JP2007534308A5 - - Google Patents
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- Publication number
- JP2007534308A5 JP2007534308A5 JP2006541541A JP2006541541A JP2007534308A5 JP 2007534308 A5 JP2007534308 A5 JP 2007534308A5 JP 2006541541 A JP2006541541 A JP 2006541541A JP 2006541541 A JP2006541541 A JP 2006541541A JP 2007534308 A5 JP2007534308 A5 JP 2007534308A5
- Authority
- JP
- Japan
- Prior art keywords
- photometrically
- labeled
- oligonucleotide
- labeling molecules
- labeling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002372 labelling Methods 0.000 claims 6
- 108091034117 Oligonucleotide Proteins 0.000 claims 5
- 230000005284 excitation Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52326303P | 2003-11-19 | 2003-11-19 | |
| PCT/US2004/038946 WO2005051967A2 (en) | 2003-11-19 | 2004-11-19 | Oligonucleotides labeled with a plurality of fluorophores |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177659A Division JP5307206B2 (ja) | 2003-11-19 | 2011-08-15 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007534308A JP2007534308A (ja) | 2007-11-29 |
| JP2007534308A5 true JP2007534308A5 (enExample) | 2011-10-06 |
Family
ID=34632765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541541A Withdrawn JP2007534308A (ja) | 2003-11-19 | 2004-11-19 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
| JP2011177659A Expired - Fee Related JP5307206B2 (ja) | 2003-11-19 | 2011-08-15 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177659A Expired - Fee Related JP5307206B2 (ja) | 2003-11-19 | 2011-08-15 | 複数のフルオロフォアで標識したオリゴヌクレオチド |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7667024B2 (enExample) |
| EP (1) | EP1689764B1 (enExample) |
| JP (2) | JP2007534308A (enExample) |
| CN (1) | CN101076537B (enExample) |
| WO (1) | WO2005051967A2 (enExample) |
Families Citing this family (57)
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| WO2007100392A2 (en) | 2005-11-30 | 2007-09-07 | Biotium, Inc. | Enzyme substrate comprising a functional dye and associated technology and methods |
| EP2016394A4 (en) * | 2006-04-04 | 2013-04-24 | Singulex Inc | METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES |
| CN101946180B (zh) | 2007-12-19 | 2013-11-13 | 神谷来克斯公司 | 单分子检测用扫描分析器和使用方法 |
| EP2321429B1 (en) | 2008-09-03 | 2016-08-17 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| US10759824B2 (en) | 2008-09-03 | 2020-09-01 | Quantumdx Group Limited | Design, synthesis and use of synthetic nucleotides comprising charge mass tags |
| US9579402B2 (en) * | 2009-12-04 | 2017-02-28 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
| CN101709335B (zh) * | 2009-12-10 | 2011-12-21 | 浙江大学 | 一种人乳头瘤病毒常见型四重荧光定量pcr分型检测方法 |
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| DE102010003781B4 (de) * | 2010-04-08 | 2012-08-16 | Aj Innuscreen Gmbh | Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen |
| EP3369828B1 (en) | 2011-02-07 | 2020-07-15 | The Governing Council Of The University Of Toronto | Bioprobes and methods of use thereof |
| WO2012152708A1 (en) * | 2011-05-06 | 2012-11-15 | Qiagen Gmbh | Oligonucleotides comprising a label associated through a linker |
| EP2782916B1 (en) | 2011-11-21 | 2018-02-28 | Promega Corporation | Carboxy x rhodamine analogs |
| EP4361607A3 (en) | 2012-02-03 | 2024-07-17 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
| EP2880184B1 (en) | 2012-08-03 | 2021-03-31 | California Institute of Technology | Multiplexing and quantification in pcr with reduced hardware and requirements |
| JP6178430B2 (ja) | 2012-12-27 | 2017-08-09 | シージーン アイエヌシー | Pto切断及び延長依存的非ハイブリダイゼーションアッセイによるターゲット核酸配列の検出 |
| US20140213471A1 (en) * | 2013-01-24 | 2014-07-31 | California Institute Of Technology | Chromophore-based characterization and detection methods |
| CN105142789A (zh) | 2013-03-15 | 2015-12-09 | 纳诺拜希姆公司 | 用于移动设备分析核酸和蛋白质的系统和方法 |
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| EP3404112B1 (en) * | 2013-10-25 | 2020-08-26 | BioMadison, Inc. | Enzyme assay with duplicate fluorophores |
| JP6442534B2 (ja) * | 2014-06-02 | 2018-12-19 | ベース4 イノベーション リミテッド | ヌクレオチド多型の検出方法 |
| WO2016081551A1 (en) * | 2014-11-20 | 2016-05-26 | Ampliwise Inc. | Compositions and methods for nucleic acid amplification |
| WO2016138457A1 (en) | 2015-02-26 | 2016-09-01 | Sony Corporation | Phenylethynylnaphthalene dyes and methods for their use |
| KR102676814B1 (ko) | 2015-02-26 | 2024-06-21 | 소니그룹주식회사 | 접합 그룹을 포함하는 수용성 형광 또는 착색 염료 |
| JP2019503174A (ja) | 2016-01-04 | 2019-02-07 | クァンタムディーエックス グループ リミテッドQuantumdx Group Limited | 電荷量タグを含む合成ヌクレオチドのデザイン、合成、および使用 |
| KR102530707B1 (ko) | 2016-04-01 | 2023-05-11 | 소니그룹주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| KR20180133890A (ko) | 2016-04-06 | 2018-12-17 | 소니 주식회사 | 스페이싱 링커 그룹을 포함하는 초고명도 이량체성 또는 중합체성 염료 |
| WO2017196954A1 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| EP3455300A1 (en) | 2016-05-11 | 2019-03-20 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| JP7068191B2 (ja) | 2016-06-06 | 2022-05-16 | ソニーグループ株式会社 | 蛍光または有色レポーター基を含むイオン性ポリマー |
| WO2017218777A1 (en) | 2016-06-17 | 2017-12-21 | California Institute Of Technology | Nucleic acid reactions and related methods and compositions |
| US12018159B2 (en) | 2016-07-29 | 2024-06-25 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| JP7551056B2 (ja) | 2017-10-05 | 2024-09-17 | ソニーグループ株式会社 | プログラマブルなポリマー薬物 |
| EP3691689A1 (en) | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmable dendritic drugs |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| WO2019140301A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| EP4616912A3 (en) | 2018-01-12 | 2025-11-19 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| KR102742386B1 (ko) | 2018-03-19 | 2024-12-16 | 소니그룹주식회사 | 형광 신호 향상을 위한 2가 금속의 사용 |
| WO2019182766A1 (en) | 2018-03-21 | 2019-09-26 | Sony Corporation | Polymeric tandem dyes with linker groups |
| EP3781710A4 (en) | 2018-04-17 | 2022-01-05 | Chromacode, Inc. | METHODS AND SYSTEMS FOR MULTIPLEX ANALYSIS |
| KR102854332B1 (ko) | 2018-06-27 | 2025-09-03 | 소니그룹주식회사 | 디옥시리보오스를 포함하는 링커 군을 갖는 중합체성 염료 |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| EP3820943A1 (en) | 2018-07-13 | 2021-05-19 | Quantum-si Incorporated | Biconjugatable labels and methods of use |
| BR112021013787A2 (pt) * | 2019-01-23 | 2021-10-05 | Quantum-Si Incorporated | Composições reagentes marcadas com alta densidade e métodos para sequenciamento |
| CN114040919A (zh) * | 2019-07-05 | 2022-02-11 | 南京金斯瑞生物科技有限公司 | 一种荧光标记核酸及其合成方法 |
| KR102486779B1 (ko) | 2019-09-26 | 2023-01-12 | 소니그룹주식회사 | 링커 그룹을 갖는 중합체성 탠덤 염료 |
| WO2021067483A1 (en) * | 2019-09-30 | 2021-04-08 | Sony Corporation | Nucleotide probes |
| EP4256078A1 (en) | 2020-12-07 | 2023-10-11 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| US20230279479A1 (en) * | 2021-12-29 | 2023-09-07 | Co-Diagnostics, Inc. | Methods and systems for analyzing nucleic acids using increased ifret with multiple acceptor fluorophores |
| US20230366038A1 (en) | 2022-05-16 | 2023-11-16 | Bioo Scientific Corporation | Compositions and methods relating to loop mediated isothermal amplification (lamp) |
| US12347527B2 (en) * | 2022-08-23 | 2025-07-01 | Leica Microsystems Cms Gmbh | Data storage device and method for storing data using an oligonucleotide nanostructure backbone and labels with dyes |
| WO2025207981A1 (en) * | 2024-03-27 | 2025-10-02 | 3D Medicines Biomedical Technologies, Inc. | Tethered probes for multiplexed nucleic acid amplification assays |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766062A (en) | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
| US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5654419A (en) * | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
| WO1997027317A1 (en) * | 1996-01-23 | 1997-07-31 | Affymetrix, Inc. | Nucleic acid analysis techniques |
| US6312894B1 (en) | 1995-04-03 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders |
| US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
| DE69610304T2 (de) * | 1995-05-05 | 2001-04-05 | Perkin-Elmer Corp., Foster City | Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
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| US5800996A (en) * | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| AU726501B2 (en) | 1996-06-04 | 2000-11-09 | University Of Utah Research Foundation | Monitoring hybridization during PCR |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
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| US6635427B2 (en) * | 2000-08-11 | 2003-10-21 | University Of Utah Research Foundation | Single-labeled oligonucleotide probes for homogeneous nucleic acid sequence analysis |
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-
2004
- 2004-11-19 US US10/993,625 patent/US7667024B2/en not_active Expired - Fee Related
- 2004-11-19 JP JP2006541541A patent/JP2007534308A/ja not_active Withdrawn
- 2004-11-19 WO PCT/US2004/038946 patent/WO2005051967A2/en not_active Ceased
- 2004-11-19 EP EP04811635A patent/EP1689764B1/en not_active Expired - Lifetime
- 2004-11-19 CN CN200480040647.1A patent/CN101076537B/zh not_active Expired - Fee Related
-
2009
- 2009-12-23 US US12/646,514 patent/US20100240103A1/en not_active Abandoned
-
2011
- 2011-08-15 JP JP2011177659A patent/JP5307206B2/ja not_active Expired - Fee Related
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