JP2008136493A - アラキドン酸の生成方法 - Google Patents
アラキドン酸の生成方法 Download PDFInfo
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- JP2008136493A JP2008136493A JP2007336075A JP2007336075A JP2008136493A JP 2008136493 A JP2008136493 A JP 2008136493A JP 2007336075 A JP2007336075 A JP 2007336075A JP 2007336075 A JP2007336075 A JP 2007336075A JP 2008136493 A JP2008136493 A JP 2008136493A
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- Prior art keywords
- mortierella
- arachidonic acid
- food
- subgenus
- schumakari
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
【解決手段】好ましくは複合窒素源成分を含有する発酵培地において、モルティエラ シュマッカリ亜属の微生物を培養する。アラキドン酸は幼児の栄養素として重要なエイコサノイドの前駆体であり、食品にモルティエラ シュマッカリ亜属の微生物、又はこれらの微生物から分離される脂質を配合して、アラキドン酸含量を向上させた幼児用調合乳やベビーフードが製造される。
【選択図】なし
Description
例1:
この例はモルティエラ シュマッカリの株の1つであるモルティエラ シュマッカリ亜属のS12株によるアラキドン酸の生成を説明している。
この例では、発酵培地の炭素・窒素比を変動させることがモルティエラ シュマッカリ株S12の細胞の発酵におけるアラキドン酸生成に与える影響を説明している。
この例では、栄養素を操作することにより、モルティエラ シュマッカリ株S12及びモルティエラ カマルジェンシス株S3によるアラキドン酸生成に与える影響を示す。
この例では、複合窒素源であるコーンスティープリカーが存在する状態にて生育された細胞と、コーンスティープリカーが存在しない状態にて生育された細胞との場合において、モルティエラ カマルジェンシス株S3によるアラキドン酸生成を比較している。
この例では、モルティエラ カマルジェンシス株S3及びモルティエラ シュマッカリ株S12のアラキドン酸含量につき、モルティエラのシュマッカリ亜属の周知のATCC株と比較している。3株、即ちモルティエラ カマルジェンシス株S3、モルティエラ シュマッカリ株S12及びモルティエラ シュマッカリ(ATCC 42658番)を、例4において説明したように、コーンスティープリカーが存在する状態にて、又はコーンスティープリカーが存在しない状態にて培養した。S3株及び周知の2株の細胞の脂肪酸含量を、例1において説明した方法に基づいて測定した。総脂肪酸の収率とアラキドン酸の収率との比較を表6に示す。
この例では、発酵生産性及びモルティエラ シュマッカリ株S12から得られるオイルの脂質含量の分析について説明している。
Claims (26)
- 同化性有機炭素源及び同化性窒素源を備えた培地において、モルティエラ属シュマッカリ亜属(genus Mortierella sect. schmuckeri)の微生物を培養してアラキドン酸を生成する方法。
- 前記モルティエラ シュマッカリ亜属は1日当たり少なくとも約0.70g/Lのアラキドン酸を生成可能である請求項1に記載の方法。
- 前記モルティエラ シュマッカリ亜属は1日当たり少なくとも約0.80g/Lのアラキドン酸を生成可能である請求項1に記載の方法。
- 前記モルティエラ シュマッカリ亜属は1日当たり少なくとも約0.86g/Lのアラキドン酸を生成可能である請求項1に記載の方法。
- 前記方法はモルティエラ シュマッカリ亜属のモルティエラ シュマッカリ種を培養する請求項1に記載の方法。
- 前記方法はモルティエラ シュマッカリ亜属のモルティエラ カマルジェンシス(camargensis)種を培養する請求項1に記載の方法。
- 前記モルティエラ シュマッカリ亜属は液体培養条件下にて生育される時に、分散繊維状形態として生育可能である請求項1に記載の方法。
- 前記培地は複合窒素源を備える請求項1に記載の方法。
- 前記複合窒素源は複合窒素源が存在しない状態にて生育されるモルティエラ シュマッカリ亜属と比較し、オイル中の細胞乾燥重量%及び総脂肪酸%のいずれかにより測定し、モルティエラ シュマッカリ亜属によるアラキドン酸生成を少なくとも約50%増大させる請求項8に記載の方法。
- 前記複合窒素源は複合窒素源が存在しない状態にて生育されるモルティエラ シュマッカリ亜属と比較し、オイル中の細胞乾燥重量%及び総脂肪酸%のいずれかにより測定し、モルティエラ シュマッカリ亜属によるアラキドン酸生成を少なくとも約100%増大させる請求項8に記載の方法。
- 前記微生物における脂質生成を十分に刺激するように非炭素栄養素を制限する請求項1に記載の方法。
- 前記非炭素栄養素は窒素を備える請求項11に記載の方法。
- 前記方法は更にアラキドン酸を備える脂質をモルティエラ シュマッカリ亜属から回収する請求項1に記載の方法。
- モルティエラ シュマッカリ亜属の微生物と食材とを含む食品。
- 前記食材は動物食を含む請求項14に記載の食品。
- モルティエラ属シュマッカリ亜属の微生物と食材とから回収される脂質を含む食品。
- 前記モルティエラ シュマッカリ亜属は1日当たり少なくとも約0.70g/Lのアラキドン酸を生成可能である請求項16に記載の食品。
- 前記モルティエラ シュマッカリ亜属はモルティエラ シュマッカリ種である請求項16に記載の食品。
- 前記モルティエラ シュマッカリ亜属はモルティエラ カマルジェンシス種である請求項16に記載の食品。
- 前記食品は総脂肪酸の約20重量%までがアラキドン酸である総脂肪酸含量を有する請求項16に記載の食品。
- 前記食品は総脂肪酸の約10重量%までがアラキドン酸である総脂肪酸含量を有する請求項16に記載の食品。
- 前記食品は総脂肪酸の約0.1〜約1.0重量%がアラキドン酸である総脂肪酸含量を有する請求項16に記載の食品。
- 前記食材は幼児用食材を含む請求項16に記載の食品。
- 前記食材は幼児用調合乳及びベビーフードからなる群から選択される請求項16に記載の食品。
- モルティエラ属シュマッカリ亜属の微生物から回収される脂質を備える治療剤。
- 前記治療剤はカプセル、非経口製剤及び液状食製剤からなる群から選択される媒体により搬送される請求項25に記載の治療剤。
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US08/377,766 US5583019A (en) | 1995-01-24 | 1995-01-24 | Method for production of arachidonic acid |
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JP2006200185A Division JP2006345866A (ja) | 1995-01-24 | 2006-07-24 | アラキドン酸の生成方法 |
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JP2006200185A Withdrawn JP2006345866A (ja) | 1995-01-24 | 2006-07-24 | アラキドン酸の生成方法 |
JP2007336075A Withdrawn JP2008136493A (ja) | 1995-01-24 | 2007-12-27 | アラキドン酸の生成方法 |
JP2009259658A Pending JP2010042024A (ja) | 1995-01-24 | 2009-11-13 | アラキドン酸の生成方法 |
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JP2006200185A Withdrawn JP2006345866A (ja) | 1995-01-24 | 2006-07-24 | アラキドン酸の生成方法 |
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AU (1) | AU711967B2 (ja) |
CA (1) | CA2163278C (ja) |
DE (1) | DE69621663T2 (ja) |
HK (1) | HK1045628A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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US5583019A (en) | 1995-01-24 | 1996-12-10 | Omegatech Inc. | Method for production of arachidonic acid |
MY121221A (en) * | 1995-05-30 | 2006-01-28 | Suntory Holdings Ltd | Domestic fowl eggs having a high content of highly unsaturated fatty acid, their production process and their use |
US6428832B2 (en) * | 1996-03-26 | 2002-08-06 | Dsm N.V. | Late addition of PUFA in infant formula preparation process |
JP3792309B2 (ja) * | 1996-08-30 | 2006-07-05 | サントリー株式会社 | 不飽和脂肪酸含有油脂の製造方法 |
JP4633204B2 (ja) * | 1996-10-11 | 2011-02-16 | サントリーホールディングス株式会社 | アラキドン酸含有食用油脂およびそれを含有する食品 |
US6746857B2 (en) | 1996-12-27 | 2004-06-08 | Suntory Limited | Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same |
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1995
- 1995-01-24 US US08/377,766 patent/US5583019A/en not_active Expired - Lifetime
- 1995-11-20 AU AU37991/95A patent/AU711967B2/en not_active Ceased
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- 1995-12-01 JP JP7314330A patent/JPH08214893A/ja active Pending
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- 1996-01-16 EP EP06008737A patent/EP1726217A1/en not_active Withdrawn
- 1996-01-16 DE DE69621663T patent/DE69621663T2/de not_active Expired - Lifetime
- 1996-01-16 EP EP96200072A patent/EP0726321B1/en not_active Expired - Lifetime
- 1996-01-16 AT AT96200072T patent/ATE219144T1/de not_active IP Right Cessation
- 1996-12-10 US US08/763,973 patent/US5882703A/en not_active Expired - Lifetime
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- 1999-03-15 US US09/270,294 patent/US6245365B1/en not_active Expired - Lifetime
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2000
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2001
- 2001-02-19 US US09/789,057 patent/US6541049B2/en not_active Expired - Fee Related
- 2001-10-05 US US09/972,550 patent/US6749849B2/en not_active Expired - Fee Related
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2002
- 2002-09-20 HK HK02106865.7A patent/HK1045628A1/zh unknown
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2004
- 2004-03-04 US US10/802,392 patent/US7195791B2/en not_active Expired - Fee Related
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EP0726321B1 (en) | 2002-06-12 |
DE69621663T2 (de) | 2003-02-13 |
US20010016218A1 (en) | 2001-08-23 |
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US20080044389A1 (en) | 2008-02-21 |
ATE219144T1 (de) | 2002-06-15 |
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CA2163278C (en) | 2011-01-25 |
US20020037561A1 (en) | 2002-03-28 |
DE69621663D1 (de) | 2002-07-18 |
JPH08214893A (ja) | 1996-08-27 |
US20080044388A1 (en) | 2008-02-21 |
US7195791B2 (en) | 2007-03-27 |
US7736885B2 (en) | 2010-06-15 |
US6749849B2 (en) | 2004-06-15 |
US7601523B2 (en) | 2009-10-13 |
US6245365B1 (en) | 2001-06-12 |
US5583019A (en) | 1996-12-10 |
HK1045628A1 (zh) | 2002-12-06 |
US7666657B2 (en) | 2010-02-23 |
US6541049B2 (en) | 2003-04-01 |
CA2163278A1 (en) | 1996-07-25 |
JP2010042024A (ja) | 2010-02-25 |
AU3799195A (en) | 1996-08-01 |
US6319698B1 (en) | 2001-11-20 |
EP1726217A1 (en) | 2006-11-29 |
AU711967B2 (en) | 1999-10-28 |
US20070026050A1 (en) | 2007-02-01 |
EP0726321A3 (en) | 1997-08-06 |
US20040248266A1 (en) | 2004-12-09 |
EP1188383A1 (en) | 2002-03-20 |
US5882703A (en) | 1999-03-16 |
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