JP2007532496A5 - - Google Patents
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- Publication number
- JP2007532496A5 JP2007532496A5 JP2007506660A JP2007506660A JP2007532496A5 JP 2007532496 A5 JP2007532496 A5 JP 2007532496A5 JP 2007506660 A JP2007506660 A JP 2007506660A JP 2007506660 A JP2007506660 A JP 2007506660A JP 2007532496 A5 JP2007532496 A5 JP 2007532496A5
- Authority
- JP
- Japan
- Prior art keywords
- solid
- reaction
- esters
- mmol
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 239000007787 solid Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 3
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 description 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 235000019439 ethyl acetate Nutrition 0.000 description 1
- 229960004979 fampridine Drugs 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- DRZYCRFOGWMEES-UHFFFAOYSA-N tert-butyl n-pyridin-4-ylcarbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=NC=C1 DRZYCRFOGWMEES-UHFFFAOYSA-N 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400576 | 2004-04-08 | ||
| DKPA200400693 | 2004-05-01 | ||
| DKPA200401153 | 2004-07-27 | ||
| DKPA200401216 | 2004-08-11 | ||
| PCT/DK2005/000244 WO2005097107A2 (en) | 2004-04-08 | 2005-04-08 | Diphenyl - indol-2-on compounds and their use in the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532496A JP2007532496A (ja) | 2007-11-15 |
| JP2007532496A5 true JP2007532496A5 (enExample) | 2008-05-22 |
Family
ID=34965522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506660A Pending JP2007532496A (ja) | 2004-04-08 | 2005-04-08 | ジフェニルオキソ−インドール−２−オン化合物および癌の処置におけるそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20070299102A1 (enExample) |
| EP (1) | EP1734951A2 (enExample) |
| JP (1) | JP2007532496A (enExample) |
| KR (1) | KR20060130781A (enExample) |
| CN (1) | CN1953747A (enExample) |
| AU (1) | AU2005230232A1 (enExample) |
| BR (1) | BRPI0509745A (enExample) |
| CA (1) | CA2562399A1 (enExample) |
| CR (1) | CR8673A (enExample) |
| EA (1) | EA013209B1 (enExample) |
| EC (1) | ECSP066913A (enExample) |
| IL (1) | IL178012A0 (enExample) |
| NO (1) | NO20065034L (enExample) |
| NZ (1) | NZ550222A (enExample) |
| WO (1) | WO2005097107A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1718611A4 (en) | 2004-02-13 | 2009-09-23 | Harvard College | 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION |
| MY158766A (en) * | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| MY145694A (en) | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| AR053713A1 (es) * | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| EP1946120A2 (en) | 2005-10-18 | 2008-07-23 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| CL2007002953A1 (es) * | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia. |
| ATE545416T1 (de) | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| JP2010522690A (ja) * | 2006-10-12 | 2010-07-08 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 三環式スピロオキシインドール誘導体および治療薬としてのその使用 |
| WO2008071387A1 (en) * | 2006-12-11 | 2008-06-19 | Topotarget A/S | Prodrugs of diphenyl ox- indol- 2 -one compounds for the treatment of cancers |
| JP2010525024A (ja) * | 2007-04-24 | 2010-07-22 | トポターゲット・アクティーゼルスカブ | 置換３−（４−ヒドロキシフェニル）−インドリン−２−オン化合物 |
| MX2010009372A (es) | 2008-02-26 | 2010-09-22 | Takeda Pharmaceutical | Derivado heterociclico fusionado y su uso. |
| US20100048914A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| AU2009225434B2 (en) | 2008-03-21 | 2014-05-22 | The University Of Chicago | Treatment with opioid antagonists and mTOR inhibitors |
| WO2010045197A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| HRP20150882T1 (hr) | 2008-10-17 | 2015-09-25 | Xenon Pharmaceuticals Inc. | Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva |
| US8110578B2 (en) * | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
| EP3023433A1 (en) | 2009-02-05 | 2016-05-25 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| WO2010109008A1 (en) | 2009-03-26 | 2010-09-30 | Topotarget A/S | Prodrugs of substituted 3-(4-hydroxyphenyl)-indolin-2-ones |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| MY165579A (en) | 2009-10-14 | 2018-04-05 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| CN102573472A (zh) * | 2009-10-23 | 2012-07-11 | 健康研究公司 | 治疗雄激素受体阳性癌症的方法 |
| JP2013521232A (ja) | 2010-02-26 | 2013-06-10 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 局所投与のためのスピロオキシインドール化合物の医薬組成物および治療剤としてのその使用 |
| AU2014207272A1 (en) * | 2013-01-18 | 2015-07-30 | Neal D. Andruska | Estrogen receptor inhibitors |
| KR20150127720A (ko) | 2013-03-14 | 2015-11-17 | 유니버시티 오브 매릴랜드, 발티모어 | 안드로겐 수용체 하향 조절제 및 그의 용도 |
| WO2015023710A1 (en) | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| EP3094314B1 (en) | 2014-01-16 | 2021-06-23 | MUSC Foundation For Research Development | Targeted nanocarriers for the administration of immunosuppressive agents |
| TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
| EP3749302B1 (en) * | 2018-02-08 | 2024-10-23 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Oxyphenisatin acetate, oxyphenisatin and bisacodyl for treating triple-negative breast cancer |
| CA3103958A1 (en) * | 2018-07-03 | 2020-01-09 | The Board Of Trustees Of The University Of Illinois | Activators of the unfolded protein response |
| EP3912625A1 (en) * | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
| CN114213396B (zh) * | 2022-01-27 | 2023-03-24 | 深圳市乐土生物医药有限公司 | 一种吲哚-2-酮类化合物及其制备方法与用途 |
| CN119019312B (zh) * | 2024-10-24 | 2025-01-28 | 苏州宜联生物医药有限公司 | 一种吲哚-2-酮衍生物、其抗体药物偶联物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2258505A1 (de) * | 1971-12-02 | 1973-06-07 | Ciba Geigy Ag | Oxindoldiamine und verfahren zu ihrer herstellung |
| ES426436A1 (es) * | 1974-05-18 | 1976-07-01 | Andreu Sa Dr | Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona. |
| JPS5590943A (en) * | 1978-12-28 | 1980-07-10 | Fuji Photo Film Co Ltd | Photosensitive material and image forming method applicable thereto |
| DE3510730A1 (de) * | 1985-03-08 | 1986-09-11 | Möve-Werk GmbH & Co KG, 7410 Reutlingen | Verfahren zur herstellung eines baumwollgewebes |
| NZ505279A (en) * | 1997-11-20 | 2003-10-31 | Nuchem Pharmaceuticals Inc | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation |
| US6800658B2 (en) * | 1997-11-20 | 2004-10-05 | Children's Medical Center Corporation | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation |
| US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| US7250442B2 (en) * | 2002-03-15 | 2007-07-31 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
| EP1718611A4 (en) * | 2004-02-13 | 2009-09-23 | Harvard College | 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION |
-
2005
- 2005-04-08 US US10/599,121 patent/US20070299102A1/en not_active Abandoned
- 2005-04-08 WO PCT/DK2005/000244 patent/WO2005097107A2/en not_active Ceased
- 2005-04-08 BR BRPI0509745-2A patent/BRPI0509745A/pt not_active IP Right Cessation
- 2005-04-08 EP EP05715161A patent/EP1734951A2/en not_active Withdrawn
- 2005-04-08 CA CA002562399A patent/CA2562399A1/en not_active Abandoned
- 2005-04-08 KR KR1020067023439A patent/KR20060130781A/ko not_active Ceased
- 2005-04-08 EA EA200601879A patent/EA013209B1/ru not_active IP Right Cessation
- 2005-04-08 CN CNA2005800102502A patent/CN1953747A/zh active Pending
- 2005-04-08 AU AU2005230232A patent/AU2005230232A1/en not_active Abandoned
- 2005-04-08 NZ NZ550222A patent/NZ550222A/en unknown
- 2005-04-08 JP JP2007506660A patent/JP2007532496A/ja active Pending
-
2006
- 2006-09-11 IL IL178012A patent/IL178012A0/en unknown
- 2006-10-05 CR CR8673A patent/CR8673A/es not_active Application Discontinuation
- 2006-10-10 EC EC2006006913A patent/ECSP066913A/es unknown
- 2006-11-02 NO NO20065034A patent/NO20065034L/no not_active Application Discontinuation
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