JP2007536932A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007536932A5 JP2007536932A5 JP2007513268A JP2007513268A JP2007536932A5 JP 2007536932 A5 JP2007536932 A5 JP 2007536932A5 JP 2007513268 A JP2007513268 A JP 2007513268A JP 2007513268 A JP2007513268 A JP 2007513268A JP 2007536932 A5 JP2007536932 A5 JP 2007536932A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- humanized antibody
- amino acid
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Claims (28)
- 天然ヒトFcγRIIAの細胞外ドメインと結合するよりも高い親和性で天然ヒトFcγRIIBの細胞外ドメインと特異的に結合するモノクローナル抗体由来のCDRを含むアミノ酸配列を有するヒト化抗体。
- 前記抗体がモノクローナル抗体2B6または3H7由来のCDRを含む、請求項１に記載のヒト化抗体。
- 前記抗体がモノクローナル抗体1D5、2E1、2H9、2D11、または1F2由来のCDRを含む、請求項１に記載のヒト化抗体。
- 前記抗体が重鎖領域と軽鎖領域を有するヒト化可変領域を含み、該重鎖領域が配列番号24または配列番号37のアミノ酸配列を有し、該軽鎖領域が配列番号18、配列番号20、配列番号22、または配列番号46のアミノ酸配列を有する、請求項１に記載のヒト化抗体。
- 前記抗体が、配列番号1または配列番号29のアミノ酸配列を有するVH CDR1、配列番号2または配列番号30のアミノ酸配列を有するVH CDR2、および配列番号3または配列番号31のアミノ酸配列を有するVH CDR3を含む、請求項１に記載のヒト化抗体。
- 前記抗体が、配列番号8または配列番号38のアミノ酸配列を有するVL CDR1、配列番号9、配列番号10、配列番号11または配列番号39のアミノ酸配列を有するVL CDR2、および配列番号12または配列番号40のアミノ酸配列を有するVL CDR3を含む、請求項１に記載のヒト化抗体。
- 変異型CDR領域を含み、変異型CDR領域がVL CDR2中に少なくとも1つのアミノ酸改変を含む、請求項１に記載のヒト化抗体。
- 少なくとも1つのアミノ酸改変がチロシンによる50位での置換を含む、請求項７に記載のヒト化抗体。
- 少なくとも1つのアミノ酸改変がアラニンによる51位での置換を含む、請求項７に記載のヒト化抗体。
- 前記抗体がフレームワーク領域中にはアミノ酸改変を含まない、請求項１〜９のいずれか１項に記載のヒト化抗体。
- F(ab')2フラグメントまたはF(ab)フラグメントである、請求項１に記載のヒト化抗体のフラグメント。
- 前記抗体が一本鎖抗体である、請求項１に記載のヒト化抗体。
- 前記抗体が異種ポリペプチドと機能的に連結されている、請求項１に記載のヒト化抗体。
- 前記抗体が治療薬または細胞毒素にコンジュゲートされている、請求項１に記載のヒト化抗体。
- Ig-FcのFcγRIIBへの結合をブロックする、請求項１に記載のヒト化抗体。
- 前記抗体がリツキシン（Rituxin）よりも効果的に腫瘍増殖を軽減する、請求項１に記載のヒト化抗体。
- 請求項１に記載のヒト化抗体またはそのフラグメントの重鎖もしくは軽鎖をコードするヌクレオチド配列を含んでなる、単離された核酸。
- 異種プロモーターと機能的に連結された第1の核酸、および同一のまたは異なる異種プロモーターと機能的に連結された第2の核酸を含有する宿主細胞であって、第1の核酸と第2の核酸が請求項１に記載のヒト化抗体のそれぞれ重鎖および軽鎖をコードしている、上記宿主細胞。
- 癌抗原を特徴とする癌にかかった患者において癌を治療するための医薬の製造における、請求項１〜９のいずれか１項に記載のヒト化抗体、および該癌抗原と特異的に結合しかつ細胞傷害性である第２抗体の使用。
- 前記癌が乳癌、卵巣癌、前立腺癌、子宮頸癌、または膵臓癌である、請求項19に記載の使用。
- (i) 治療に有効な量の請求項１〜９のいずれか１項に記載のヒト化抗体、(ii) 癌抗原と特異的に結合する細胞傷害性抗体、および(iii) 製薬上許容される担体、を含有する医薬組成物。
- 患者の自己免疫疾患を治療するための医薬の製造における、請求項１〜９のいずれか１項に記載のヒト化抗体の使用。
- 患者のIgE依存性アレルギー疾患を治療または予防するための医薬の製造における、請求項１〜９のいずれか１項に記載のヒト化抗体の使用。
- IgE依存性アレルギー疾患が喘息、アレルギー性鼻炎、胃腸のアレルギー、好酸球増加症、結膜炎、または糸球体腎炎である、請求項23に記載の使用。
- 細胞傷害性抗体で治療される被験者において抗体依存性細胞傷害作用を増強するための医薬の製造における、請求項１〜９のいずれか１項に記載のヒト化抗体の使用。
- 被験者の自己免疫疾患を判定するための検査方法であって、
(a) 被験者から得られた生物学的サンプルを、有効量の請求項１〜９のいずれか１項に記載のヒト化抗体と接触させること、
(b) 該抗体の結合を検出すること、
を含んでなり、その際、該検出可能なマーカーがバックグラウンドまたは標準レベルを上回って検出されれば、該被験者が自己免疫疾患にかかっていることを示す、上記方法。 - 被験者においてワクチン組成物に対する免疫応答を高めるための医薬の製造における、請求項１〜９のいずれか１項に記載のヒト化抗体の使用。
- 癌抗原を特徴とする癌にかかった患者において癌を治療するための医薬の製造における、請求項１〜９のいずれか１項に記載のヒト化抗体の使用であって、該医薬はFcγRIIBを発現する癌細胞の集団を減少させるものである、上記使用。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56988204P | 2004-05-10 | 2004-05-10 | |
| US58204304P | 2004-06-21 | 2004-06-21 | |
| PCT/US2005/016260 WO2005110474A2 (en) | 2004-05-10 | 2005-05-10 | HUMANIZED FcϜRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007536932A JP2007536932A (ja) | 2007-12-20 |
| JP2007536932A5 true JP2007536932A5 (ja) | 2008-06-19 |
Family
ID=35394679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513268A Pending JP2007536932A (ja) | 2004-05-10 | 2005-05-10 | ヒト化ＦｃγＲＩＩＢ特異的抗体とその利用法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7521542B2 (ja) |
| EP (1) | EP1761563A4 (ja) |
| JP (1) | JP2007536932A (ja) |
| KR (1) | KR101297146B1 (ja) |
| AU (1) | AU2005244058B2 (ja) |
| CA (1) | CA2565874C (ja) |
| IL (1) | IL179102A (ja) |
| MX (1) | MXPA06012601A (ja) |
| WO (1) | WO2005110474A2 (ja) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8968730B2 (en) * | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US20050260213A1 (en) * | 2004-04-16 | 2005-11-24 | Scott Koenig | Fcgamma-RIIB-specific antibodies and methods of use thereof |
| US8187593B2 (en) * | 2002-08-14 | 2012-05-29 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8530627B2 (en) * | 2002-08-14 | 2013-09-10 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8946387B2 (en) * | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8193318B2 (en) * | 2002-08-14 | 2012-06-05 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8044180B2 (en) * | 2002-08-14 | 2011-10-25 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
| US7763256B2 (en) | 2002-12-23 | 2010-07-27 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes and for detecting fibrocyte differentiation |
| WO2007094776A1 (en) * | 2006-02-15 | 2007-08-23 | William Marsh Rice University | Compositions and methods for suppressing fibrocyte differentiation |
| WO2004059318A2 (en) | 2002-12-23 | 2004-07-15 | William Marsh Rice University | Methods of detecting the inhibition of fibrocyte formation and methods and compositions for enhancing fibrocyte formation |
| US8012472B2 (en) | 2002-12-23 | 2011-09-06 | William Marsh Rice University | Compositions and methods for suppressing fibrocytes |
| EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| WO2005110474A2 (en) | 2004-05-10 | 2005-11-24 | Macrogenics, Inc. | HUMANIZED FcϜRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
| US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| US7655229B2 (en) | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| EP1786836A2 (en) * | 2004-09-02 | 2007-05-23 | Genentech, Inc. | Anti-fc-gamma riib receptor antibody and uses therefor |
| WO2006047357A2 (en) * | 2004-10-22 | 2006-05-04 | Biogen Idec Ma Inc. | Human ly6-big molecules and methods of use |
| WO2007024249A2 (en) | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
| US8367805B2 (en) * | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US20070135620A1 (en) * | 2004-11-12 | 2007-06-14 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP2845865A1 (en) | 2004-11-12 | 2015-03-11 | Xencor Inc. | Fc variants with altered binding to FcRn |
| US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| WO2006066078A2 (en) * | 2004-12-15 | 2006-06-22 | Magrogenics, Inc. | Fcϝriib-specific antibodies and methods of use thereof |
| EP1835935A4 (en) * | 2004-12-30 | 2009-06-17 | Univ Rockefeller | COMPOSITIONS AND METHODS FOR IMPROVED DENDRITIC CELL REPRODUCTION AND FUNCTION |
| US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US9963510B2 (en) * | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| US9284375B2 (en) * | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| ES2707152T3 (es) * | 2005-04-15 | 2019-04-02 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos |
| US8217147B2 (en) | 2005-08-10 | 2012-07-10 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| CA2644903A1 (en) * | 2006-03-10 | 2007-09-20 | Macrogenics, Inc. | Identification and engineering of antibodies with variant heavy chains and methods of using same |
| EP2021029B1 (en) * | 2006-05-26 | 2014-06-11 | MacroGenics, Inc. | Humanized fc gamma riib-specific antibodies and methods of use thereof |
| WO2008002933A2 (en) * | 2006-06-26 | 2008-01-03 | Macrogenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
| JP5764290B2 (ja) * | 2006-06-26 | 2015-08-19 | マクロジェニクス，インコーポレーテッド | ＦｃγＲＩＩＢ特異的抗体およびその使用法 |
| US20080112961A1 (en) * | 2006-10-09 | 2008-05-15 | Macrogenics, Inc. | Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same |
| EP2094289B1 (en) | 2006-12-04 | 2013-03-13 | Promedior, Inc. | Combination of sap and enalapril for use in the treatment of fibrotic or fibroproliferative disorders |
| WO2008140603A2 (en) | 2006-12-08 | 2008-11-20 | Macrogenics, Inc. | METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING |
| AR060424A1 (es) * | 2007-04-11 | 2008-06-18 | Consejo Nac Invest Cient Tec | Lineas celulares , composiciones para el tratamiento de melanomas que las comprenden procedimientos para preparar las composiciones y metodos de tratamiento |
| US9884899B2 (en) | 2007-07-06 | 2018-02-06 | Promedior, Inc. | Methods for treating fibrosis using CRP antagonists |
| US8497243B2 (en) | 2007-07-06 | 2013-07-30 | Promedior, Inc. | Methods and compositions useful in the treatment of mucositis |
| AU2008287426B2 (en) * | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US8795667B2 (en) | 2007-12-19 | 2014-08-05 | Macrogenics, Inc. | Compositions for the prevention and treatment of smallpox |
| EP3825329A1 (en) | 2007-12-26 | 2021-05-26 | Xencor, Inc. | Fc variants with altered binding to fcrn |
| MX2010010737A (es) | 2008-04-02 | 2010-12-20 | Macrogenics Inc | Anticuerpos especificos para her2/neu y metodos para utilizar los mismos. |
| CN102046655B (zh) | 2008-04-02 | 2016-09-14 | 宏观基因有限公司 | Bcr-复合体-特异性抗体和其使用方法 |
| EP2282770B1 (en) * | 2008-06-04 | 2018-03-07 | MacroGenics, Inc. | Antibodies with altered binding to fcrn and methods of using same |
| WO2010096394A2 (en) * | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| PT2405928T (pt) | 2009-03-11 | 2017-02-07 | Promedior Inc | Métodos de tratamento e de diagnóstico para patologias de hipersensibilidade |
| JP5980508B2 (ja) | 2009-03-11 | 2016-08-31 | プロメディオール， インコーポレイテッド | 自己免疫障害に対する処置方法 |
| UA110323C2 (en) | 2009-06-04 | 2015-12-25 | Promedior Inc | Derivative of serum amyloid p and their receipt and application |
| PL2987803T3 (pl) | 2009-06-17 | 2019-04-30 | Promedior Inc | Warianty SAP i ich zastosowanie |
| US9493578B2 (en) * | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| TR201804897T4 (tr) | 2009-10-07 | 2018-06-21 | Macrogenics Inc | Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler |
| US8198035B2 (en) | 2009-11-25 | 2012-06-12 | Siemens Healthcare Diagnostics Inc. | Galactose-α-1,3-galactose-macromolecule conjugates and methods employing same |
| GEP201706660B (en) | 2010-03-04 | 2017-04-25 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| US8802091B2 (en) | 2010-03-04 | 2014-08-12 | Macrogenics, Inc. | Antibodies reactive with B7-H3 and uses thereof |
| KR20130048242A (ko) | 2010-07-22 | 2013-05-09 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 항-종양 항원 항체 및 이용 방법 |
| AU2011286024B2 (en) | 2010-08-02 | 2014-08-07 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| GB201013989D0 (en) * | 2010-08-20 | 2010-10-06 | Univ Southampton | Biological materials and methods of using the same |
| KR20140019284A (ko) | 2010-09-03 | 2014-02-14 | 아카데미아 시니카 | 항-C-Met 항체 및 이의 이용 방법들 |
| JP6162606B2 (ja) | 2011-01-14 | 2017-07-12 | レッドウッド バイオサイエンス， インコーポレイテッド | アルデヒド−タグ付き免疫グロブリンポリペプチド及びその使用方法 |
| WO2012142286A1 (en) * | 2011-04-12 | 2012-10-18 | University Of Cincinnati | Methods for suppressing allergic reactions |
| CN104080804B (zh) | 2011-05-21 | 2017-06-09 | 宏观基因有限公司 | 去免疫化的血清结合结构域及其延长血清半衰期的用途 |
| BR122016016837A2 (pt) | 2011-05-21 | 2019-08-27 | Macrogenics Inc | moléculas de ligação a cd3; anticorpos de ligação a cd3; composições farmacêuticas; e usos da molécula de ligação a cd3 |
| EP3741773A1 (en) | 2011-10-10 | 2020-11-25 | City of Hope | Meditopes and meditope-binding antibodies and uses thereof |
| JP6405242B2 (ja) | 2012-02-07 | 2018-10-17 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | Ｍｉｃａ結合剤 |
| ES2637151T3 (es) | 2013-02-14 | 2017-10-11 | Innate Pharma | Tratamiento del linfoma de células T periféricas |
| DK3521312T3 (da) | 2013-02-20 | 2021-06-28 | Innate Pharma | Forbindelse, der binder specifikt til kir3dl2, til anvendelse til behandling af perifert t-cellelymfom |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| CA2906417C (en) | 2013-03-14 | 2022-06-21 | Robert Ziemann | Hcv core lipid binding domain monoclonal antibodies |
| EP2968526A4 (en) | 2013-03-14 | 2016-11-09 | Abbott Lab | ANTIGEN-ANTIBODY COMBINATION ASSAY OF HEPATITIS C VIRUS AND METHODS AND COMPOSITIONS FOR USE THEREWITH |
| WO2014143342A1 (en) | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection |
| PL2968520T3 (pl) | 2013-03-14 | 2022-01-03 | Macrogenics, Inc. | Dwuspecyficzne cząsteczki, które są immunoreaktywne wobec immunologicznych komórek efektorowych wykazujących ekspresję receptora aktywującego |
| US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
| UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
| EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| US10100115B2 (en) | 2014-02-14 | 2018-10-16 | Macrogenics, Inc. | Methods for the treatment of vascularizing cancers |
| PL3116908T3 (pl) | 2014-03-14 | 2020-01-31 | Innate Pharma | Humanizowane przeciwciała kir3dl2 |
| AU2015279316B2 (en) | 2014-06-27 | 2021-03-04 | Innate Pharma | Multispecific NKp46 binding proteins |
| WO2015197598A2 (en) | 2014-06-27 | 2015-12-30 | Innate Pharma | Multispecific antigen binding proteins |
| CA2955984A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| EP2985295A1 (en) * | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Antibodies specific for MMP9 |
| WO2016030488A1 (en) | 2014-08-27 | 2016-03-03 | Innate Pharma | Treatment of celiac disease |
| CA2963991A1 (en) | 2014-09-29 | 2016-04-07 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| KR20170063881A (ko) | 2014-10-02 | 2017-06-08 | 시티 오브 호프 | 다가 메디토프, 메디토프 결합 항체 및 이의 용도 |
| EP3659625A1 (en) | 2014-10-23 | 2020-06-03 | Innate Pharma | Treatment of cancers using anti-nkg2a agents |
| JP6971153B2 (ja) | 2015-06-23 | 2021-11-24 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | 多重特異的ｎｋエンゲイジャータンパク質 |
| CA2990511A1 (en) | 2015-06-23 | 2016-12-29 | Innate Pharma | Multispecific antigen binding proteins |
| KR20180089510A (ko) | 2015-12-18 | 2018-08-08 | 노파르티스 아게 | CD32b를 표적화하는 항체 및 그의 사용 방법 |
| CA3016765A1 (en) | 2016-03-15 | 2017-09-21 | Innate Pharma | Anti-mica antibodies |
| MX2018012433A (es) | 2016-04-15 | 2019-03-01 | Macrogenics Inc | Moleculas de union b7-h3 novedosas, conjugados anticuerpo-farmaco de los mismos y metodos de uso de los mismos. |
| WO2017189432A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| US20190248895A1 (en) | 2016-10-21 | 2019-08-15 | Innate Pharma | Treatment with anti-kir3dl2 agents |
| US20190322767A1 (en) | 2016-12-23 | 2019-10-24 | Innate Pharma | Heterodimeric antigen binding proteins |
| WO2018138607A1 (en) * | 2017-01-24 | 2018-08-02 | Nestec Sa | Compositions comprising anti-fel d1 antibodies and methods for reducing at least one symptom of human allergy to cats |
| CN110325209A (zh) | 2017-02-24 | 2019-10-11 | 宏观基因有限公司 | 能够结合cd137和肿瘤抗原的双特异性结合分子及其用途 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| US20210040205A1 (en) | 2017-10-25 | 2021-02-11 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
| EP3713959A1 (en) | 2017-11-21 | 2020-09-30 | Innate Pharma | Multispecific antigen binding proteins |
| WO2019109238A1 (en) * | 2017-12-05 | 2019-06-13 | Lyvgen Biopharma Co., Ltd. | Anti-cd137 antibodies and uses thereof |
| MX2020006155A (es) | 2017-12-12 | 2020-08-13 | Macrogenics Inc | Moleculas de union a cd-16 biespecificas y su uso en el tratamiento de enfermedades. |
| US11685781B2 (en) | 2018-02-15 | 2023-06-27 | Macrogenics, Inc. | Variant CD3-binding domains and their use in combination therapies for the treatment of disease |
| KR20210029158A (ko) | 2018-06-03 | 2021-03-15 | 람카프 바이오 베타 엘티디. | Ceacam5 및 cd47에 대한 이중특이성 항체 |
| JP2022523656A (ja) | 2019-01-22 | 2022-04-26 | イナート・ファルマ・ソシエテ・アノニム | Ｔ細胞リンパ腫の処置 |
| EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| HUE065728T2 (hu) | 2020-12-18 | 2024-06-28 | Lamkap Bio Beta Ag | CEACAM5 és CD47 elleni bispecifikus antitestek |
| BR112023019138A2 (pt) | 2021-03-26 | 2023-10-24 | Innate Pharma | Proteína multiespecífica, composição farmacêutica, célula recombinante, método de preparação de uma composição de célula nk, composição de células nk, uso de uma proteína ou composição, métodos e uso |
| WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
| CN117529504A (zh) | 2021-06-09 | 2024-02-06 | 先天制药公司 | 结合至cd20、nkp46、cd16并缀合至il-2的多特异性抗体 |
| WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
| CN117616050A (zh) | 2021-06-09 | 2024-02-27 | 先天制药公司 | 与nkp46、细胞因子受体、肿瘤抗原和cd16a结合的多特异性蛋白质 |
| AU2023291779A1 (en) | 2022-06-16 | 2024-10-17 | Lamkap Bio Beta Ltd | Combination therapy of bispecific antibodies against ceacam5 and cd47 and bispecific antibodies against ceacam5 and cd3 |
| US12030945B2 (en) | 2022-10-25 | 2024-07-09 | Seismic Therapeutic, Inc. | Variant IgG Fc polypeptides and uses thereof |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4189337A (en) * | 1978-04-10 | 1980-02-19 | Camsco, Inc. | Real time labeler system |
| US4752601A (en) | 1983-08-12 | 1988-06-21 | Immunetech Pharmaceuticals | Method of blocking immune complex binding to immunoglobulin FC receptors |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6548640B1 (en) * | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5985599A (en) | 1986-05-29 | 1999-11-16 | The Austin Research Institute | FC receptor for immunoglobulin |
| US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル． モリソン，シェリー | ドメイン‐変性不変部を有する抗体 |
| FR2626882B1 (fr) | 1988-02-08 | 1991-11-08 | Ire Celltarg Sa | Conjugues de derives de vinca comportant une chaine detergente en position c-3 |
| US4861579A (en) | 1988-03-17 | 1989-08-29 | American Cyanamid Company | Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies |
| WO1989011490A1 (en) | 1988-05-27 | 1989-11-30 | Schering Biotech Corporation | HUMAN Fcgamma RECEPTOR III |
| US5576184A (en) | 1988-09-06 | 1996-11-19 | Xoma Corporation | Production of chimeric mouse-human antibodies with specificity to human tumor antigens |
| EP0359096B1 (en) * | 1988-09-15 | 1997-11-05 | The Trustees Of Columbia University In The City Of New York | Antibodies having modified carbohydrate content and methods of preparation and use |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8916400D0 (en) | 1989-07-18 | 1989-09-06 | Dynal As | Modified igg3 |
| GB9105245D0 (en) | 1991-03-12 | 1991-04-24 | Lynxvale Ltd | Binding molecules |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| PT682710E (pt) | 1993-02-10 | 2004-03-31 | Unilever Nv | Processo de isolamento utilizando proteinas imobilizadas com capacidades de ligacao especificas |
| US5877396A (en) | 1993-04-23 | 1999-03-02 | Sloan Kettering Institute For Cancer Research | Mice mutant for functional Fc receptors and method of treating autoimmune diseases |
| AU6668094A (en) | 1993-04-23 | 1994-11-21 | Sloan-Kettering Institute For Cancer Research | Method for screening for targets for anti-inflammatory or anti-allergic agents |
| CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
| DE69434520T3 (de) | 1993-07-30 | 2009-10-15 | Affymax, Inc., Palo Alto | Biotinylierung von proteinen |
| GB9316989D0 (en) | 1993-08-16 | 1993-09-29 | Lynxvale Ltd | Binding molecules |
| NZ276943A (en) * | 1993-11-10 | 1998-02-26 | Schering Corp Substituted For | Alpha-interferon conjugated to a non-antigenic polymer (preferably a polyalkylene oxide) and its preparation |
| US6132764A (en) * | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US6019968A (en) * | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6410690B1 (en) * | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| EP0904107B1 (en) | 1996-03-18 | 2004-10-20 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| US6300065B1 (en) | 1996-05-31 | 2001-10-09 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US6025485A (en) | 1997-02-14 | 2000-02-15 | Arcaris, Inc. | Methods and compositions for peptide libraries displayed on light-emitting scaffolds |
| US6339069B1 (en) * | 1996-10-15 | 2002-01-15 | Elan Pharmaceuticalstechnologies, Inc. | Peptide-lipid conjugates, liposomes and lipsomal drug delivery |
| DE69840723D1 (de) * | 1997-02-11 | 2009-05-20 | Immunomedics Inc | Stimulation einer immunantwort durch antikörper, welche mit dem alpha-galaktosylepitop markiert sind |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US20030207346A1 (en) | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
| AU4754397A (en) | 1997-10-15 | 1999-05-03 | Medarex, Inc. | Bispecific molecules directed to tumor associated glycoprotein-72 and fc receptor |
| CA2248971A1 (en) * | 1997-10-31 | 1999-04-30 | Kyowa Hakko Kogyo Co., Ltd. | .beta.1, 3-n-acetylglucosaminyltransferase, dna encoding it and its use |
| US20020058284A1 (en) | 1998-02-17 | 2002-05-16 | Jan G.J. Van De Winkel | Methods and compositions for treating macrophage-mediated diseases |
| US6455263B2 (en) | 1998-03-24 | 2002-09-24 | Rigel Pharmaceuticals, Inc. | Small molecule library screening using FACS |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6528624B1 (en) * | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| EP0953639A1 (en) | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6696550B2 (en) | 1998-07-23 | 2004-02-24 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| US7315786B2 (en) | 1998-10-16 | 2008-01-01 | Xencor | Protein design automation for protein libraries |
| EP1006183A1 (en) | 1998-12-03 | 2000-06-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Recombinant soluble Fc receptors |
| KR20060067983A (ko) | 1999-01-15 | 2006-06-20 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1272647B1 (en) | 2000-04-11 | 2014-11-12 | Genentech, Inc. | Multivalent antibodies and uses therefor |
| JP2003531149A (ja) * | 2000-04-13 | 2003-10-21 | ザ・ロツクフエラー・ユニバーシテイ | 抗体由来の免疫応答の増強 |
| WO2002002781A1 (en) * | 2000-06-30 | 2002-01-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Heterodimeric fusion proteins |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| DE60230736D1 (de) | 2001-04-30 | 2009-02-26 | Lilly Co Eli | HUMANISIERTE ANTIKÖRPER DIE DAS BETA-AMYLOID PEPTID ERKENNEN& x9; |
| US6972324B2 (en) * | 2001-05-18 | 2005-12-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Antibodies specific for CD44v6 |
| EP1439857B1 (en) * | 2001-10-12 | 2009-02-25 | Schering Corporation | USE OF BISPECIFIC ANTIBODIES BINDING TO THE ACTIVATING RECEPTOR FcEpsilonRI AND TO THE INHIBITING RECEPTOR OX2Ra (CD200Ra) TO REGULATE IMMUNE RESPONSES |
| AU2002337935B2 (en) | 2001-10-25 | 2008-05-01 | Genentech, Inc. | Glycoprotein compositions |
| WO2003066095A2 (en) | 2002-02-07 | 2003-08-14 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | MODULATING TOLERANCE BY MODULATING FcϜRIIB RECEPTOR SIGNALLING |
| US20040002587A1 (en) | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| US7662925B2 (en) | 2002-03-01 | 2010-02-16 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
| US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| US20040110226A1 (en) | 2002-03-01 | 2004-06-10 | Xencor | Antibody optimization |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| CA2494310A1 (en) | 2002-08-01 | 2004-02-12 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
| US8187593B2 (en) | 2002-08-14 | 2012-05-29 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
| US20050260213A1 (en) * | 2004-04-16 | 2005-11-24 | Scott Koenig | Fcgamma-RIIB-specific antibodies and methods of use thereof |
| EP3502133A1 (en) | 2002-09-27 | 2019-06-26 | Xencor, Inc. | Optimized fc variants and methods for their generation |
| EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
| US20090010920A1 (en) | 2003-03-03 | 2009-01-08 | Xencor, Inc. | Fc Variants Having Decreased Affinity for FcyRIIb |
| AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| AU2003265522A1 (en) | 2003-08-18 | 2005-03-10 | Macrogenics, Inc. | FCGammaRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
| CN1918178B (zh) | 2004-01-12 | 2012-08-22 | 应用分子进化公司 | Fc区变体 |
| WO2005110474A2 (en) | 2004-05-10 | 2005-11-24 | Macrogenics, Inc. | HUMANIZED FcϜRIIB SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF |
| EP1776384B1 (en) | 2004-08-04 | 2013-06-05 | Mentrik Biotech, LLC | Variant fc regions |
| EP1786836A2 (en) | 2004-09-02 | 2007-05-23 | Genentech, Inc. | Anti-fc-gamma riib receptor antibody and uses therefor |
| US7655229B2 (en) * | 2004-09-02 | 2010-02-02 | Chan Andrew C | Anti-FC-gamma RIIB receptor antibody and uses therefor |
| US7662926B2 (en) | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| WO2007024249A2 (en) | 2004-11-10 | 2007-03-01 | Macrogenics, Inc. | Engineering fc antibody regions to confer effector function |
| WO2006066078A2 (en) | 2004-12-15 | 2006-06-22 | Magrogenics, Inc. | Fcϝriib-specific antibodies and methods of use thereof |
| ES2707152T3 (es) | 2005-04-15 | 2019-04-02 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos |
| US8217147B2 (en) | 2005-08-10 | 2012-07-10 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| WO2007055916A2 (en) | 2005-11-07 | 2007-05-18 | The Rockefeller University | Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof |
| CA2644903A1 (en) | 2006-03-10 | 2007-09-20 | Macrogenics, Inc. | Identification and engineering of antibodies with variant heavy chains and methods of using same |
| EP2021029B1 (en) | 2006-05-26 | 2014-06-11 | MacroGenics, Inc. | Humanized fc gamma riib-specific antibodies and methods of use thereof |
| JP5764290B2 (ja) | 2006-06-26 | 2015-08-19 | マクロジェニクス，インコーポレーテッド | ＦｃγＲＩＩＢ特異的抗体およびその使用法 |
| WO2008002933A2 (en) | 2006-06-26 | 2008-01-03 | Macrogenics, Inc. | Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof |
| CN101484471B (zh) | 2006-06-30 | 2013-11-06 | 诺沃-诺迪斯克有限公司 | 抗-nkg2a抗体及其用途 |
| US8802089B2 (en) | 2008-01-03 | 2014-08-12 | Genmab A/S | Monoclonal antibodies against CD32B |
| CN102046655B (zh) | 2008-04-02 | 2016-09-14 | 宏观基因有限公司 | Bcr-复合体-特异性抗体和其使用方法 |
-
2005
- 2005-05-10 WO PCT/US2005/016260 patent/WO2005110474A2/en active Application Filing
- 2005-05-10 US US11/126,978 patent/US7521542B2/en active Active
- 2005-05-10 CA CA2565874A patent/CA2565874C/en not_active Expired - Fee Related
- 2005-05-10 JP JP2007513268A patent/JP2007536932A/ja active Pending
- 2005-05-10 MX MXPA06012601A patent/MXPA06012601A/es active IP Right Grant
- 2005-05-10 AU AU2005244058A patent/AU2005244058B2/en not_active Ceased
- 2005-05-10 EP EP05745396A patent/EP1761563A4/en not_active Ceased
- 2005-05-10 KR KR1020067025895A patent/KR101297146B1/ko not_active IP Right Cessation
-
2006
- 2006-11-07 IL IL179102A patent/IL179102A/en not_active IP Right Cessation
-
2009
- 2009-01-07 US US12/349,876 patent/US8133982B2/en not_active Expired - Fee Related
-
2012
- 2012-02-07 US US13/367,626 patent/US8784808B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007536932A5 (ja) | ||
| CN112424224B (zh) | 抗白细胞介素-17a抗体、其药物组合物及其用途 | |
| RU2558301C2 (ru) | Полипептиды для связывания с "рецептором конечных продуктов гликирования", а также их композиции и способы, в которых они принимают участие | |
| ES2746805T3 (es) | Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo | |
| RU2421464C2 (ru) | Человеческие антитела к il-13 и их терапевтическое применение | |
| RU2492185C2 (ru) | Связывающие протеины, специфичные по отношению к инсулин-подобным факторам роста, и их использование | |
| JP2021008487A (ja) | 抗ｎｋｇ２ａ抗体を使用した治療計画 | |
| JP2024113039A (ja) | 腫瘍壊死因子 （ｔｎｆ） スーパーファミリー受容体結合分子およびその使用 | |
| WO2017148424A1 (zh) | 一种pdl-1抗体、其药物组合物及其用途 | |
| WO2021180205A1 (zh) | Pvrig结合蛋白及其医药用途 | |
| JP6359492B2 (ja) | 抗ＩＬ−１α抗体による癌の処置方法 | |
| BR112019019111A2 (pt) | anticorpo de b7-h3, seu fragmento de ligação ao antígeno e seu uso médico | |
| JP2007532139A5 (ja) | ||
| AU2016233309A1 (en) | Anti-MUC16 antibodies and uses thereof | |
| JP2020523413A (ja) | 操作された抗体化合物およびこれらの抱合体 | |
| JP2013502913A5 (ja) | ||
| CN112166125B (zh) | 全人源的抗lag-3抗体及其应用 | |
| JP2021535149A (ja) | Ｃｄ１３７／ｈｅｒ２二重特異性物質とｐｄ−１系阻害物質とを含む併用療法およびその使用法 | |
| WO2021254481A1 (zh) | 抗Claudin18.2抗体以及其用途 | |
| TWI701260B (zh) | 抗pacap抗體 | |
| WO2023274201A1 (zh) | 抗cd40抗体、其抗原结合片段及医药用途 | |
| KR20200017493A (ko) | Lgr5와 결합하는 항체 약물 접합체 | |
| US11680102B2 (en) | Anti-BAFF receptor antibodies and uses thereof | |
| KR20210108972A (ko) | 항페리오스틴 항체 및 이의 용도 | |
| KR20200143385A (ko) | Mospd2와, t 세포 또는 nk 세포 특이적 분자에 대한 2중 특이적 항체 |