JP2007530722A5 - - Google Patents

Info

Publication number

JP2007530722A5

JP2007530722A5 JP2007504379A JP2007504379A JP2007530722A5 JP 2007530722 A5 JP2007530722 A5 JP 2007530722A5 JP 2007504379 A JP2007504379 A JP 2007504379A JP 2007504379 A JP2007504379 A JP 2007504379A JP 2007530722 A5 JP2007530722 A5 JP 2007530722A5

Authority

JP

Japan

Prior art keywords

heparin

permanganate

glycoserine

product

oxidation

Prior art date

2005-03-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 16
• 229960002897 heparin Drugs 0.000 claims description 15
• 229920000669 heparin Polymers 0.000 claims description 15
• 230000003647 oxidation Effects 0.000 claims description 5
• 238000007254 oxidation reaction Methods 0.000 claims description 5
• 239000012286 potassium permanganate Substances 0.000 claims description 3
• 238000000034 method Methods 0.000 claims 10
• 239000003055 low molecular weight heparin Substances 0.000 claims 2
• 229940127215 low-molecular weight heparin Drugs 0.000 claims 2
• JYLNVJYYQQXNEK-UHFFFAOYSA-N 3-amino-2-(4-chlorophenyl)-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(CN)C1=CC=C(Cl)C=C1 JYLNVJYYQQXNEK-UHFFFAOYSA-N 0.000 claims 1
• 229960000610 enoxaparin Drugs 0.000 claims 1
• 229960005153 enoxaparin sodium Drugs 0.000 claims 1
• 230000001590 oxidative effect Effects 0.000 claims 1
• 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
• CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 claims 1