JP2007531731A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007531731A5 JP2007531731A5 JP2007506319A JP2007506319A JP2007531731A5 JP 2007531731 A5 JP2007531731 A5 JP 2007531731A5 JP 2007506319 A JP2007506319 A JP 2007506319A JP 2007506319 A JP2007506319 A JP 2007506319A JP 2007531731 A5 JP2007531731 A5 JP 2007531731A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- formula
- independently
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C1=CC=CC=I1 Chemical compound C*C1=CC=CC=I1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55940504P | 2004-04-01 | 2004-04-01 | |
| US58699204P | 2004-07-08 | 2004-07-08 | |
| US60/586,992 | 2004-07-08 | ||
| PCT/US2005/011124 WO2005094897A2 (en) | 2004-04-01 | 2005-03-31 | Pegylated ion channel modulating compounds |
| US60/559,405 | 2005-04-01 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008088707A Division JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
| JP2008088708A Division JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007531731A JP2007531731A (ja) | 2007-11-08 |
| JP2007531731A5 true JP2007531731A5 (https=) | 2008-05-15 |
| JP4991037B2 JP4991037B2 (ja) | 2012-08-01 |
Family
ID=34972985
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506319A Expired - Fee Related JP4991037B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物を含む薬物結合体 |
| JP2007506547A Expired - Fee Related JP4954864B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物のプロドラッグおよびその使用 |
| JP2008088708A Pending JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
| JP2008088707A Pending JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506547A Expired - Fee Related JP4954864B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物のプロドラッグおよびその使用 |
| JP2008088708A Pending JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
| JP2008088707A Pending JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7786119B2 (https=) |
| EP (1) | EP1729814A2 (https=) |
| JP (4) | JP4991037B2 (https=) |
| CA (1) | CA2561733A1 (https=) |
| MX (1) | MXPA06011420A (https=) |
| WO (1) | WO2005094897A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| US7754897B2 (en) | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| MXPA06011419A (es) | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Profarmacos de compuestos moduladores de canales ionicos y usos de los mismos. |
| JP4991037B2 (ja) * | 2004-04-01 | 2012-08-01 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物を含む薬物結合体 |
| EP1828099B1 (en) | 2004-11-18 | 2020-01-22 | Correvio International Sàrl | Synthetic process for aminocyclohexyl ether compounds |
| JP2007131597A (ja) * | 2005-11-11 | 2007-05-31 | Toray Fine Chemicals Co Ltd | ベンジルオキシピロリジン誘導体の製造方法 |
| JP5004067B2 (ja) * | 2005-10-31 | 2012-08-22 | 東レ・ファインケミカル株式会社 | ベンジルオキシ含窒素環状化合物の製造法 |
| JP5004073B2 (ja) * | 2006-06-13 | 2012-08-22 | 東レ・ファインケミカル株式会社 | 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法 |
| CA2627502C (en) * | 2005-10-31 | 2014-04-01 | Toray Fine Chemicals Co., Ltd. | Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative |
| WO2008112287A1 (en) | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
| US8748648B2 (en) | 2007-09-06 | 2014-06-10 | Nektar Therapeutics | Oligomer-calcium channel blocker conjugates |
| WO2009089053A1 (en) * | 2008-01-11 | 2009-07-16 | Nektar Therapeutics Al, Corporation | Oligomer-guanidine class conjugates |
| JP5773877B2 (ja) * | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
| US20120010144A1 (en) * | 2009-04-03 | 2012-01-12 | Ragheb Assaly | Peg-albumin composition having at least one protected thiol region as a platform for medications |
| US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
| US9974759B2 (en) | 2013-05-31 | 2018-05-22 | Indiana University Research And Technology Corporation | Beta 2 adrenoceptor antagonists for treating orthostatic hypotension |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684728A (en) * | 1979-01-12 | 1987-08-04 | Bayer Aktiengesellschaft | Solubilizing biologically active compounds with reactive hydrogen atoms |
| IT1145362B (it) | 1980-03-06 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
| US5160734A (en) * | 1987-11-25 | 1992-11-03 | American Cyanamid Company | Sustained release delivery system for substituted dihydropyridine calcium channel blockers |
| ATE76292T1 (de) * | 1987-11-25 | 1992-06-15 | American Cyanamid Co | System fuer die verzoegerte (kontrollierte) freisetzung von substituierten dihydropyridincalciumantagonisten. |
| US20030186869A1 (en) | 1990-05-14 | 2003-10-02 | George Poiani | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US6517824B1 (en) | 1990-05-14 | 2003-02-11 | University Of Medicine & Denistry Of New Jersey | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US5219564A (en) | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
| US5244889A (en) | 1991-11-26 | 1993-09-14 | Ciba-Geigy Corporation | Certain macrocyclic lactam derivatives |
| US6217869B1 (en) | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
| US5298492A (en) | 1992-08-04 | 1994-03-29 | Schering Corporation | Diamino acid derivatives as antihypertensives |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US6191105B1 (en) | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
| JP3563738B2 (ja) | 1993-06-11 | 2004-09-08 | エーザイ株式会社 | アミノ酸誘導体 |
| DE69429524T2 (de) * | 1993-09-24 | 2002-08-08 | The University Of British Columbia, Vancouver | Aminocyclohexylester und ihre anwendung |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| DE69735057T2 (de) * | 1996-03-12 | 2006-08-31 | PG-TXL Co., L.P., Houston | Wasserlösliche paclitaxel-prodrogen |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| AU5194998A (en) | 1996-11-01 | 1998-05-29 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and uses therefor |
| EP0884325A1 (en) | 1997-04-24 | 1998-12-16 | Akzo Nobel N.V. | Thrombin inhibitors containing a peptidyl heterocycle |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| EP0991660B8 (en) | 1997-10-08 | 2006-04-05 | Isotechnika,Inc. | DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS |
| CA2326777C (en) | 1998-04-01 | 2011-12-20 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
| CA2319142A1 (en) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel therapeutic agents for membrane transporters |
| EP1143896B1 (en) * | 1998-10-20 | 2006-12-13 | The University of North Carolina at Chapel Hill | Methods of hydrating the nasal mucosal surface |
| WO2000047547A2 (en) * | 1999-02-12 | 2000-08-17 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
| WO2000066110A1 (en) | 1999-04-29 | 2000-11-09 | Merck Patent Gmbh | Glycine cleavage system inhibitors as potential antipsychotics |
| CA2311483A1 (en) * | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
| WO2002028412A1 (en) | 2000-10-05 | 2002-04-11 | Zealand Pharmaceuticals A/S | Novel use of peptide |
| CA2422916A1 (en) * | 2000-09-26 | 2002-04-04 | The University Of Arizona Foundation | Compounds and methods for use thereof in the treatment of cancer or viral infections |
| JP2002105067A (ja) | 2000-09-28 | 2002-04-10 | Teijin Ltd | 2−フェニルチアゾール誘導体、およびそれを有効成分とする医薬組成物 |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US6631745B2 (en) | 2001-07-02 | 2003-10-14 | Fmc Technologies, Inc. | Riser pull-in method and apparatus |
| US6623729B2 (en) | 2001-07-09 | 2003-09-23 | Korea Advanced Institute Of Science And Technology | Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
| JP2005501052A (ja) | 2001-07-31 | 2005-01-13 | イムノメディクス, インコーポレイテッド | ポリマー送達系 |
| JP2003113084A (ja) | 2001-10-02 | 2003-04-18 | Mitsubishi Pharma Corp | 肺高血圧症の治療及び/または予防薬 |
| IL147953A (en) | 2002-02-01 | 2008-04-13 | Meir Bialer | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl- |
| TW200407310A (en) | 2002-06-07 | 2004-05-16 | Glaxo Group Ltd | Compounds |
| BR0312176A (pt) * | 2002-06-21 | 2005-04-05 | Suven Life Sciences Ltd | Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario |
| PL374781A1 (en) * | 2002-06-28 | 2005-10-31 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| WO2004014973A2 (en) | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
| WO2004082585A2 (en) | 2003-03-20 | 2004-09-30 | Sirus Pharmaceuticals Ltd | Water-soluble conjugates of phenytoin |
| WO2004098525A2 (en) | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| CA2524323C (en) | 2003-05-02 | 2012-05-15 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| KR100495009B1 (ko) | 2003-07-02 | 2005-06-14 | 삼성전자주식회사 | 화상형성 장치의 전사벨트 텐션 자동 인가 장치 |
| WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| WO2005079861A2 (en) * | 2004-02-13 | 2005-09-01 | Safeway Investments Ltd. | Polymeric water soluble prodrugs |
| MXPA06011419A (es) * | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Profarmacos de compuestos moduladores de canales ionicos y usos de los mismos. |
| WO2005097203A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Serum protein conjugates of ion channel modulating compounds and uses thereof |
| US7754897B2 (en) | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
| JP4991037B2 (ja) * | 2004-04-01 | 2012-08-01 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物を含む薬物結合体 |
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| US7845611B1 (en) * | 2007-11-16 | 2010-12-07 | Sholander Alfred M | Door operated page turner device, system and method for books |
-
2005
- 2005-03-31 JP JP2007506319A patent/JP4991037B2/ja not_active Expired - Fee Related
- 2005-03-31 EP EP05763506A patent/EP1729814A2/en not_active Withdrawn
- 2005-03-31 WO PCT/US2005/011124 patent/WO2005094897A2/en not_active Ceased
- 2005-03-31 JP JP2007506547A patent/JP4954864B2/ja not_active Expired - Fee Related
- 2005-03-31 US US11/547,419 patent/US7786119B2/en not_active Expired - Lifetime
- 2005-03-31 CA CA002561733A patent/CA2561733A1/en not_active Abandoned
- 2005-03-31 MX MXPA06011420A patent/MXPA06011420A/es unknown
-
2008
- 2008-03-28 JP JP2008088708A patent/JP2008214353A/ja active Pending
- 2008-03-28 JP JP2008088707A patent/JP2008179653A/ja active Pending
-
2010
- 2010-07-07 US US12/831,804 patent/US20100273724A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2007531731A5 (https=) | ||
| JP7398391B2 (ja) | N-[4-オキソ-2,3-ジヒドロ-1,5-ベンズオキサゼピン-3-イル]-5,6-ジヒドロ-4H-ピロロ[1,2-b]ピラゾール-2-カルボキサミド誘導体及び例えば過敏性腸症候群(IBS)を処置するためのRIP1キナーゼ阻害剤としての関連化合物 | |
| JP7759877B2 (ja) | 治療用化合物 | |
| ES2620446T3 (es) | Nuevo compuesto heterocíclico bicíclico | |
| JP5387997B2 (ja) | 血管の収縮または拡張による疾患治療剤 | |
| JP6760249B2 (ja) | 三環性スピロ化合物 | |
| BR112019012688A2 (pt) | método para produção de derivado de 7h-pirrol[2,3-d]pirimidina e intermediário sintético do mesmo | |
| KR940007021A (ko) | 흥분성 아미노산 수용체 길항물질 | |
| US10555951B2 (en) | Targeted treatment of leiomyosarcoma | |
| JP2007531766A5 (https=) | ||
| CN108366979B (zh) | 与泛素化-蛋白酶体系统有关的化合物及医药组合物 | |
| JP2005531516A5 (https=) | ||
| JP2005504011A5 (https=) | ||
| JP2006504621A5 (https=) | ||
| JP2013529619A (ja) | タンパク質キナーゼ阻害剤としてのヘテロアリール化合物および組成物 | |
| WO2014047393A1 (en) | N-substituted bis(fluoroalkyl)-1,4-benzodiazepinone compounds as notch inhibitors | |
| CN112638376B (zh) | 取代的四氢环戊二烯并[c]吡咯、取代的二氢吡咯嗪、其类似物和其使用方法 | |
| WO2006043655A1 (ja) | 吸入用医薬組成物 | |
| ES2609459T3 (es) | Compuestos heterocíclicos condensados y su uso | |
| JP6922712B2 (ja) | 医薬用途 | |
| KR20230117574A (ko) | 암 치료를 위한 metap2 억제제 및 cdk4/6 억제제의 조합 | |
| MX2024010403A (es) | Derivado de imidazopiridazina, y método de preparación del mismo, composición farmacéutica del mismo y uso del mismo | |
| CA3157778A1 (en) | Substituted isoindolonyl 2,2'-bipyrimidinyl compounds, analogues thereof, and methods using same | |
| TW201805267A (zh) | 與泛素化-蛋白酶體系統有關之化合物及醫藥組合物 | |
| JP7713954B2 (ja) | 核内受容体に対して活性な化合物 |