JP2005531516A5 - - Google Patents
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- Publication number
- JP2005531516A5 JP2005531516A5 JP2003575963A JP2003575963A JP2005531516A5 JP 2005531516 A5 JP2005531516 A5 JP 2005531516A5 JP 2003575963 A JP2003575963 A JP 2003575963A JP 2003575963 A JP2003575963 A JP 2003575963A JP 2005531516 A5 JP2005531516 A5 JP 2005531516A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- prodrug
- alkoxy
- selective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 ***CCN(*CC1)C1=O Chemical compound ***CCN(*CC1)C1=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36571102P | 2002-03-18 | 2002-03-18 | |
| PCT/IB2003/000844 WO2003077910A1 (en) | 2002-03-18 | 2003-03-06 | Methods of treatment with selective ep4 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005531516A JP2005531516A (ja) | 2005-10-20 |
| JP2005531516A5 true JP2005531516A5 (https=) | 2006-03-23 |
Family
ID=28042041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003575963A Withdrawn JP2005531516A (ja) | 2002-03-18 | 2003-03-06 | 選択的ｅｐ４受容体アゴニストによる治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7414071B2 (https=) |
| EP (1) | EP1487437B1 (https=) |
| JP (1) | JP2005531516A (https=) |
| AT (1) | ATE336247T1 (https=) |
| AU (1) | AU2003207900A1 (https=) |
| BR (1) | BR0308738A (https=) |
| CA (1) | CA2478653A1 (https=) |
| DE (1) | DE60307607T2 (https=) |
| ES (1) | ES2268327T3 (https=) |
| MX (1) | MXPA04005555A (https=) |
| TW (1) | TW200304816A (https=) |
| WO (1) | WO2003077910A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4834224B2 (ja) | 1999-03-05 | 2011-12-14 | デューク ユニバーシティ | Ｃ１６不飽和ｆｐ−選択的プロスタグランジン類縁体 |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US6573294B1 (en) * | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| AU2011202937B2 (en) * | 2002-05-14 | 2012-06-07 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| GB0219143D0 (en) * | 2002-08-16 | 2002-09-25 | Univ Leicester | Modified tailed oligonucleotides |
| US7256211B1 (en) | 2003-01-21 | 2007-08-14 | Ono Pharmaceutical Co., Ltd. | 8-azaprostaglandin derivatives and medical use thereof |
| US6734206B1 (en) * | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| WO2005053683A1 (en) | 2003-11-26 | 2005-06-16 | Duke University | A method of preventing or treating glaucoma |
| ATE550323T1 (de) * | 2004-06-04 | 2012-04-15 | Allergan Inc | Piperidinyl-prostaglandinanaloga als den augeninnendruck senkende mittel |
| ES2282062T1 (es) | 2004-06-04 | 2007-10-16 | Teva Pharmaceutical Industries Ltd. | Composicion farmaceutica que contiene irbesartan. |
| AU2005299473B2 (en) * | 2004-10-26 | 2012-06-28 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin EP4 agonists |
| WO2006052893A2 (en) | 2004-11-08 | 2006-05-18 | Allergan, Inc. | Substituted pyrrolidone compounds as ep4 agonists |
| BRPI0611257A2 (pt) * | 2005-05-06 | 2010-08-24 | Allergan Inc | beta-lactamas substituÍdas e uso em medicina do mesmo |
| WO2006121822A1 (en) * | 2005-05-06 | 2006-11-16 | Allergan, Inc. | USE OF β-LACTAMS FOR THE TREATMENTOF IBD AND GLAUCOMA |
| US7674786B2 (en) | 2005-05-06 | 2010-03-09 | Allergan, Inc. | Therapeutic β-lactams |
| US7893107B2 (en) * | 2005-11-30 | 2011-02-22 | Allergan, Inc. | Therapeutic methods using prostaglandin EP4 agonist components |
| UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| WO2008058766A1 (en) | 2006-11-16 | 2008-05-22 | Bayer Schering Pharma Aktiengesellschaft | Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection |
| US20080167377A1 (en) | 2006-12-15 | 2008-07-10 | Alessandra Gaiba | Novel compounds |
| GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
| US8063033B2 (en) * | 2008-01-18 | 2011-11-22 | Allergan, Inc. | Therapeutic beta-lactams |
| US8202855B2 (en) | 2008-03-04 | 2012-06-19 | Allergan, Inc | Substituted beta-lactams |
| EP2149551A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors |
| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| WO2010116270A1 (en) | 2009-04-10 | 2010-10-14 | Pfizer Inc. | Ep2/4 agonists |
| AR091429A1 (es) | 2012-06-29 | 2015-02-04 | Lilly Co Eli | Compuestos de fenoxietil piperidina |
| WO2014015247A1 (en) | 2012-07-19 | 2014-01-23 | Cayman Chemical Company, Inc. | Difluorolactam compounds as ep4 receptor-selective agonists for use in the treatment of ep4-mediated disease and conditions |
| US9676712B2 (en) | 2013-03-15 | 2017-06-13 | Cayman Chemical Company, Inc. | Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions |
| PT2989098T (pt) | 2013-03-15 | 2017-08-16 | Cayman Chemical Co Inc | Compostos de lactama como agonistas selectivos do receptor ep4 para uso no tratamento de doenças e condições mediadas por ep4 |
| CA2903314C (en) | 2013-03-15 | 2023-02-14 | Cayman Chemical Company, Inc. | Methods of synthesizing a difluorolactam analog |
| KR20160048054A (ko) | 2013-07-19 | 2016-05-03 | 카이맨 케미칼 컴파니 인코포레이티드 | 골 성장의 촉진을 위한 방법, 시스템 및 조성물 |
| ME02896B (me) | 2013-12-17 | 2018-04-20 | Lilly Co Eli | Fenoksietilni derivati prstenastog amina i njihova aktivnost kao modulatora receptora ep4 |
| US9540357B1 (en) * | 2014-07-31 | 2017-01-10 | Allergan, Inc. | 15-aryl prostaglandins as EP4 agonists, and methods of use thereof |
| CN114259992B (zh) * | 2021-12-23 | 2023-06-27 | 复旦大学 | 正离子超分子有机框架固体材料在吸附生物毒素中的应用 |
| GB202211232D0 (en) | 2022-08-02 | 2022-09-14 | Heptares Therapeutics Ltd | Prostaglandin EP4 receptor agonist compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113873A (en) * | 1975-04-26 | 1978-09-12 | Tanabe Seiyaku Co. Ltd. | 8-azaprostanoic acid derivatives |
| DE2528664A1 (de) * | 1975-06-27 | 1977-01-13 | Hoechst Ag | Pyrrolidone und verfahren zu ihrer herstellung |
| US4177346A (en) * | 1976-08-06 | 1979-12-04 | Pfizer Inc. | 1,5-Disubstituted-2-pyrrolidones |
| SE423813B (sv) * | 1976-08-06 | 1982-06-07 | Pfizer | Forfarande for framstellning av 1,5-disubstituerade pyrrolidoner med terapeutiska egenskaper |
| AU2211700A (en) * | 1998-12-24 | 2000-07-31 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of glaucoma |
| AU2001290250A1 (en) * | 2000-09-21 | 2002-04-02 | Ono Pharmaceutical Co. Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| OA12533A (en) * | 2000-11-27 | 2006-06-05 | Pfizer Prod Inc | Ep4 receptor selective agonists in the treatment of osteoporosis. |
| US20040254230A1 (en) * | 2001-12-03 | 2004-12-16 | Ogidigben Miller J. | Method for treating ocular hypertension |
-
2003
- 2003-03-06 WO PCT/IB2003/000844 patent/WO2003077910A1/en not_active Ceased
- 2003-03-06 AU AU2003207900A patent/AU2003207900A1/en not_active Abandoned
- 2003-03-06 CA CA002478653A patent/CA2478653A1/en not_active Abandoned
- 2003-03-06 MX MXPA04005555A patent/MXPA04005555A/es unknown
- 2003-03-06 JP JP2003575963A patent/JP2005531516A/ja not_active Withdrawn
- 2003-03-06 ES ES03704902T patent/ES2268327T3/es not_active Expired - Lifetime
- 2003-03-06 DE DE60307607T patent/DE60307607T2/de not_active Expired - Fee Related
- 2003-03-06 AT AT03704902T patent/ATE336247T1/de not_active IP Right Cessation
- 2003-03-06 EP EP03704902A patent/EP1487437B1/en not_active Expired - Lifetime
- 2003-03-06 BR BR0308738A patent/BR0308738A/pt not_active IP Right Cessation
- 2003-03-11 US US10/386,307 patent/US7414071B2/en not_active Expired - Fee Related
- 2003-03-17 TW TW092105829A patent/TW200304816A/zh unknown
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