JP2007534308A5 - - Google Patents
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- Publication number
- JP2007534308A5 JP2007534308A5 JP2006541541A JP2006541541A JP2007534308A5 JP 2007534308 A5 JP2007534308 A5 JP 2007534308A5 JP 2006541541 A JP2006541541 A JP 2006541541A JP 2006541541 A JP2006541541 A JP 2006541541A JP 2007534308 A5 JP2007534308 A5 JP 2007534308A5
- Authority
- JP
- Japan
- Prior art keywords
- photometrically
- labeled
- oligonucleotide
- labeling molecules
- labeling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002372 labelling Methods 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 5
- 230000005284 excitation Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52326303P | 2003-11-19 | 2003-11-19 | |
| PCT/US2004/038946 WO2005051967A2 (en) | 2003-11-19 | 2004-11-19 | Oligonucleotides labeled with a plurality of fluorophores |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177659A Division JP5307206B2 (ja) | 2003-11-19 | 2011-08-15 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007534308A JP2007534308A (ja) | 2007-11-29 |
| JP2007534308A5 true JP2007534308A5 (enExample) | 2011-10-06 |
Family
ID=34632765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541541A Withdrawn JP2007534308A (ja) | 2003-11-19 | 2004-11-19 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
| JP2011177659A Expired - Fee Related JP5307206B2 (ja) | 2003-11-19 | 2011-08-15 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177659A Expired - Fee Related JP5307206B2 (ja) | 2003-11-19 | 2011-08-15 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7667024B2 (enExample) |
| EP (1) | EP1689764B1 (enExample) |
| JP (2) | JP2007534308A (enExample) |
| CN (1) | CN101076537B (enExample) |
| WO (1) | WO2005051967A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006002167A2 (en) * | 2004-06-17 | 2006-01-05 | University Of Florida Research Foudation, Inc. | Multi-acceptor molecular probes and applications thereof |
| US8685711B2 (en) | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
| US9040305B2 (en) | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
| WO2007100392A2 (en) | 2005-11-30 | 2007-09-07 | Biotium, Inc. | Enzyme substrate comprising a functional dye and associated technology and methods |
| CA3086149A1 (en) * | 2006-04-04 | 2007-10-11 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
| US7914734B2 (en) | 2007-12-19 | 2011-03-29 | Singulex, Inc. | Scanning analyzer for single molecule detection and methods of use |
| US10759824B2 (en) | 2008-09-03 | 2020-09-01 | Quantumdx Group Limited | Design, synthesis and use of synthetic nucleotides comprising charge mass tags |
| WO2017120148A1 (en) | 2016-01-04 | 2017-07-13 | Quantumdx Group Limited | Design, synthesis and use of synthetic nucleotides comprising charge mass tags |
| EP2321429B1 (en) | 2008-09-03 | 2016-08-17 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| CN101709335B (zh) * | 2009-12-10 | 2011-12-21 | 浙江大学 | 一种人乳头瘤病毒常见型四重荧光定量pcr分型检测方法 |
| BR112012018394B8 (pt) * | 2009-12-21 | 2021-07-27 | Seegene Inc | método para detecção de uma sequência de ácido nucleico alvo e kit para detecção de uma sequência de ácido nucleico alvo |
| JP5709897B2 (ja) * | 2009-12-24 | 2015-04-30 | シージーン アイエヌシー | 偽シグナルが排除されるターゲット核酸配列のリアルタイムマルチプレッキシング検出 |
| DE102010003781B4 (de) * | 2010-04-08 | 2012-08-16 | Aj Innuscreen Gmbh | Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen |
| WO2012109157A2 (en) | 2011-02-07 | 2012-08-16 | The Governing Council Of The University Of Toronto | Bioprobes and methods of use thereof |
| EP2705160B1 (en) * | 2011-05-06 | 2018-08-22 | Qiagen GmbH | Nucleotides and oligonucleotides comprising a label associated through a linker |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
| BR112014019168B1 (pt) | 2012-02-03 | 2021-10-05 | California Institute Of Technology | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
| CN104662172B (zh) | 2012-08-03 | 2018-07-06 | 加州理工学院 | Pcr中具有减少的硬件和要求的多重化和定量 |
| CA2896213C (en) * | 2012-12-27 | 2018-12-11 | Seegene, Inc. | Detection of target nucleic acid sequence by pto cleavage and extension-dependent non-hybridization assay |
| EP4570924A3 (en) | 2013-01-24 | 2025-09-03 | California Institute of Technology | Chromophore-based characterization and detection methods |
| US10077475B2 (en) | 2013-01-24 | 2018-09-18 | California Institute Of Technology | FRET-based analytes detection and related methods and systems |
| SG10201900209WA (en) | 2013-03-15 | 2019-02-27 | Nanobiosym Inc | Systems and methods for mobile device analysis of nucleic acids and proteins |
| JP6190534B2 (ja) | 2013-08-22 | 2017-08-30 | ソニー株式会社 | 水溶性蛍光染料又は有色染料及びその使用方法 |
| CN113073129A (zh) * | 2013-10-25 | 2021-07-06 | 拜奥麦迪逊公司 | 双荧光团的酶测定法 |
| EP3149195B1 (en) | 2014-06-02 | 2018-12-05 | Base4 Innovation Ltd | Nucleotide polymorphism detection method |
| CN114606228B (zh) * | 2014-11-20 | 2025-01-07 | 杭州智灵龙生物科技有限公司 | 用于核酸扩增的组合物和方法 |
| US11827661B2 (en) | 2015-02-26 | 2023-11-28 | Sony Group Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| EP3262022A4 (en) | 2015-02-26 | 2018-08-15 | Sony Corporation | Phenylethynylnaphthalene dyes and methods for their use |
| AU2017240154B2 (en) | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| EP3440136B1 (en) | 2016-04-06 | 2025-07-23 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with spacing linker groups |
| JP7068192B2 (ja) | 2016-05-10 | 2022-05-16 | ソニーグループ株式会社 | ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用 |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| US11685835B2 (en) | 2016-05-11 | 2023-06-27 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| JP7068191B2 (ja) | 2016-06-06 | 2022-05-16 | ソニーグループ株式会社 | 蛍光または有色レポーター基を含むイオン性ポリマー |
| US10066263B2 (en) | 2016-06-17 | 2018-09-04 | California Institute Of Technology | Nucleic acid reactions and related methods and compositions |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| CN111315415A (zh) | 2017-10-05 | 2020-06-19 | 索尼公司 | 可编程的聚合药物 |
| EP3691689A1 (en) | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmable dendritic drugs |
| WO2019099789A1 (en) | 2017-11-16 | 2019-05-23 | Sony Corporation | Programmable polymeric drugs |
| JP2021510698A (ja) | 2018-01-12 | 2021-04-30 | ソニー株式会社 | 生物学的に活性な化合物を含むホスホアルキルリボースポリマー |
| JP7813098B2 (ja) | 2018-01-12 | 2026-02-12 | ソニーグループ株式会社 | 生物学的に活性な化合物を含む剛性間隔基を有するポリマー |
| EP3737419B1 (en) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| CN112041680A (zh) | 2018-03-19 | 2020-12-04 | 索尼公司 | 二价金属用于增强荧光信号的应用 |
| EP3768689A1 (en) | 2018-03-21 | 2021-01-27 | Sony Corporation | Polymeric tandem dyes with linker groups |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| CN112313242A (zh) | 2018-06-27 | 2021-02-02 | 索尼公司 | 具有含脱氧核糖的连接体基团的聚合物染料 |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| KR20210032434A (ko) | 2018-07-13 | 2021-03-24 | 소니 주식회사 | 유기인산염 단위를 포함하는 백본을 갖는 중합체성 염료 |
| WO2020014681A1 (en) | 2018-07-13 | 2020-01-16 | Quantum-Si Incorporated | Biconjugatable labels and methods of use |
| US11613772B2 (en) * | 2019-01-23 | 2023-03-28 | Quantum-Si Incorporated | High intensity labeled reactant compositions and methods for sequencing |
| WO2021004379A1 (zh) * | 2019-07-05 | 2021-01-14 | 南京金斯瑞生物科技有限公司 | 一种荧光标记核酸及其合成方法 |
| CN113383043A (zh) | 2019-09-26 | 2021-09-10 | 索尼集团公司 | 具有连接体基团的聚合物串联染料 |
| KR20220075399A (ko) * | 2019-09-30 | 2022-06-08 | 소니그룹주식회사 | 뉴클레오티드 프로브 |
| JP2023552448A (ja) | 2020-12-07 | 2023-12-15 | ソニーグループ株式会社 | 二量体色素又はポリマー色素における輝度を増強するためのスペーシングリンカー基の設計 |
| AU2022426779A1 (en) * | 2021-12-29 | 2024-07-18 | Co-Diagnostics, Inc. | Methods and systems for analyzing nucleic acids using increased ifret with multiple acceptor fluorophores |
| JP2023103945A (ja) * | 2022-01-14 | 2023-07-27 | 株式会社日立製作所 | 構造多型変異検出法 |
| US20230366038A1 (en) | 2022-05-16 | 2023-11-16 | Bioo Scientific Corporation | Compositions and methods relating to loop mediated isothermal amplification (lamp) |
| US12347527B2 (en) * | 2022-08-23 | 2025-07-01 | Leica Microsystems Cms Gmbh | Data storage device and method for storing data using an oligonucleotide nanostructure backbone and labels with dyes |
| WO2025207981A1 (en) * | 2024-03-27 | 2025-10-02 | 3D Medicines Biomedical Technologies, Inc. | Tethered probes for multiplexed nucleic acid amplification assays |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766062A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5654419A (en) * | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| ATE196322T1 (de) * | 1995-05-05 | 2000-09-15 | Perkin Elmer Corp | Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| JP2002515738A (ja) * | 1996-01-23 | 2002-05-28 | アフィメトリックス,インコーポレイティド | 核酸分析法 |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US6174670B1 (en) | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
| US6893868B2 (en) * | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
| US6037137A (en) | 1997-02-20 | 2000-03-14 | Oncoimmunin, Inc. | Fluorogenic peptides for the detection of protease activity |
| US5846726A (en) * | 1997-05-13 | 1998-12-08 | Becton, Dickinson And Company | Detection of nucleic acids by fluorescence quenching |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6485901B1 (en) * | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| JP4318856B2 (ja) | 1998-03-05 | 2009-08-26 | ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド | チモーゲン性核酸検出方法、および関連分子およびキット |
| GB2341189B (en) | 1998-08-31 | 2001-06-13 | Amersham Pharm Biotech Inc | Energy transfer dyes |
| US6573047B1 (en) * | 1999-04-13 | 2003-06-03 | Dna Sciences, Inc. | Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation |
| US6472153B1 (en) | 1999-10-26 | 2002-10-29 | Epoch Biosciences, Inc. | Hybridization-triggered fluorescent detection of nucleic acids |
| GB2359809B (en) | 1999-12-24 | 2004-01-14 | Sumitomo Chemical Co | Phenylacetylene compound liquid crystal composition, polymer optically anisotropic product, and liquid crystal or optical element |
| EP1307592B1 (en) * | 2000-08-11 | 2006-07-05 | University of Utah Research Foundation | Single-labeled oligonucleotide probes |
| CA2423806C (en) | 2000-09-29 | 2009-12-22 | Molecular Probes, Inc. | Modified carbocyanine dyes and their conjugates |
-
2004
- 2004-11-19 JP JP2006541541A patent/JP2007534308A/ja not_active Withdrawn
- 2004-11-19 EP EP04811635A patent/EP1689764B1/en not_active Expired - Lifetime
- 2004-11-19 US US10/993,625 patent/US7667024B2/en not_active Expired - Fee Related
- 2004-11-19 CN CN200480040647.1A patent/CN101076537B/zh not_active Expired - Fee Related
- 2004-11-19 WO PCT/US2004/038946 patent/WO2005051967A2/en not_active Ceased
-
2009
- 2009-12-23 US US12/646,514 patent/US20100240103A1/en not_active Abandoned
-
2011
- 2011-08-15 JP JP2011177659A patent/JP5307206B2/ja not_active Expired - Fee Related
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