JP2007515468A5 - - Google Patents
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- Publication number
- JP2007515468A5 JP2007515468A5 JP2006546356A JP2006546356A JP2007515468A5 JP 2007515468 A5 JP2007515468 A5 JP 2007515468A5 JP 2006546356 A JP2006546356 A JP 2006546356A JP 2006546356 A JP2006546356 A JP 2006546356A JP 2007515468 A5 JP2007515468 A5 JP 2007515468A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- triazol
- het
- chloro
- nitrogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 22
- 229910052717 sulfur Inorganic materials 0.000 claims 20
- 125000004430 oxygen atom Chemical group O* 0.000 claims 19
- 125000004434 sulfur atom Chemical group 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 208000005171 Dysmenorrhea Diseases 0.000 claims 6
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- -1 SR 6 Inorganic materials 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 208000001362 Fetal Growth Retardation Diseases 0.000 claims 2
- 206010070531 Foetal growth restriction Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000029422 Hypernatremia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 206010030113 Oedema Diseases 0.000 claims 2
- 208000005107 Premature Birth Diseases 0.000 claims 2
- 206010036590 Premature baby Diseases 0.000 claims 2
- 208000003782 Raynaud disease Diseases 0.000 claims 2
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 2
- 206010047700 Vomiting Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000030941 fetal growth restriction Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000037805 labour Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000003152 motion sickness Diseases 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 206010036596 premature ejaculation Diseases 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- XHPHSOZYGISEAZ-UHFFFAOYSA-N (3-chloro-2-fluorophenyl)-[4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]methanone Chemical compound FC1=C(Cl)C=CC=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 XHPHSOZYGISEAZ-UHFFFAOYSA-N 0.000 claims 1
- UBFDBZJSKMAZDG-UHFFFAOYSA-N (3-chloro-4-fluorophenyl)-[4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]methanone Chemical compound C1=C(Cl)C(F)=CC=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 UBFDBZJSKMAZDG-UHFFFAOYSA-N 0.000 claims 1
- FLZIDSRGIJIVFN-UHFFFAOYSA-N (3-chloro-5-fluorophenyl)-[4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]methanone Chemical compound FC1=CC(Cl)=CC(C(=O)N2CCC(CC2)C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)=C1 FLZIDSRGIJIVFN-UHFFFAOYSA-N 0.000 claims 1
- PVYZGGMIFZFKCP-UHFFFAOYSA-N (3-chlorophenyl)-[4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]methanone Chemical compound C1=CC(Cl)=CC=C1N1C(C2CCN(CC2)C(=O)C=2C=C(Cl)C=CC=2)=NN=C1CN1N=CC=N1 PVYZGGMIFZFKCP-UHFFFAOYSA-N 0.000 claims 1
- MIUBKEKUTWHZMT-UHFFFAOYSA-N (4-chlorophenyl)-[4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]methanone Chemical compound C1=CC(Cl)=CC=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 MIUBKEKUTWHZMT-UHFFFAOYSA-N 0.000 claims 1
- MFTSQXXMRGCCKB-UHFFFAOYSA-N (5-chloro-2-fluorophenyl)-[4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]methanone Chemical compound FC1=CC=C(Cl)C=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 MFTSQXXMRGCCKB-UHFFFAOYSA-N 0.000 claims 1
- 229940124638 COX inhibitor Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 1
- 229930064664 L-arginine Natural products 0.000 claims 1
- 235000014852 L-arginine Nutrition 0.000 claims 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- YKQKOLQUEUZSHC-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-(1h-indazol-3-yl)methanone Chemical compound C1=CC(Cl)=CC=C1N1C(C2CCN(CC2)C(=O)C=2C3=CC=CC=C3NN=2)=NN=C1CN1N=CC=N1 YKQKOLQUEUZSHC-UHFFFAOYSA-N 0.000 claims 1
- BNZQOEAHHLSUEW-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-(2,3-difluorophenyl)methanone Chemical compound FC1=CC=CC(C(=O)N2CCC(CC2)C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)=C1F BNZQOEAHHLSUEW-UHFFFAOYSA-N 0.000 claims 1
- NFLMENLIEHOARN-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-(3,5-difluorophenyl)methanone Chemical compound FC1=CC(F)=CC(C(=O)N2CCC(CC2)C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)=C1 NFLMENLIEHOARN-UHFFFAOYSA-N 0.000 claims 1
- VLIXGVJICOKWRC-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-(3-fluorophenyl)methanone Chemical compound FC1=CC=CC(C(=O)N2CCC(CC2)C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)=C1 VLIXGVJICOKWRC-UHFFFAOYSA-N 0.000 claims 1
- IYULYXZKQXAJRY-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-[2-(trifluoromethyl)phenyl]methanone Chemical compound FC(F)(F)C1=CC=CC=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 IYULYXZKQXAJRY-UHFFFAOYSA-N 0.000 claims 1
- BFPGAZVFSBGHKU-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-[3-(trifluoromethyl)phenyl]methanone Chemical compound FC(F)(F)C1=CC=CC(C(=O)N2CCC(CC2)C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)=C1 BFPGAZVFSBGHKU-UHFFFAOYSA-N 0.000 claims 1
- JBWXOKPIDBBFMY-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-[4-(difluoromethyl)phenyl]methanone Chemical compound C1=CC(C(F)F)=CC=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 JBWXOKPIDBBFMY-UHFFFAOYSA-N 0.000 claims 1
- QMDDAYQXHTVIDU-UHFFFAOYSA-N [4-[4-(4-chlorophenyl)-5-(triazol-2-ylmethyl)-1,2,4-triazol-3-yl]piperidin-1-yl]-[4-(trifluoromethyl)phenyl]methanone Chemical compound C1=CC(C(F)(F)F)=CC=C1C(=O)N1CCC(C=2N(C(CN3N=CC=N3)=NN=2)C=2C=CC(Cl)=CC=2)CC1 QMDDAYQXHTVIDU-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000002840 nitric oxide donor Substances 0.000 claims 1
- 229940127234 oral contraceptive Drugs 0.000 claims 1
- 239000003539 oral contraceptive agent Substances 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0329693A GB0329693D0 (en) | 2003-12-22 | 2003-12-22 | Compounds useful in therapy |
| GB0329693.6 | 2003-12-22 | ||
| GB0408789A GB0408789D0 (en) | 2004-04-20 | 2004-04-20 | Triazole derivatives |
| GB0408789.6 | 2004-04-20 | ||
| PCT/IB2004/004059 WO2005063754A1 (en) | 2003-12-22 | 2004-12-09 | Triazole derivatives as vasopressin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007515468A JP2007515468A (ja) | 2007-06-14 |
| JP2007515468A5 true JP2007515468A5 (https=) | 2008-01-24 |
| JP4698604B2 JP4698604B2 (ja) | 2011-06-08 |
Family
ID=34740750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006546356A Expired - Fee Related JP4698604B2 (ja) | 2003-12-22 | 2004-12-09 | バソプレシン・アンタゴニストとしてのトリアゾール誘導体 |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1701959A1 (https=) |
| JP (1) | JP4698604B2 (https=) |
| KR (1) | KR100854872B1 (https=) |
| AP (1) | AP2331A (https=) |
| AR (1) | AR047340A1 (https=) |
| AU (1) | AU2004309164B2 (https=) |
| BR (1) | BRPI0417267A (https=) |
| CA (1) | CA2551038C (https=) |
| CR (1) | CR8481A (https=) |
| DO (1) | DOP2004001062A (https=) |
| EA (1) | EA010132B1 (https=) |
| EC (1) | ECSP066647A (https=) |
| GE (1) | GEP20084571B (https=) |
| IL (1) | IL176349A (https=) |
| IS (1) | IS8472A (https=) |
| MA (1) | MA28393B1 (https=) |
| NL (1) | NL1027833C2 (https=) |
| NO (1) | NO20063380L (https=) |
| OA (1) | OA13347A (https=) |
| PA (1) | PA8620501A1 (https=) |
| PE (1) | PE20051051A1 (https=) |
| TW (1) | TWI287541B (https=) |
| UY (1) | UY28693A1 (https=) |
| WO (1) | WO2005063754A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2361872C2 (ru) | 2004-05-26 | 2009-07-20 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Циннамидное соединение |
| AU2005286647A1 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| BRPI0515500A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| DE602005019602D1 (de) | 2004-10-26 | 2010-04-08 | Eisai R&D Man Co Ltd | Amorphe form einer zimtsäureamidverbindung |
| AP2007004047A0 (en) | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| EP2392571A3 (en) * | 2005-07-29 | 2012-03-14 | F. Hoffmann-La Roche AG | Indol-3-yl-carbonyl-piperidin and piperazin derivatives |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| US7737141B2 (en) | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| DE602007006990D1 (de) * | 2006-12-07 | 2010-07-15 | Hoffmann La Roche | Spiropiperidinderivate als antagonisten des via-rezeptors |
| DE602007006989D1 (en) * | 2006-12-07 | 2010-07-15 | Hoffmann La Roche | Spiropiperidinderivate |
| CN101563323B (zh) * | 2006-12-22 | 2012-07-04 | 弗·哈夫曼-拉罗切有限公司 | 螺-哌啶衍生物 |
| ATE486877T1 (de) * | 2006-12-29 | 2010-11-15 | Hoffmann La Roche | Azaspiroderivate |
| CL2008000582A1 (es) | 2007-02-28 | 2008-06-27 | Eisai R&D Man Co Ltd | Compuestos ciclicos derivados de oximorfolina condensados; farmacos que comprenden a dichos compuestos; y su uso para tratar enfermedad de alzheimer, demencia senil, sindrome de down o amiloidosis. |
| BRPI0815773A2 (pt) | 2007-08-31 | 2019-09-24 | Eisai R&D Man Co Ltd | composto, e, medicamento. |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| WO2010051245A1 (en) | 2008-11-03 | 2010-05-06 | Merck Sharp & Dohme Corp. | Benzimidazole and aza-benzimidazole carboxamides |
| PL2623499T3 (pl) | 2010-10-01 | 2015-09-30 | Taisho Pharmaceutical Co Ltd | Pochodne 1,2,4-triazolonu |
| US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| CA2932039A1 (en) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Bicyclic alkyl compounds and synthesis |
| CN113336653A (zh) | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| US10308609B2 (en) | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| EP3197891B1 (de) | 2014-09-24 | 2018-11-21 | Bayer Pharma Aktiengesellschaft | Faktor xia hemmende pyridobenzazepin- und pyridobenzazocin-derivate |
| SI3215498T1 (sl) | 2014-11-03 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Hidroksialkil-substituirani derivati feniltriazola in njihove uporabe |
| RU2637101C2 (ru) * | 2016-01-11 | 2017-11-29 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр вирусологии и микробиологии" (ФГБНУ ФИЦВиМ) | Устройство для определения аспирированной дозы аэрозолей |
| EP3419626A1 (en) * | 2016-02-23 | 2019-01-02 | Servicio Andaluz De Salud | Piperazine derivatives as antiviral agents with increased therapeutic activity |
| WO2017191115A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | Oxoalkyl-substituted phenyltriazole derivatives and uses thereof |
| AR108263A1 (es) | 2016-05-03 | 2018-08-01 | Bayer Pharma AG | Procedimiento para la preparación de derivados de 1-fenilo-1,2,4-triazol sustituidos por 5-hidroxialquilo |
| US9988367B2 (en) * | 2016-05-03 | 2018-06-05 | Bayer Pharma Aktiengesellschaft | Amide-substituted pyridinyltriazole derivatives and uses thereof |
| US20190119251A1 (en) | 2016-05-03 | 2019-04-25 | Bayer Pharma Aktiengesellschaft | Amide-substituted aryltriazole derivatives and uses thereof |
| EP3452469A1 (en) | 2016-05-03 | 2019-03-13 | Bayer Pharma Aktiengesellschaft | Fluoroalkyl-substituted aryltriazole derivatives and uses thereof |
| EP3452472A1 (en) | 2016-05-03 | 2019-03-13 | Bayer Aktiengesellschaft | Hydroxyalkyl-substituted heteroaryltriazole derivatives and uses thereof |
| JP6710273B2 (ja) * | 2016-05-09 | 2020-06-17 | 日本曹達株式会社 | 環状アミン化合物および有害生物防除剤 |
| WO2018073144A1 (en) | 2016-10-20 | 2018-04-26 | Bayer Pharma Aktiengesellschaft | Hydroxyalkyl-substituted triazole derivatives and uses thereof |
| US11242327B2 (en) | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
| EP3700896A1 (en) | 2017-10-24 | 2020-09-02 | Bayer Pharma Aktiengesellschaft | Amine substituted triazole derivatives and uses thereof |
| WO2019081303A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Pharma Aktiengesellschaft | SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF |
| EP3700900A1 (en) | 2017-10-24 | 2020-09-02 | Bayer Aktiengesellschaft | Substituted triazole derivatives and uses thereof |
| WO2019081291A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | PRODRUGS OF SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF |
| WO2019081306A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Pharma Aktiengesellschaft | SUBSTITUTED TRIAZOLE DERIVATIVES AND USES THEREOF |
| US20210253557A1 (en) | 2017-10-24 | 2021-08-19 | Bayer Pharma Aktiengesellschaft | Substituted triazole derivatives and uses thereof |
| PT3700913T (pt) | 2017-10-24 | 2022-01-31 | Bayer Pharma AG | Profármacos de derivados de triazol substituído e utilizações dos mesmos |
| TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物 |
| HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
| WO2021154966A1 (en) * | 2020-01-29 | 2021-08-05 | Kamari Pharma Ltd. | Compounds and compositions for use in treating skin disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481360A (en) * | 1983-08-26 | 1984-11-06 | The Upjohn Company | 4H-1,2,4-Triazol-3-yl compounds |
| WO2001058880A1 (en) * | 2000-02-08 | 2001-08-16 | Yamanouchi Pharmaceutical Co., Ltd. | Novel triazole derivatives |
| SK16242002A3 (sk) * | 2000-05-19 | 2003-04-01 | Merck Patent Gmbh | Derivát triazolu a farmaceutický prostriedok, ktorý ho obsahuje |
-
2004
- 2004-12-09 EA EA200600925A patent/EA010132B1/ru not_active IP Right Cessation
- 2004-12-09 CA CA2551038A patent/CA2551038C/en not_active Expired - Fee Related
- 2004-12-09 KR KR1020067012328A patent/KR100854872B1/ko not_active Expired - Fee Related
- 2004-12-09 WO PCT/IB2004/004059 patent/WO2005063754A1/en not_active Ceased
- 2004-12-09 JP JP2006546356A patent/JP4698604B2/ja not_active Expired - Fee Related
- 2004-12-09 AU AU2004309164A patent/AU2004309164B2/en not_active Ceased
- 2004-12-09 AP AP2006003631A patent/AP2331A/xx active
- 2004-12-09 OA OA1200600206A patent/OA13347A/en unknown
- 2004-12-09 EP EP04801354A patent/EP1701959A1/en not_active Withdrawn
- 2004-12-09 BR BRPI0417267-1A patent/BRPI0417267A/pt active Search and Examination
- 2004-12-09 GE GEAP20049469A patent/GEP20084571B/en unknown
- 2004-12-17 TW TW093139507A patent/TWI287541B/zh active
- 2004-12-21 UY UY28693A patent/UY28693A1/es unknown
- 2004-12-21 AR ARP040104826A patent/AR047340A1/es not_active Application Discontinuation
- 2004-12-21 NL NL1027833A patent/NL1027833C2/nl not_active IP Right Cessation
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2005
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- 2006-06-15 IL IL176349A patent/IL176349A/en not_active IP Right Cessation
- 2006-06-22 MA MA29125A patent/MA28393B1/fr unknown
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- 2006-07-21 NO NO20063380A patent/NO20063380L/no not_active Application Discontinuation
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