抗ngf抗体 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US8296079B2 (OSRAM) |
| EP (4) | EP2138512B8 (OSRAM) |
| JP (4) | JP4652341B2 (OSRAM) |
| CN (2) | CN101724070B (OSRAM) |
| AT (1) | ATE534665T1 (OSRAM) |
| AU (4) | AU2004303633B2 (OSRAM) |
| BR (1) | BRPI0418202A (OSRAM) |
| CA (2) | CA2688944C (OSRAM) |
| CY (2) | CY1112611T1 (OSRAM) |
| DK (3) | DK2218737T3 (OSRAM) |
| ES (2) | ES2559429T3 (OSRAM) |
| HU (1) | HUE027475T2 (OSRAM) |
| IL (2) | IL176495A (OSRAM) |
| IT (1) | ITRM20030601A1 (OSRAM) |
| PL (2) | PL2218737T3 (OSRAM) |
| PT (2) | PT2138512E (OSRAM) |
| SI (2) | SI2138512T1 (OSRAM) |
| WO (1) | WO2005061540A2 (OSRAM) |
| ZA (1) | ZA200605200B (OSRAM) |
Families Citing this family (79)
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| BRPI0607486B8 (pt) | 2005-03-03 | 2021-05-25 | Immunomedics Inc | anticorpo humanizado l243 contra hla-dr presente nas células hladr+,composição farmacêutica, kit e uso dos referidos anticorpos. |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
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| PL1976880T3 (pl) * | 2005-12-21 | 2017-01-31 | Amgen Research (Munich) Gmbh | Kompozycje farmaceutyczne odporne na rozpuszczalny cea |
| BRPI0815370B8 (pt) | 2007-08-10 | 2021-05-25 | Regeneron Pharma | anticorpos humanos de alta afinidade contra o fator de crescimento neural humano e seu uso, molécula de ácido nucleico, vetor de expressão, método para produção de um anticorpo anti-ngf humano e composiçao farmacêutica |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
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| PL2252633T3 (pl) * | 2008-02-04 | 2014-02-28 | Lay Line Genomics Spa | Przeciwciała anty-TrkA i ich pochodne |
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| EP2297208A4 (en) | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| KR20110031369A (ko) | 2008-07-08 | 2011-03-25 | 아보트 러보러터리즈 | 프로스타글란딘 e2 이원 가변 도메인 면역글로불린 및 이의 용도 |
| KR101805754B1 (ko) * | 2008-12-08 | 2017-12-07 | 먼디파머 인터내셔널 코포레이션 리미티드 | 단백질 수용체 티로신 키나아제 억제제의 조성물 |
| RU2011129459A (ru) * | 2008-12-18 | 2013-01-27 | Эрасмус Юниверсити Медикал Сентр Роттердам | Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение |
| US8614295B2 (en) * | 2009-02-17 | 2013-12-24 | Ucb Pharma S.A. | Antibody molecules having specificity for human OX40 |
| AR076650A1 (es) * | 2009-05-04 | 2011-06-29 | Pangenetics 110 B V | Anticuerpos contra el factor de crecimiento nervioso (ngf) con una estabilidad in vivo mejorada |
| EP2429582A4 (en) | 2009-05-13 | 2013-01-23 | Genzyme Corp | IMMUNOGLOBULINS ANTI-CD52 HUMAN |
| TW201119676A (en) * | 2009-10-15 | 2011-06-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| CA2790699A1 (en) | 2010-03-17 | 2011-09-22 | Abbott Research B.V. | Anti-nerve growth factor (ngf) antibody compositions |
| EP2601218A4 (en) | 2010-08-03 | 2015-02-18 | Abbvie Inc | VARIABLE DOUBLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF |
| JP6121903B2 (ja) | 2010-08-19 | 2017-04-26 | ゾエティス・ベルジャム・エス・アー | 抗ngf抗体およびその使用 |
| BR112013004581A2 (pt) | 2010-08-26 | 2017-06-27 | Abbvie Inc | imunoglobulinas de domínio variável dual e seus usos |
| MX359070B (es) | 2010-12-01 | 2018-09-13 | Alderbio Holdings Llc | Composiciones anti-ngf y uso de las mismas. |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| CA2835094C (en) * | 2011-05-06 | 2020-12-22 | David Gearing | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB2528401A (en) * | 2011-05-06 | 2016-01-20 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| GB201114858D0 (en) | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
| KR101783929B1 (ko) * | 2011-05-06 | 2017-10-11 | 넥스베트 오스트레일리아 피티와이 리미티드 | 항신경성 성장 인자 항체 및 그의 제조방법과 이용방법 |
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| JP6629069B2 (ja) | 2012-06-06 | 2020-01-15 | ゾエティス・エルエルシー | イヌ化抗ngf抗体およびその方法 |
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| US12391746B2 (en) | 2018-02-20 | 2025-08-19 | Emory University | HPV proteins, antibodies, and uses in managing abnormal epithelial cell growth |
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| CN111819197B (zh) | 2018-03-12 | 2025-03-11 | 硕腾服务有限责任公司 | 抗ngf抗体及其方法 |
| CN113365697B (zh) * | 2018-09-25 | 2024-07-19 | 百进生物科技公司 | 抗tlr9药剂和组合物及其制备方法和使用方法 |
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2003
- 2003-12-24 IT IT000601A patent/ITRM20030601A1/it unknown
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2004
- 2004-12-23 EP EP09008366A patent/EP2138512B8/en not_active Expired - Lifetime
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