|
DE3280400D1
(de)
|
1981-10-23 |
1992-06-04 |
Molecular Biosystems Inc |
Oligonukleotides heilmittel und dessen herstellungsverfahren.
|
|
US4541087A
(en)
*
|
1983-06-27 |
1985-09-10 |
Confertech International, Inc. |
Digital teleconferencing control device, system and method
|
|
CA1339596C
(en)
|
1987-08-07 |
1997-12-23 |
New England Medical Center Hospitals, Inc. |
Viral expression inhibitors
|
|
US4958013A
(en)
*
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
|
EP0468520A3
(en)
|
1990-07-27 |
1992-07-01 |
Mitsui Toatsu Chemicals, Inc. |
Immunostimulatory remedies containing palindromic dna sequences
|
|
ATE162198T1
(de)
|
1992-07-27 |
1998-01-15 |
Hybridon Inc |
Oligonukleotid alkylphosphonothiate
|
|
US5558988A
(en)
*
|
1992-11-13 |
1996-09-24 |
Thomas Jefferson University |
Primers and methods for detecting mutations in the procollagen II gene that indicate a genetic predisposition for osteoarthritis
|
|
US6605708B1
(en)
|
1993-07-28 |
2003-08-12 |
Hybridon, Inc. |
Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom
|
|
DE4338704A1
(de)
|
1993-11-12 |
1995-05-18 |
Hoechst Ag |
Stabilisierte Oligonucleotide und deren Verwendung
|
|
US5646126A
(en)
|
1994-02-28 |
1997-07-08 |
Epoch Pharmaceuticals |
Sterol modified oligonucleotide duplexes having anticancer activity
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
US6727230B1
(en)
|
1994-03-25 |
2004-04-27 |
Coley Pharmaceutical Group, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
US20030050263A1
(en)
|
1994-07-15 |
2003-03-13 |
The University Of Iowa Research Foundation |
Methods and products for treating HIV infection
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
EP1167379A3
(en)
|
1994-07-15 |
2004-09-08 |
University Of Iowa Research Foundation |
Immunomodulatory oligonucleotides
|
|
US20030026782A1
(en)
*
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
|
US7935675B1
(en)
|
1994-07-15 |
2011-05-03 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
DE19502912A1
(de)
*
|
1995-01-31 |
1996-08-01 |
Hoechst Ag |
G-Cap Stabilisierte Oligonucleotide
|
|
US5968909A
(en)
|
1995-08-04 |
1999-10-19 |
Hybridon, Inc. |
Method of modulating gene expression with reduced immunostimulatory response
|
|
US5780448A
(en)
|
1995-11-07 |
1998-07-14 |
Ottawa Civic Hospital Loeb Research |
DNA-based vaccination of fish
|
|
US7432048B2
(en)
*
|
1996-11-29 |
2008-10-07 |
Third Wave Technologies, Inc. |
Reactions on a solid surface
|
|
US6030955A
(en)
*
|
1996-03-21 |
2000-02-29 |
The Trustees Of Columbia University In The City Of New York And Imclone Systems, Inc. |
Methods of affecting intracellular phosphorylation of tyrosine using phosphorothioate oligonucleotides, and antiangiogenic and antiproliferative uses thereof
|
|
US5856462A
(en)
|
1996-09-10 |
1999-01-05 |
Hybridon Incorporated |
Oligonucleotides having modified CpG dinucleosides
|
|
ATE292980T1
(de)
|
1996-10-11 |
2005-04-15 |
Univ California |
Immunostimulierende oligonucleotidekonjugate
|
|
EP0855184A1
(en)
*
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
|
|
WO1998037919A1
(en)
|
1997-02-28 |
1998-09-03 |
University Of Iowa Research Foundation |
USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
|
|
US6406705B1
(en)
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
US6426334B1
(en)
|
1997-04-30 |
2002-07-30 |
Hybridon, Inc. |
Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
|
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
|
EP1003531B1
(en)
|
1997-05-20 |
2007-08-22 |
Ottawa Health Research Institute |
Processes for preparing nucleic acid constructs
|
|
EP1003850B1
(en)
|
1997-06-06 |
2009-05-27 |
The Regents of the University of California |
Inhibitors of dna immunostimulatory sequence activity
|
|
US20040006034A1
(en)
|
1998-06-05 |
2004-01-08 |
Eyal Raz |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
|
US6589940B1
(en)
|
1997-06-06 |
2003-07-08 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
|
WO1999001154A1
(en)
|
1997-07-03 |
1999-01-14 |
University Of Iowa Research Foundation |
Method for inhibiting immunostimulatory dna associated responses
|
|
DE19750702A1
(de)
*
|
1997-11-15 |
1999-05-27 |
Hoechst Marion Roussel De Gmbh |
Antisense Oligonucleotide gegen Tenascin zur Behandlung von Vitiligo
|
|
US7393630B2
(en)
*
|
1997-12-16 |
2008-07-01 |
Novartis Vaccines And Diagnostics, Inc. |
Use of microparticles combined with submicron oil-in-water emulsions
|
|
AU760549B2
(en)
|
1998-04-03 |
2003-05-15 |
University Of Iowa Research Foundation, The |
Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
|
|
CA2369172A1
(en)
*
|
1998-04-14 |
1999-10-21 |
Sugen, Inc. |
Ste20-related protein kinases
|
|
EP1595946A3
(en)
*
|
1998-04-14 |
2006-01-11 |
Sugen, Inc. |
STE20-related protein kinases
|
|
CA2328602A1
(en)
|
1998-05-06 |
1999-11-11 |
University Of Iowa Research Foundation |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
|
JP2002514397A
(ja)
|
1998-05-14 |
2002-05-21 |
コーリー ファーマシューティカル ゲーエムベーハー |
ＣｐＧオリゴヌクレオチドを用いる造血調節の方法
|
|
SI1077722T1
(sl)
|
1998-05-22 |
2007-02-28 |
Ottawa Health Research Inst |
Metode in produkti za induciranje sluznicne imunosti
|
|
US6562798B1
(en)
*
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
JP2002521489A
(ja)
|
1998-07-27 |
2002-07-16 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
ＣｐＧオリゴヌクレオチドの立体異性体および関連する方法
|
|
CA2839037A1
(en)
*
|
1998-08-20 |
2000-03-02 |
E.I. Du Pont De Nemours And Company |
Genes for plant fatty acid modifying enzymes associated with conjugated double bond formation
|
|
FR2783170B1
(fr)
|
1998-09-11 |
2004-07-16 |
Pasteur Merieux Serums Vacc |
Emulsion immunostimulante
|
|
AU1915500A
(en)
*
|
1998-11-20 |
2000-06-13 |
Bristol-Myers Squibb Company |
Water soluble prodrugs of azole compounds
|
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
|
WO2000054803A2
(en)
|
1999-03-16 |
2000-09-21 |
Panacea Pharmaceuticals, Llc |
Immunostimulatory nucleic acids and antigens
|
|
EP1176966B1
(en)
*
|
1999-04-12 |
2013-04-03 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US6977245B2
(en)
*
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
EP1377554A1
(en)
|
1999-06-16 |
2004-01-07 |
University Of Iowa Research Foundation |
Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
|
|
US6514948B1
(en)
|
1999-07-02 |
2003-02-04 |
The Regents Of The University Of California |
Method for enhancing an immune response
|
|
DE19935756A1
(de)
|
1999-07-27 |
2001-02-08 |
Mologen Forschungs Entwicklung |
Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
|
|
DE19935302A1
(de)
*
|
1999-07-28 |
2001-02-08 |
Aventis Pharma Gmbh |
Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen
|
|
US6822086B1
(en)
*
|
1999-08-09 |
2004-11-23 |
The General Hospital Corporation |
Drug-carrier complexes and methods of use thereof
|
|
EP2314693A3
(en)
|
1999-08-13 |
2012-11-28 |
Idera Pharmaceuticals, Inc. |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
|
|
NZ517929A
(en)
|
1999-09-25 |
2004-02-27 |
Univ Iowa Res Found |
Immunostimulatory nucleic acids
|
|
US6949520B1
(en)
*
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
AU2001227889A1
(en)
*
|
2000-01-14 |
2001-07-24 |
The United States of America, represented by The Secretary, Department of Health & Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US20010044416A1
(en)
|
2000-01-20 |
2001-11-22 |
Mccluskie Michael J. |
Immunostimulatory nucleic acids for inducing a Th2 immune response
|
|
CA2398432C
(en)
|
2000-01-26 |
2012-06-19 |
Hybridon, Inc. |
Modulation of oligonucleotide cpg-mediated immune stimulation by positional modification of nucleosides
|
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
|
US20020156033A1
(en)
|
2000-03-03 |
2002-10-24 |
Bratzler Robert L. |
Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
|
|
US20040131628A1
(en)
|
2000-03-08 |
2004-07-08 |
Bratzler Robert L. |
Nucleic acids for the treatment of disorders associated with microorganisms
|
|
JP3585420B2
(ja)
*
|
2000-04-20 |
2004-11-04 |
株式会社椿本チエイン |
チェーン用巻き加工品及びその製造方法
|
|
WO2001085751A1
(en)
|
2000-05-09 |
2001-11-15 |
Reliable Biopharmaceutical, Inc. |
Polymeric compounds useful as prodrugs
|
|
US6339630B1
(en)
*
|
2000-05-18 |
2002-01-15 |
The United States Of America As Represented By The United States Department Of Energy |
Sealed drive screw operator
|
|
EP1296714B1
(en)
|
2000-06-22 |
2009-08-26 |
University Of Iowa Research Foundation |
Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer.
|
|
US20020165178A1
(en)
|
2000-06-28 |
2002-11-07 |
Christian Schetter |
Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
|
|
US20020198165A1
(en)
|
2000-08-01 |
2002-12-26 |
Bratzler Robert L. |
Nucleic acids for the prevention and treatment of gastric ulcers
|
|
US20020091097A1
(en)
|
2000-09-07 |
2002-07-11 |
Bratzler Robert L. |
Nucleic acids for the prevention and treatment of sexually transmitted diseases
|
|
JP2005500806A
(ja)
|
2000-09-15 |
2005-01-13 |
コーリー ファーマシューティカル ゲーエムベーハー |
ＣｐＧに基づく免疫アゴニスト／免疫アンタゴニストの高スループットスクリーニングのためのプロセス
|
|
AU2001294750C1
(en)
|
2000-09-26 |
2008-09-18 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
|
|
FR2814958B1
(fr)
|
2000-10-06 |
2003-03-07 |
Aventis Pasteur |
Composition vaccinale
|
|
GB0025577D0
(en)
|
2000-10-18 |
2000-12-06 |
Smithkline Beecham Biolog |
Vaccine
|
|
ES2307568T3
(es)
|
2000-12-08 |
2008-12-01 |
Coley Pharmaceutical Gmbh |
Acidos nucleicos de tipo cpg y metodos de uso de los mismos.
|
|
WO2002053141A2
(en)
|
2000-12-14 |
2002-07-11 |
Coley Pharmaceutical Group, Inc. |
Inhibition of angiogenesis by nucleic acids
|
|
US20030050268A1
(en)
|
2001-03-29 |
2003-03-13 |
Krieg Arthur M. |
Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
|
|
US20030052063A1
(en)
*
|
2001-03-30 |
2003-03-20 |
Motoaki Sakashita |
Decontamination method and apparatus
|
|
US7713942B2
(en)
|
2001-04-04 |
2010-05-11 |
Nordic Vaccine Technology A/S |
Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides
|
|
US7105495B2
(en)
|
2001-04-30 |
2006-09-12 |
Idera Pharmaceuticals, Inc. |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
|
|
EP2423335B1
(en)
|
2001-06-21 |
2014-05-14 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same
|
|
US7785610B2
(en)
*
|
2001-06-21 |
2010-08-31 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same—III
|
|
US20040132677A1
(en)
|
2001-06-21 |
2004-07-08 |
Fearon Karen L. |
Chimeric immunomodulatory compounds and methods of using the same-IV
|
|
US6893572B2
(en)
*
|
2001-07-12 |
2005-05-17 |
Western Environmental Engineering Company |
Solids accumulating flotation separator
|
|
WO2003040308A2
(en)
*
|
2001-07-27 |
2003-05-15 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Use of sterically stabilized cationic liposomes to efficiently deliver cpg oligonucleotides in vivo
|
|
US7666674B2
(en)
*
|
2001-07-27 |
2010-02-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
|
|
US20030148316A1
(en)
|
2001-08-01 |
2003-08-07 |
Lipford Grayson B. |
Methods and compositions relating to plasmacytoid dendritic cells
|
|
WO2003020884A2
(en)
*
|
2001-08-14 |
2003-03-13 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services |
Method for rapid generation of mature dendritic cells
|
|
ATE411054T1
(de)
|
2001-08-17 |
2008-10-15 |
Coley Pharm Gmbh |
Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung
|
|
WO2003019187A1
(en)
*
|
2001-08-22 |
2003-03-06 |
Institute For Antibodies Co., Ltd |
Method of selecting binding molecule
|
|
EP2168598A1
(en)
|
2001-09-28 |
2010-03-31 |
Purdue Research Foundation |
Method of Treatment Using Ligand-Immunogen Conjugates
|
|
CN1633598A
(zh)
|
2001-10-05 |
2005-06-29 |
科勒制药股份公司 |
Toll样受体3信号传导的激动剂和拮抗剂
|
|
US20030139364A1
(en)
|
2001-10-12 |
2003-07-24 |
University Of Iowa Research Foundation |
Methods and products for enhancing immune responses using imidazoquinoline compounds
|
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
|
US7276489B2
(en)
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
|
WO2003054161A2
(en)
*
|
2001-12-20 |
2003-07-03 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
|
|
WO2003066649A1
(en)
|
2002-02-04 |
2003-08-14 |
Biomira Inc. |
Immunostimulatory, covalently lipidated oligonucleotides
|
|
EP3006043B1
(en)
|
2002-04-04 |
2019-05-29 |
Zoetis Belgium S.A. |
Immunostimulatory g,u-containing oligoribonucleotides
|
|
KR101092043B1
(ko)
|
2002-04-22 |
2011-12-12 |
바이오니취 라이프 사이언시즈 인코포레이티드 |
올리고뉴클레오티드 조성물 및 면역 반응 조절시 이의 용도
|
|
EP1503793A2
(en)
|
2002-05-10 |
2005-02-09 |
Inex Pharmaceuticals Corp. |
Cancer vaccines and methods of using the same
|
|
US20040009949A1
(en)
|
2002-06-05 |
2004-01-15 |
Coley Pharmaceutical Group, Inc. |
Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids
|
|
US7807803B2
(en)
|
2002-07-03 |
2010-10-05 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US7569553B2
(en)
|
2002-07-03 |
2009-08-04 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US7576066B2
(en)
|
2002-07-03 |
2009-08-18 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US7605138B2
(en)
|
2002-07-03 |
2009-10-20 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US20040053880A1
(en)
*
|
2002-07-03 |
2004-03-18 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
WO2004007743A2
(en)
|
2002-07-17 |
2004-01-22 |
Coley Pharmaceutical Gmbh |
Use of cpg nucleic acids in prion-disease
|
|
CN100471486C
(zh)
*
|
2002-08-12 |
2009-03-25 |
戴纳伐克斯技术股份有限公司 |
免疫调节组合物,其制备方法和使用方法
|
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
US8043622B2
(en)
*
|
2002-10-08 |
2011-10-25 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides
|
|
CN1753687A
(zh)
*
|
2002-10-29 |
2006-03-29 |
科勒制药集团股份有限公司 |
Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用
|
|
WO2004098491A2
(en)
*
|
2002-11-01 |
2004-11-18 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
METHOD OF PREVENTING INFECTIONS FROM BIOTERRORISM AGENTS WITH IMMUNOSTIMULATORY CpG OLIGONUCLEOTIDES
|
|
CA2502015A1
(en)
|
2002-12-11 |
2004-06-24 |
Coley Pharmaceutical Group, Inc. |
5' cpg nucleic acids and methods of use
|
|
WO2004058159A2
(en)
|
2002-12-23 |
2004-07-15 |
Dynavax Technologies Corporation |
Branched immunomodulatory compounds and methods of using the same
|
|
CA2512484A1
(en)
|
2003-01-16 |
2004-05-08 |
Hybridon, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
|
|
AU2004226605A1
(en)
*
|
2003-04-02 |
2004-10-14 |
Coley Pharmaceutical Group, Ltd. |
Immunostimulatory nucleic acid oil-in-water formulations for topical application
|
|
EP1631687A2
(en)
|
2003-04-22 |
2006-03-08 |
Coley Pharmaceutical GmbH |
Methods and products for identification and assessment of tlr ligands
|
|
MXPA05013658A
(es)
*
|
2003-06-11 |
2006-03-02 |
Hybridon Inc |
Oligonucleotidos inmunomoduladores estabilizados.
|
|
MXPA05013922A
(es)
|
2003-06-20 |
2006-02-24 |
Coley Pharm Group Inc |
Antagonistas de receptor tipo toll de molecula pequena.
|
|
MXPA06000619A
(es)
|
2003-07-15 |
2006-04-11 |
Hybridon Inc |
Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion.
|
|
JP2007504232A
(ja)
*
|
2003-09-05 |
2007-03-01 |
アナディス ファーマシューティカルズ インク |
Ｃ型肝炎ウイルス感染治療用のｔｌｒ７リガンド及びそのプロドラッグの投与
|
|
AU2004275876B2
(en)
*
|
2003-09-25 |
2011-03-31 |
Coley Pharmaceutical Gmbh |
Nucleic acid-lipophilic conjugates
|
|
US20050215501A1
(en)
|
2003-10-24 |
2005-09-29 |
Coley Pharmaceutical Group, Inc. |
Methods and products for enhancing epitope spreading
|
|
EP1678303A2
(en)
*
|
2003-10-30 |
2006-07-12 |
Coley Pharmaceutical GmbH |
C-class oligonucleotide analogs with enhanced immunostimulatory potency
|
|
US20050100983A1
(en)
|
2003-11-06 |
2005-05-12 |
Coley Pharmaceutical Gmbh |
Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling
|
|
CA2549173A1
(en)
|
2003-12-08 |
2005-07-07 |
Hybridon, Inc. |
Modulation of immunostimulatory properties by small oligonucleotide-based compounds
|
|
US20080113929A1
(en)
*
|
2004-06-08 |
2008-05-15 |
Coley Pharmaceutical Gmbh |
Abasic Oligonucleotide as Carrier Platform for Antigen and Immunostimulatory Agonist and Antagonist
|
|
JP4942646B2
(ja)
|
2004-06-15 |
2012-05-30 |
イデラ ファーマシューティカルズ インコーポレイテッド |
免疫賦活オリゴヌクレオチドマルチマー
|
|
EP1776105A2
(en)
*
|
2004-07-18 |
2007-04-25 |
Coley Pharmaceutical Group, Ltd |
Methods and compositions for inducing innate immune responses
|
|
MY159370A
(en)
*
|
2004-10-20 |
2016-12-30 |
Coley Pharm Group Inc |
Semi-soft-class immunostimulatory oligonucleotides
|
|
WO2006056142A1
(en)
*
|
2004-11-29 |
2006-06-01 |
Changchun Huapu Biotechnology Co., Ltd. |
Cpg single-strand deoxynucleotides for use as adjuvant
|
|
CN1810970B
(zh)
*
|
2005-01-27 |
2011-05-18 |
长春华普生物技术有限公司 |
含CpG的单链脱氧核苷酸与其疫苗组合物及其应用
|
|
CN1847256B
(zh)
*
|
2005-04-13 |
2011-06-15 |
长春华普生物技术有限公司 |
含CpG单链脱氧寡核苷酸和利巴韦林联合应用产生的抗病毒作用
|
|
US7792535B2
(en)
*
|
2005-05-31 |
2010-09-07 |
Alcatel-Lucent Usa Inc. |
Enhanced mobile station paging in a wireless telecommunications network
|
|
KR20080030656A
(ko)
*
|
2005-07-07 |
2008-04-04 |
콜레이 파마시티컬 그룹, 인코포레이티드 |
암 치료를 위한 항-ＣＴＬＡ-4 항체 및 ＣｐＧ-모티프-함유합성 올리고데옥시뉴클레오티드의 조합 요법
|
|
US7965675B2
(en)
*
|
2005-08-22 |
2011-06-21 |
Motorola Mobility, Inc. |
System and method for detecting an unlicensed mobile alliance (UMA) service in GSM wireless communication networks
|
|
CA2620582C
(en)
*
|
2005-08-31 |
2015-11-10 |
Dennis M. Klinman |
Methods of altering an immune response induced by cpg oligodeoxynucleotides
|
|
US8399423B2
(en)
*
|
2005-10-12 |
2013-03-19 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
JP4538522B2
(ja)
*
|
2005-11-25 |
2010-09-08 |
コーリー ファーマシューティカル ゲーエムベーハー |
免疫刺激性オリゴリボヌクレオチド
|
|
DK2405002T3
(en)
*
|
2006-02-15 |
2015-01-05 |
Adiutide Pharmaceuticals Gmbh |
Compositions and methods for oligonukleotidformuleringer
|
|
KR101221589B1
(ko)
*
|
2006-04-07 |
2013-01-15 |
이데라 파마슈티칼즈, 인코포레이티드 |
Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물
|
|
PT2078080E
(pt)
*
|
2006-09-27 |
2015-09-18 |
Coley Pharm Gmbh |
Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
|
|
US8377898B2
(en)
*
|
2006-10-12 |
2013-02-19 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
|
JP2010511408A
(ja)
*
|
2006-12-04 |
2010-04-15 |
ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ |
癌をＣｐＧリッチＤＮＡおよびキュプレドキシンで治療するための組成物および方法
|
|
KR20100053598A
(ko)
*
|
2007-08-01 |
2010-05-20 |
이데라 파마슈티칼즈, 인코포레이티드 |
Ｔｌｒ９의 신규한 합성 효능제
|
|
CA2696460A1
(en)
*
|
2007-08-13 |
2009-02-19 |
Pfizer Inc. |
Combination motif immune stimulatory oligonucleotides with improved activity
|
|
CA2704853C
(en)
*
|
2007-11-06 |
2017-08-15 |
Eugen Uhlmann |
Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties
|
|
JP2012508013A
(ja)
*
|
2008-11-04 |
2012-04-05 |
イデラ ファーマシューティカルズ インコーポレイテッド |
アンチセンスオリゴヌクレオチドによるＴｏｌｌ様受容体５発現の調節
|