DE69621663D1 - Verfahren zur Herstellung von Arachidonsäure - Google Patents

Verfahren zur Herstellung von Arachidonsäure

Info

Publication number
DE69621663D1
DE69621663D1 DE69621663T DE69621663T DE69621663D1 DE 69621663 D1 DE69621663 D1 DE 69621663D1 DE 69621663 T DE69621663 T DE 69621663T DE 69621663 T DE69621663 T DE 69621663T DE 69621663 D1 DE69621663 D1 DE 69621663D1
Authority
DE
Germany
Prior art keywords
arachidonic acid
micro organisms
preparation
schmuckeri
food product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621663T
Other languages
English (en)
Other versions
DE69621663T2 (de
Inventor
William R Barclay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martek Biosciences Corp
Original Assignee
OmegaTech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23490445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69621663(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by OmegaTech Inc filed Critical OmegaTech Inc
Publication of DE69621663D1 publication Critical patent/DE69621663D1/de
Application granted granted Critical
Publication of DE69621663T2 publication Critical patent/DE69621663T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/065—Microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/68—Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/946—Microorganisms using algae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pediatric Medicine (AREA)
  • Physiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
DE69621663T 1995-01-24 1996-01-16 Verfahren zur Herstellung von Arachidonsäure Expired - Lifetime DE69621663T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/377,766 US5583019A (en) 1995-01-24 1995-01-24 Method for production of arachidonic acid

Publications (2)

Publication Number Publication Date
DE69621663D1 true DE69621663D1 (de) 2002-07-18
DE69621663T2 DE69621663T2 (de) 2003-02-13

Family

ID=23490445

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621663T Expired - Lifetime DE69621663T2 (de) 1995-01-24 1996-01-16 Verfahren zur Herstellung von Arachidonsäure

Country Status (8)

Country Link
US (10) US5583019A (de)
EP (3) EP0726321B1 (de)
JP (4) JPH08214893A (de)
AT (1) ATE219144T1 (de)
AU (1) AU711967B2 (de)
CA (1) CA2163278C (de)
DE (1) DE69621663T2 (de)
HK (1) HK1045628A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
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KR100277808B1 (ko) * 1995-05-30 2001-01-15 다카후미 이시하라 가금난으로부터 수득된 고도 불포화 지방산 함량이 높은 지질 및 이의 제조방법
US6428832B2 (en) * 1996-03-26 2002-08-06 Dsm N.V. Late addition of PUFA in infant formula preparation process
JP3792309B2 (ja) * 1996-08-30 2006-07-05 サントリー株式会社 不飽和脂肪酸含有油脂の製造方法
JP4633204B2 (ja) * 1996-10-11 2011-02-16 サントリーホールディングス株式会社 アラキドン酸含有食用油脂およびそれを含有する食品
EP0960943B1 (de) 1996-12-27 2014-02-12 Suntory Holdings Limited Kulturmedien für mikroorganismen und verfahren zur herstellung ungesättigter fettsäuren oder diese enthaltende lipide
PT970236E (pt) * 1997-02-20 2006-08-31 Dsm Ip Assets Bv Producao fermentativa de compostos valiosos a escala industrial utilizando meios quimicamente definidos
ATE408701T1 (de) * 1997-03-04 2008-10-15 Suntory Ltd Verfahren zur herstellung von hochungesättigten fettsäuren und hochungesättigte fettsäuren enthaltendes lipid
PT893064E (pt) * 1997-07-22 2003-04-30 Nestle Sa Composicao lipidica para formulacao infantil e processo de preparacao
KR20010052854A (ko) * 1998-06-17 2001-06-25 윌리암 로엘프 드 보에르 해사료용 미생물유래 아라키돈산(ａｒａ)
JP2000069987A (ja) * 1998-08-28 2000-03-07 Suntory Ltd アラキドン酸含有脂質並びにジホモ−γ−リノレン酸含有脂質の製造方法
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RU2165218C1 (ru) * 1999-09-01 2001-04-20 Кубанский государственный технологический университет Способ производства основы из цитрусовых плодов для замутненных напитков
RU2165216C1 (ru) * 1999-09-01 2001-04-20 Кубанский государственный технологический университет Способ производства основы из цитрусовых плодов для замутненных напитков
RU2165214C1 (ru) * 1999-09-01 2001-04-20 Кубанский государственный технологический университет Способ производства основы из цитрусовых плодов для замутненных напитков
RU2165213C1 (ru) * 1999-09-01 2001-04-20 Кубанский государственный технологический университет Способ производства основы из цитрусовых плодов для замутненных напитков
RU2165209C1 (ru) * 1999-09-01 2001-04-20 Кубанский государственный технологический университет Способ производства основы из цитрусовых плодов для замутненных напитков
KR101591834B1 (ko) * 2000-01-19 2016-02-18 마텍 바이오싸이언스스 코포레이션 무용매 추출 방법
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EP1178118A1 (de) * 2000-08-02 2002-02-06 Dsm N.V. Isolation von mikrobiellen Ölen
CA2424570A1 (en) * 2000-09-07 2002-03-14 University Of Maryland Biotechnology Institute Use of arachidonic acid for enhanced culturing of fish larvae and broodstock
PT1239022E (pt) * 2001-03-09 2009-06-05 Nestle Sa Óleo contendo um ou mais ácido(s) gordo(s) polinsaturado(s) de cadeia longa provenientes de biomassa, processo de preparação, alimento, composição nutricional, cosmética ou farmacêutica contendo o mesmo
EP1392623A4 (de) * 2001-05-14 2005-05-04 Martek Biosciences Corp Herstellung und verwendung einer an polaren lipiden reichen fraktion, die hoch ungesättigte omega-3- und/oder omega-6-fettsäuren aus mikroben, samen genetisch modifizierter pflanzen und marinen organismen enthält
EP1392278A4 (de) * 2001-05-14 2005-05-04 Martek Biosciences Corp Herstellung und verwendung einer polaren lipidreichen fraktion mit stearidonsäure und gamma-linolensäure aus pflanzensamen und mikroben
EP1277412A1 (de) * 2001-07-17 2003-01-22 Societe Des Produits Nestle S.A. Haustierfutterzusammensetzung zur Regulierung des Körpergewichts und zur Verhinderung der Fettleibigkeit und ähnlicher Störungen bei Haustieren
JP2003048831A (ja) * 2001-08-02 2003-02-21 Suntory Ltd 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物
RU2209000C1 (ru) * 2002-04-03 2003-07-27 Краснодарский научно-исследовательский институт хранения и переработки сельскохозяйственной продукции Способ производства основы из цитрусовых плодов для замутнённых напитков
RU2209001C1 (ru) * 2002-04-03 2003-07-27 Краснодарский научно-исследовательский институт хранения и переработки сельскохозяйственной продукции Способ производства основы из цитрусовых плодов для замутнённых напитков
JP4088097B2 (ja) * 2002-04-26 2008-05-21 サントリー株式会社 高度不飽和脂肪酸含有脂質の製造方法
US9101151B2 (en) * 2002-05-03 2015-08-11 Dsm Ip Assets B.V. High-quality lipids produced by enzymatic liberation from biomass
RU2217965C1 (ru) * 2002-06-07 2003-12-10 Научно-исследовательский институт пищеконцентратной промышленности и специальной пищевой технологии (Государственное научное учреждение) Способ производства консервов с использованием сушёного растительного сырья
RU2218784C1 (ru) * 2002-06-07 2003-12-20 Кубанский государственный технологический университет Способ производства стерилизуемых консервов
RU2217964C1 (ru) * 2002-06-07 2003-12-10 Научно-исследовательский институт пищеконцентратной промышленности и специальной пищевой технологии (Государственное научное учреждение) Способ производства консервов с использованием сушёного растительного сырья
RU2217961C1 (ru) * 2002-06-07 2003-12-10 Научно-исследовательский институт пищеконцентратной промышленности и специальной пищевой технологии (Государственное научное учреждение) Способ производства стерилизуемых консервов
US20060165735A1 (en) 2002-06-18 2006-07-27 Abril Jesus R Stable emulsions of oils in aqueous solutions and methods for producing same
AU2003281542A1 (en) * 2002-06-19 2004-02-09 Dsm Ip Assets B.V. Preparation of microbial oil containing polyunsaturated fatty acids
KR101195574B1 (ko) * 2002-09-24 2012-10-30 산토리 홀딩스 가부시키가이샤 아라키돈산을 단독으로 또는 도코사헥사엔산과의 조합으로함유하는 인지 능력 향상용 조성물
JP4522075B2 (ja) * 2003-10-29 2010-08-11 サントリーホールディングス株式会社 血管の老化に起因する症状あるいは疾患の予防又は改善作用を有する組成物
CA2542574C (en) * 2003-11-12 2014-03-18 E. I. Du Pont De Nemours And Company Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast
EP1731616A4 (de) * 2004-03-01 2011-08-17 Suntory Holdings Ltd Verfahren zur herstellung von phospholipid mit langkettiger mehrfach ungesättigter fettsäure als dessen bestandteil sowie verwendung davon
JP2006061021A (ja) * 2004-08-24 2006-03-09 Suntory Ltd １種類の高度不飽和脂肪酸残基３個から成るトリグリセライドの製造方法、およびその利用
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JP4993852B2 (ja) 2004-09-17 2012-08-08 サントリーホールディングス株式会社 ストレスに起因する行動異常を伴う症状あるいは疾患の予防又は改善作用を有する組成物
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JP5967855B2 (ja) * 2005-06-30 2016-08-10 サントリーホールディングス株式会社 日中活動量の低下および／又はうつ症状の改善作用を有する組成物
JP5697293B2 (ja) * 2005-06-30 2015-04-08 サントリーホールディングス株式会社 器質的脳障害に起因する高次脳機能の低下に対する改善作用を有する組成物
BRPI0613295A2 (pt) 2005-07-01 2010-12-28 Martek Biosciences Corp produto oleoso contendo ácido graxo poliinsaturado e usos e produção do mesmo
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BRPI0714390B1 (pt) * 2006-07-19 2018-05-15 Monsanto Technology Llc Polinucleotídeo, construção de dna, célula hospedeira fúngica ou bacteriana, processo para produção de alimento ou de produto alimentício e composição para alimento ou produto alimentício
US9023616B2 (en) 2006-08-01 2015-05-05 Dsm Nutritional Products Ag Oil producing microbes and method of modification thereof
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EP1726217A1 (de) 2006-11-29
US7195791B2 (en) 2007-03-27
CA2163278A1 (en) 1996-07-25
US6245365B1 (en) 2001-06-12
US5583019A (en) 1996-12-10
EP0726321A3 (de) 1997-08-06
US7736885B2 (en) 2010-06-15
US7666657B2 (en) 2010-02-23
US6319698B1 (en) 2001-11-20
JPH08214893A (ja) 1996-08-27
US7601523B2 (en) 2009-10-13
EP0726321B1 (de) 2002-06-12
US20070026050A1 (en) 2007-02-01
JP2006345866A (ja) 2006-12-28
US20080044388A1 (en) 2008-02-21
CA2163278C (en) 2011-01-25
HK1045628A1 (en) 2002-12-06
US20010016218A1 (en) 2001-08-23
EP0726321A2 (de) 1996-08-14
EP1188383A1 (de) 2002-03-20
US5882703A (en) 1999-03-16
US6541049B2 (en) 2003-04-01
AU3799195A (en) 1996-08-01
US20080044389A1 (en) 2008-02-21
US20040248266A1 (en) 2004-12-09
US6749849B2 (en) 2004-06-15
US20020037561A1 (en) 2002-03-28
ATE219144T1 (de) 2002-06-15
AU711967B2 (en) 1999-10-28
JP2008136493A (ja) 2008-06-19
JP2010042024A (ja) 2010-02-25
DE69621663T2 (de) 2003-02-13

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